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arXiv 2025年

作者： Almagro-Pérez, Cristina Song, Andrew H. Weishaupt, Luca Kim, Ahrong Jaume, Guillaume Williamson, Drew F.K. Hemker, Konstantin Lu, Ming Y. Singh, Kritika Chen, Bowen Le, Long Phi Baras, Alexander S. Jiang, Sizun Bashashati, Ali Liu, Jonathan T.C. Mahmood, Faisal Department of Pathology Mass General Brigham Harvard Medical School BostonMA United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA United States Data Science Program Dana-Farber Cancer Institute BostonMA United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States Department of Pathology Pusan National University Busan Korea Republic of Department of Pathology and Laboratory Medicine Emory University School of Medicine AtlantaGA United States Department of Computer Science & Technology University of Cambridge Cambridge United Kingdom Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Rutgers Robert Wood Johnson Medical School New BrunswickNJ United States Department of Pathology Johns Hopkins Hospital BaltimoreMD United States Department of Biomedical Engineering Johns Hopkins Hospital BaltimoreMD United States Broad Institute of Harvard and MIT CambridgeMA United States Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Harvard Medical School BostonMA United States Department of Pathology Dana Farber Cancer Institute BostonMA United States Department of Pathology and Laboratory Medicine University of British Columbia VancouverBC Canada School of Biomedical Engineering University of British Columbia VancouverBC Canada Department of Mechanical Engineering Bioengineering Laboratory Medicine & Pathology University of Washington SeattleWA United States Harvard Data Science Initiative Harvard University CambridgeMA United States

A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedical applications1. However, most spatial transcriptomics (ST) approaches remain limited to two-dimensional (2D) sections of tissue2–4. Although current 3D ST methods hold promise, they typically require extensive tissue sectioning, are complex, are not compatible with non-destructive 3D tissue imaging technologies, and often lack scalability5–8. Here, we present VOlumetrically Resolved Transcriptomics EXpression (VORTEX), an AI framework that leverages 3D tissue morphology and minimal 2D ST to predict volumetric 3D ST. By pretraining on diverse 3D morphology–transcriptomic pairs from heterogeneous tissue samples and then fine-tuning on minimal 2D ST data from a specific volume of interest, VORTEX learns both generic tissue-related and sample-specific morphological correlates of gene expression. This approach enables dense, high-throughput, and fast 3D ST, scaling seamlessly to large tissue volumes far beyond the reach of existing 3D ST techniques. By offering a cost-effective and minimally destructive route to obtaining volumetric molecular insights, we anticipate that VORTEX will accelerate biomarker discovery and our understanding of morphomolecular associations and cell states in complex tissues. Interactive 3D ST volumes can be viewed at https://***/. © 2025, CC BY-NC-ND.

关键词： Vortex flow

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Analytical Maximum Energy Product (BH)_max Model for Rare-Earth-Free Magnets: Core-Shell Nanostructure

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IEEE Transactions on Magnetics 2025年

作者： Hong, Yang-Ki Bae, Seok Park, Jihoon Choi, Minyeong Lee, Won-Cheol Yeo, Chang-Dong Wahed, Md Abdul Lee, Kisuk Yim-Choi, Haein Lee, Woo-Young Department of Electrical and Computer Engineering Materials Science Ph.D. Program The University of Alabama Tuscaloosa 35487 AL United States LG Innotek R&D Division Seoul South Korea Korea Institute of Materials Science Gyeongsangnam-Do Changwon South Korea Hyundai Motors Company R&D Division Namyang Gyeonggi-Do South Korea RF Development Team S.LSI Samsung Electronics Gyeonggi-Do Hwaseong 18448 South Korea Texas Tech University Department of Mechanical Engineering 79409 TX United States Ulsan National Institute of Science and Technology Department of Materials Science and Engineering Gyeongsangnam-Do Ulsan South Korea SookMyung Women’s University Department of Applied Physics Seoul South Korea Yonsei University Department of Materials Science and Engineering Seoul South Korea

This paper presents an analytical model for the maximum energy product ((BH)max) in core-shell structured magnetic exchange-coupled nanomagnets. The model was validated by comparing its results to the (BH)max from cor... 详细信息

