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Wireless sequential dual light delivery for programmed PDT in vivo

Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-Joon Kim Shu Uin Gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

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Single-channel, ultraportable, real-time imaging system based on deep learning: a proof-of-concept

Single-channel, ultraportable, real-time imaging system base...

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2023 IEEE International Ultrasonics Symposium, IUS 2023

作者： Meacci, Valentino Bosco, Edoardo Ramalli, Alessandro Boni, Enrico Tortoli, Piero Mazierli, Daniele Spairani, Edoardo Matrone, Giulia University of Florence Department of Information Engineering Florence Italy University of Pavia Department of Electrical Computer and Biomedical Engineering Pavia Italy

ISBN: (纸本)9798350346459

There is a growing demand for user-friendly technologies that may empower individuals to independently monitor their physiological parameters. Ultrasound systems are highly promising for healthcare self-monitoring. To address these challenges, in this work, we present the proof of concept (PoC) of a real-time ultraportable system with a single-channel transmission and reception strategy and a deep learning-based image reconstruction method. The PoC uses the ULA-OP 256 scanner, employing a monostatic synthetic aperture focusing technique, along with a convolutional neural network (CNN) trained to generate B-mode images. Testing was carried out using a CNN running on a mid-range graphics processing unit (GPU), both on phantoms and in vivo scenarios, comparing the image quality achieved by the CNN with that of a delay-and-sum (DAS) beamformer. The results highlight that the CNN outperformed the DAS, showing a better image quality. Furthermore, the CNN achieved a real-time frame rate of 37.0 frames per second, proving that ultraportable ultrasound systems are highly promising for the future of self-monitoring instruments. © 2023 IEEE.

关键词： Graphics processing unit

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Laser Machined Fiber‑Based Microprobe: Application in Microscale Electroporation

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Advanced Fiber Materials 2022年第4期4卷 859-872页

作者： Jongwoon Kim Yajun Zhao Shuo Yang Ziang Feng Anbo Wang Rafael V.Davalos Xiaoting Jia Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVA 24060USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA

Microscale electroporation devices are mostly restricted to in vitro experiments(i.e.,microchannel and microcapillary).Novel fiber-based microprobes enable in vivo microscale electroporation and arbitrarily select the cell groups of interest to *** developed a flexible,fiber-based microscale electroporation device through a thermal drawing process and femtosecond laser micromachining *** fiber consists of four copper electrodes(80μm),one microfluidic channel(30μm),and has an overall diameter of 400μ*** dimensions of the exposed electrodes and channel were customizable through a delicate femtosecond laser *** feasibility of the fiber probe was validated through numerical simulations and in vitro *** reversible and irreversible microscale electroporation was observed in a 3D collagen scaffold(seeded with U251 human glioma cells)using fluorescent *** ablation regions were estimated by performing the covariance error ellipse method and compared with the numerical *** computational and experimental results of the working fiber-based microprobe suggest the feasibility of in vivo microscale electroporation in space-sensitive areas,such as the deep brain.

关键词： Fiber probe Polymer Micromachine Irreversible electroporation Reversible electroporation Microscale electroporation

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Monte Carlo modelling of Raman signal enhancement using power-efficient Apple processors 15

Monte Carlo modelling of Raman signal enhancement using powe...

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biomedical Light Scattering XV 2025

作者： Vladyko, Ilya Yakovlev, Vladislav Doronin, Alexander School of Engineering and Computer Science Victoria University of Wellington Wellington6140 New Zealand Department of Biomedical Engineering Department of Electrical and Computer Engineering Department of Physics and Astronomy Institute for Quantum Science and Engineering Texas A&M University College StationTX77843 United States

ISBN: (纸本)9781510683884

Modern optical technologies encompass classical light phenomena and non-linear effects, crucial for biomedical imaging and therapies. Despite substantial interest and many experimental studies, non-linear optical effects in inhomogeneous scattering media require extensive computer modeling to understand light-material interactions. This report focuses on Monte Carlo simulations of Raman scattering in turbid media, such as biological tissues, essential for clinical applications. We developed a novel, open-source, power-efficient Monte Carlo algorithm optimized for Apple s M-series chips. By incorporating single-photon tracking, the algorithm accurately models time-resolved light-Tissue interactions. Validated against experiments, it matches traditional methods accuracy while offering superior efficiency, advancing Raman functional imaging. © 2025 SPIE.

