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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： E. Stan J. McNames S.S. Kohles C. Biber N. Biberic N. Leech R.W. Mangan T.J. McKinney M. Surdu B. Goldstein Department of Electrical and computer engineering Portland state university Portland OR USA Department of Electrical and Computer Engineering Center for Micromagnetics and Information Technologies Portland state university Portland OR USA Kohles Bioengineering Portland OR USA Department of Mechanical and Materials Engineering Portland State University Portland OR USA Complex Systems Laboratory Department of Pediatrics Oregon Health and Sciences University Portland OR USA

This work presents the design of a mechanical vasoconstriction mechanism with application for cerebral autoregulation. The relationship between the applied voltage of a DC motor and the tension within a pressurized vessel wall was utilized for constricting an arteriole segment within an intracranial vascular model. Using current proportional to the string tension, options for closed loop feedback control are considered.

关键词： DC motors Laboratories Biomedical engineering Voltage Cranial pressure Brain injuries Monitoring Medical treatment Humans Biomedical signal processing

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Background activity originating from same area as events in the EEG of paediatric patients with focal epilepsy

Background activity originating from same area as events in ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： B. Vanrumste R.D. Jones P.J. Bones G.J. Carroll Department of Electrical and Computer Engineering University of Canterbury Christchurch New Zealand Department of Medical Physics & Bioengineering Christchurch Hospital Christchurch New Zealand Department of Electrical Engineering (ESAT/SCD) Katholieke Universiteit Leuven Leuven Belgium Department of Medicine Christchurch School of Medicine and Health Science Christchurch New Zealand

The aim of this study was to investigate the presence of apparent non-epileptiform activity arising in the same brain area as epileptiform activity in the EEG of paediatric patients with focal epilepsy. The EEG from eight patients was analyzed by an automated method which detects epochs with a single underlying source having a dipolar potential distribution. The EEG with the highlighted detections was then rated by an EEGer with respect to epileptiform activity. Although EEGer-marked events and computer detections often coincided, in five out of the eight patients a substantial number of other detections were found to arise from the same area as the marked events. The morphology of a high proportion of these other detections did not resemble typical epileptiform activity.

关键词： Epilepsy Electroencephalography Pediatrics Event detection Lesions Hospitals Singular value decomposition Bones Physics Biomedical engineering

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Multi-modality three-dimensional optical imaging of engineered tissues

Multi-modality three-dimensional optical imaging of engineer...

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Biomedical Topical Meeting, BIOMED 2004

作者： Tan, Wei Fahrner, Lester J. Sendemir-Urkmez, Aylin Jamison, Russell D. Leckband, Deborah E. Boppart, Stephen A. Beckman Institute for Advanced Science and Technology University of Illinois at Champaign-Urbana UrbanaIL61801 United States Department of Materials Science and Engineering University of Illinois at Champaign-Urbana UrbanaIL61801 United States Department of Chemical Engineering University of Illinois at Champaign-Urbana UrbanaIL61801 United States Department of Electrical and Computer Engineering Bioengineering Program Beckman Institute for Advanced Science and Technology College of Medicine University of Illinois at Urbana-Champaign 405 North Mathews Avenue UrbanaIL61801 United States

Optical coherence tomography (OCT), confocal, and multiphoton microscopy are used to nondestructively monitor in situ cell distribution and cell-matrix interaction in 3-D engineered tissues composed of chitosan scaffo... 详细信息

ISBN: (纸本)1557527695

关键词： Tissue

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Polarization-modulated second harmonic generation imaging: method for quantitative assessment of disorganization in anulus

Polarization-modulated second harmonic generation imaging: m...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： K.M. Reiser I. Rocha-Mendoza M. Wang D.R. Yankelevich C. Bratton A. Knoesen J.C. Lotz E. Liebenman Department of Neurological Surgery University of California Davis Davis CA USA Electrical and Computer Engineering University of California슠Davis Davis CA USA Electrical and Computer Engineering University of California Davis Davis CA USA Physics Department University of California슠Davis Davis CA USA Orthopaedic Bioengineering Laboratory Department of Orthopaedic Surgery University of California San Francisco CA USA