This paper presents an analytical model for the maximum energy product ((BH)_max) in core-shell structured magnetic exchange-coupled nanomagnets. The model was validated by comparing its results to the (BH)_max from core-shell magnets reported in the literature. This approach can serve as a universal model for designing core-shell magnets that achieve the desired (BH)_max. The (BH)_max was determined under two distinct nucleation field (H_N) conditions: H_N ≤ M_r/2 and H_N ≥ M_r/2, where M_r is the remanent magnetization. Additionally, two different values of magnetic hysteresis loop squareness (SQ = M_r/M_S) were used: 1.0 and 0.7. The soft magnetic shell’s remanent magnetic flux density (B_r) ranged from 0.7 to 2.2 T, while the core diameter (D_h) varied between 50 and 250 nm in this (BH)_max model. The LTP (low-temperature phase) MnBi-core/soft-shell nanomagnet can achieve a (BH)_max of 40 MGOe at a B_r of 1.6 T, with a shell thickness (δ_S) of 40 nm, a D_h of 250 nm, and a volume fraction of the hard-core (f_h) of 0.43. The (BH)_max of the hexaferrite (SrFe₁₂O₁₉)/soft-shell (1.9 T) nanomagnet can be improved from 5.8 (single hexaferrite phase) to 20 MGOe. This approach achieves the desired (BH)_max of the rare-earth-free permanent magnet, thereby tackling issues related to rare-earth mineral security and unstable supply chains. © 1965-2012 IEEE.

关键词： core-shell nanomagnet magnetic exchange coupling maximum energy product

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Unitary Excitation Transfer between Coupled Cavities Using Temporal Switching

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Physical Review Letters 2021年第1期127卷 013902-013902页

作者： Yarden Mazor Michele Cotrufo Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA School of Electrical Engineering Tel-Aviv University Ramat-Aviv Tel-Aviv 69978 Israel Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center of the City University of New York New York New York 10016 USA

Tailored time variations can enable efficient control over signal flows, giving rise to exotic wave phenomena. In this work, we demonstrate how abrupt temporal switching of the coupling between two cavities can tailor the energy flow between them beyond the limitations of static scenarios, enabling unitary excitation transfer. The proposed scheme is robust with respect to a wide range of nonidealities, with implications for classical and quantum phenomena, from computing to nanophotonic systems.

关键词： Metamaterials Coupled oscillators

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Nanoparticle localization within chiral liquid crystal defect lines and nanoparticle interactions

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Physical Review E 2023年第3期107卷 034701-034701页

作者： Mykola Tasinkevych Sungoh Park Haridas Mundoor Ivan I. Smalyukh SOFT Group School of Science and Technology Nottingham Trent University Clifton Lane Nottingham NG11 8NS United Kingdom Departamento de Física and Centro de Física Teórica e Computacional Faculdade de Ciências Universidade de Lisboa 1749-016 Lisboa Portugal International Institute for Sustainability with Knotted Chiral Meta Matter Hiroshima University Higashihiroshima 739-8511 Japan Department of Physics University of Colorado Boulder Colorado 80309 USA Soft Materials Research Center Department of Electrical Computer and Energy Engineering and Materials Science and Engineering Program and Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado Boulder Colorado 80309 USA

Self-assembly of colloidal particles into predefined structures is a promising way to design inexpensive manmade materials with advanced macroscopic properties. Doping of nematic liquid crystals (LCs) with nanoparticles has a series of advantages in addressing these grand scientific and engineering challenges. It also provides a very rich soft matter platform for the discovery of unique condensed matter phases. The LC host naturally allows the realization of diverse anisotropic interparticle interactions, enriched by the spontaneous alignment of anisotropic particles due to the boundary conditions of the LC director. Here we demonstrate theoretically and experimentally that the ability of LC media to host topological defect lines can be used as a tool to probe the behavior of individual nanoparticles as well as effective interactions between them. LC defect lines irreversibly trap nanoparticles enabling controlled particle movement along the defect line with the use of a laser tweezer. Minimization of Landau–de Gennes free energy reveals a sensitivity of the ensuing effective nanoparticle interaction to the shape of the particle, surface anchoring strength, and temperature, which determine not only the strength of the interaction but also its repulsive or attractive character. Theoretical results are supported qualitatively by experimental observations. This work may pave the way toward designing controlled linear assemblies as well as one-dimensional crystals of nanoparticles such as gold nanorods or quantum dots with tunable interparticle spacing.

关键词： Charged colloids Complex fluids Liquid crystals

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Ultrastrong Spin-Photon Coupling in Gadolinium Gallium Garnet

Ultrastrong Spin-Photon Coupling in Gadolinium Gallium Garne...

