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Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts

Advanced Science 2025年第22期12卷 e2417003页

作者： Jin, Yifu He, Fei Rathore, Haad Sun, Yingchu Zhang, Jia-ao Li, Xinyu Yin, Rongkang Zhu, Hanlin Xie, Chong Luan, Lan Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Neuroengineering Initiative Rice University HoustonTX77005 United States Applied Physics Program Rice University HoustonTX77005 United States Department of Bioengineering Rice University HoustonTX77005 United States

Microinfarcts, the "invisible lesions", are prevalent in aged and injured brains and associated with cognitive impairments, yet their neurophysiological impact remains largely unknown. Using a multimodal chronic neural platform that combines functional microvasculature imaging with spatially resolved neural recording, the neurovascular effect of a single microinfarct is investigated. Unlike larger strokes, microinfarcts induced only temporary suppression of neural activity with minimal cell death, with recovery paralleling vasculature remodeling at the infarct core. Neural activity is more severely suppressed at the shallower cortical layer despite milder vascular damage compared to deeper layers, and the excitability of fast-spiking interneurons attenuation is accompanied by heightened bursting of regular spiking neurons. Spike phase locking at the low-gamma band is disrupted, indicating a lasting impairment of long-range assembly communication. These results highlight the subtle yet significant neurovascular disruptions of a single microinfarct. © 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH.

关键词： Flexible electronics

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Physics-based learned design for Fourier DiffuserScope

Physics-based learned design for Fourier DiffuserScope

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Computational Optical Sensing and Imaging, COSI 2021 - Part of OSA Imaging and Applied Optics Congress 2021

作者： Markley, Eric Liu, Fanglin Linda Kellman, Michael Antipa, Nick Waller, Laura UCB/UCSF Joint Graduate Program in Bioengineering University of California Berkeley United States Department of Electrical Engineering and Computer Sciences University of California Berkeley United States Department of Pharmaceutical Chemistry University of California San Francisco United States Department of Electrical and Computer Engineering University of California San Diego United States

We couple a differentiable forward model of diffuser-based single-shot 3D microscopy (Fourier DiffuserScope) with an invertible and differentiable reconstruction algorithm to jointly optimize the imaging system and th... 详细信息

ISBN: (纸本)9781557528209

关键词： Imaging systems

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GranatumX:A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 452-460页

作者： David G.Garmire Xun Zhu Aravind Mantravadi Qianhui Huang Breck Yunits Yu Liu Thomas Wolfgruber Olivier Poirion Tianying Zhao Cédric Arisdakessian Stefan Stanojevic Lana X.Garmire Department of Electrical Engineering&Computer Science University of MichiganAnn ArborMI 48109USA Epidemiology Program University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Biostatistics University of MichiganAnn ArborMI 48109USA Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48105USA Molecular Biosciences and Bioengineering Graduate Program University of Hawaii at ManoaHonoluluHI 96822USA

We present GranatumX,a next-generation software environment for single-cell RNA sequencing(scRNA-seq)data *** is inspired by the interactive webtool *** enables biologists to access the latest scRNA-seq bioinformatics methods in a web-based graphical *** also offers software developers the opportunity to rapidly promote their own tools with others in customizable *** architecture of GranatumX allows for easy inclusion of plugin modules,named Gboxes,which wrap around bioinformatics tools written in various programming languages and on various *** can be run on the cloud or private servers and generate reproducible *** is a community-engaging,flexible,and evolving software ecosystem for scRNA-seq analysis,connecting developers with bench *** is freely accessible at http://***/granatumx/app.

关键词： Single-cell RNA sequencing Analysis Pipeline Webtool Module

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Optimizing Marker Design to Improve Precision of Optical Camera-Based Rigid-Body Motion Tracking and Correction in Medical Imaging

Optimizing Marker Design to Improve Precision of Optical Cam...