关键词： Tissue

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A Time-Frequency Analysis for Broken Rotor Bar Detection in Closed Loop Inverter Fed Induction Motor at Imposed Speed 14

A Time-Frequency Analysis for Broken Rotor Bar Detection in ...

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14th IEEE International Symposium on Diagnostics for electrical Machines, Power Electronics and Drives, SDEMPED 2023

作者： Mantione, Lorenzo Fernandez-Cavero, Vanesa Morinigo-Sotelo, Daniel Frosini, Lucia University of Pavia Department of Electrical Computer and Biomedical Engineering Pavia Italy Universidad de Valladolid School of Industrial Engineering Department of Electrical Engineering Valladolid Spain Valladolid Spain

ISBN: (纸本)9798350320770

In this paper, an analysis to detect broken rotor bars while the motor is operating in closed loop control is presented. Due to changes in the supply frequency, which occur to keep the speed constant, a time-frequency technique is required even when the transient is completed. Signals from the phase current of the induction motor are analysed using traditional methods such as the Fast Fourier Transform and the Short Time Fourier Transform. Finally, the same signals are analysed through the Dragon Transform, that ensures high resolution frequency and time and allows to detect trajectories of the harmonics with different load conditions. © 2023 IEEE.

关键词： Induction motors

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Mode-Division Multiplexing at Visible Wavelengths

Mode-Division Multiplexing at Visible Wavelengths

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CLEO: Science and Innovations in CLEO 2024, CLEO: S and I 2024 - Part of Conference on Lasers and Electro-Optics

作者： Shah, Priyansh Mellouk, Elias Ben Levine, Jeremy Mohanty, Aseema Department of Electrical and Computer Engineering Tufts University MedfordMA02155 United States Department of Biomedical Engineering Tufts University MedfordMA02155 United States

We demonstrate mode-division multiplexing at visible wavelengths (473 nm) for the first time using adiabatic mode couplers. We measure less than -15 dB and -20 dB crosstalk for TE2 and TE3 higher-order mode couplers, ... 详细信息

关键词： Tellurium compounds

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Mode-Division Multiplexing at Visible Wavelengths

Mode-Division Multiplexing at Visible Wavelengths

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

ISBN: (纸本)9781957171395

关键词： Laser beams

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Modified CNN VoxNet Based Depthwise Separable Convolution for Voxel-Driven Body Orientation Classification

Modified CNN VoxNet Based Depthwise Separable Convolution fo...

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2024 IEEE International Conference on Imaging Systems and Techniques, IST 2024

作者： Riansyah, Moch. Iskandar Putra, Oddy Virgantara Priyadi, Ardyono Sardjono, Tri Arief Yuniarno, Eko Mulyanto Purnomo, Mauridhi Hery Institut Teknologi Sepuluh Nopember Department of Electrical Engineering Indonesia Telkom University Department of Electrical Engineering Indonesia Universitas Darussalam Gontor Department of Informatics Ponorogo Indonesia Institut Teknologi Sepuluh Nopember Department of Electrical Engineering Surabaya Indonesia Institut Teknologi Sepuluh Nopember Department of Biomedical Engineering Surabaya Indonesia Institut Teknologi Sepuluh Nopember Department of Electrical Engineering Department of Computer Engineering Surabaya Indonesia

