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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Hubert de Bruin Gary Hasey Julie Hemily Electrical and Computer Engineering Department McMaster University Department of Psychiatry and Behavioual Neurosciences McMaster University Electrical and Biomedical Engineering Program McMaster University

ISBN: (纸本)9781424441211

This paper presents the preliminary results of a study to determine dorsolateral prefrontal cortex sensitivity to rTMS stimulation presented at clinically accepted amplitudes, frequencies and locations. A specially developed EEG system with 10-20 electrode locations was used to record the short latency magnetically evoked potentials. Sixteen normal subjects were stimulated using 10 Hz for the left hemisphere and 1 Hz for the right. The evoked potentials recorded for left sided stimulation were significantly larger than for the right sided stimulation. Further, the stimulation energies, though within the range used clinically for the treatment of depression were insufficient to excite evoked potentials in several subjects.

关键词： Evoked potentials RTMS Stimulus cortical sensitivity Transcranial magnetic stimulation

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A reliable password-based user authentication scheme for web-based human genome database system

A reliable password-based user authentication scheme for web...

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5th IEEE International Conference on Digital Ecosystems and Technologies, DEST 2011

作者： Chen, Wei-Hsin Wu, Zhen-Yu Lai, Feipei Chien, Yin-Hsiu Hwu, Wu-Liang Graduate Institute of Biomedical Electronic and Bioinfomatics National Taiwan University Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University and Hospital Taipei Taiwan Department of Electrical Engineering National Taiwan University and Hospital Taipei Taiwan Department of Medical Genetics National Taiwan University and Hospital Taipei Taiwan

ISBN: (纸本)9781457708725

With the initial completion of Human Genome Project, the post-genomic era is coming. Although the genome map of human has been decoded, the roles that each segment of sequences acts are not totally discovered. On the other hand, with the rapid expansion of sequence information, the issues of data compilation and data storage are increasingly important. Recently, a Web-based Human Genome Database System is implemented in National Taiwan University Hospital. The achievement of this system is that it integrates the modules of sequence alignment and data compression on genome. For goals of secure accessing this system over insecure networks, protocols of user authentication become more important. They are able to ensure the security of data transmission and users' communication. In this paper, a password-based user authentication scheme, because of its convenience, efficiency, and property of simplicity for human memory, is proposed for the system. © 2011 IEEE.

关键词： Database systems

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SYSTEMS BIOLOGY IN BARLEY POWDERY MILDEW INTERACTIONS

SYSTEMS BIOLOGY IN BARLEY POWDERY MILDEW INTERACTIONS

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The 13th International Cereal Rusts and Powdery Mildews Conference(第13届国际禾谷类锈病与白粉病大会)

作者： Roger WISE Priyanka SURANA Greg FUERST Ruo XU Dan NETTLETON Divya MISTRY Julie DICKERSON Lin WANG Tom BRUTNELL Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Department of Statistics Iowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA Department of Plant Pathology and MicrobiologyCenter for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Crop and Insect Genetics Genomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA Department of Plant Pathology and Microbiology Center for Plant Responses to Environmental StressesIowa State UniversityAmesIowa 50011USA Department of StatisticsIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate ProgramIowa State UniversityAmesIowa 50011USA Bioinformatics and Computational Biology Graduate Program Iowa State UniversityAmesIowa 50011USA Crop and Insect GeneticsGenomicsand Informatics Research UnitU.S.Department of Agriculture-Agricultural Research ServiceIowa State UniversityAmesIowa 50011USA Department of Electrical and Computer Engineering Iowa State UniversityAmesIowa 50011USA Boyce Thompson Institute for Plant ResearchCornell UniversityIthacaNY

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A Radial Basis Function Spike Model for Indirect Learning via Integrate-and-Fire Sampling and Reconstruction Techniques

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Advances in Artificial Neural Systems 2012年第1期2012卷

作者： X. Zhang G. Foderaro C. Henriquez A. M. J. VanDongen S. Ferrari Laboratory for Intelligent Systems and Control (LISC) Department of Mechanical Engineering and Materials Science Duke University Durham NC 27708 USAduke.edu Department of Biomedical Engineering and Department of Computer Science Duke University Durham NC 27708 USAduke.edu Program in Neuroscience & Behavioral Disorders Duke-NUS Graduate Medical School Singapore Singapore