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2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021

作者： Fisher, Jonathan Kim, Chris C. Groll, Andrew Levin, Craig S. Stanford University Department of Electrical Engineering CA United States Stanford University Department of Computer Science CA United States Stanford University Department of Radiology Molecular Imaging Program CA United States Bioengineering at Stanford University Department of Radiology and by Courtesy Physics Electrical Engineering CA United States

ISBN: (纸本)9781665421133

In this work we evaluated the performance of a camera-based rigid body motion correction solution using a 2D checkerboard marker and a 3D encoded marker. The context of the results presented is in PET/MR imaging, but in principle this motion compensation method could be used in any type of medical imaging modality. A high precision, computer-controlled motion stage with four degrees of freedom was used to control the marker positions and orientations (a.k.a. 'poses'). Still images of the markers taken in different poses mimicking a patient moving her/his head from side to side, were used to assess performance of this method. Comparing the known stage motion to the estimated motion, our results indicate that the 2D marker achieves better angular accuracy while the 3D marker's translational (linear) accuracy is superior. For all axes, the angular error was less than 0.96, 0.35 [deg], and the translational error was less than 2.24, 4.76 [mm] for the 3D and 2D markers, respectively. © 2021 IEEE.

关键词： Medical imaging

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Ultrathin-shell epitaxial Ag@Au core-shell nanowires for high-performance and chemically-stable electronic, optical, and mechanical devices

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Nano Research 2021年第11期14卷 4294-4303页

作者： Yangzhi Zhu Sanggon Kim Xuezhi Ma Peter Byrley Ning Yu Qiushi Liu Xiaoming Sun Da Xu Sangshan Peng Martin C.Hartel Shiming Zhang Vadim Jucaud Mehmet R.Dokmeci Ali Khademhosseini Ruoxue Yan Department of Chemical and Environmental Engineering Bourns College of EngineeringUniversity of California-RiversideRiversideCA92521USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA Department of Electrical and Computer Engineering University of California-RiversideRiversideCA92521USA State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Bioengineering University of California-Los AngelesLos AngelesCA90095USA Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina Material Science and Engineering Program University of California-RiversideRiversideCA92521USA

Silver nanowires (AgNWs) hold great promise for applications in wearable electronics, flexible solar cells, chemical and biological sensors, photonic/plasmonic circuits, and scanning probe microscopy (SPM) due to their unique plasmonic, mechanical, and electronic properties. However, the lifetime, reliability, and operating conditions of AgNW-based devices are significantly restricted by their poor chemical stability, limiting their commercial potentials. Therefore, it is crucial to create a reliable oxidation barrier on AgNWs that provides long-term chemical stability to various optical, electrical, and mechanical devices while maintaining their high performance. Here we report a room-temperature solution-phase approach to grow an ultra-thin, epitaxial gold coating on AgNWs to effectively shield the Ag surface from environmental oxidation. The Ag@Au core-shell nanowires (Ag@Au NWs) remain stable in air for over six months, under elevated temperature and humidity (80 °C and 100% humidity) for twelve weeks, in physiological buffer solutions for three weeks, and can survive overnight treatment of an oxidative solution (2% H2O2). The Ag@Au core-shell NWs demonstrated comparable performance as pristine AgNWs in various electronic, optical, and mechanical devices, such as transparent mesh electrodes, surface-enhanced Raman spectroscopy (SERS) substrates, plasmonic waveguides, plasmonic nanofocusing probes, and high-aspect-ratio, high-resolution atomic force microscopy (AFM) probes. These Au@Ag core-shell NWs offer a universal solution towards chemically-stable AgNW-based devices without compromising material property or device performance.

