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Fluidic intraocular lens with a large accommodation range

IEEE Photonics Technology Letters 2009年第5期21卷 304-306页

作者： Qiao, Wen Tsai, Frank S. Cho, Sung Hwan Yan, Huimin Lo, Yu-Hwa for Optical Instrument Zhejiang University Hangzhou 310027 China Department of Electrical and Computer Engineering Jacobs School of Engineering University of California San Diego CA 92093-0407 United States Materials Science and Engineering Program Jacobs School of Engineering University of California San Diego San DiegoCA 92093-0418 United States

Fluidic lenses with tunable focal distances were experimented in a human eye model as intraocular lenses (IOLs). Fluidic IOL shows superior performance to fixed or optic-shift accommodating IOLs because of their much wider accommodation range. Our results demonstrate that fluidic IOL can achieve an accommodation range of eight diopters, equivalent to the performance of young adults. Finite-element analysis shows that the required force for the fluidic IOL to achieve the desired amount of accommodation is comparable to the force generated from ciliary muscles of human eyes, as an initial indication that an implanted fluidic IOL may be controllable by eye muscles. © 2009 IEEE.

关键词： Intraocular lenses

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Fiber-to-bundle registration of white matter tracts

Fiber-to-bundle registration of white matter tracts

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Medical Imaging 2009 - Image Processing

作者： Xu, Qing Anderson, Adam W. Gore, John C. Ding, Zhaohua Vanderbilt University Institute of Imaging Science United States Department of Electrical Engineering and Computer Science Vanderbilt University United States Department of Biomedical Engineering Vanderbilt University United States Chemical and Physical Biology Program Vanderbilt University United States

ISBN: (纸本)9780819475107

Magnetic resonance diffusion tensor imaging (DTI) is being widely used to reconstruct brain white matter (WM) fiber tracts. For further characterization of the tracts, the fibers with similar courses often need to be grouped into a fiber bundle that corresponds to certain underlying WM anatomic structure. In addition, the alignments of fibers from different studies are often desirable for bundle comparisons and group analysis. In this work, a novel registration algorithm based on fiber-to-bundle matching was proposed to address the above two needs. Using an Expectation Maximization (EM) algorithm, the proposed method is capable of estimating a Thin-Plate- Spline transformation that optimally aligns whole-brain target fiber sets with a reference bundle model. Based on the resulting transformations, the fibers from different target datasets can all be warped into the reference coordinate system for comparisons and group analysis. The fibers can be further automatically labeled according to their similarity to the reference model. The algorithm was evaluated with eight human brain DTI data volumes acquired in vivo at 3T. After registration, the warped target bundles exhibit good similarity to the reference bundles. Quantitative experiments further demonstrated that the detected target bundles agree with ground truth obtained by manual segmentation at a sub-voxel accuracy. © 2009 Copyright SPIE - The International Society for Optical engineering.

关键词： Fibers

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Microstructural and pinning properties of YBa2Cu 307-δ thin films doped with magnetic nanoparticles

Microstructural and pinning properties of YBa2Cu 307-δ thin...

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作者： Wang, Jie Tsai, Chen-Fong Bi, Zhenxing Naugle, Donald G. Wang, Haiyan Department of Electrical and Computer Engineering Material Science and Engineering Program Texas A and M University College Station TX 77843 United States Department of Physics Texas A and M University College Station TX 77843 United States

In this paper, we report a strong enhancement in the in-field transport properties of the YBa2Cu307-δ (YBCO) thin films doped with magnetic Fe203 nanoparticles. We incorporated magnetic Fe2o3nanoparticles with two different architectures by laser ablation of the YBCO and dopant targets. YBCO film ' thickness was controlled at around 1 μm for all the samples. We conducted a detailed microstructural characterization on all the doped samples by X-ray diffraction (XRD) and cross-sectional transmission electron microscopy (TEM) and compared with the pure YBCO films. A systematic study on the superconducting properties has been conducted on all the thin film samples. The critical current densities at both self-field and in-field (Jcf and j in-field (h//c)) and the critical transition temperature (Tc) of the doped and un-doped YBCO sample were measured by a Superconducting Quantum Interference Device (SQUID). The Tc of the doped YBCO films varies from 84 K-90 K and the Jc is in the range of 1.2-3.9 MA/cm2 (at 65 K) depending on the doping approach. The pinning properties of these doped YBCO films were explored at different temperatures (5 K, 40 K, and 65 K) and correlated with their microstructural characteristics. © 2009 IEEE.

