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The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future

The Lancet 2021年第10311期398卷 1619-1662页

作者： Romanello, Marina McGushin, Alice Di Napoli, Claudia Drummond, Paul Hughes, Nick Jamart, Louis Kennard, Harry Lampard, Pete Solano Rodriguez, Baltazar Arnell, Nigel Ayeb-Karlsson, Sonja Belesova, Kristine Cai, Wenjia Campbell-Lendrum, Diarmid Capstick, Stuart Chambers, Jonathan Chu, Lingzhi Ciampi, Luisa Dalin, Carole Dasandi, Niheer Dasgupta, Shouro Davies, Michael Dominguez-Salas, Paula Dubrow, Robert Ebi, Kristie L Eckelman, Matthew Ekins, Paul Escobar, Luis E Georgeson, Lucien Grace, Delia Graham, Hilary Gunther, Samuel H Hartinger, Stella He, Kehan Heaviside, Clare Hess, Jeremy Hsu, Shih-Che Jankin, Slava Jimenez, Marcia P Kelman, Ilan Kiesewetter, Gregor Kinney, Patrick L Kjellstrom, Tord Kniveton, Dominic Lee, Jason K W Lemke, Bruno Liu, Yang Liu, Zhao Lott, Melissa Lowe, Rachel Martinez-Urtaza, Jaime Maslin, Mark McAllister, Lucy McMichael, Celia Mi, Zhifu Milner, James Minor, Kelton Mohajeri, Nahid Moradi-Lakeh, Maziar Morrissey, Karyn Munzert, Simon Murray, Kris A Neville, Tara Nilsson, Maria Obradovich, Nick Sewe, Maquins Odhiambo Oreszczyn, Tadj Otto, Matthias Owfi, Fereidoon Pearman, Olivia Pencheon, David Rabbaniha, Mahnaz Robinson, Elizabeth Rocklöv, Joacim Salas, Renee N Semenza, Jan C Sherman, Jodi Shi, Liuhua Springmann, Marco Tabatabaei, Meisam Taylor, Jonathon Trinanes, Joaquin Shumake-Guillemot, Joy Vu, Bryan Wagner, Fabian Wilkinson, Paul Winning, Matthew Yglesias, Marisol Zhang, Shihui Gong, Peng Montgomery, Hugh Costello, Anthony Hamilton, Ian Institute for Global Health University College London London UK United Kingdom Institute for Sustainable Resources University College London London UK United Kingdom UCL Energy Institute University College London London UK United Kingdom Institute for Environmental Design and Engineering University College London London UK United Kingdom Department of Geography University College London London UK United Kingdom The Bartlett School of Sustainable Construction University College London London UK United Kingdom Centre for Human Health and Performance University College London London UK United Kingdom School of Agriculture Policy and Development University of Reading Reading United Kingdom Department of Meteorology University of Reading Reading United Kingdom The Walker Institute University of Reading Reading United Kingdom Department of Health Sciences University of York York United Kingdom Institute for Environment and Human Security United Nations University Bonn Germany Centre on Climate Change and Planetary Health London School of Hygiene & Tropical Medicine London UK United Kingdom Centre for Mathematical Modelling of Infectious Diseases London School of Hygiene & Tropical Medicine London UK United Kingdom Department of Public Health Environments and Society London School of Hygiene & Tropical Medicine London UK United Kingdom Department of Earth System Science Tsinghua University Beijing China Department of Environment Climate Change and Health World Health Organization Geneva Switzerland Institute for Environmental Sciences World Health Organization Geneva Switzerland Centre for Climate Change and Social Transformations School of Psychology Cardiff University Cardiff United Kingdom Yale Center on Climate Change and Health Yale University New Haven CT United States School of Government University of Birmingham Birmingham United Kingdom Economic analysis of Climate Impacts and Policy Centro Euro-Mediterraneo sui Cambiamenti Climatic