关键词： epitaxial growth core-shell nanowire plasmonic waveguides atomic force microscopy(AFM)probe transparent electrode wearable electronics

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Fast non-iterative algorithm for 3D point-cloud holography

arXiv

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arXiv 2023年

作者： Ersaro, Nathan Tessema Yalcin, Cem Murray, Liz Kabuli, Leyla Waller, Laura Muller, Rikky Graduate Program in Bioengineering University of California Berkeley University of California San Francisco BerkeleyCA94720 United States Department of Electrical Engineering and Computer Sciences University of California Berkeley BerkeleyCA94720 United States

Recently developed iterative and deep learning-based approaches to computer-generated holography (CGH) have been shown to achieve high-quality photorealistic 3D images with spatial light modulators. However, such approaches remain overly cumbersome for patterning sparse collections of target points across a photoresponsive volume in applications including biological microscopy and material processing. Specifically, in addition to requiring heavy computation that cannot accommodate real-time operation in mobile or hardware-light settings, existing sampling-dependent 3D CGH methods preclude the ability to place target points with arbitrary precision, limiting accessible depths to a handful of planes. Accordingly, we present a non-iterative point cloud holography algorithm that employs fast deterministic calculations in order to efficiently allocate patches of SLM pixels to different target points in the 3D volume and spread the patterning of all points across multiple time frames. Compared to a matched-performance implementation of the iterative Gerchberg-Saxton algorithm, our algorithm's relative computation speed advantage was found to increase with SLM pixel count, reaching >100,000x at 512x512 array format. Copyright © 2023, The Authors. All rights reserved.

关键词： Iterative methods

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Sample Preconcentration Through Airjet-Induced Liquid Phase Enrichment

SSRN

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SSRN 2023年

作者： Wang, Edward Laurent, Louise C. Hall, Drew A. Lo, Yu-Hwa Department of Aerospace and Mechanical Engineering Materials Science and Engineering Program University of California La Jolla San DiegoCA United States Sanford Consortium of Regenerative Medicine United States Department of Electrical and Computer Engineering University of California La Jolla San DiegoCA United States Department of Bioengineering

Sample preparation is essential for nucleic acid assays, affecting their sensitivity and reliability. However, this process often results in a significant loss or dilution of the analyte, which becomes a bottleneck that limits downstream assay performance, particularly for assays that accept a limited input sample volume. To overcome this challenge, we present an evaporative-based sample enrichment method that uses an airjet to concentrate analytes within a small, defined volume by reversing the coffee-ring effect. A small, concentrated sample can then be collected for analysis to increase the initial sample load. The effectiveness of the reported airjet enrichment was quantified using qPCR of λ-DNA, HeLa-S3 RNA, and heat-inactivated SARS-CoV-2 samples. Comparisons between airjet enrichment and conventional evaporative concentration methods demonstrated significant advantages of airjet enrichment, including the ability to concentrate a high percentage of analyte within a 1 µL volume. The enrichment method was then integrated and adapted for various fluid volumes commonly found in nucleic acid sample preparation procedures. Here, airjet enrichment reduced the overall [[EQUATION]] by an average of 9.27 cycles for each analyte, resulting in a 600-fold enrichment from the initial concentration. In addition, to perform selective enrichment and prevent salt-based interference in downstream analysis, PEG was added to reduce the co-enrichment of salt. These studies show how airjet enrichment technology can be easily integrated into existing laboratory protocols with minimal modification and significantly improve the performance of nucleic acid amplification assays. © 2023, The Authors. All rights reserved.

关键词： Biomolecules

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Comprehensive Study on Cherenkov Radiation for Ultrafast PET Detectors, Considering Refractive Index and Wavelength

Comprehensive Study on Cherenkov Radiation for Ultrafast PET...

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： H.S. Shim H. Kang J. Kim J.S. Lee Y. Jeong Interdisciplinary Program of Bioengineering Seoul National University Seoul Republic of Korea Integrated Major in Innovative Medical Science Seoul National University Seoul Republic of Korea Department of Electrical and Computer Engineering Seoul National University Seoul Republic of Korea

This study aims to investigate the characteristics of Cherenkov radiation with respect to wavelength and refractive index. Refractive index is a function of wavelength, and when it changes, not only does the gain of Cherenkov radiation increase, but also the photon loss in the medium increases. Therefore, we examine how photons of different wavelengths behave under changing refractive index conditions. We adjust the refractive index to maintain a constant emission angle of Cherenkov radiation based on the deceleration rate of electrons moving in the medium. When electrons generating Cherenkov radiation move a total of 200 μm, both long-wavelength and short-wavelength photons are emitted at the initial stage; however, only short-wavelength photons are emitted at the late stage. Although the shorter-wavelength photons arrive first among the photons that reach the detector, the longer-wavelength photons are detected more, forming a significant peak, which is due to the fact that the former experience more absorption-based photon loss in the medium than the latter.