An experimental method for quantifying disorder within the anulus fibrosus is described based on polarization-modulated second harmonic generation imaging (PM-SHG-I). This method is demonstrated by imaging the anular lamellar architecture of a mouse model of compressive loading. Results were consistent with those obtained in an earlier study where organization was quantified directed secants image analysis on photomicrographs. In this study the orientation within individual lamellia is quantified by average orientation of the collagen molecules within a defined volume of a single lamellar as measured by the PM-SHG-I. Lamellar boundaries can be identified through the SHG intensity images, and confirmed through co-registration with photomicrographs of the same region. The orientation within the lamellar is quantified by the polarization angle of the maximum second harmonic intensity. PM-SHG-I offers several advantages as compared with the method of directed secants: first, it is nondestructive, allowing repeated measurements of the same tissue; second, images are captured on the order of seconds and capable of obtaining information up to a depth of 200-300 microns, thus allowing for real-time assessment of load damage; third, organization is measured at a much higher resolution, as it is based on disorder within the molecular arrays of a single lamella.

关键词： Polarization Frequency conversion Optical harmonic generation Mice Pins Biological system modeling Orthopedic surgery Animals Optical imaging Biological tissues

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Patterning to influence in vitro neuronal interfaces

Patterning to influence in vitro neuronal interfaces

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： B.C. Wheeler Yoonkey Nam G.J. Brewer Department of Bioengineering University of Illinois Urbana-Champaign Urbana-Champaign IL USA Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana-Champaign IL USA Department of Medical Microbiology and Immunology School of Medicine Southem Illinois University Springfield IL USA

Microlithographic techniques applied to control surface chemistry can be used to guide neurons to surface electrodes in in vitro culture. Here we report on the effectiveness of these techniques as measured by the like... 详细信息

关键词： In vitro Neurons Electrodes Resists Page description languages Microelectrodes Proteins Immune system Nitrogen Chemistry

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Optical coherence tomography of breast cancer: Feasibility for surgical guidance

Optical coherence tomography of breast cancer: Feasibility f...

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Biomedical Topical Meeting, BIOMED 2004

作者： Bredfeldt, Jeremy S. Luo, Wei Marks, Daniel L. Singletary, Keith W. Wisseman, Charles L. Johnson, Patricia A. Boppart, Stephen A. Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign United States Department of Food Science and Human Nutrition Functional Foods for Health Program University of Illinois at Urbana-Champaign United States Surgical Pathology and Oncology Carle Foundation Hospital UrbanaIL United States Department of Electrical and Computer Engineering Beckman Institute for Advanced Science and Technology Bioengineering Program College of Medicine University of Illinois at Urbana-Champaign 405 N. Mathews Avenue UrbanaIL61801 United States

We present the use of OCT for breast cancer imaging. In situ rat mammary and excised human breast tumors were imaged. The feasibility of OCT for applications in surgical oncology of the breast is discussed. © 200... 详细信息

ISBN: (纸本)1557527695

关键词： Optical tomography

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Model of the electromagnetic power pattern of the AIDS virus

Model of the electromagnetic power pattern of the AIDS virus

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Southeastern Symposium on System Theory

作者： Y. Samurin S. Giles H.W. Vayo J. Johnson Electrical Engineering and Computer Science Department University of Tolctlo and Eötvös Lárand University Toledo OH USA Mathematics Department University of Tolctlo and Eötvös Lárand University Toledo OH USA Electrical Engineering Department Tuskegee University Tuskegee AL USA Bioengineering Department University of Tolctlo and Eötvös Lárand University Toledo OH USA

We designed an antenna model of the spherically distributed receptors of the HIV. The model consisted of a combination of electric Hertzian dipole and magnetic dipole antennas. We derived field equations for a 72-element spherical array of electric dipoles, and field equations for a 72-element array of magnetic dipoles. We combined these equations using superposition to model the virus receptors as receiving antennas. The resulting power pattern showed definite maximums at 80- and 280-degree positions, suggesting the virus acted as a radar when scanning for objects such as foreign cells. This work extended results of treating the AIDS virus as an antenna.

