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Author Correction: Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

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Nature neuroscience 2023年第12期26卷 2250页

作者： Kyungchul Noh Woo-Hyun Cho Byung Hun Lee Dong Wook Kim Yoo Sung Kim Keebum Park Minkyu Hwang Ellane Barcelon Yoon Kyung Cho C Justin Lee Bo-Eun Yoon Se-Young Choi Hye Yoon Park Sang Beom Jun Sung Joong Lee Department of Physiology and Neuroscience Dental Research Institute Seoul National University School of Dentistry Seoul Republic of Korea. Department of Physics and Astronomy Seoul National University Seoul Republic of Korea. Department of Molecular Biology Dankook University Cheonan Republic of Korea. Department of Electronic and Electrical Engineering Ewha Womans University Seoul Republic of Korea. Center for Cognition and Sociality Institute for Basic Science (IBS) Daejeon Republic of Korea. Department of Electrical and Computer Engineering University of Minnesota Minneapolis MN USA. Graduate Program in Smart Factory Ewha Womans University Seoul Republic of Korea. Department of Brain & Cognitive Sciences Ewha Womans University Seoul Republic of Korea. Department of Physiology and Neuroscience Dental Research Institute Seoul National University School of Dentistry Seoul Republic of Korea. sjlee87@snu.ac.kr.

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Transferable individual brain regional atrophy progression prediction model using structural connectome

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Yu Xiao Joanna Su Xian Chong Bing Cai Kok Kwun Kei Ng Christopher Li-Hsian Chen Juan Helen Zhou Quantitative Biology and Medicine Program Duke-NUS Medical School Singapore Singapore Centre for Sleep and Cognition & Centre for Translational Magnetic Resonance Research Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Correspondece Department of Pharmacology Clinical Research Centre National University Health System National University of Singapore Singapore Singapore Memory Ageing and Cognition Centre National University Health System Singapore Singapore Electrical and Computer Engineering National University of Singapore Singapore Singapore Integrative Sciences and Engineering Programme (ISEP) NUS Graduate School National University of Singapore Singapore Singapore

Background Brain microstructure, as measured by diffusion MR imaging (dMRI), is an early biomarker of Alzheimer’s disease (AD) and has been previously demonstrated to predict whole brain atrophy and cognition. The network-based neurodegeneration hypothesis posits that the onset of AD occurs within key vulnerable regions, whose network connectivity guides the spread of atrophy into new regions. Graph convolutional network (GCN) models can mimic this spread through its convolution process. Here we present a GCN-based model to predict future individual nodal atrophy and disease progression across the AD spectrum using structural connectome. Method We analyzed 371 participants with baseline dMRI scans (154 cognitively normal (CN), 161 mild cognitive impairment (MCI), 56 AD) and longitudinal T1 scans (2.7±1.2 years) from the ADNI study. To predict annual nodal atrophy rates (126 nodes) from baseline structural connectivity (SC), we constructed a two-layer GCN followed by multilayer perceptron (GCN-MLP). Five-fold nested cross-validation and Optuna were used for hyperparameter tuning. We applied the trained GCN-MLP model to predict future disease progression via transfer learning. GNNExplainer was used to identify the predictive SC features for atrophy or cognition. The GCN-MLP model was validated in another independent dataset from Singapore (MACC) with 226 participants (61 CN, 112 MCI, 53 AD, follow-up period of T1 scans (3.1±1.3 years)) using transfer learning. Result The proposed GCN-MLP model predicted the annual rate of regional atrophy at the individual level in the main (R = 0.5407±0.0480; MAE = 0.0013±0.0001; EV = 0.2930±0.0516) and validation (R = 0.5323±0.0564; MAE = 0.0009±0.0001; EV = 0.2808±0.0559) datasets (Table 1; Figure 1). Graph edge SC of the target network contributed most to the atrophy prediction of its own network (Figure 2A&C). Nodal feature SC in hippocampus, striatum, and temporal network were major predictors of atrophy progression across all 1

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The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2

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Cell 2025年第12期188卷 3167-3183.e18页