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Wearable Active Vibration Sensing for Mid-Activity Knee Health Assessment

Wearable Active Vibration Sensing for Mid-Activity Knee Heal...

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International Workshop on Wearable and Implantable Body Sensor Networks (BSN)

作者： Goktug C. Ozmen Christopher J. Nichols Lan Lan Emily Moise Christopher Sugino Alper Erturk Omer T. Inan School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA BioEngineering Graduate Program Georgia Institute of Technology Atlanta GA USA Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA USA George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology Atlanta GA USA Coulter Department of Biomedical Engineering School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA

Non-invasive vibration measurements from the knee offer a convenient and affordable alternative to benchtop or biomechanics lab joint health monitoring systems. Recently, joint acoustic emissions (JAEs) measured from the knee were shown to be an indicator of knee health. However, the origin of JAEs is still not fully understood, which limits its acceptance and use by clinical experts. In this proof-of-concept study, rather than relying on the movements of the knee and corresponding frictional rubbing of internal surfaces to produce vibrations, we propose using an active vibration sensing approach with a known vibration source interrogating the knee. We aim to elucidate the linkage between knee vibration characteristics and structural changes in the joint following injuries. We measured tibial vibration responses of two participants using a laser vibrometer system to quantify the frequency band where the most repeatable tibial vibration measurement can be taken. Subsequently, a custom-designed wearable system measured mid-activity tibial vibration characteristics from four participants (five healthy knees and three knees with prior acute injury) during unloaded knee flexion-extensions. An active sensing knee health score was defined as the ratio of the changes in low- to high-frequency response during flexion-extension. Since changes in the boundary of tibia would alter low-frequency response more than high frequency response, we found that increased knee laxity with acute injuries resulted in an increased active sensing knee health score. Our findings demonstrate the potential of active vibration sensing as an interpretable, computationally inexpensive alternative to JAEs for wearable knee health assessment.

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Implantable Biosensor for Continuous Serotonin Detection in Freely Moving Crayfish 22

Implantable Biosensor for Continuous Serotonin Detection in ...

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22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

作者： Han, Jinjing Ho, Tawen Stine, Justin M. Straker, Michael A. Herberholz, Jens Ghodssi, Reza University Of Maryland Department Of Electrical And Computer Engineering College ParkMD United States University Of Maryland Institute For System Research College ParkMD United States University Of Maryland Robert E. Fischell Institute For Biomedical Devices College ParkMD United States University Of Maryland Department Of Psychology College ParkMD United States University Of Maryland Program In Neuroscience And Cognitive Science College ParkMD United States University Of Maryland Fischell Department Of Bioengineering College ParkMD United States

ISBN: (纸本)9784886864352

This work presents, for the first time, an implantable biosensor for continuous in vivo serotonin (5-HT) monitoring in freely moving crayfish. 5-HT is an important neurotransmitter that regulates animal behaviors. Conventional methods for detecting 5-HT do not provide real-time information. Our approach facilitates continuous electrochemical monitoring of 5-HT levels without impeding animal natural behavior. The sensing system shows a linear range of 0.4 - 1.2 μΜ with a sensitivity of 0.07 μA/μΜ for 5-HT detection. With a 3D-printed package, the sensor can be easily attached to crayfish dorsal carapace allowing electrodes implantation into crayfish heart to monitor neurohormonal dynamics of 5-HT. The implantable biosensor system displayed a significant increase in oxidation currents after 5-HT injections. The device successfully demonstrates the application for in vivo detection of 5-HT in the hemolymph (i.e., blood) of freely behaving crayfish underwater. © 2023 IEEJ.

关键词： Biosensing Electrochemical Device Electrochemistry Implantable Electrode In Vivo Sensing

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