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Decoding the Molecular Universe - Workshop Report

arXiv

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arXiv 2023年

作者： Metz, Thomas O. Adkins, Joshua N. Armentrout, Peter B. Chain, Patrick Chu, Fanny Corley, Courtney D. Cort, John R. Denis, Elizabeth Drell, Daniel Duncan, Katherine R. Ewing, Robert G. Fernandez, Facundo M. Fiehn, Oliver Garg, Neha Grimme, Stefan Henry, Christopher Hettich, Robert L. Kind, Tobias Linington, Roger G. Miller, Gary W. Northen, Trent Overdahl, Kirsten Patrinos, Ari Raftery, Daniel Rigor, Paul Smith, Richard D. Sobus, Jon Teeguarden, Justin Vertes, Akos Waters, Katrina Webb-Robertson, Bobbie-Jo Williams, Antony Wishart, David Biological Sciences Division Earth and Biological Sciences Directorate Pacific Northwest National Laboratory RichlandWA United States Department of Chemistry University of Utah Salt Lake CityUT United States Biosciences Division Chemical Earth and Life Sciences Directorate Los Alamos National Laboratory Los AlamosNM United States Nuclear Chemistry and Biology Division National Security Directorate Pacific Northwest National Laboratory RichlandWA United States AI and Data Analytics Division Pacific Northwest National Laboratory RichlandWA United States Office of Biological and Environmental Research U.S. Department of Energy WashingtonDC United States University of Strathclyde Strathclyde Institute of Pharmacy and Biomedical Sciences Glasgow United Kingdom School of Chemistry and Biochemistry Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology AtlantaGA United States University of California Davis West Coast Metabolomics Center DavisCA United States School of Chemistry and Biochemistry Petit Institute for Bioengineering and Bioscience Center for Microbial Dynamics and Infection Georgia Institute of Technology AtlantaGA United States Mulliken Center for Theoretical Chemistry Clausius Institute for Physical and Theoretical Chemistry University of Bonn Germany Data Science and Learning Division Argonne National Laboratory LemontIL United States Biosciences Division Oak Ridge National Laboratory Oak RidgeTN United States Enveda Biosciences BoulderCO United States Department of Chemistry Simon Fraser University BurnabyBC Canada Department of Environmental Health Sciences Mailman School of Public Health Columbia University New YorkNY United States Environmental Genomics and System Biology Division Lawrence Berkeley National Laboratory CA United States Metabolomics Core Facility National Institute of Environmental Health Sciences Research Triangle Park NC United States Novim Group Santa BarbaraCA United States Nor

On August 9-10, 2023, a workshop was convened at the Pacific Northwest National Laboratory (PNNL) in Richland, WA that brought together a group of internationally recognized experts in metabolomics, natural products discovery, chemical ecology, chemical and biological threat assessment, cheminformatics, computational chemistry, cloud computing, artificial intelligence, and novel technology development. These experts were invited to assess the value and feasibility of a grand-scale project to create new technologies that would allow the identification and quantification of all small molecules, or to "decode the molecular universe." The Decoding the Molecular Universe project would extend and complement the success of the Human Genome Project (HGP) by developing new capabilities and technologies to measure small molecules – defined as non-protein, non-polymer molecules less than ~1500 Daltons – of any origin and generated in biological systems or produced abiotically. The workshop was inspired by recognition that these new technologies would drive the next revolution in multiple fields of strategic importance to the nation: biological sciences, medical sciences, national security, chemistry, and the bio-economy. The workshop was supported by PNNL’s investment to advance the field of computational mass spectrometry in support of department of Energy and department of Homeland security missions via a project named the m/q Initiative. The workshop was modeled on similar workshops and related efforts held in the mid-1980s that were the catalyst for the HGP. Workshop participants and observers included representatives from academia, government agencies, industry, and national laboratories whose research involves or where the success of programs and mission areas depends heavily on the study or measurement of such small molecules. Primary motivations for the workshop were a nearly universal need – across scientific disciplines and applied and basic research domains – to ide

关键词： Proteins

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A rich ranking model based on the matthew effect optimization 7th

A rich ranking model based on the matthew effect optimizatio...