作者： Pekar, Jonathan E. Lytras, Spyros Ghafari, Mahan Magee, Andrew F. Parker, Edyth Wang, Yu Ji, Xiang Havens, Jennifer L. Katzourakis, Aris Vasylyeva, Tetyana I. Suchard, Marc A. Hughes, Alice C. Hughes, Joseph Rambaut, Andrew Robertson, David L. Dellicour, Simon Worobey, Michael Wertheim, Joel O. Lemey, Philippe Institute of Ecology and Evolution University of Edinburgh Edinburgh United Kingdom Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla 92093 CA United States Department of Biomedical Informatics University of California San Diego La Jolla 92093 CA United States Department of Medicine University of California San Diego La Jolla 92093 CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Medical Research Council University of Glasgow Centre for Virus Research Glasgow United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States Department of Immunology and Microbiology The Scripps Research Institute La Jolla 92037 CA United States Institute of Genomics and Global Health Redeemer's University Osun State Ede Nigeria Department of Computer Science and Engineering University of California San Diego La Jolla 92093 CA United States Department of Mathematics School of Science and Engineering Tulane University New Orleans LA United States Department of Population Health and Disease Prevention University of California Irvine Irvine 92617 CA United States Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles 90095 CA United States Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles 90095 CA United States School of Biological Sciences University of Hong Kong Hong Kong Hong Kong China Biodiversity Green Development Foundation Beijing China Spatial Epidemiology Lab (SpELL) Université Libre de Bruxelles CP160/12 50 av. FD Roosevelt Bruxelles 1050 Belgium Department of Microbiology Immunology and Transplantation Rega Institute

The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 led to increased sampling of sarbecoviruses circulating in horseshoe bats. Employing phylogenetic inference while accounting for recombination of bat sarbecoviruses, we find that the closest-inferred bat virus ancestors of SARS-CoV and SARS-CoV-2 existed less than a decade prior to their emergence in humans. Phylogeographic analyses show bat sarbecoviruses traveled at rates approximating their horseshoe bat hosts and circulated in Asia for millennia. We find that the direct ancestors of SARS-CoV and SARS-CoV-2 are unlikely to have reached their respective sites of emergence via dispersal in the bat reservoir alone, supporting interactions with intermediate hosts through wildlife trade playing a role in zoonotic spillover. These results can guide future sampling efforts and demonstrate that viral genomic regions extremely closely related to SARS-CoV and SARS-CoV-2 were circulating in horseshoe bats, confirming their importance as the reservoir species for SARS viruses. © 2025 The Authors

关键词： molecular epidemiology phylogeography sarbecoviruses virus evolution

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Magnetic Micromanipulation for In Vivo Measurement of Stiffness Heterogeneity and Anisotropy in the Mouse Mandibular Arch

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研究（英文） 2020年第3期 43-53页

作者： Min Zhu Kaiwen Zhang Hirotaka Tao Sevan Hopyan Yu Sun Department of Mechanical and Industrial Engineering University of Toronto Canada M5S 3G8 Program in Developmental and Stem Cell Biology Research Institute The Hospital for Sick Children Toronto ON Canada M5G 0A4 Department of Molecular Genetics University of Toronto Canada M5S 1A8 Division of Orthopaedic Surgery The Hospital for Sick Children and University of Toronto Canada M5G 1X8 Institute of Biomaterials and Biomedical Engineering University of Toronto Canada M5S 3G9 Department of Electrical and Computer Engineering University of Toronto Canada M5S 3G4

The mechanical properties of tissues are pivotal for morphogenesis and disease *** approaches have enabled measurements of the spatial distributions of viscoelastic properties among embryonic and pathological model systems and facilitated the generation of important hypotheses such as durotaxis and tissue-scale phase *** likely are many unexpected aspects of embryo biomechanics we have yet to discover which will change our views of mechanisms that govern development and *** area in the blind spot of even the most recent approaches to measuring tissue stiffness is the potentially anisotropic nature of that ***,we report a magnetic micromanipulation device that generates a uniform magnetic field gradient within a large workspace and permits measurement of the variation of tissue stiffness along three orthogonal *** applying the device to the organ-stage mouse embryo,we identify spatially heterogenous and directionally anisotropic stiffness within the mandibular *** properties correspond to the domain of expression and the angular distribution of fibronectin and have potential implications for mechanisms that orient collective cell movements and shape tissues during *** of anisotropic properties extends the repertoire of current methods and will enable the generation and testing of hypotheses.