ISBN: (纸本)9798350378214

In this research, LiDAR sensor technology introduces a new representation of point cloud data for tasks in 3D object recognition. Point clouds provide rich information that can be utilized to predict the orientation pose of the human body. The orientation of the human body is crucial for various needs such as autonomous vehicles, robotics, and human activity monitoring. However, the inherently unstructured nature and permutation invariance of point cloud data pose significant challenges in accurately predicting human body orientation using 3D data. In this paper, we propose a solution by introducing a volumetric method based on CNN to effectively recognize human body ori-entation. A novel approach is proposed by embedding depthwise sparse convolution into 2D CNN to process voxel data of human body orientation. We evaluate the performance using KITTI data divided into four orientation classes: east, west, north, and south. Additionally, we compare it with other architectures using the ModelNet10 and ModelNet40 datasets. The comparison with other architectures shows superior performance with accuracies of 84.31 % for the KITTI dataset, 86.67 % for ModelNet10, and 75.20 % for ModelNet40. This evidence strongly supports the effectiveness of our proposed method, highlighting its potential in enhancing 3D object recognition systems significantly. © 2024 IEEE.

关键词： CNN depthwise sparse convolution human body orientation lidar point cloud

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On-chip hyperspectral detectors for fluorescence lifetime imaging 9

On-chip hyperspectral detectors for fluorescence lifetime im...

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High-Speed biomedical Imaging and Spectroscopy IX 2024

作者： Ahamed, Ahasan Rawat, Amita McPhillips, Lisa N. Marcu, Laura Saif Islam, M. Electrical and Computer Engineering Department University of California DavisCA95616 United States Biomedical Engineering Department University of California DavisCA95616 United States

ISBN: (纸本)9781510669659

Fluorescence Lifetime Imaging (FLIM) is a powerful technique that measures the decay time of fluorophores present in tissue samples alluding to their constituent molecules. FLIM has gained popularity in biomedical imaging for applications such as detecting cancerous tumors, surgical guidance, etc. However, conventional FLIM systems are limited by a reduced number of spectral bands and long acquisition time. Moreover, the large footprint, complexity, and cost of the instrumentation make it difficult for clinical applications. In this paper, we demonstrate a reconstruction-based hyperspectral detector that can resolve decay time and intensities in broad spectral ranges while providing high sensitivity, high gain, and fast response time. The hyperspectral detector is comprised of an array of efficient, ultrafast avalanche photodetectors integrated with nanophotonic structures. We utilize different nanostructures in the detectors to modulate light-matter interactions in spectral channels. This allows us to computationally reconstruct the spectral profile of the incoming fluorescence spectrum without the need for additional filters or dispersive optics. Also, the nanophotonic structures enhance efficiency (by a factor of 2 to 10 over different wavelengths) while providing fast response time. An innovative detector design has been employed to reduce the breakdown of the avalanche photodetectors to-7.8V while maintaining high gain (∼50) across the spectral range. Therefore, enabling low light detection with a high signal-To-noise ratio for FLIM applications. Added spectral channels would provide valuable information about tissue materials, morphology, and disease diagnosis. Such innovative hyperspectral sensors can now be integrated on-chip capable of miniaturizing the FLIM system and making it a commercially viable tool for clinical use. This technology has the potential to revolutionize the current FLIM system with improved detection capabilities opening doors for new ho

关键词： Hyperspectral imaging

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Extracting 3D Information from Widefield Birefringence Microscopy Images of Sparse Myelinated Fibers in Human Brain Gray Matter

Extracting 3D Information from Widefield Birefringence Micro...

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Microscopy Histopathology and Analytics, Microscopy 2024 - Part of Optica Biophotonics Congress: biomedical Optics

作者： Novoseltseva, Anna Xie, Ting Bigio, Irving J. Department of Biomedical Engineering Boston University BostonMA02215 United States Department of Electrical & Computer Engineering Boston University BostonMA02215 United States

We report the application of widefield birefringence microscopy for 3D rendering of sparse myelinated fibers in human brain gray matter. This inexpensive and simple method offers the potential to inform studies of the... 详细信息

ISBN: (纸本)9781957171340

关键词： Birefringence

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