引用

7th International Conference on Computational data and Social Networks, CSoNet 2018

作者： Li, Jinzhong Liu, Guanjun Department of Computer Science and Technology College of Electronic and Information Engineering Jinggangshan University Ji’an343009 China Network and Data Security Key Laboratory of Sichuan Province University of Electronic Science and Technology of China Chengdu610054 China Department of Computer Science and Technology College of Electronic and Information Engineering Tongji University Shanghai201804 China Key Laboratory of Embedded System and Service Computing Ministry of Education Tongji University Shanghai201804 China

ISBN: (纸本)9783030046477

Most existing approaches of learning to rank treat the effectiveness of each query equally which results in a relatively lower ratio of queries with high effectiveness (i.e. rich queries) in the produced ranking model. Such ranking models need to be further optimized to increase the number of rich queries. In this paper, queries with different effectiveness are distinguished, and the queries with higher effectiveness are given higher weights. We modify the gradient in the LambdaMART algorithm based on a new perspective of Matthew effect to highlight the optimization of the rich queries and to produce the rich ranking model, and we present a consistency theorem for the modified optimization objective. Based on the effectiveness evaluation criteria for information retrieval, we introduce the Gini coefficient, mean-variance and quantity statistics to measure the performances of the ranking models. Experimental results show that the ranking models produced by the gradient-modified LambdaMART algorithm based on Matthew effect exhibit a stronger Matthew effect compared to the original LambdaMART algorithm. © Springer Nature Switzerland AG 2018.

关键词： Artificial intelligence

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A Multi-label Classifier for Human Protein Subcellular Localization Based on LSTM Networks

A Multi-label Classifier for Human Protein Subcellular Local...

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2018 International Conference on Advanced Control, Automation and Artificial Intelligence (ACAAI2018)

作者： Zhiying Gao Lijun Sun Zhihua Wei Department of Computer Science and Technology Tongji University Research Center of Big Data and Network Security Tongji University Key Laboratory of Embedded System and Service Computing Tongji University

Nowadays, with the increasing number of protein sequences all over the world, more and more people are paying their attention to predicting protein subcellular location. Since wet experiment is costly and time-consuming, the automatic computational methods are urgent. In this paper, we propose a variant model based on Long Short-Term Memory(LSTM) to predict protein subcellular location. In this model, we employ LSTM to capture long distance dependency features of the sequence data. Moreover, we adjust the loss function of the loss layer to solve multi-label classification problem. Experimental results demonstrate that, compared with the traditional machine learning methods, our method achieves the best performance in various evaluation metrics.

关键词： LSTM multi-label classification protein subcellular localization

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VulDeePecker: A deep learning-based system for vulnerability detection

arXiv

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arXiv 2018年

作者： Li, Zhen Zou, Deqing Xu, Shouhuai Ou, Xinyu Jin, Hai Wang, Sujuan Deng, Zhijun Zhong, Yuyi Services Computing Technology and System Lab Big Data Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Technology Huazhong University of Science and Technology School of Cyber Security and Computer Hebei University Shenzhen Huazhong University of Science and Technology Research Institute Department of Computer Science University of Texas at San Antonio

The automatic detection of software vulnerabilities is an important research problem. However, existing solutions to this problem rely on human experts to define features and often miss many vulnerabilities (i.e., incurring high false negative rate). In this paper, we initiate the study of using deep learning-based vulnerability detection to relieve human experts from the tedious and subjective task of manually defining features. Since deep learning is motivated to deal with problems that are very different from the problem of vulnerability detection, we need some guiding principles for applying deep learning to vulnerability detection. In particular, we need to find representations of software programs that are suitable for deep learning. For this purpose, we propose using code gadgets to represent programs and then transform them into vectors, where a code gadget is a number of (not necessarily consecutive) lines of code that are semantically related to each other. This leads to the design and implementation of a deep learning-based vulnerability detection system, called Vulnerability Deep Pecker (VulDeePecker). In order to evaluate VulDeePecker, we present the first vulnerability dataset for deep learning approaches. Experimental results show that VulDeePecker can achieve much fewer false negatives (with reasonable false positives) than other approaches. We further apply VulDeePecker to 3 software products (namely Xen, Seamonkey, and Libav) and detect 4 vulnerabilities, which are not reported in the National Vulnerability database but were "silently" patched by the vendors when releasing later versions of these products;in contrast, these vulnerabilities are almost entirely missed by the other vulnerability detection systems we experimented with. Copyright © 2018, The Authors. All rights reserved.

关键词： Computer software

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An Improved Convolutional Neural Network Algorithm for Multi-Label Classification

An Improved Convolutional Neural Network Algorithm for Multi...