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Conference on Lasers and Electro-Optics (CLEO)

作者： T. Elijah Kritzell Junzhe Bao Jacques Doumani Jae Joon Lee Hongjing Xu Fuyang Tay Hiroyuki Nojiri Motoaki Bamba Andrey Baydin Junichiro Kono Department of Electrical and Computer Engineering Rice University Houston Texas USA Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston Texas USA Department of Physics and Astronomy Rice University Houston Texas USA Institute for Materials Research Tohoku University Senai Japan The Hakubi Center for Advanced Research Kyoto University Kyoto Japan Department of Physics I Kyoto University Kyoto Japan Smalley-Curl Institute Rice University Houston Texas USA Department of Material Science and NanoEngineering Rice University Houston Texas USA

We examine ultrastrong coupling of an ensemble of paramagnetic spins in Gd 3 Ga 5 O 12 with terahertz photons in the presence of a high external magnetic field both in the bulk and thin-film limits.

ISBN: (纸本)9781957171258

We examine ultrastrong coupling of an ensemble of paramagnetic spins in Gd 3 Ga 5 O 12 with terahertz photons in the presence of a high external magnetic field both in the bulk and thin-film limits.

关键词： CCD cameras Condensed matter Magnetic fields Photons Quantum optics Terahertz spectroscopy

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Landau Polaritons in a Full-Dielectric Three-Dimensional Photonic-Crystal Cavity

Landau Polaritons in a Full-Dielectric Three-Dimensional Pho...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Fuyang Tay Ali Mojibpour Shuang Liang Andrey Baydin Arash Ahmadivand Nicolas Marquez Peraca Hongjing Xu Geoff C. Gardner Michael J. Manfra David Hagenmüller Junichiro Kono Department of Electrical and Computer Engineering Rice University Houston Texas USA Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston Texas USA Department of Physics and Astronomy Purdue University West Lafayette IN USA Birck Nanotechnology Center Purdue University West Lafayette IN USA Smalley-Curl Institute Rice University Houston Texas USA Department of Physics and Astronomy Rice University Houston Texas USA Microsoft Quantum Purdue Purdue University West Lafayette IN USA School of Electrical and Computer Engineering Purdue University West Lafayette IN USA School of Materials Engineering Purdue University West Lafayette IN USA ISIS (UMR 7006) Université de Strasbourg and CNRS Strasbourg France Department of Materials Science and Nano Engineering Rice University Houston Texas USA

We fabricated a full-dielectric three-dimensional photonic-crystal cavity containing an ultrahigh-mobility two-dimensional electron gas. By applying a strong perpendicular magnetic field, we created Landau polaritons ... 详细信息

ISBN: (数字)9781957171050

ISBN: (纸本)9781665466660

关键词： Couplings HEMTs Laser modes Polaritons Magnetic fields Gas lasers MODFETs

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Monitoring blood pressure through a single hybrid hemodynamic signal with a flexible optoelectronic patch

Device

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Device 2025年

作者： Zhong, Yizhou Zhang, Yongcao Pu, Jing Wustoni, Shofarul Uribe, Johana Lopez-Larrea, Naroa Marks, Adam McCulloch, Iain Mecerreyes, David Baran, Derya Inal, Sahika Organic Bioelectronics Laboratory Biological and Environmental Science and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia Materials Science and Engineering Program (MSE) Physical Sciences and Engineering Division (PSE) KAUST Thuwal 23955-6900 Saudi Arabia POLYMAT University of the Basque Country UPV/EHU Avenida Tolosa 72 Guipuzcoa Donostia-San Sebastian 20018 Spain Department of Chemistry University of Oxford Oxford OX1 3TF United Kingdom Andlinger Center for Energy and the Environment and Department of Electrical and Computer Engineering Princeton University Princeton 08544 NJ United States IKERBASQUE Basque Foundation for Science Plaza Euskadi 5 Bilbao 48009 Spain

Hemodynamics, the study of blood flow and circulatory forces, is fundamental for assessing cardiovascular health, disease states, and therapeutic outcomes. Here, we introduce a skin-conformable organic optoelectronic thin-film patch (ePatch) designed to simultaneously capture electrocardiography (ECG) and photoplethysmography (PPG) signals as a single hybrid signal, named the electrocardio-photoplethysmogram (EC-PPG). The ePatch integrates an organic electrochemical transistor (OECT), an organic photodiode, surface-mounted light-emitting diodes, and electrochemical electrodes on a flexible, skin-conforming substrate. By training deep learning models on the hybrid EC-PPG data, we achieved accurate arterial blood pressure estimations, with mean errors of just 1.69 mmHg for systolic and 0.89 mmHg for diastolic blood pressure, outperforming traditional predictions that rely on individual physiological signals as inputs. Our findings underscore the potential of EC-PPG as a compound hemodynamic signal for AI-driven vital sign monitoring and integrated, solution-processable soft electronics for clinical and point-of-care applications. © 2025 The Authors