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Considerations for the development of LMR-based optical fiber sensors for gas sensing applications

Considerations for the development of LMR-based optical fibe...

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Bragg Gratings, Photosensitivity and Poling in Glass Waveguides and Materials, BGPPM 2018

作者： Dreyer, Uilian José Ozcariz, Aritz Zubiate, Pablo Martelli, Cicero da Silva, Jean C.C. Zamarreño, Carlos Ruiz Graduate Program in Electrical and Computer Engineering Federal University of Technology - Paraná Curitiba80230-901 Brazil Electric and Electronic Engineering Department Public University of Navarra Campus Arrosadia Pamplona31006 Spain

This work presents a preliminary study of a LMR-based gas sensor. Results of the device subjected to annealing process show a stable and repetitive response that is required for the utilization in gas sensing applicat... 详细信息

ISBN: (纸本)9781943580439

关键词： Gas detectors

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Multi-Coil MRI reconstruction challenge - Assessing brain MRI reconstruction models and their generalizability to varying coil configurations

arXiv

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arXiv 2020年

作者： Beauferris, Youssef Teuwen, Jonas Karkalousos, Dimitrios Moriakov, Nikita Caan, Matthan Yiasemis, George Rodrigues, Lúvia Lopes, Alexandre Pedrini, Helio Rittner, Letícia Dannecker, Maik Studenyak, Viktor Gröger, Fabian Vyas, Devendra Faghih-Roohi, Shahrooz Jethi, Amrit Kumar Raju, Jaya Chandra Sivaprakasam, Mohanasankar Lasby, Mike Nogovitsyn, Nikita Loos, Wallace Frayne, Richard Souza, Roberto Radiology and Clinical Neurosciences University of Calgary Canada Hotchkiss Brain Institute University of Calgary Canada Seaman Family Mr Research Centre Foothills Medical Center Canada Department of Medical Imaging Radboud University Medical Center Netherlands Department of Radiation Oncology Netherlands Cancer Institute Netherlands ICAI-AI for Oncology University of Amsterdam Netherlands Department of Biomedical Engineering and Physics Amsterdam Umc University of Amsterdam Netherlands School of Electrical and Computer Engineering University of Campinas Brazil Institute of Computing University of Campinas Brazil Computer Aided Medical Procedures Technical University of Munich Germany India Iitm India Department of Electrical and Software Engineering University of Calgary Canada Centre for Depression and Suicide Studies St. Michael's Hospital Canada Mood Disorders Program Department of Psychiatry and Behavioural Neurosciences McMaster University Canada

Deep-learning-based brain magnetic resonance imaging (MRI) reconstruction methods have the potential to accelerate the MRI acquisition process. Nevertheless, the scientific community lacks appropriate benchmarks to assess MRI reconstruction quality of high-resolution brain images, and evaluate how these proposed algorithms will behave in the presence of small, but expected data distribution shifts. The Multi-Coil Magnetic Resonance Image (MC-MRI) Reconstruction Challenge provides a benchmark that aims at addressing these issues, using a large dataset of high-resolution, threedimensional, T1-weighted MRI scans. The challenge has two primary goals: 1) to compare different MRI reconstruction models on this dataset and 2) to assess the generalizability of these models to data acquired with a different number of receiver coils. In this paper, we describe the challenge experimental design, and summarize the results of a set of baseline and state of the art brain MRI reconstruction models. We provide relevant comparative information on the current MRI reconstruction state-of-the-art and highlight the challenges of obtaining generalizable models that are required prior to broader clinical adoption. The MC-MRI benchmark data, evaluation code and current challenge leaderboard are publicly available. They provide an objective performance assessment for future developments in the field of brain MRI reconstruction. Copyright © 2020, The Authors. All rights reserved.