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International Conference on Audio, Language and Image Processing, ICALIP

作者： Xinsheng Wang Lijun Sun Zhihua Wei Department of Computer Science and Technology Tongji University Shanghai China Research Center of Big Data and Network Security Tongji University Shanghai China Key Laboratory of Embedded System and Service Computing Tongji University Shanghai China

Recent years conventional neural network(CNN) has been applied to different natural language processing(NLP) tasks such as sentence classification, sentence modeling, etc. Some researchers use CNN to do multi-label classification but their work mainly focus on image rather than text. In this paper, we propose an improved CNN via hierarchical dirichlet process(HDP) model to deal with the multi-label classification problem in NLP. We first apply an HDP model to discard some words which are less important semantically. Then we use word embedding methods to transform words to vectors. Finally, we train CNN based on word vectors. Experimental results demonstrate that our method is superior to most traditional multi-label classification methods and TextCNN in terms of performance.

关键词： Feature extraction Training Convolutional neural networks Natural language processing Vocabulary Transforms

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Sysevr: A framework for using deep learning to detect software vulnerabilities

arXiv

引用

arXiv 2018年

作者： Li, Zhen Zou, Deqing Xu, Shouhuai Jin, Hai Zhu, Yawei Chen, Zhaoxuan Services Computing Technology and System Lab Cluster and Grid Computing Lab Big Data Security Engineering Research Center School of Computer Science and Technology Huazhong University of Science and Technology Wuhan430074 China Department of Computer Science University of Texas at San Antonio San AntonioTX78249 United States

The detection of software vulnerabilities (or vulnerabilities for short) is an important problem that has yet to be tackled, as manifested by many vulnerabilities reported on a daily basis. This calls for machine learning methods to automate vulnerability detection. Deep learning is attractive for this purpose because it does not require human experts to manually define features. Despite the tremendous success of deep learning in other domains, its applicability to vulnerability detection is not systematically understood. In order to fill this void, we propose the first systematic framework for using deep learning to detect vulnerabilities. The framework, dubbed Syntax-based, Semantics-based, and Vector Representations (SySeVR), focuses on obtaining program representations that can accommodate syntax and semantic information pertinent to vulnerabilities. Our experiments with 4 software products demonstrate the usefulness of the framework: we detect 15 vulnerabilities that are not reported in the National Vulnerability database. Among these 15 vulnerabilities, 7 are unknown and have been reported to the vendors, and the other 8 have been "silently" patched by the vendors when releasing newer versions of the products. Copyright © 2018, The Authors. All rights reserved.

关键词： Syntactics

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A second update on mapping the human genetic architecture of COVID-19

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Nature 2023年第7977期621卷 E7-E26页