关键词： Electromagnetic modeling Acquired immune deficiency syndrome Dipole antennas Equations Toroidal magnetic fields Antenna arrays Receiving antennas computer science Mathematics Biomedical engineering

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Optimization of power compression and stability of relativistic and ponderomotive self-channeling of 248nm laser pulses in underdense plasmas

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Physical Review E 2004年第6期70卷 066406-066406页

作者： J. Davis A. B. Borisov C. K. Rhodes Plasma Physics Division Naval Research Laboratory 4555 Overlook Avenue SW Washington D.C. 20375 USA Laboratory for X-Ray Microimaging and Bioinformatics Department of Physics M∕C 273 University of Illinois at Chicago 845 West Taylor Street Chicago Illinois 60607-7059 USA Department of Bioengineering M∕C 063 University of Illinois at Chicago 851 South Morgan Street Chicago Illinois 60607-7052 USA Department of Computer Science M∕C 102 University of Illinois at Chicago 851 South Morgan Street Chicago Illinois 60607-7042 USA Department of Electrical and Computer Engineering M∕C 154 University of Illinois at Chicago 851 South Morgan Street Chicago Illinois 60607-7053 USA

The controlled formation in an underdense plasma of stable multi-PW relativistic micrometer-scale channels, which conduct a confined power at 248nm exceeding 104 critical powers and establish a peak channel intensity of ∼1023W∕cm2, can be achieved with the use of an appropriate gradient in the electron density in the initial launching phase of the confined propagation. This mode of channel formation optimizes both the power compression and the stability by smoothing the transition from the incident spatial profile to that associated with the lowest channel eigenmode, the dynamically robust structure that governs the confined propagation. A chief outcome is the ability to stably conduct coherent energy at fluences greater than 109J∕cm2.

关键词： Laser pulses

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Nonlinear regimes of coherent optical phonon generation in quantum wells under electric current pumping

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Physical Review B 2003年第15期68卷 155308-155308页

作者： S. M. Komirenko K. W. Kim V. A. Kochelap V. V. Koroteev M. A. Stroscio Department of Bioengineering and Electrical and Computer Engineering University of Illinois at Chicago Chicago Illinois 60707 USA

We present an analysis of nonlinear regimes of the coherent optical phonon generation under the electron drift in quantum wells. The phonon and electron subsystems are treated self-consistently. This allows us to find the steady-state generation regimes with macroscopic populations of optical phonon modes and the electron transport controlled in part by the generated phonons. The generation regimes demonstrate a pronounced threshold character. At high electric fields above the threshold, practically single-mode generation occurs and the current-voltage characteristic is considerably changed. We demonstrate high efficiency generation of the coherent optical phonons by the electric current. The coherent macroscopic optical displacements and the amplitudes of oscillating electrostatic fields are evaluated. The proposed model based on the electron nonlinearities predicts a range of the pumping electric fields under which the steady state phonon generation is realized. Our results suggest that the phonon avalanche occurs beyond this field range.

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Nanostructured Electrodes for Improved Neural Recording

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MRS Online Proceedings Library 2003年第1期729卷 4111-4116页

作者： Cheung, Karen C. Choi, Yang-Kyu Kubow, Tim Lee, Luke P. Berkeley Sensor & Actuator Center and Department of Bioengineering University of California Berkeley USA Department of Electrical Engineering and Computer Science University of California Berkeley USA

We present a new method of increasing the effective electrode surface for improved neural recording. To optimize the electrode, the impedance can be decreased by introducing surface roughness or nanostructures on the electrode. High aspect ratio pillar-like polysilicon nanostructures are created in a reactive ion etch. Nanostructure robustness in cell culture is examined.

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