Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while ...
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Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.
This article proposes a versatile Multiple Input Multiple Output (MIMO) antenna designed for contemporary wireless systems spanning frequencies from 3 to 20 GHz. It serves applications such as 5G mobile, WiFi, WiFi-6E...
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Maintaining power quality is a critical challenge due to deviations in voltage, current, and frequency, which can lead to equipment malfunction. The increasing energy demand, rising fossil fuel costs, and climate conc...
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There is a growing demand for user-friendly technologies that may empower individuals to independently monitor their physiological parameters. Ultrasound systems are highly promising for healthcare self-monitoring. To...
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Microscale electroporation devices are mostly restricted to in vitro experiments(i.e.,microchannel and microcapillary).Novel fiber-based microprobes enable in vivo microscale electroporation and arbitrarily select the...
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Microscale electroporation devices are mostly restricted to in vitro experiments(i.e.,microchannel and microcapillary).Novel fiber-based microprobes enable in vivo microscale electroporation and arbitrarily select the cell groups of interest to *** developed a flexible,fiber-based microscale electroporation device through a thermal drawing process and femtosecond laser micromachining *** fiber consists of four copper electrodes(80μm),one microfluidic channel(30μm),and has an overall diameter of 400μ*** dimensions of the exposed electrodes and channel were customizable through a delicate femtosecond laser *** feasibility of the fiber probe was validated through numerical simulations and in vitro *** reversible and irreversible microscale electroporation was observed in a 3D collagen scaffold(seeded with U251 human glioma cells)using fluorescent *** ablation regions were estimated by performing the covariance error ellipse method and compared with the numerical *** computational and experimental results of the working fiber-based microprobe suggest the feasibility of in vivo microscale electroporation in space-sensitive areas,such as the deep brain.
Fast fluctuations in wind farm power produce voltage flicker in the *** way to mitigate the flicker is to place a static VAr compensator(SVC).Due to the operating delay of SVCs,it is essential to predict the wind farm...
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Fast fluctuations in wind farm power produce voltage flicker in the *** way to mitigate the flicker is to place a static VAr compensator(SVC).Due to the operating delay of SVCs,it is essential to predict the wind farm reactive ***,a novel fuzzy nonlinear modeling approach is suggested and used in the one-step-ahead prediction of the power *** base of the developed fuzzy modeling is the Takagi-Sugeno fuzzy representation and a dual-unscented Kalman filter(D-UKF).In other words,a nonlinear TS fuzzy system is trained online via the *** forecasted value is used as the SVC’s reference signal.A large amount of actual data gathered from a wind farm is used for the performance *** data is collected in winter and summer for different climate *** the actual data,a current source with changing amplitude and phase which is updated every half-cycle,is used to model the wind *** results,including the flicker indices,confirm the improvement in the SVC’s performance.
Handwrítten digil recognition remains a cumplcx challenge ín computer visión, characlcrized by diverse wriling stylcs, varying dislortivn levéis, and datase! noisc. This pnper introduces a novel mo...
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Depression is a common and serious mental illness that affects millions of people worldwide. Early diagnosis and treatment of depression are essential to improve the quality of life of those affected. Traditional meth...
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Although Deep Neural Networks (DNNs) have established a solid place for themselves in different applications, their mysterious inner working impedes their usage in sensitive applications. Interpretability-based method...
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The application of virtual reality (VR) technologies during physical therapy is gaining popularity due to enhanced outcomes and increased patient engagement. However, the neurological mechanisms responsible for the ob...
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