关键词： DTI-3: Develop electrocardiography electrophysiology flexible electronics OECT OPD organic electrochemical transistor photoplethysmography wearable electronics

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Compressibility-Near-Zero Acoustic Radiation

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Physical Review Applied 2021年第2期15卷 024022-024022页

作者： Curtis Rasmussen Andrea Alù Department of Mechanical Engineering The University of Texas at Austin Austin Texas 78712 USA Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Photonics Initiative CUNY Advanced Science Research Center New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10026 USA

A hallmark of near-zero-index materials is the uniform phase profile that the waves experience as they propagate with staticlike properties in these media. This feature is exploited in electromagnetics for several applications, including for the realization of compact highly directive antennas illuminated by a single source. Here, we discuss the promise of near-zero metamaterials for acoustic radiation, based on the cutoff of a higher-order mode in a waveguide with small holes. We show that the near-zero nature of this phenomenon ensures unusual robustness to disorder, which is analyzed using a statistical description of the radiation patterns for randomly generated location of the holes. The radiation pattern can be made more directive by simply increasing the overall radiating aperture, without having to worry about the specific location of individual holes and their relative distance. The proposed zero-compressibility material offers a promising alternative to traditional acoustic directive sources due to its design simplicity, inherent robustness, and compact profile.

关键词： Acoustic metamaterials Acoustic wave phenomena Disordered systems Acoustic techniques Cavity resonators Green's function methods

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A Platform for Monitoring Student Commuting in the Use of School Transport in Smart Cities - A Facial Recognition Based Approach

A Platform for Monitoring Student Commuting in the Use of Sc...

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International Conference on Smart Communications and Networking (SmartNets)

作者： Jessé Da Costa Rocha Marcela Alves de Souza Evelin Helena Silva Cardoso Nandamudi Vijaykumar Jasmine Priscyla Leite de Araújo Renato Lisboa Francês Graduate Program in Electrical Engineering Institute of Technology Federal University of Pará (UFPA) Belém Pará Brazil Information and Communication Technology Center Federal University of the South and Southeast of Para (Unifesspa) Marabá Pará Brazil Department of Computer Science Federal Rural University of the Amazon (UFRA) Capitão Poço Pará Brazil Coordination of Applied Research and Technological Development National Institute for Space Research (INPE) São Paulo Brazil

This article proposes an intelligent platform for monitoring students' steps on their way to school until they leave the school to their homes. This platform can identify students and notify those responsible and competent authorities in various situations of school life, such as: entering and leaving the school bus, entering and leaving school, entering the school cafeteria, etc. The first application aims to control access to the school bus through facial recognition. In the tests carried out, the recognition system achieved excellent results in all metrics.

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Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy

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Nanoscale 2021年第15期13卷 7285-7293页

作者： Casasanta, Michael A. Jonaid, G.M. Kaylor, Liam Luqiu, William Y. Solares, Maria J. Schroen, Mariah L. Dearnaley, William J. Wilson, Jarad Dukes, Madeline J. Kelly, Deborah F. Department of Biomedical Engineering Pennsylvania State University University Park 16802 PA United States Materials Research Institute Pennsylvania State University University Park 16802 PA United States Bioinformatics and Genomics Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park 16802 PA United States Molecular Cellular and Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park 16802 PA United States Department of Electrical and Computer Engineering Duke University Durham 27708 NC United States RayBiotech Life Peachtree Corners 30092 GA United States Applications Science Protochips Inc Morrisville 27560 NC United States

Interest in cryo-Electron Microscopy (EM) imaging has skyrocketed in recent years due to its pristine views of macromolecules and materials. As advances in instrumentation and computing algorithms spurred this progress, there is renewed focus to address specimen-related challenges. Here we contribute a microchip-based toolkit to perform complementary structural and biochemical analysis on low-molecular weight proteins. As a model system, we used the SARS-CoV-2 nucleocapsid (N) protein (48 kDa) due to its stability and important role in therapeutic development. Cryo-EM structures of the N protein monomer revealed a flexible N-terminal "top hat"motif and a helical-rich C-terminal domain. To complement our structural findings, we engineered microchip-based immunoprecipitation assays that led to the discovery of the first antibody binding site on the N protein. The data also facilitated molecular modeling of a variety of pandemic and common cold-related coronavirus proteins. Such insights may guide future pandemic-preparedness protocols through immuno-engineering strategies to mitigate viral outbreaks. This journal is © The Royal Society of Chemistry.

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