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Integrating multi-omics with neuroimaging and behavior: A preliminary model of dysfunction in football athletes

Neuroimage: Reports 2021年第3期1卷 100032-100032页

作者： Bari, Sumra Vike, Nicole L. Stetsiv, Khrystyna Walter, Alexa Newman, Sharlene Kawata, Keisuke Bazarian, Jeffrey J. Papa, Linda Nauman, Eric A. Talavage, Thomas M. Slobounov, Semyon Breiter, Hans C. Warren Wright Adolescent Center Department of Psychiatry and Behavioral Sciences Feinberg School of Medicine Northwestern University Chicago IL United States Department of Kinesiology Pennsylvania State University University Park PA United States Department of Psychological and Brain Sciences Indiana University Bloomington IN United States Department of Kinesiology School of Public Health-Bloomington Indiana University Bloomington IN United States Program in Neuroscience College of Arts and Sciences Indiana University Bloomington IN United States Department of Emergency Medicine University of Rochester Rochester NY United States Department of Emergency Medicine Orlando Regional Medical Center Orlando FL United States Weldon School of Biomedical Engineering Purdue University West Lafayette IN United States School of Mechanical Engineering Purdue University West Lafayette IN United States Department of Basic Medical Sciences Purdue University West Lafayette IN United States School of Electrical and Computer Engineering Purdue University West Lafayette IN United States Department of Biomedical Engineering University of Cincinnati Cincinnati OH United States Laboratory of Neuroimaging and Genetics Department of Psychiatry Massachusetts General Hospital and Harvard School of Medicine Boston MA United States

Contact sports affect measures at multiple scales such as transcriptomics, metabolomics, brain function, and behavior, but studies have not yet studied the statistical structure of how they are integrated. This preliminary study, examining collegiate American football players, integrated across-season changes (Δ) from transcriptomic and metabolomic variables (neuroinflammatory miRNAs and metabolites), neuroimaging (resting-state fMRI network fingerprint similarity), and virtual reality (VR)-based motor control. These findings were then assessed against head acceleration events (HAE). Using permutation-based moderation analysis (all pF^perm,pβ3^perm ≤0.05), we observed that (1) Δtridecenedioate, a mono-unsaturated fatty acid, interacted with ΔmiR-505 to predict default mode network (DMN) fingerprint similarity, meaning the interaction between two molecular biology measures predicted a neuroimaging measure. Further, (2) Δtridecenedioate and DMN fingerprint similarity interacted to predict motor control, indicating the interaction of a molecular and a neuroimaging measure predicted behavior. ΔmiR-505 was positively related to HAE and DMN fingerprint similarity was negatively related to HAE and reduced relative to non-athlete subjects. These multi-scale, moderating relationships between a potential ROS scavenger, neuroinflammatory miRNA, reduced brain connectivity, and diminished motor control argue that seemingly healthy athletes with frequent HAE may experience chronic neuroinflammation. This imaging-omics framework using permutation-based mediation/moderation analysis has general applicability for human-animal translational studies.

关键词： Football Head impacts miR-505 Motor control rs-fMRI Tridecenedioate

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An artificial neural network for hand movement classification using surface electromyography 12

An artificial neural network for hand movement classificatio...

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12th International Conference on Bio-Inspired Systems and Signal Processing, BIOSIGNALS 2019 - Part of 12th International Joint Conference on biomedical engineering Systems and Technologies, BIOSTEC 2019

作者： Viana, Paulo L. Fujii, Victoria S. Lima, Larissa M. Ouriques, Gabriel L. Oliveira, Gustavo C. Varoto, Renato Cliquet, Alberto Department of Electrical and Computer Engineering Trabalhador São-Carlense Avenue 400 São Carlos Brazil University of São Paulo Interunits Graduate Program in Bioengineering Trabalhador São-Carlense Avenue 400 São Carlos Brazil Department of Orthopedics and Traumatology University of Campinas Cidade Universitária Zeferino Vaz Campinas Brazil

ISBN: (纸本)9789897583537

In this paper we present the development of an artificial neural network that uses surface EMG data from two forearm muscles to classify hand movements and gestures. We trained our network to classify three different sets of movements, using EMG data from six healthy subjects. We were able to achieve hit rates of above 99% in the training sets and hit rates of above 85% in all three test sets, with a maximum of 88.8% for the second movement set. Advantages of the proposed method include small number of electrodes, reduced complexity, computational cost and response time. Copyright © 2019 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved.

