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Information Theory and Applications Workshop, ITA

作者： Gil Alterovitz Michael Xiang Marco F. Ramoni Harvard Partners Center for Genetics and Genomics Harvard Medical School Boston MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Biology Massachusetts Institute of Technology Cambridge MA USA Division of Health Sciences and Technology Harvard Medical School and Massachusetts Institute of Technology Boston MA Children's Hospital Informatics Program Boston MA Harvard Partners Center for Genetics and Genomics Harvard Medical School Boston MA.

With myriad information being generated from high-throughput experiments such as microarrays and sequencing technologies, an ever-increasing amount of data is being recorded and analyzed with the help of hierarchical ontologies, such as the gene ontology (GO). We have developed a novel framework- based on the well established foundations of information theory- that allows for the evaluation of new types of hypotheses. The framework, encapsulated in open biomedical ontology-based exploration and search (OBOES), has already been applied in the investigation of different kinds of questions. The resulting framework enables the new field of information theoretic ontology-based analysis. We have applied this framework to create methods to re-engineer ontologies, explore fundamental questions on the evolution of biological complexity, determine optimal ontology terms for bioinformatics analysis, and quantify the usefulness of biofluids as proxies for tissues/diseases. In each case, we found that our methods provide novel, significant findings. An open source Java implementation of OBOES is available at: http://***.

关键词： Ontologies Bioinformatics Genomics Information analysis Biological information theory Information theory Genetic communication Humans Biochemistry Frequency

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Workshop on imaging science development for cancer prevention and preemption

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Cancer Biomarkers 2007年第1期3卷 1-33页

作者： Kelloff, Gary J. Sullivan, Daniel C. Baker, Houston Clarke, Lawrence P. Nordstrom, Robert Tatum, James L. Dorfman, Gary S. Jacobs, Paula Berg, Christine D. Pomper, Martin G. Birrer, Michael J. Tempero, Margaret Higley, Howard R. Petty, Brenda Gumbs Sigman, Caroline C. Maley, Carlo Sharma, Prateek Wax, Adam Ginsberg, Gregory G. Dannenberg, Andrew J. Hawk, Ernest T. Messing, Edward M. Grossman, H. Barton Harisinghani, Mukesh Bigio, Irving J. Griebel, Donna Henson, Donald E. Fabian, Carol J. Ferrara, Katherine Fantini, Sergio Schnall, Mitchell D. Zujewski, Jo Anne Hayes, Wendy Klein, Eric A. DeMarzo, Angelo Ocak, Iclal Ketterling, Jeffrey A. Tempany, Clare Shtern, Faina Parnes, Howard L. Gomez, Jorge Srivastava, Sudhir Szabo, Eva Lam, Stephen Seibel, Eric J. Massion, Pierre McLennan, Geoffrey Cleary, Kevin Suh, Robert Burt, Randall W. Pfeiffer, Ruth M. Hoffman, John M. Roy, Hemant K. Wang, Thomas Limburg, Paul J. El-Deiry, Wafik S. Papadimitrakopoulou, Vali Hittelman, Walter N. MacAulay, Calum Veltri, Robert W. Solomonzz, Diane Jeronimo, Jose Richards-Kortum, Rebecca Johnson, Karen A. Viner, Jaye L. Stratton, Steven P. Rajadhyaksha, Milind Dhawan, Atam NIH/NCI/DCTD Cancer Imaging Program Bethesda MD United States NIH/NCI/DCTD Cancer Imaging Program NCI-Frederick Frederick MD United States NIH/NCI/DCP Early Detection Research Group Bethesda MD United States The Johns Hopkins University School of Medicine Departments of Radiology Pharmacology and Oncology Division of Neuroradiology Baltimore MD United States NIH/NCI/CCR Cell and Cancer Biology Branch Bethesda MD United States University of California San Francisco Department of Medicine Division of Medical Oncology San Francisco CA United States CCS Associates Inc. Mountain View CA United States Wistar Institute Molecular and Cellular Oncogenesis Program Philadelphia PA United States University of Kansas School of Medicine VA Hospital Kansas City MO United States Duke University Department of Biomedical Engineering Medical Physics Program Durham NC United States University of Pennsylvania School of Medicine Department of Gastroenterology Philadelphia PA United States New York Presbyterian Hospital Weill Medical College of Cornell University New York NY United States NIH/NCI/OD Office of Centers for Training and Resources Bethesda MD United States University of Rochester Medical Center Department of Urology Rochester NY United States University of Texas MD Anderson Cancer Center Department of Urology Houston TX United States Massachusetts General Hospital Abdominal Imaging/Interventional Radiology Boston MA United States Boston University Biomedical Engineering Electrical and Computer Engineering and Physics Boston MA United States NIH/NCI/DCP Gastrointestinal and Other Cancers Research Group Bethesda MD United States The George Washington University Cancer Institute Office of Cancer Prevention and Control Washington DC United States University of Kansas Cancer Center Clinical Oncology Kansas City KS United States University of California Davis Department of Biomedical Engineering Davis CA United States Tufts University De

