Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
Due to recent expansion of wireless communications, it has become impossible to cope with the allotment of the precious spectrum while resources for wireless communication are bounded and finite. Hence, the cognitive ...
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Light clients implement a simple solution for Bitcoin’s scalability problem, as they do not store the entire blockchain but only the state of particular addresses of interest. To be able to keep track of the updated ...
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Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in ***,dynamic resource allocation and multi-connectivity can be adopt...
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Unmanned Aerial Vehicles(UAvs)as aerial base stations to provide communication services for ground users is a flexible and cost-effective paradigm in ***,dynamic resource allocation and multi-connectivity can be adopted to further harness the potentials of UAVs in improving communication capacity,in such situations such that the interference among users becomes a pivotal disincentive requiring effective *** this end,we investigate the Joint UAV-User Association,Channel Allocation,and transmission Power Control(J-UACAPC)problem in a multi-connectivity-enabled UAV network with constrained backhaul links,where each UAV can determine the reusable channels and transmission power to serve the selected ground *** goal was to mitigate co-channel interference while maximizing long-term system *** problem was modeled as a cooperative stochastic game with hybrid discrete-continuous action space.A Multi-Agent Hybrid Deep Reinforcement Learning(MAHDRL)algorithm was proposed to address this *** simulation results demonstrated the effectiveness of the proposed algorithm and showed that it has a higher system utility than the baseline methods.
Cyberbullying,a critical concern for digital safety,necessitates effective linguistic analysis tools that can navigate the complexities of language use in online *** tackle this challenge,our study introduces a new ap...
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Cyberbullying,a critical concern for digital safety,necessitates effective linguistic analysis tools that can navigate the complexities of language use in online *** tackle this challenge,our study introduces a new approach employing Bidirectional Encoder Representations from the Transformers(BERT)base model(cased),originally pretrained in *** model is uniquely adapted to recognize the intricate nuances of Arabic online communication,a key aspect often overlooked in conventional cyberbullying detection *** model is an end-to-end solution that has been fine-tuned on a diverse dataset of Arabic social media(SM)tweets showing a notable increase in detection accuracy and sensitivity compared to existing *** results on a diverse Arabic dataset collected from the‘X platform’demonstrate a notable increase in detection accuracy and sensitivity compared to existing methods.E-BERT shows a substantial improvement in performance,evidenced by an accuracy of 98.45%,precision of 99.17%,recall of 99.10%,and an F1 score of 99.14%.The proposed E-BERT not only addresses a critical gap in cyberbullying detection in Arabic online forums but also sets a precedent for applying cross-lingual pretrained models in regional language applications,offering a scalable and effective framework for enhancing online safety across Arabic-speaking communities.
Supply chain management and Hyperledger are two interconnected domains. They leverage blockchain technology to enhance efficiency, transparency, and security in supply chain operations. Together, they provide a decent...
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Coping with noise in computing is an important problem to consider in large systems. With applications in fault tolerance (Hastad et al., 1987;Pease et al., 1980;Pippenger et al., 1991), noisy sorting (Shah and Wainwr...
