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arXiv 2020年

作者： Rahman, Tawsifur Khandakar, Amith Qiblawey, Yazan Tahir, Anas Kiranyaz, Serkan Kashem, Saad Bin Abul Islam, Mohammad Tariqul Maadeed, Somaya Al Zughaier, Susu M. Khan, Muhammad Salman Chowdhury, Muhammad E.H. Department of Biomedical Physics & Technology University of Dhaka Dhaka 1000 Bangladesh Department of Electrical Engineering Qatar University Doha2713 Qatar Faculty of Robotics and Advanced Computing Qatar Armed Forces‐Academic Bridge Program Qatar Foundation Doha24404 Qatar Dept. of Electrical Electronics and Systems Engineering Universiti Kebangsaan Malaysia BangiSelangor43600 Malaysia Department of Computer Science and Engineering Qatar University Doha2713 Qatar Department of Basic Medical Sciences College of Medicine Biomedical and Pharmaceutical Research Unit QU Health Qatar University Doha2713 Qatar University of Engineering and Technology Peshawar Pakistan

The use of computer-aided diagnosis in the reliable and fast detection of corona virus disease (COVID-19) has become a necessity to prevent the spread of the virus during the pandemic to ease the burden on the medical infrastructure. Chest X-ray (CXR) imaging has several advantages over other imaging techniques as it is cheap, easily accessible, fast and portable. CXR images are sometimes of poor quality and so image enhancement techniques can help the machine learning models to extract valuable discriminating features from the image. Numerous works have been reported on COVID-19 detection from smaller set of original X-ray images. However, the effect of image enhancement in COVID-19 detection was not reported in the literature. This paper explores the effect of various popular image enhancement techniques and states the © 2020, CC BY.

关键词： Image enhancement

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The cysteine-altering p.R544C variant in the NOTCH3 gene is a probable candidate for blood pressure and relevant traits in the Taiwan Biobank

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Journal of neurology 2023年第11期270卷 5536-5544页

作者： Eugene Lin Po-Hsiu Kuo Yu-Li Liu Tso-Jen Wang Albert C Yang Shih-Jen Tsai Department of Biostatistics University of Washington 3980 15th Avenue NE Box 351617 Seattle WA 98195 USA. lines@uw.edu. Department of Electrical and Computer Engineering University of Washington Seattle WA 98195 USA. lines@uw.edu. Graduate Institute of Biomedical Sciences China Medical University Taichung 40402 Taiwan. lines@uw.edu. Department of Public Health Institute of Epidemiology and Preventive Medicine National Taiwan University Taipei 10617 Taiwan. Department of Psychiatry National Taiwan University Hospital Taipei 100 Taiwan. Center for Neuropsychiatric Research National Health Research Institutes Miaoli County 35053 Taiwan. Taoyuan Psychiatric Center Ministry of Health and Welfare Taoyuan 33058 Taiwan. Brain Research Center National Yang Ming Chiao Tung University Taipei 11221 Taiwan. Department of Psychiatry Taipei Veterans General Hospital No. 201 Shih-Pai Road Sec. 2 Taipei 11217 Taiwan. tsai610913@***. Division of Psychiatry National Yang Ming Chiao Tung University Taipei 112304 Taiwan. tsai610913@***.

BACKGROUND:The cysteine-altering variants in NOTCH3 have been suggested to be associated with stroke, dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), where aberrant blood pressure levels represent the characteristics of these diseases. We aimed to assess whether the cysteine-altering ***544Cys (p.R544C; rs201118034) variant and common single nucleotide variants (SNVs) in NOTCH3 could contribute to systolic and diastolic blood pressure and related phenotypes in the Taiwan Biobank. METHODS:We employed a discovery sample of 68,925 individuals, an independent replication sample of 45,676 individuals, and a combined/total sample of 114,601 individuals; all from the Taiwan Biobank. Blood pressure, such as systolic and diastolic blood pressure, was measured for all participants. Association was evaluated using a general linear model, where results were considered statistically significant if the P value < 0.05 divided by the number of independent tests per model. RESULTS:From our analysis, we identified and replicated three novel candidates for blood pressure that have not previously been reported: the cysteine-altering p.R544C variant for systolic blood pressure, the common SNV rs11669950 for diastolic blood pressure, and the common SNV rs4808235 for diastolic blood pressure. We also generalized two previously identified SNVs (i.e., rs10418305 and rs7408868) in NOTCH3 for blood pressure in European and non-Taiwanese East Asian populations to the Taiwanese population. Moreover, the participants with NOTCH3 p.R544C had an increased stroke frequency (P < 1.0 × 10) and a higher dementia frequency (P = 2.0 × 10) compared with the whole Taiwan Biobank population in the combined/total sample. CONCLUSION:NOTCH3 is a strong candidate for a role in stroke, dementia, and CADASIL, which has previously been linked to blood pressure changes. While our preliminary study suggests that NOTCH3 p.R544C may influence blood

关键词： Biobank Blood pressure CADASIL Dementia NOTCH3 Neurology Stroke

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Gold-silver alloy nanodisk array for smartphone colorimetric biosensing

Gold-silver alloy nanodisk array for smartphone colorimetric...