关键词： Nanoparticles

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System identification of magneto-rheological damper using group method of data handling (GMDH)

System identification of magneto-rheological damper using gr...

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2009 6th International Symposium on Mechatronics and its Applications, ISMA 2009

作者： Assaleh, Khaled Shanableh, Tamer Kheil, Yasmeen Abu Department of Electrical Engineering American University of Sharjah United Arab Emirates Department of Computer Science and Engineering American University of Sharjah United Arab Emirates Mechatronics Graduate Program American University of Sharjah United Arab Emirates

ISBN: (纸本)9781424434817

In this paper Group Method of Data Handling (GMDH) technique is implemented and applied to the system identification problem of a Magneto-Rheological (MR) damper. GMDH networks are used to approximate the forward and inverse dynamic behaviors of a MR damper. The difficulty of this identification problem stems from the inherent hysteretic and highly nonlinear dynamics of MR dampers. The GMDH-based solution exhibits comparable identification accuracy in both the forward and inverse models as compared to state-of-the-art more computationally extensive solutions. © 2009 IEEE.

关键词： Inverse problems

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Quantum Systems Connected by a Time-Dependent Canonical Transformation

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Communications in Theoretical Physics 2009年第9期52卷 416-420页

作者： Kyu Hwang Yeon Jeong Ryeol Choi ZHANG Shou BK21 Physics Program and Department of Physics College of Natural Science Chungbuk National University Cheongju Chungbuk 361-763 Korea School of Electrical Engineering and Computer Science Kyungpook National University 1370 Sankyuk-dong Buk-gu Daegu 702-701 Korea Center for the Condensed-Matter Science and Technology Harbin Institute of Technology Harbin 150001 China Department of Physics College of Science Yanbinn University Yanji 133002 China

We study both classical and quantum relation between two Hamiltonian systems which are mutually connected by time-dependent canonical transformation. One is ordinary conservative system and the other is timedependent Hamiltonian system. The quantum unitary operator relevant to classical canonical transformation between the two systems are obtained through rigorous evaluation. With the aid of the unitary operator, we have derived quantum states of the time-dependent Hamiltonian system through transforming the quantum states of the conservative system. The invariant operators of the two systems are presented and the relation between them are addressed. We showed that there exist numerous Hamiltonians, which gives the same classical equation of motion. Though it is impossible to distinguish the systems described by these Hamiltonians within the realm of classical mechanics, they can be distinguishable quantum mechanically.

关键词： canonical transformation innumerable kind of Hamiltonians canonical quantization invariant operator unitary transformation

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programmable neural processing on a smartdust

Programmable neural processing on a smartdust

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2009 46th ACM/IEEE Design Automation Conference, DAC 2009

作者： Shimeng, Huang Oresko, Joseph Yuwen, Sun Cheng, Allen C. Department of Electrical and Computer Engineering University of Pittsburgh Pittsburgh PA 15260 United States Department of BioEngineering University of Pittsburgh Pittsburgh PA 15260 United States Department of Neurological Surgery University of Pittsburgh Pittsburgh PA 15260 United States Department of Computer Science University of Pittsburgh Pittsburgh PA 15260 United States

ISBN: (纸本)9781605584973

To date, spike sorting for neural processing in brain-computer interfaces has been performed using off-chip analysis or custom ASIC designs. In this paper, we propose and test the feasibility of performing on-chip, real-time spike sorting on a commercially available and programmable smartdust wireless sensor network mote since such a platform is currently the closest to an implantable chip due to its small size and similar physical and environmental constraints. Copyright 2009 ACM.

关键词： Brain computer interface

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Predicting cardiovascular disease from real-time electrocardiographic monitoring: An adaptive machine learning approach on a cell phone

Predicting cardiovascular disease from real-time electrocard...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Zhanpeng Jin Yuwen Sun Allen C. Cheng Department of Electrical and Computer Engineering University of Pittsburgh Pittsburgh PA USA Departments of Electrical and Computer Engineering Bioengineering Neurological Surgery and Computer Science University of Pittsburgh Pittsburgh PA USA

To date, cardiovascular disease (CVD) is the leading cause of global death. The Electrocardiogram (ECG) is the most widely adopted clinical tool that measures the electrical activities of the heart from the body surface. However, heart rhythm irregularities cannot always be detected on a standard resting ECG machine, since they may not occur during an individual's recording session. Common Holter-based portable solutions that record ECG for up to 24 to 48 hours lack the capability to provide real-time feedback. In this research, we seek to establish a cell phone-based real-time monitoring technology for CVD, capable of performing continuous on-line ECG processing, generating a personalized cardiac health summary report in layman's language, automatically detecting and classifying abnormal CVD conditions, all in real time. Specifically, we developed an adaptive artificial neural network (ANN)-based machine learning technique, combining both an individual's cardiac characteristics and information from clinical ECG databases, to train the cell phone to learn to adapt to its user's physiological conditions to achieve better ECG feature extraction and more accurate CVD classification on cell phones.