作者： Masahiro Kanai Christine Stevens Benjamin M. Neale Mark Daly Andrea Ganna Amy Trankiem Mary K. Balaconis Samuli Ripatti Lindo Nkambul Mark J. Daly Sam Bryant Matthew Solomonson Shea J. Andrews Mattia Cordioli Juha Karjalainen Juha Mehtonen Matti Pirinen Andrea Corbetta Bradley Jermy Kati Donner Katja Kivinen Aarno Palotie Mari Kaunisto Kumar Veerapen Konrad J. Karczewski Alicia R. Martin Elizabeth G. Atkinson Kristin Tsuo Nikolas Baya Rahul Gupta Raymond K. Walters Duncan S. Palmer Gopal Sarma Nathan Cheng Wenhan Lu Claire Churchhouse Jacqueline I. Goldstein Daniel King Wei Zhou Cotton Seed Hilary Finucane F. Kyle Satterstrom Gita A. Pathak Akiko Iwasaki Karolina Chwialkowska Karolina Chwiałkowska Brooke N. Wolford Hajar Fauzan Ahmad Shea Andrews Kathrin Aprile von Hohenstaufen Puoti Palwende R. Boua Guillaume Butler-Laporte Celia M. T. Greenwood Bartha M. Knoppers Mark Lathrop Carmen L. Cadilla Francesca Colombo Nicole Dueker Chloe Kirk Atanu Kumar Dutta Yasser M. El-Sherbiny Jehan J. El-Jawhari Doaa Shahin Ahmed Elzeiny Tamer A. Mansour Madonna M. Eltoukhy Attia A. S. Mohamed Sahar Esmaeeli Annika Faucon Israel Fernández Cadenas Israel Fernandez-Cadenas Laia Llucià-Carol Natalia Cullell Elena Muiño Jara Cárcel-Márquez Margherita Francescatto Laurent Francioli Lindokuhle Nkambule Jatin Arora Soumya Raychaudhuri Caroline Cusick Lude Franke Macarena Fuentes Macarena Fuentes-Guajardo David Gómez Cabrero Emi N. Harry Philip Jansen József L. Szentpéteri Réka Várnai Elżbieta Kaja Athanasios Kousathanas Dorote Pasko Mark J. Caulfield Alex Stuckey Christopher A. Odhams Susan Walker Daniel Rhodes Richard H. Scott Loukas Moutsianas Afshan Siddiq Peter Goddard Sally Donovan Tala Zainy Fiona Maleady-Crowe Linda Todd Shahla Salehi Greg Elgar Georgia Chan Prabhu Arumugam Christine Patch Augusto Rendon Tom A. Fowler Jose E. Krieger Sanjay K. Patel Audrey Lemaçon Sophie Limou Pietro Lió Eirini Marouli Charles Hinds Minttu M. Marttila Carolina Medina-Gómez Isabelle Migeotte Soumyajit Mondal Andrés Moreno-Estrada Leire Moya Tomok Broad Institute of MIT and Harvard Cambridge MA USA Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Program in Bioinformatics and Integrative Genomics Harvard Medical School Boston MA USA Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland Institute for Molecular Medicine Finland University of Helsinki Helsinki Finland Institute for Molecular Medicine Finland (FIMM) HiLIFE University of Helsinki Helsinki Finland Public Health Faculty of Medicine University of Helsinki Helsinki Finland Analytic & Translational Genetics Unit Massachusetts General Hospital Boston MA USA Stanley Center for Psychiatric Research & Program in Medical and Population Genetics Cambridge UK Institute for Molecular Medicine Finland (FIMM) Univerisity of Helsinki Helsinki Finland University of California San Francisco San Francisco CA USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Program in Biological and Biomedical Sciences Harvard Medical School Boston MA USA Department of Psychiatry School of Medicine Yale University New Haven CT USA Veteran Affairs Connecticut Healthcare System West Haven CT USA Yale University New Haven CT USA Centre for Bioinformatics and Data Analysis Medical University of Bialystok Bialystok Poland Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Pahang Malaysia Icahn School of Medicine at Mount Sinai New York NY USA Genolier Innovation Network and Hub Swiss Medical Network Genolier Healthcare Campus Genolier Switzerland Immediate Independent Multidisciplinary Med & Biotech Research Association Milan Italy Clinical Research Unit of Nanor

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ROLE OF SIMULATION IN RAPID PROTOTYPING FOR CONCEPT DEVELOPMENT

引用

NAVAL ENGINEERS JOURNAL 1991年第3期103卷 204-211页

作者： KING, JF BARTON, DE J. Fred King:is the manager of the Advanced Technology Department for Unisys in Reston Virginia. He earned his Ph.D. in mathematics from the University of Houston in 1977. He has been principal investigator of research projects in knowledge engineering pattern recognition and heuristic problem-solving. Efforts include the development of a multi-temporal multispectral classifier for identifying graincrops using LANDSAT satellite imagery data for NASA. Also as a member of the research team for a NCI study with Baylor College of Medicine and NASA he helped develop techniques for detection of carcinoma using multispectral microphotometer scans of lung tissue. He established and became technical director of the AI Laboratory for Ford Aerospace where he developed expert scheduling modeling and knowledge acquisition systems for NASA. Since joining Unisys in 1985 he has led the development of object-oriented programming environments blackboard architectures data fusion techniques using neural networks and intelligent data base systems. Douglas E. Barton:is manager of Logistics Information Systems for Unisys in Reston Virginia. He earned his B.A. degree in computer science from the College of William and Mary in 1978 and did postgraduate work in London as a Drapers Company scholar. Since joining Unisys in 1981 his work has concentrated on program management and software engineering of large scale data base management systems and design and implementation of knowledge-based systems in planning and logistics. As chairman of the Logistics Data Subcommittee of the National Security Industrial Association (NSIA) he led an industry initiative which examined concepts in knowledge-based systems in military logistics. His responsibilities also include evaluation development and tailoring of software engineering standards and procedures for data base and knowledge-based systems. He is currently program manager of the Navigation Information Management System which provides support to the Fleet Ballistic Missile Progr