关键词： Neural networks

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FLAIR MRI biomarkers of the Normal-Appearing Brain Matter (NABM) are related to APOE-4 status and CSF markers Aβ42 and Tau

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Alzheimer's & Dementia 2023年第S3期19卷

作者： Karissa Chan Corinne E. Fischer Houman Khosravani Sandra E. Black Pascal Tyrrell Pejman Jabehdar Maralani Alan R. Moody April Khademi Electrical Computer and Biomedical Engineering Department Ryerson University Toronto ON Canada St. Michael’s Hospital Toronto ON Canada University of Toronto Toronto ON Canada Keenan Research Centre for Biomedical Science St. Michael’s Hospital Toronto ON Canada Faculty of Medicine Department of Psychiatry University of Toronto Toronto ON Canada Institute of Medical Sciences University of Toronto Toronto ON Canada Keenan Research Centre for Biomedical Science the Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto ON Canada Division of Neurology Department of Medicine University of Toronto Toronto ON Canada Heart and Stroke Foundation Canadian Partnership for Stroke Recovery Toronto ON Canada Sunnybrook Research Institute Toronto ON Canada Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto ON Canada Toronto Dementia Research Alliance Toronto ON Canada LC Campbell Cognitive Neurology Research Unit Sunnybrook Research Institute Toronto ON Canada Department of Statistical Science University of Toronto Toronto ON Canada Department of Medical Imaging University of Toronto Toronto ON Canada Keenan Research Centre for Biomedical Research the Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto ON Canada Ryerson University IAMLAB Department of Electrical Computer and Biomedical Engineering Toronto ON Canada

Background Reduced amyloid-beta-42 (Aβ42) and elevated total tau (t-tau) protein concentrations in the CSF are characteristic of Alzheimer’s disease (AD) pathology [1]. Aβ42 contributes to extracellular plaque formation between neurons [2]. The total level of tau, a microtubule-stabilizer in neuron axons [3], is associated with neuronal death [1]. Additionally, presence of ApoE4 (ε4) alleles is an established identifier for increased risk of AD [4]. Non-invasive imaging-based correlates of the CSF markers are lacking. This study examines correlations of novel FLAIR texture, intensity, and volume biomarkers, along with white matter lesion (WML) burden, with Aβ42, t-tau, and ε4 status. Method FLAIR volumes (n = 4044) from the ADNI database were used for analysis with CSF biomarkers. A subset (n = 921) was used for ε4 analysis based on available data. Normal-appearing brain matter (NABM) was obtained by removing CSF and WML. Macrostructural damage (MAD), microstructural damage (MID), and integrity (MII) texture biomarkers [5] were extracted from each NABM volume (Fig. 1), along with median intensity, NABM/ICV ratio, and normalized WML volume [5]. Relationships between FLAIR biomarkers and AD markers were described using parametric statistical analyses. Statistical significance was set at p<0.05. Result All FLAIR biomarkers were statistically significantly correlated with CSF Aβ42 levels. All features except MID and WML burden were significantly correlated with CSF t-tau levels (Table 1). MAD, MID, and WML burden showed negative correlations with Aβ42, while MAD showed a positive correlation with t-tau. Opposite trends were seen with MII, intensity, and NABM/ICV (Fig. 2). Significant differences between groups without and with one ε4 allele were found in all FLAIR biomarkers except WML burden. Significant differences in MAD, MII and NABM/ICV were found between groups with one and two ε4 alleles (Table 2). Conclusion FLAIR biomarkers were inversely associated with CSF Aβ

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Implementation of Mobile game for Religion Learning

Implementation of Mobile game for Religion Learning

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2019 IEEE International Conference on engineering, Technology and Education, TALE 2019

作者： Sulistiyo, Edy Vindy Anwar, Nizirwan Warnars, Diana Teresia Spits Wibawa, Setya Chendra Brotosaputro, Goenawan Kristiadi, Dedy Prasetya Warnars, Harco Leslie Hendric Spits Hashimoto, Kiyota Universitas Negeri Surabaya Electrical Engineering Department Jawa Timur60213 Indonesia School of Computer Science Bina Nusantara University Game Application Technology Program Jakarta11480 Indonesia Esa Unggul University Faculty of Computer Science Jakarta11510 Indonesia Bina Nusantara University Information Systems Department Jakarta11480 Indonesia Universitas Budi Luhur Information System Department Jakarta12260 Indonesia Raharja University Computer Science Department Tangerang15117 Indonesia Binus Graduate Program - Doctor of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia Prince Songkla University Faculty of Technology and Environment Phuket Campus Thailand

ISBN: (纸本)9781728126654

Currently, the growth of information and technology is rapid. It makes a lot of things in various fields including education becoming more effective and efficient. In education, one of its implementation which is a game is proven to be a useful tool to support conventional teaching methods and bring a more natural understanding of learning materials. Moreover, as a product of the popular culture in modern society, video game mirrors the general culture practice in real life and reflects it via its own culture inside the game. This makes a video game can give a contribution to the social construction of reality as it affects the player's view towards learning in real life and vice versa. From there, we see that there is an opportunity for learning about religion to be supported by its utilization to provide an interactive and fun learning experience. In this paper, we discuss how a video game is implemented to support religious learning. The game was developed with the scrum method where we surveyed to gather the user requirements before the design step. The game design was made by using the use case diagram and storyboard, and it was built using Unity version 2017.3.0f3. © 2019 IEEE.