The article provides information on a workshop on the development of imaging systems for cancer prevention and preemption convened by the U.S. National Cancer Institute (NCI) Cancer Imaging program held in Gaithersburg, Maryland. Doctor Katherine Ferrara of the University of California discussed the function of ultrasound in breast tumor imaging. Ways to close the gap between development and application of imaging approaches were tackled in a roundtable discussion on cervix and skin cancer.

关键词： FORUMS (Discussion & debate) IMAGING systems in medicine CANCER prevention

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Guest editorial nonlinear optimization of communication systems

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IEEE Journal on Selected Areas in Communications 2006年第8期24卷 1421-1423页

作者： Chiang, Mung Low, Steven H. Luo, Zhi-Quan Shroff, Ness B. Yu, Wei Steenstrup, M. Princeton University Department of Electrical Engineering Program in Applied and Computational Mathematics Princeton NJ 08544 United States California Institute of Technology Department of Computer Science Pasadena CA 91125 United States University of Minnesota Department of Electrical and Computer Engineering Minneapolis MN 55455 United States Purdue University School of Electrical and Computer Engineering West Lafayette IN 47907 United States University of Toronto Edward S. Rogers Sr. Department of Electrical and Computer Engineering Toronto Ont. M4S 3G5 Canada

No abstract available

关键词： Communication systems Design optimization Communication system control Optimization methods Protocols Distributed algorithms Power system modeling Nonlinear control systems Lagrangian functions Surges

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Modeling of biochemical pathways: Physical interpretation of network behavior

Modeling of biochemical pathways: Physical interpretation of...

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IEEE 32nd Annual Northeast Bioengineering Conference, 2006

作者： Sarvia, Tricia A. Sun, Ying Biomedical Engineering Program Department of Electrical and Computer Engineering University of Rhode Island Kingston RI 02881 United States

ISBN: (纸本)0780395638

The development of computational models allows one to easily reveal certain behaviors of the biochemical network of interest. In this project we seek to represent the set of rate equations used to describe the dynamics of a system with a common physical model. This allows for the reduction of such complexities that can restrict the model's overall stability. Conclusions from preliminary data have shown that the model produces valid results consistent with experimental data. We also have tested the model's reliability by reversing the reaction's driving potential. It has been concluded that this modeling approach gives logical and consistent results. The next phase of this project would be to apply this approach to a larger biochemical process, such as glycolysis. © 2006 IEEE.

关键词： Medical computing

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Shortening-deactivation and stretch-activation during spontaneous contraction and relaxation of bivalve cardiac muscles

Shortening-deactivation and stretch-activation during sponta...

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IEEE 32nd Annual Northeast Bioengineering Conference, 2006

作者： Pizza, Christopher Donoian, Armen Booker, Shyla Sun, Ying Biomedical Engineering Program Department of Electrical and Computer Engineering University of Rhode Island Kingston RI 02881-0805 United States

ISBN: (纸本)0780395638

Shortening-deactivation and Stretch-activation are well established techniques to study the dynamics of muscles. However, very limited data exists for comparing the two techniques. This study was conducted to perform stretch and release on the same muscle specimen and to determine whether a correlation exists between the two data sets. The entire heart of the clam (Venus mercenaria) was used in a muscle bath preparation. The neurotransmitter 5-hydroxytryptamine (5HT) was used to modulate the cardiac rhythmicity. Stretch-activation and shortening-deactivation at different phases of a spontaneous contraction cycle were introduced by used a computer-controller lever system. A preliminary analysis based on the time integral of the deviation of a perturbed force curve from the normal curve did not show a significant correlation between stretch-activation and shortening-deactivaton. Future study will include additional experiments and more sophisticated model-based analyses. © 2006 IEEE.