This paper presents a deterministic and adaptive spike model derived from radial basis functions and a leaky integrate-and-fire sampler developed for training spiking neural networks without direct weight manipulation. Several algorithms have been proposed for training spiking neural networks through biologically-plausible learning mechanisms, such as spike-timing-dependent synaptic plasticity and Hebbian plasticity. These algorithms typically rely on the ability to update the synaptic strengths, or weights, directly, through a weight update rule in which the weight increment can be decided and implemented based on the training equations. However, in several potential applications of adaptive spiking neural networks, including neuroprosthetic devices and CMOS/memristor nanoscale neuromorphic chips, the weights cannot be manipulated directly and, instead, tend to change over time by virtue of the pre- and postsynaptic neural activity. This paper presents an indirect learning method that induces changes in the synaptic weights by modulating spike-timing-dependent plasticity by means of controlled input spike trains. In place of the weights, the algorithm manipulates the input spike trains used to stimulate the input neurons by determining a sequence of spike timings that minimize a desired objective function and, indirectly, induce the desired synaptic plasticity in the network.

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Handling failures of static sensor nodes in wireless sensor network by use of mobile sensors

Handling failures of static sensor nodes in wireless sensor ...

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25th IEEE International Conference on Advanced Information Networking and Applications Workshops, WAINA 2011

作者： Pignaton De Freitas, Edison Heimfarth, Tales Netto, Ivayr Farah Pereira, Carlos Eduardo Ferreira, Armando Morado Wagner, Flávio Rech Larsson, Tony IDE Halmstad University Halmstad Sweden Institute of Informatics Federal University of Rio Grande Do Sul Porto Alegre Brazil Computer Science Department Federal University of Lavras Lavras Brazil Electrical Engineering Department Federal University of Rio Grande Do Sul Porto Alegre Brazil Defense Engineering Graduate Program Military Institute of Engineering Rio de Janeiro Brazil

ISBN: (纸本)9780769543383

Node failures in Wireless Sensor Networks composed by static sensor nodes are common due to the nature of the sensor devices and the usually harsh environments in which they are deployed. Node failures can diminish the performance of the network as a whole, thus affecting its functionality in delivering the desired services. For instance, significant regions can become uncovered due to failure of several nearby nodes. This paper reports a study about the use of mobile sensor nodes acting in cooperation with static ones in order to fill gaps created by faulty static nodes. The proposed fault handling mechanism presents alternative policies with pros and cons, depending on the user priorities imposed to the system and the occurrence of failures. A discussion about this topic is presented based on results obtained by simulation of the proposed mechanisms. © 2011 IEEE.

关键词： Sensor nodes

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282

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Cytokine 2013年第3期63卷 310-310页

作者： Elia D. Tait Wojno Mario Noti Brian S. Kim Mark C. Siracusa Paul R. Giacomin Meera G. Nair Alain J. Benitez Kathryn R. Ruymann Amanda B. Muir David A. Hill Kudakwashe R. Chikwava Amin E. Moghaddam Quentin J. Sattentau Aneesh Alex Chao Zhou Paul Menard-Katcher Masato Kubo Kazushige Obata-Ninomiya Hajime Karasuyama Michael R. Comeau David Artis Department of Microbiology University of Pennsylvania Philadelphia PA USA Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Queensland Tropical Health Alliance and School of Public Health and Tropical Medicine James Cook University Cairns Australia Division of Gastroenterology Hepatology and Nutrition Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pediatrics Division of Allergy and Immunology Children’s Hospital of Philadelphia Philadelphia PA USA Department of Pathology and Laboratory Medicine Children’s Hospital of Philadelphia Philadelphia PA USA The Sir William Dunn School of Pathology The University of Oxford Oxford UK Department of Electrical and Computer Engineering Lehigh University Bethlehem PA USA Center for Photonics and Nanoelectronics Lehigh University BethlehemPA USA Bioengineering Program Lehigh University Bethlehem PA USA Division of Gastroenterology Hospital of the University of Pennsylvania Philadelphia PA USA Laboratory for Signal Network Research Center for Allergy and Immunology RIKEN Yokohama Institute Yokohama Japan Division of Molecular Pathology Research Institute for Biological Science Tokyo University of Science Chiba Japan Department of Immune Regulation Tokyo Medical and Dental University Graduate School Tokyo Japan JST CREST Tokyo Medical and Dental University Graduate School Tokyo Japan Inflammation Research Amgen Inc. Seattle WA USA Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA

Eosinophilic esophagitis (EoE) is a food allergy-associated disease characterized by esophageal eosinophilia and associated inflammation. EoE has become increasingly common in industrialized countries. However, current management strategies, such as treatment with swallowed steroids and dietary restrictions, are nonspecific or negatively impact the quality of life of EoE patients. In addition, use of more specific therapies that target immunoglobulin E (IgE) and interleukin (IL)-5 have been largely unsuccessful in ameliorating EoE. Thus, there is an urgent need to identify novel, specific immunological pathways that underlie the pathogenesis of EoE that could be targeted to treat this disease. Recently, a genome-wide association study identified that EoE is associated with a gain-of-function polymorphism in the gene that encodes thymic stromal lymphopoietin (TSLP). TSLP is an IL-7 family member cytokine that promotes allergic inflammation by eliciting T helper type 2 cytokine responses, IgE production, and the expansion of a distinct population of basophils . However, whether TSLP directly promotes allergic inflammation in the esophagus and the mechanisms by which TSLP might contribute to the pathogenesis of EoE remain unknown. Here, we describe a new murine model of experimental EoE-like disease that was used to investigate the role of TSLP in allergic inflammation of the esophagus. Murine experimental EoE-like disease developed independently of IgE but was dependent on TSLP-elicited basophils. Critically, therapeutic antibody-mediated neutralization of TSLP or depletion of basophil populations ameliorated established EoE-like disease in mice. Finally, elevated TSLP levels and exaggerated basophil responses were observed in esophageal biopsies from EoE patients, and a gain-of-function polymorphism in TSLP correlated with increased basophil responses in patients with EoE. Together, these data indicate that TSLP-elicited basophil responses may play a key role in medi

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Automatic Generation of Balletic Motions

Automatic Generation of Balletic Motions

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IEEE/ACM International Conference on Cyber-Physical Systems (ICCPS)

作者： Amy LaViers Magnus Egerstedt Yushan Chen Calin Belta School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA USA Department of Electrical and Computer Engineering Boston University Boston MA USA Department of Mechanical Engineering Division of Systems Engineering and the Bioinformatics Graduate Program Boston University MA USA

As cyber-physical systems become more prevalent, specifications for these systems must be formulated in a more nuanced manner. This paper presents a particular instantiation of such specification by proposing a framework that endows robotic motions with a sense of aesthetic style. Drawing inspiration from classical ballet, poses are cast as discrete states and movements as the transitions between these states. Thus, a given movement style is encoded in the availability of transitions at each state, and the dynamics of a complex physical trajectory are abstracted as a system which moves between these states. Using Linear Temporal Logic (LTL), we are able to further constrain the set of possible sequences through the transition system and thus prevent it from evolving through a sequence of states that is physically impossible or aesthetically undesirable. Our overarching objective is to facilitate subtle degrees of control over systems as such subtleties are required, more and more, to interact in a social and aesthetically driven world.

关键词： Automata Leg Legged locomotion Humans Trajectory Hip

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Responses of human fetal mesenchymal stem cells to various poly(Ε-caprolactone) films: A comparison study

Responses of human fetal mesenchymal stem cells to various p...