A valuable technique during concept development is rapid prototyping of software for key design components. This approach is particularly useful when the optimum design approach is not readily apparent or several known alternatives need to be rapidly evaluated. A problem inherent in rapid prototyping is the lack of a "target system" with which to interface. Some alternatives are to develop test driver libraries, integrate the prototype with an existing working simulator, or build one for the specific problem. This paper presents a unique approach to concept development using rapid prototyping for concept development and scenario-based simulation for concept verification. The rapid prototyping environment, derived from artificial intelligence technology, is based on a blackboard architecture. The rapid prototype simulation capability is provided through an object-oriented modeling environment. It is shown how both simulation and blackboard technologies are used collectively to rapidly gain insight into a tenacious problem. A specific example will be discussed where this approach was used to evolve the logic of a mission controller for an autonomous underwater vehicle.

关键词： Military Engineering

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COMPUTER-system ARCHITECTURE CONCEPTS FOR FUTURE COMBAT systemS

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NAVAL ENGINEERS JOURNAL 1990年第3期102卷 43-62页

作者： ZITZMAN, LH FALATKO, SM PAPACH, JL Dr. Lewis H. Zitzman:is the group supervisor of the Advanced Systems Design Group Fleet Systems Department The Johns Hopkins University Applied Physics Laboratory (JHU/APL). He has been employed at JHU/APL since 1972 performing applied research in computer science and in investigating and applying advanced computer technologies to Navy shipboard systems. He is currently chairman of Aegis Computer Architecture Data Bus and Fiber Optics Working Group from which many concepts for this paper were generated. Dr. Zitzman received his B.S. degree in physics from Brigham Young University in 1963 and his M.S. and Ph.D. degrees in physics from the University of Illinois in 1967 and 1972 respectively. Stephen M. Falatko:was a senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated for the majority of this effort. He is currently employed at ManTech Services Corporation. During his eight-year career first at The Johns Hopkins University Applied Physics Laboratory and currently with ManTech Mr. Falatko's work has centered around the development of requirements and specifications for future Navy systems and the application of advanced technology to Navy command and control systems. He is a member of both the Computer Architecture Fiber Optics and Data Bus Working Group and the Aegis Fiber Optics Working Group. Mr. Falatko received his B.S. degree in aerospace engineering with high distinction from the University of Virginia in 1982 and his M.S. degree in applied physics from The Johns Hopkins University in 1985. Mr. Falatko is a member of Tau Beta Pi Sigma Gamma Tau the American Society of Naval Engineers and the U.S. Naval Institute. Janet L. Papach:is a section leader and senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated. She has ten years' experience as an analyst supporting NavSea Spa War and the U.S. Department of State. She currently participates in working group efforts under Aegis Combat System Doctrin

This paper sets forth computer systems architecture concepts for the combat system of the 2010–2030 timeframe that satisfy the needs of the next generation of surface combatants. It builds upon the current Aegis computer systems architecture, expanding that architecture while preserving, and adhering to, the Aegis fundamental principle of thorough systems engineering, dedicated to maintaining a well integrated, highly reliable, and easily operable combat system. The implementation of these proposed computer systems concepts in a coherent architecture would support the future battle force capable combat system and allow the expansion necessary to accommodate evolutionary changes in both the threat environment and the technology then available to effectively counter that threat. Changes to the current Aegis computer architecture must be carefully and effectively managed such that the fleet will retain its combat readiness capability at all times. This paper describes a possible transition approach for evolving the current Aegis computer architecture to a general architecture for the future. The proposed computer systems architecture concepts encompass the use of combinations of physically distributed, microprocessor-based computers, collocated with the equipment they support or embedded within the equipment itself. They draw heavily on widely used and available industry standards, including instruction set architectures (ISAs), backplane busses, microprocessors, computer programming languages and development environments, and local area networks (LANs). In this proposal, LANs, based on fiber optics, will provide the interconnection to support system expandability, redundancy, and higher data throughput rates. A system of cross connected LANs will support a high level of combat system integration, spanning the major warfare areas, and will facilitate the coordination and development of a coherent multi-warfare tactical picture supporting the future combatant command st

关键词： Computer Architecture

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