关键词： Inverse problems

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The bulk van der Waals layered magnet CrSBr is a quasi-1D material

arXiv

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arXiv 2022年

作者： Klein, Julian Pingault, Benjamin Florian, Matthias Heißenbüttel, Marie-Christin Steinhoff, Alexander Song, Zhigang Torres, Kierstin Dirnberger, Florian Curtis, Jonathan B. Weile, Mads Penn, Aubrey Deilmann, Thorsten Dana, Rami Bushati, Rezlind Quan, Jiamin Luxa, Jan Sofer, Zdenek Alù, Andrea Menon, Vinod M. Wurstbauer, Ursula Rohlfing, Michael Narang, Prineha Lončar, Marko Ross, Frances M. Department of Materials Science and Engineering Massachusetts Institute of Technology CambridgeMA02139 United States John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA02138 United States QuTech Delft University of Technology Delft2600 GA Netherlands Department of Electrical and Computer Engineering Department of Physics University of Michigan Ann ArborMI48109 United States Institut für Festkörpertheorie Westfälische Wilhelms-Universität Münster Münster48149 Germany Institut für Theoretische Physik Universität Bremen P.O. Box 330 440 Bremen28334 Germany Bremen Center for Computational Materials Science University of Bremen Bremen28359 Germany Department of Physics City College of New York New YorkNY10031 United States College of Letters and Science UCLA Los AngelesCA90095 United States Department of Physics Technical University of Denmark Kgs. LyngbyDK-2800 Denmark MIT.nano Massachusetts Institute of Technology CambridgeMA02139 United States Department of Physics The Graduate Center City University of New York New YorkNY10016 United States Photonics Initiative CUNY Advanced Science Research Center New YorkNY10031 United States Physics Program Graduate Center City University of New York New YorkNY10026 United States Department of Inorganic Chemistry University of Chemistry and Technology Prague Technická 5 Prague 6166 28 Czech Republic Institute of Physics Center for Nanotechnology University of Münster Münster48149 Germany

Correlated quantum phenomena in one-dimensional (1D) systems that exhibit competing electronic and magnetic order are of strong interest for studying fundamental interactions and excitations, such as Tomonaga-Luttinger liquids and topological orders and defects with properties completely different from the quasiparticles expected in their higher-dimensional counterparts. However, clean 1D electronic systems are difficult to realize experimentally, particularly magnetically ordered systems. Here, we show that the van der Waals layered magnetic semiconductor CrSBr behaves like a quasi-1D material embedded in a magnetically ordered environment. The strong 1D electronic character originates from the Cr-S chains and the combination of weak interlayer hybridization and anisotropy in effective mass and dielectric screening with an effective electron mass ratio of meX/meY ∼ 50. This extreme anisotropy experimentally manifests in strong electron-phonon and exciton-phonon interactions, a Peierls-like structural instability and a Fano resonance from a van Hove singularity of similar strength of metallic carbon nanotubes. Moreover, due to the reduced dimensionality and interlayer coupling, CrSBr hosts spectrally narrow (1 meV) excitons of high binding energy and oscillator strength that inherit the 1D character. Overall, CrSBr is best understood as a stack of weakly hybridized monolayers and appears to be an experimentally attractive candidate for the study of exotic exciton and 1D correlated many-body physics in the presence of magnetic order. Copyright © 2022, The Authors. All rights reserved.

关键词： Excitons

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Shot noise in a strange metal

arXiv

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arXiv 2022年

作者： Chen, Liyang Lowder, Dale T. Bakali, Emine Andrews, Aaron Maxwell Schrenk, Werner Waas, Monika Svagera, Robert Eguchi, Gaku Prochaska, Lukas Wang, Yiming Setty, Chandan Sur, Shouvik Si, Qimiao Paschen, Silke Natelson, Douglas Applied Physics Graduate Program Rice University 6100 Main St. HoustonTX77005 United States Department of Physics and Astronomy Rice Center for Quantum Materials Rice University 6100 Main St. HoustonTX77005 United States Institute of Solid State Physics TU Wien Wiedner Hauptstraße 8-10 Vienna1040 Austria Institute of Solid State Electronics TU Wien Gußhausstraße 25-25a Gebäude CH Vienna1040 Austria Center for Micro and Nanostructures TU Wien Gußhausstraße 25-25a Gebäude CH Vienna1040 Austria Department of Electrical and Computer Engineering Rice University 6100 Main St. HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University 6100 Main St. HoustonTX77005 United States

Strange-metal behavior has been observed in materials ranging from high-temperature superconductors to heavy fermion metals. In conventional metals, current is carried by quasiparticles;although it has been suggested that quasiparticles are absent in strange metals, direct experimental evidence is lacking. We measured shot noise to probe the granularity of the current-carrying excitations in nanowires of the heavy fermion strange metal YbRh2Si2. When compared with conventional metals, shot noise in these nanowires is strongly suppressed. This suppression cannot be attributed to either electron-phonon or electron-electron interactions in a Fermi liquid, which suggests that the current is not carried by well-defined quasiparticles in the strange-metal regime that we probed. Our work sets the stage for similar studies of other strange metals. Copyright © 2022, The Authors. All rights reserved.