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Coping with noise in computing is an important problem to consider in large systems. With applications in fault tolerance (Hastad et al., 1987;Pease et al., 1980;Pippenger et al., 1991), noisy sorting (Shah and Wainwright, 2018;Agarwal et al., 2017;Falahatgar et al., 2017;Heckel et al., 2019;Wang et al., 2024a;Gu and Xu, 2023;Kunisky et al., 2024), noisy searching (Berlekamp, 1964;Horstein, 1963;Burnashev and Zigangirov, 1974;Pelc, 1989;Karp and Kleinberg, 2007), among many others, the goal is to devise algorithms with the minimum number of queries that are robust enough to detect and correct the errors that can happen during the computation. In this work, we consider the noisy computing of the threshold-k function. For n Boolean variables x = (x1, ..., xn) ∈ {0, 1}n, the threshold-k function THk(·) computes whether the number of 1's in x is at least k or not, i.e., (Equation presented) The noisy queries correspond to noisy readings of the bits, where at each time step, the agent queries one of the bits, and with probability p, the wrong value of the bit is returned. It is assumed that the constant p ∈ (0, 1/2) is known to the agent. Our goal is to characterize the optimal query complexity for computing the THk function with error probability at most δ. This model for noisy computation of the THk function has been studied by Feige et al. (1994), where the order of the optimal query complexity is established;however, the exact tight characterization of the optimal number of queries is still open. In this paper, our main contribution is tightening this gap by providing new upper and lower bounds for the computation of the THk function, which simultaneously improve the existing upper and lower bounds. The main result of this paper can be stated as follows: for any 1 ≤ k ≤ n, there exists an algorithm that computes the THk function with an error probability at most δ = o(1), and the algorithm uses at most (Equation presented) queries in expectation. Here we define m (Eq
Topology is usually perceived intrinsically immutable for a given *** argue that optical topologies do not immediately enjoy such ***'optical skyrmions'as an example,we show that they will exhibit varying text...
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Topology is usually perceived intrinsically immutable for a given *** argue that optical topologies do not immediately enjoy such ***'optical skyrmions'as an example,we show that they will exhibit varying textures and topological invariants(skyrmion numbers),depending on how to construct the skyrmion vector when projecting from real to parameter *** demonstrate the fragility of optical skyrmions under a ubiquitous scenario-simple reflection off an optical *** topology is not without benefit,but it must not be assumed.
Transition towards carbon-neutral power systems has necessitated optimization of power dispatch in active distribution networks(ADNs)to facilitate integration of distributed renewable *** to unavailability of network ...
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Transition towards carbon-neutral power systems has necessitated optimization of power dispatch in active distribution networks(ADNs)to facilitate integration of distributed renewable *** to unavailability of network topology and line impedance in many distribution networks,physical model-based methods may not be applicable to their *** tackle this challenge,some studies have proposed constraint learning,which replicates physical models by training a neural network to evaluate feasibility of a decision(i.e.,whether a decision satisfies all critical constraints or not).To ensure accuracy of this trained neural network,training set should contain sufficient feasible and infeasible ***,since ADNs are mostly operated in a normal status,only very few historical samples are ***,the historical dataset is highly imbalanced,which poses a significant obstacle to neural network *** address this issue,we propose an enhanced constraint learning ***,it leverages constraint learning to train a neural network as surrogate of ADN's ***,it introduces Synthetic Minority Oversampling Technique to generate infeasible samples to mitigate imbalance of historical *** incorporating historical and synthetic samples into the training set,we can significantly improve accuracy of neural ***,we establish a trust region to constrain and thereafter enhance reliability of the *** confirm the benefits of the proposed method in achieving desirable optimality and feasibility while maintaining low computational complexity.
Industrial cyber-physical systems closely integrate physical processes with cyberspace, enabling real-time exchange of various information about system dynamics, sensor outputs, and control decisions. The connection b...
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Industrial cyber-physical systems closely integrate physical processes with cyberspace, enabling real-time exchange of various information about system dynamics, sensor outputs, and control decisions. The connection between cyberspace and physical processes results in the exposure of industrial production information to unprecedented security risks. It is imperative to develop suitable strategies to ensure cyber security while meeting basic performance *** the perspective of control engineering, this review presents the most up-to-date results for privacy-preserving filtering,control, and optimization in industrial cyber-physical systems. Fashionable privacy-preserving strategies and mainstream evaluation metrics are first presented in a systematic manner for performance evaluation and engineering *** discussion discloses the impact of typical filtering algorithms on filtering performance, specifically for privacy-preserving Kalman filtering. Then, the latest development of industrial control is systematically investigated from consensus control of multi-agent systems, platoon control of autonomous vehicles as well as hierarchical control of power systems. The focus thereafter is on the latest privacy-preserving optimization algorithms in the framework of consensus and their applications in distributed economic dispatch issues and energy management of networked power systems. In the end, several topics for potential future research are highlighted.
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