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Bio-Optics: Design and Application, BODA 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019

作者： Misbah, Ibrahim Shih, Wei-Chuan Department of Electrical and Computer Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Biomedical Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Program of Materials Science and Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Chemistry University of Houston 4800 Calhoun Rd HoustonTX77004 United States

Plasmonic hybridization in a gold-silver alloy nanodisks array results in a pair of high and low energy LSPR modes. This high energy mode is applied for colorimetric detection of sub-nM and sub-monolayer biotin-strept... 详细信息

ISBN: (纸本)9781943580545

关键词： Smartphones

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Plasmonic sensors on invisible substrates

Plasmonic sensors on invisible substrates

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Bio-Optics: Design and Application, BODA 2019

Gold nanodisks array with minimal effect from the glass substrates have been fabricated using nanosphere lithography and HF undercutting. The undercut substrates have blueshifted plasmonic resonance with higher bulk r... 详细信息

ISBN: (纸本)9781943580545

关键词： Glass substrates

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Holographic photothermal microbubble assisted imaging spectroscopy

Holographic photothermal microbubble assisted imaging spectr...

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Optical Manipulation and Its Applications, OMA 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019

作者： Ohannesian, Nareg Misbah, Ibrahim Shih, Wei-Chuan Department of Electrical and Computer Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Biomedical Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Program of Materials Science and Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Chemistry University of Houston 4800 Calhoun Rd HoustonTX77004 United States

We present holographic generation of photothermal microbubbles on high-density nanoporous gold array, which allows dynamic control of size and location, and can be used for assembling micro/nanoparticles readily measu...

ISBN: (纸本)9781943580545

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Smartphone light sheet fluorescence microscopy for molecular diagnostics

Smartphone light sheet fluorescence microscopy for molecular...

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Bio-Optics: Design and Application, BODA 2019

作者： Nguyen, Hoang Shih, Wei-Chuan Department of Electrical and Computer Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Biomedical Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Program of Materials Science and Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Chemistry University of Houston 4800 Calhoun Rd HoustonTX77004 United States

A new design and implementation of smartphone light sheet microscopy based on inkjet-printed DotLens is presented. Its ultimate simplicity, yet high quality imaging and sensing capabilities would find applications in ... 详细信息

ISBN: (纸本)9781943580545

关键词： Smartphones

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Multiplex sensing of lead and mercury in drinking water using smartphone nano-colorimetry

Multiplex sensing of lead and mercury in drinking water usin...

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Bio-Optics: Design and Application, BODA 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019

We report smartphone nano-colorimetry (SNC) for mobile and multiplex detection and quantitation of lead and mercury ions in drinking water. The detection limit is below EPA action levels set for both metal ions. ©... 详细信息

ISBN: (纸本)9781943580545

关键词： Colorimetry

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Holographic optical tweezers assisted imaging spectroscopy

Holographic optical tweezers assisted imaging spectroscopy

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Optical Manipulation and Its Applications, OMA 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019

作者： Rakhshandehroo, Mohsen Shih, Wei-Chuan Department of Electrical and Computer Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Biomedical Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Program of Materials Science and Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Chemistry University of Houston 4800 Calhoun Rd HoustonTX77004 United States

Holographic optical tweezers (HOT) is an effective means for optical manipulation. Herein we demonstrate its integration with imaging spectroscopy for biological and biomedical applications. © 2019 The Author(s).

ISBN: (纸本)9781943580545

关键词： Holography

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Glucose sensing by stamping surface-enhanced Raman spectroscopy (S-SERS)

Glucose sensing by stamping surface-enhanced Raman spectrosc...

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Bio-Optics: Design and Application, BODA 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019

作者： Lin, Chun-Jen Misbah, Ibrahim Shih, Wei-Chuan Department of Electrical and Computer Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Biomedical Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Program of Materials Science and Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Chemistry University of Houston 4800 Calhoun Rd HoustonTX77004 United States

We report glucose sensing 10 mM to 0.1 mM in water using stamping surface-enhanced Raman spectroscopy (S-SERS) technique with nanoporous gold disk (NPGD) plasmonic substrates, a reagent- and separation-free technique.... 详细信息

ISBN: (纸本)9781943580545

关键词： Stamping

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Aptamer-based SERS detection and quantitation of small molecules and enzymes on plasmonic nanostructures

Aptamer-based SERS detection and quantitation of small molec...

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Bio-Optics: Design and Application, BODA 2019 - Part of Biophotonics Congress: Optics in the Life Sciences Congress 2019

作者： Qiu, Suyan Shih, Wei-Chuan Department of Electrical and Computer Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Biomedical Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Program of Materials Science and Engineering University of Houston 4800 Calhoun Rd HoustonTX77004 United States Department of Chemistry University of Houston 4800 Calhoun Rd HoustonTX77004 United States

Sensitive and selective detection and quantitation of small molecules and enzymatic activities have been attempted using surface-enhanced Raman spectroscopy (SERS). Preimmobilized aptamers and in situ assembled aptame... 详细信息

ISBN: (纸本)9781943580545

关键词： Molecules

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