关键词： Nanowires

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Effect of Zeeman coupling on the Majorana vortex modes in iron-based topological superconductors

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Physical Review B 2020年第2期101卷 020504(R)-020504(R)页

作者： Areg Ghazaryan P. L. S. Lopes Pavan Hosur Matthew J. Gilbert Pouyan Ghaemi IST Austria (Institute of Science and Technology Austria) Am Campus 1 3400 Klosterneuburg Austria Stewart Blusson Quantum Matter Institute University of British Columbia Vancouver British Columbia Canada V6T 1Z4 Department of Physics University of Houston Houston Texas 77204 USA Micro and Nanotechnology Laboratory University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA Department of Electrical Engineering Stanford University Stanford California 94305 USA Physics Department City College of the City University of New York New York New York 10031 USA Physics Program Graduate Center of the City University of New York New York 10031 USA

In the superconducting regime of FeTe(1−x)Sex, there exist two types of vortices which are distinguished by the presence or absence of zero-energy states in their core. To understand their origin, we examine the interplay of Zeeman coupling and superconducting pairings in three-dimensional metals with band inversion. Weak Zeeman fields are found to suppress intraorbital spin-singlet pairing, known to localize the states at the ends of the vortices on the surface. On the other hand, an orbital-triplet pairing is shown to be stable against Zeeman interactions, but leads to delocalized zero-energy Majorana modes which extend through the vortex. In contrast, the finite-energy vortex modes remain localized at the vortex ends even when the pairing is of orbital-triplet form. Phenomenologically, this manifests as an observed disappearance of zero-bias peaks within the cores of topological vortices upon an increase of the applied magnetic field. The presence of magnetic impurities in FeTe(1−x)Sex, which are attracted to the vortices, would lead to such Zeeman-induced delocalization of Majorana modes in a fraction of vortices that capture a large enough number of magnetic impurities. Our results provide an explanation for the dichotomy between topological and nontopological vortices recently observed in FeTe(1−x)Sex.

关键词： Majorana bound states Topological superconductors Iron-based superconductors

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Magnetless Circulators with Harmonic Rejection Based on N-Way Cyclic-Symmetric Time-Varying Networks

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Physical Review Applied 2019年第2期12卷 024046-024046页

作者： Ahmed Kord Harish Krishnaswamy Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA Department of Electrical Engineering Columbia University New York New York 10027 USA Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10026 USA Department of Electrical Engineering City College of New York New York New York 10031 USA

Magnetfree circulators are crucial devices to enable full-duplex communications with the goal of enhancing the spectral efficiency of wireless radios compared to currently deployed half-duplex systems. Nevertheless, implementations proposed to date at radio- and millimeter-wave frequencies have been based on spatiotemporally modulating a discrete number of nonlinear elements, such as varactors or switched capacitors, which, despite achieving strong nonreciprocity, suffer from spurious emission in adjacent channels and limited power handling. These problems jeopardize the practical use of these components in many applications, including wireless communications and quantum computing, and make them less attractive compared to harmonicfree magnetic devices. We address these problems by introducing N-way circulators, which consist of N spatiotemporally modulated angular-momentum (STM AM) biased units connected either in series or in parallel and modulated through a rotating phase pattern. We show that these circuits, for a sufficiently large N, effectively impart an overall linear and continuous angular-momentum bias, which significantly reduces spurious emission and increases the overall power handling. This, in turn, strengthens the argument of magnetless circulators compared to their magnetic counterparts, and opens exciting venues to address the realistic needs of practical systems.

关键词： Electromagnetism Metamaterials Photonics Quantum information with hybrid systems Devices T-symmetry

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