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2011 Defense Science Research Conference and Expo, DSR 2011

作者： Wang, Zu-Yong Jing, Lim Zhang, Qin-Yuan Teo, Erin Y. Chan, Jerry Hong, Ming-Hui Wen, Feng Teoh, Swee-Hin Department of Mechanical Engineering National University of Singapore Singapore Department of Obstetrics and Gynaecology National University of Singapore Singapore Department of Reproductive Medicine KK Women's and Children's Hospital Singapore Cancer and Stem Cell Biology Program Duke-NUS Graduate Medical School Singapore Department of Electrical and Computer Engineering National University of Singapore Singapore School of Material Science and Engineering Nanyang Technology University Singapore National University of Singapore Singapore

ISBN: (纸本)9781424492763

Poly(Ε-caprolactone) (PCL) films have been applied for vascular tissue engineering. However, few studies studied the effects of fabrication process of PCL film on vascular cell proliferation. In this study, we used different processing methods, incorporating stretching, to fabricate various PCL films. Thickness of films before and after stretch and proliferation ability of human fetal mesenchymal stem cells (hfMSCs) on these films were investigated. Our results showed that stretching significantly reduces the thickness of solvent cast, heat press and cast stretch films (0.22, 0.59, 0.60, p

关键词： Cell proliferation

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All-optical generation and detection of acoustic waves for intravascular ultrasound and photoacoustic imaging

All-optical generation and detection of acoustic waves for i...

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IEEE Symposium (IUS) Ultrasonics

作者： Bao-Yu Hsieh Sung-Liang Chen Tao Ling L. Jay Guo Pai-Chi Li Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor MI USA Graduate Institute of Biomedical Electronics and Bioinformatics Department of Electrical Engineering National Taiwan University Taipei Taiwan

ISBN: (纸本)9781457712531

The combination of intravascular ultrasound (IVUS) and photoacoustic (IVPA) imaging has been a potentially effective tool for detection of atherosclerotic plaques. Its clinical applications, however, have been hindered by several factors, including the lack of a cost-effective solution for a disposable scanhead. In this study, we propose a new scanhead design for IVUS/IVPA imaging. Specifically, the design is based on optical generation and detection of acoustic waves for both imaging modalities. No electronic components and conventional piezoelectric materials are used and the design is suitable for one-time, disposable use. The all-optical IVUS/IVPA imaging scanhead consists of an optical fiber with an axicon tip for excitation, and a microring for acoustic detection. Using a single firing of laser pulse, an ultrasound (US) signal can be generated and transmitted by the scanhead and a photoacoustic (PA) signal from the object can be induced. It has been tested on a grid phantom. The -6dB spatial resolution for lateral and axial direction were estimated at 305μm and 169μm. In our study, US and PA signals are separated by time delays and a subband imaging technique. In addition, mass production is possible with the adoption of the nanoimprint technique for fabrication. Therefore, this design has the potential to be a useful clinical tool for atherosclerosis diagnosis in the future.

关键词： Optical resonators Ultrasonic imaging Optical imaging Optical fibers Optical device fabrication

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Evoked Potentials SNR maximization by PCA and genetic algorithms

Evoked Potentials SNR maximization by PCA and genetic algori...

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International IEEE/EMBS Conference on Neural engineering, CNE

作者： Ruben Gaitan-Ortiz Oscar Yanez-Suarez Juan M Cornejo-Cruz Biomedical Engineering Graduate Program Universidad Autonoma Metropolitana Iztapalapa Mexicali Mexico Neuroimaging Laboratory of the Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexicali Mexico Audiology Laboratory of the Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexicali Mexico

Middle Latency Auditory Evoked Potentials are bioelectrical signals that constitute a key technique for the assessment and diagnosis of various clinical conditions, nonetheless background electrical activity and artifacts prevent clinically relevant information to be revealed. Many state of the art techniques allow physicians to remove noise and help them to reach assertive diagnosis, however those techniques are often related to a priori signal templates that induce bias on the resulting information. In this paper a technique based on the iterative evaluation and combination of the available EEG trials is presented and performance is evaluated by comparing the results obtained from processing data from normo-hearing and clinically deaf patients. Results suggest that the proposed methodology improves the SNR ratio of the records by the only usage of the patient's EEG and a few fixed parameters.

关键词： Genetic algorithms Electroencephalography Signal to noise ratio Conferences Electric potential Eigenvalues and eigenfunctions

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