We present a second-derivative scheme of image processing to enhance the detection of regions of higher absorbance in optical mammograms. The second-derivative images facilitate a spectral analysis that estimates the ...
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In this paper we present the recent technological development of optical coherence tomography (OCT). We also discuss the potential clinical applications of OCT for diagnosing pathological changes in different organs a...
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In this paper we present the recent technological development of optical coherence tomography (OCT). We also discuss the potential clinical applications of OCT for diagnosing pathological changes in different organs and systems.
The development of a rapid, whole blood immunoassay with the capacity to detect various analytes would greatly benefit point-of-care or public health applications, where there is a strong demand for the rapid, high th...
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The development of a rapid, whole blood immunoassay with the capacity to detect various analytes would greatly benefit point-of-care or public health applications, where there is a strong demand for the rapid, high throughput screening of blood-borne species. Immunoassays, with their high affinity/specificity, show the most promise for implementing such a system. Nevertheless, conventional methods, such as the enzyme linked immunosorbent assays (ELISAs), have failed to develop a robust, rapid, whole blood assay, as they require time-consuming sample purification, incubation, and rinsing steps prior to analysis. We have used a new class of optically-active nanoparticles called metal nanoshells to develop a new rapid, near-infrared (NIR) immunoassay capable of detecting very low concentrations of analytes in whole blood within minutes without any sample preparation.
Many applications involving Doppler signals require the accurate estimation of the power-weighted mean frequency over short durations of the signal due to it's nonstationarity. This paper presents a novel algorith...
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Many applications involving Doppler signals require the accurate estimation of the power-weighted mean frequency over short durations of the signal due to it's nonstationarity. This paper presents a novel algorithm for estimating mean frequencies using the eigenstructure of the covariance matrix of the Doppler data. Experimental results indicate that this method is superior to the competing non-parametric methods.
The Internet has opened up an unprecedented opportunity to build up powerful large-scale medical expert systems. In these systems, a cost-effective medical knowledge acquisition and management scheme is highly desirab...
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ISBN:
(纸本)0780376129
The Internet has opened up an unprecedented opportunity to build up powerful large-scale medical expert systems. In these systems, a cost-effective medical knowledge acquisition and management scheme is highly desirable to handle the large quantities of, often conflicting, medical information collected from medical experts in different medical domains and from different regions. To this end, in this paper, we demonstrate that a medical knowledge acquisition/management system can be built upon a three-tier distributed client/server structure. The knowledge in the system is stored/managed in three knowledge bases, and the knowledge flow through these knowledge bases is dependent on the degree of the maturity of the medical know-how. Furthermore, to facilitate the knowledge representation in these knowledge bases as well as information retrieval across the Internet, an 8-digit coding scheme is proposed. At present, a medical knowledge acquisition and management system based on the proposed method is being tested in clinics. The preliminary results showed that the method is a viable solution to build and grow a medical expert system through the Internet.
Quantization of electromagnetic field in isotropic dielectric medium occupying a half space is carried out. For a dielectric having a plane boundary with vacuum, we have constructed a complete orthonormal set of light...
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Quantization of electromagnetic field in isotropic dielectric medium occupying a half space is carried out. For a dielectric having a plane boundary with vacuum, we have constructed a complete orthonormal set of light waves propagating in a whole space. Using this set we calculated the rate of spontaneous emission of photons by electrons in quantum dots and quantum wells. We predict oscillations of photon emission rate as a function of the distance between a quantum nanostructure and the surface.
This account presents a survey of recent advances in quantum-dot research and technology and highlights trends of key significance as they relate to the emerging applications of quantum-dot technology in biology.
This account presents a survey of recent advances in quantum-dot research and technology and highlights trends of key significance as they relate to the emerging applications of quantum-dot technology in biology.
An algorithm has been developed for detection of epileptiform activity in the EEG. The EEG is divided into overlapping epochs, which undergo two steps. The first is singular value decomposition (SVD) which identifies ...
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An algorithm has been developed for detection of epileptiform activity in the EEG. The EEG is divided into overlapping epochs, which undergo two steps. The first is singular value decomposition (SVD) which identifies the number of uncorrelated active sources in an epoch. In the second step, EEG dipole source analysis, using a single dipole model, is applied to the EEG. This yields dipole parameters and a relative residual energy (RRE). The detection algorithm triggers an EEG epoch when SVD indicates a dominant source and the RRE is low. The algorithm is applied to simulated EEG generated by two sources which are synchronously and asynchronously active. For the synchronous case the critical measure is the RRE whereas for the asynchronous case both the SVD and RRE are critical. The algorithm has also been applied to real EEG containing two spikes and an eye-blink artifact. The SVD indicated a dominant active source and the RRE was low for all three events. These preliminary results demonstrate the potential of the method for detection of spikes and seizures with a focal origin.
A novel etching approach to high aspect ratio polymer micromachining is introduced. A switching chemistry utilizing oxygen as an etchant gas with a C/sub 4/F/sub 8/ passivation step has produced high aspect ratio poly...
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ISBN:
(纸本)0780371852
A novel etching approach to high aspect ratio polymer micromachining is introduced. A switching chemistry utilizing oxygen as an etchant gas with a C/sub 4/F/sub 8/ passivation step has produced high aspect ratio polymer structures. Polymer layers have been bound to a mechanical silicon support, patterned and etched. The silicon is subsequently undercut creating suspended polymer membranes. The polymer microstructures have also been aligned with CMOS MEMS structures in a process compatible with post CMOS micromachining. All steps in the polymer micromachining and post CMOS release are compatible with standard MEMS processing equipment. This approach holds great promise for creating devices with CMOS electronics as sensors and actuators and aligned polymer microstructures serving as integrated fluidic conduits for bioMEMS and micro total analysis systems.
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