关键词： Muscle

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electrically modeled reciprocal inhibitory oscillator

Electrically modeled reciprocal inhibitory oscillator

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IEEE 32nd Annual Northeast Bioengineering Conference, 2006

作者： Keseberg, Christoph Maio-Cannon, Shannon Mackenzie, Christopher Chabot, Eugene DiCecco, John Wu, Jiang Sun, Ying Biomedical Engineering Program Department of Electrical and Computer Engineering University of Rhode Island Kingston RI 02881-0805 United States

ISBN: (纸本)0780395638

A model of the neuronal reciprocal inhibitory oscillator was developed in this study by use of an entirely electronic platform. Neuronal Oscillators were widely studied in previous research due to their important roll as central pattern generators. Our model consisted of two electronic components, the neuron emulator for modeling the electrical activities of a neuron and the artificial synapse for mimicking a synaptic connection between two neurons. The typical bursting patterns of action potentials were demonstrated by connecting two Neuron Emulators with the Artificial Synapse. These electronic devices provided a unique hardware platform for studying reciprocal inhibitory oscillators and other neuronal networks. © 2006 IEEE.

关键词： Oscillators (electronic)

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Carbon nanostructure field emission devices

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Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures 2006年第2期24卷 1008-1012页

作者： Wong, Y.M. Kang, W.P. Davidson, J.L. Soh, K.L. Choi, B.K. Hofmeister, W. Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN 37235 Interdisciplinary Graduate Program in Material Science Vanderbilt University Nashville TN 37235 Department of Chemical Engineering Vanderbilt University Nashville TN 37235

The microwave plasma chemical vapor deposition (MPCVD) method is capable of synthesizing various forms of carbon allotropes such as diamond, carbon nanotubes (CNTs), and diamondlike carbon (DLC) while varying the growth parameters or utilizing substrate coated with catalytic thin film. In this article, needlelike carbon nanostructures (CNs) were synthesized utilizing high power (5 kW) and high working pressure (120 Torr) MPCVD on a thin catalytic film of nickel with a diffusion barrier layer of titanium on a micropatterned silicon substrate. The effects of in situ doping by trimethylboron (TMB) on the morphologies and field emission properties of the CNs were also investigated. Straight, needlelike CNs with random orientation were obtained for 15 min growth time with or without TMB doping. However, the CNs appear to transform into diamondlike nanocrystals after prolonged growth of 30 min with TMB doping. Unlike MPCVD grown CNTs, it was found that the CNs have strong adhesion to the substrate and could withstand postgrowth processing such as ultrasonic agitation cleaning in solvents. Field emission tests performed show that in situ TMB doping of the patterned needlelike CNs lowers the turn-on field of the cathode. A vacuum field emission triode with self-aligned gate utilizing CNs as the field emitter is also fabricated. © 2006 American Vacuum Society.

关键词： Carbon nanotubes

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Erratum to “Biphasic electric current stimulates proliferation and induces VEGF production in osteoblasts” [Biochim. Biophys. Acta 1763 (2006) 907–916]

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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2007年第3期1773卷 471-471页

作者： In Sook Kim Jong Keun Song Yu Lian Zhang Tae Hyung Lee Tae Hyung Cho Yun Mi Song Do Kyun Kim Sung June Kim Soon Jung Hwang Dental Research Institute Brain Korea 21 2nd Program Seoul National University Korea School of Electrical Engineering and Computer Science Seoul National University Korea Department of Oral and Maxillofacial Surgery College of Dentistry Seoul National University Brain Korea 21 2nd Program Korea

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Redesign of the core curriculum at Duke University

Redesign of the core curriculum at Duke University

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113th Annual ASEE Conference and Exposition, 2006

作者： Brown, April Ybarra, Gary Massoud, Hisham Board, John Holmes, Joseph Coonley, Kip Collins, Leslie Huettel, Lisa Gustafson, Michael Cummer, Steven Duke University United States Department of Electrical and Computer Engineering Duke University United States AcuityEdge Inc. Masters of Engineering Management Program Duke University United States Department of Practice Undergraduate Laboratories Department of Electrical and Computer Engineering Duke University United States

No abstract available

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Effectively recruiting engineers to become MBA students

Effectively recruiting engineers to become MBA students

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113th Annual ASEE Conference and Exposition, 2006

作者： Brown, Erin Tougaw, Doug Valparaiso University United States Valparaiso University Master of Business Administration Program United States Department of Engineering Department of Electrical and Computer Engineering Valparaiso University United States

No abstract available

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