关键词： Serious games

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Three-dimensional bioprinting of gelatin methacryloyl (GelMA)

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Bio-Design and Manufacturing 2018年第4期1卷 215-224页

作者： Guoliang Ying Nan Jiang Cunjiang Yu Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolCambridgeMA 02139USA School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205People's Republic of China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02139USA Departments of Mechanical Engineering Electrical and Computer EngineeringBiomedical EngineeringMaterials Science and Engineering ProgramThe Texas Center for SuperconductivityUniversity of HoustonHoustonTX 77204USA

The three-dimensional (3D)bioprinting technology has progressed tremendously over the past *** controlling the size, shape,and architecture of the bioprinted constructs,3D bioprinting allows for the fabrication of tissue/organ-like constructs with strong structural-functional similarity with their in vivo counterparts at high *** bioink,a blend of biomaterials and living cells possessing both high biocompatibility and printability,is a critical component of *** particular, gelatin methacryloyl (GelMA)has shown its potential as a viable bioink material due to its suitable biocompatibility and readily tunable physicochemical *** GelMA-based bioinks and relevant bioprinting strategies for GelMA bioprinting are briefly reviewed.

关键词： Bioprinting Bioink Gelatin methacryloyl (GelMA) Biofabrication -Tissue engineering Tissue model

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Nonreciprocal Willis Coupling in Zero-Index Moving Media

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Physical Review Letters 2019年第6期123卷 064301-064301页

作者： Li Quan Dimitrios L. Sounas Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Department of Electrical and Computer Engineering Wayne State University Detroit Michigan 48202 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10016 USA Department of Electrical Engineering City College of The City University of New York New York 10031 USA

Mechanical motion can break the symmetry in which sound travels in a medium, but significant nonreciprocity is typically achieved only for large motion speeds. We combine moving media with zero-index acoustic propagation, yielding extreme nonreciprocity and induced bianisotropy for modest applied speeds. The metamaterial is formed by an array of waveguides loaded by Helmholtz resonators, and it exhibits opposite signs of the refractive index sustained by asymmetric Willis coupling for propagation in opposite directions. We use this response to induce nonreciprocal positive-to-negative sound refraction, and we propose a nonreciprocal metamaterial lens focusing only with excitation from one side based on asymmetric Willis coupling.

关键词： Acoustic metamaterials Acoustic wave phenomena Acoustics

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Feasibility study of Information Technology Investment (a case study of ODOO ERP: Project Management Module Implementation in Indonesia Based Company)

Feasibility study of Information Technology Investment (a ca...

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International Conference on ICT For Smart Society (ICISS)

作者： Fredy Jingga Raymond Kosala Suhono Harso Supangkat Benny Ranti Computer Science Department BINUS Graduate Program - Doctor of Computer Science Information Systems Department School of Information Systems Bina Nusantara University Jakarta Indonesia Computer Science Department BINUS Graduate Program - Doctor of Computer Science Bina Nusantara University Jakarta Indonesia School of Electrical Engineering and Informatics Bandung Institute of Technology Bandung Indonesia

IT Governance are one of the needs in managing Enterprise Level IT. This study shows part of the decision domain of IT Governance Help, which are IT Investment and Prioritization. The purpose of this study is to determine feasibility of implementation open source ERP system Odoo project management module that replaces current system based on operational, economic, and technical aspects. The method used are Fit / Gap Analysis and Cost Benefit model using economic impact worksheet. The analysis is done by comparing the requirement with features owned by current system and Odoo ERP system. This research resulted that Odoo ERP System is feasible in the 3 aspects, the operational feasibility Odoo reaching 72% Fit, the economic feasibility with ROI of 84%, and technical feasibility indicating the technical requirement can be fulfilled by leasing AWS server. The conclusion is the open source ERP system Odoo project management module is feasible to be applied in terms of 3 aspects that have been studied, those are operational, economic, and technical.

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scTenifoldXct: A semi-supervised method for predicting cell-cell interactions and mapping cellular communication graphs

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Cell systems 2023年第4期14卷 302-311.e4页

作者： Yongjian Yang Guanxun Li Yan Zhong Qian Xu Yu-Te Lin Cristhian Roman-Vicharra Robert S Chapkin James J Cai Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA. Department of Statistics Texas A&M University College Station TX 77843 USA. Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University 3663 North Zhongshan Road Shanghai 200062 China. Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan. Department of Nutrition and the Program in Integrative Nutrition & Complex Diseases Texas A&M University College Station TX 77843 USA. Electronic address: r-chapkin@tamu.edu. Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA Interdisciplinary Program of Genetics Texas A&M University College Station TX 77843 USA. Electronic address: jcai@tamu.edu.