关键词： Cardiovascular diseases Condition monitoring Machine learning Cellular phones Electrocardiography Heart Electric variables measurement Rhythm Neurofeedback computerized monitoring

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Autonomous microfluidic sensing device employing liquid crystal for detection of biological interactions

Autonomous microfluidic sensing device employing liquid crys...

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TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

作者： Cheng, D. Lin, I.H. Abbott, N.L. Jiang, H. Materials Science Program University of Wisconsin-Madison Madison WI United States Department of Chemical and Biological Engineering University of Wisconsin-Madison Madison WI United States Department of Electrical and Computer Engineering University of Wisconsin-Madison Madison WI United States

ISBN: (纸本)9781424441938

We report the design of an autonomous sensing device, which employs a thermotropic nematic liquid crystal (LC) to conduct chemical or biological sensing tasks. The development of highly reproducible methods to create uniform LC thin film is critical for utilizing LCs for sensing. Herein, we describe the use of shear forces generated by the laminar flow of liquid within a microfluidic channel to create thin LC films stabilized within microfabricated structures. The orientational response of the supported LC films to targeted analytes in aqueous phases was observed through changes in the optical birefringence of the LC thin films. Experiments employing two systems are reported: (i) dodecyl trimethylammonium bromide (DTAB) dissolved in aqueous solution, and (ii) the hydrolysis of phospholipids by the enzyme phospholipase A2 (PLA2). ©2009 IEEE.

关键词： Phospholipids

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Serendipitous discoveries in microarray analysis

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BMC Bioinformatics 2010年第4期11卷 1-1页

作者： Sally R Ellingson Charles A Phillips Michael A Langston Randy Glenn Douglas Swanson Thomas Ha Daniel Goldowitz Genome Science and Technology Program University of Tennessee Knoxville TN 37996 USA Department of Electrical Engineering and Computer Science University of Tennessee Knoxville TN 37996 USA Centre for Molecular Medicine and Therapeutics University of British Columbia Vancouver BC V5Z 4H4 Canada

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Multiscale modeling in rodent ventricular myocytes

Multiscale modeling in rodent ventricular myocytes

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作者： Lu, Shaoying Michailova, Anushka Saucerman, Jeffrey Cheng, Yuhui Yu, Zeyun Kaiser, Timothy Li, Wilfred Bank, Randolph Holst, Michael McCammon, J. Hayashi, Takeharu Hoshijima, Masahiko Arzberger, Peter McCulloch, Andrew Bioengineering Department University of Illinois United States Bioengineering Department UCSD United States Department of Biomedical Engineering University of Virginia United States Department of Mathematics UCSD United States UCSD United States College of Computer Science and Technology Jilin University China Department of Mathematics Center for Computational Mathematics and the Computational Science Mathematics and Engineering Doctoral Program at UCSD Department of Pharmacology UCSD United States Center for Research in Biological Systems UCSD United States Department of Bioengineering UCSD United States Department of Bioengineering PFBH 241 University of California San Diego 9500 Gilman Drive San Diego CA 92093-0412 United States

There is a growing body of experimental evidence suggesting that the Ca2+ signaling in ventricular myocytes is characterized by a high gradient near the cell membrane and a more uniform Ca2+ distribution in the cell interior [1]--[7]. An important reason for this phenomenon might be that in these cells the t-tubular system forms a network of extracellular space, extending deep into the cell interior. This allows the electrical signal, that propagates rapidly along the cell membrane, to reach the vicinity of the sarcoplasmic reticulum (SR), where intracellular Ca2+ required for myofilament activation is stored [1], [8]--[11]. Early studies of cardiac muscle showed that the t-tubules are found at intervals of about 2 lm along the longitudinal cell axis in close proximity to the Z-disks of the sarcomeres [12]. Subsequent studies have demonstrated that the t-tubular system has also longitudinal extensions [9]--[11], [13].

关键词： Cells

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