We present scTenifoldXct, a semi-supervised computational tool for detecting ligand-receptor (LR)-mediated cell-cell interactions and mapping cellular communication graphs. Our method is based on manifold alignment, using LR pairs as inter-data correspondences to embed ligand and receptor genes expressed in interacting cells into a unified latent space. Neural networks are employed to minimize the distance between corresponding genes while preserving the structure of gene regression networks. We apply scTenifoldXct to real datasets for testing and demonstrate that our method detects interactions with high consistency compared with other methods. More importantly, scTenifoldXct uncovers weak but biologically relevant interactions overlooked by other methods. We also demonstrate how scTenifoldXct can be used to compare different samples, such as healthy vs. diseased and wild type vs. knockout, to identify differential interactions, thereby revealing functional implications associated with changes in cellular communication status.

关键词： cell-cell interaction cellular communication gene regression network machine learning manifold alignment neural networks scRNA-seq single-cell RNA sequencing

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Development and Validation of a Finger Tremor Simulator

Development and Validation of a Finger Tremor Simulator

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2018 IEEE Canadian Conference on electrical and computer engineering, CCECE 2018

作者： Zhou, Yue Naish, Michael D. Jenkins, Mary E. Luisa Trejos, Ana Biomedical Engineering Program Western University LondonON Canada Department of Mechanical and Materials Engineering Western University LondonON Canada Clinical Neurological Sciences Movement Disorders Program Western University LondonON Canada Department of Electrical and Computer Engineering Western University LondonON Canada

ISBN: (纸本)9781538624104

Tremor, being one of the most severe symptoms of Parkinson's disease, has been considered as not only a medical problem but also an engineering problem. Increasingly, wearable technologies are being considered as a viable treatment option. In order to study and control tremor in the field of engineering, the first step often includes modeling and simulation, as access to patients is limited. With the successful realization of a finger tremor simulator, a wearable tremor suppression device could be validated prior to testing on humans. In this study, a tremor simulator was designed and validated with recorded patient tremor data. Two experimental assessments were conducted on the validation of tremor motion reproduction and tremor torque reproduction. The results showed that the proposed simulator has 9%, 82%, and 141% error in the reproduction of the power of the 1st, 2nd and 3rd harmonics of the tremor, and 11.89% mean error on motion reproduction. The tremor torque measured at the index finger metacarpophalangeal joint is 0.02pm 0.02 Nm, and the output torque from the tremor simulator is 0.03 pm 0.01 Nm. Further parameter adjustment of the control system is required to improve performance. © 2018 IEEE.

关键词： Neurodegenerative diseases

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Tunneling spectroscopy of c-axis epitaxial cuprate junctions

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Physical Review B 2020年第22期101卷 224512-224512页

作者： Panpan Zhou Liyang Chen Ilya Sochnikov Tsz Chun Wu Matthew S. Foster Anthony T. Bollinger Xi He Ivan Božović Douglas Natelson Department of Physics and Astronomy Rice University Houston Texas 77005 USA Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston Texas 77005 USA Department of Physics University of Connecticut Storrs Connecticut 06269 USA Brookhaven National Laboratory Upton New York 11973–5000 USA Department of Chemistry Yale University New Haven Connecticut 06520 USA Department of Electrical and Computer Engineering Rice University Houston Texas 77005 USA Department of Materials Science and NanoEngineering Rice University Houston Texas 77005 USA

Atomically precise epitaxial structures are unique systems for tunneling spectroscopy that minimize extrinsic effects of disorder. We present a systematic tunneling spectroscopy study, over a broad doping, temperature, and bias range, in epitaxial c-axis La2−xSrxCuO4/La2CuO4/La2−xSrxCuO4 heterostructures. The behavior of these superconductor/insulator/superconductor (SIS) devices is unusual. Down to 20 mK there is complete suppression of c-axis Josephson critical current with a barrier of only 2 nm of La2CuO4, and the zero-bias conductance remains at 20–30% of the normal-state conductance, implying a substantial population of in-gap states. Tunneling spectra show greatly suppressed coherence peaks. As the temperature is raised, the superconducting gap fills in rather than closing at Tc. For all doping levels, the spectra show an inelastic tunneling feature at ∼80 meV, suppressed as T exceeds Tc. These nominally simple epitaxial cuprate junctions deviate markedly from expectations based on the standard Bardeen-Cooper-Schrieffer theory.

关键词： Coherence length Impurities in superconductors Josephson effect Quasiparticles & collective excitations Superconducting gap Superconducting phase transition d-wave Cuprates Heterostructures High-temperature superconductors Multilayer thin films Scanning tunneling spectroscopy

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