Osteoporosis is a common disease characterized by low bone density and structural deterioration of bone tissue. For a successful course of treatment and fracture avoidance, early diagnosis of this disease is essential...
Osteoporosis is a common disease characterized by low bone density and structural deterioration of bone tissue. For a successful course of treatment and fracture avoidance, early diagnosis of this disease is essential. The aim was to provide a novel method for osteoporosis prediction using Artificial Intelligence (AI)-based framework. The purpose was to predict the likelihood of osteoporosis based on the Bone Mineral Density (BMD), along with other characteristics such as age, weight, height, gender, and Body Mass Index (BMI) extracted from medical reports and images collected from a comprehensive medical center in Lebanon. Three machine-learning algorithms were implemented and tested, Logistic Regression (LR), Support Vector Machines (SVM), and Decision Trees (DT). Variety of quantitative statistical metrics were used to evaluate the performance of our framework, upon training and testing our algorithms. The metrics that were employed to evaluate our results included accuracy, precision, sensitivity, and F-score, in addition to the Receiver Operating Characteristic (ROC) Curve and the Area Under the Curve (AUC). Experimental Results demonstrated that both the SVM and LR algorithms achieved the highest accuracy of detection of osteoporosis as compared to existing algorithms applied in this field, with an accuracy of 89%. The sensitivity of diagnosis obtained was 98% by LR and 97% by SVM and surpassed the sensitivity obtained by DT. As such LR showed the best performance. The output of the algorithms could help medical doctors assess patients automatically. These findings demonstrated the potential of AI in osteoporosis prediction and thus prevention, highlighting the significance of early diagnosis. Thereby as a future prospect, choosing carefully the framework is crucial and additional algorithms have to be considered and tested.
Myocardial strain imaging provides a valuable tool for detecting subclinical left ventricular (LV) dysfunction and adding prognostic value in assessing various types of heart disease. Recent studies have utilized high...
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We present a discrete-event system formalism to capture experimentally observed activity of genes in single cells, where a gene can stochastically switch between an active state (synthesis of gene products, such as mR...
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We present a discrete-event system formalism to capture experimentally observed activity of genes in single cells, where a gene can stochastically switch between an active state (synthesis of gene products, such as mRNA and proteins) and an inactive state (synthesis is turned OFF). Extending prior work that focused on memory-less switching kinetics, this contribution extends the models considering the time spent in each state to be an arbitrary positively-valued random variable. Here, memory-based switching is captured via the introduction of molecular timers that measure the time spent in a state, and switching rates are timer-dependent. Hence, a gene is more likely to turn OFF if it has been active for a long period. We provide exact analytical derivations of the mean and extent of stochasticity in the gene product level for these models and systematically study how different model parameters can be calibrated to attenuate or amplify noise in gene expression. These results can be combined with experimental data on measured levels inside individual cells to gain valuable insights into the gene expression process across different cell types, from bacterial to human cells.
The BI‐RADS score is a probabilistic reporting tool used by radiologists to express the level of uncertainty in predicting breast cancer based on some morphological features in mammography images. There is a signific...
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The canonical approach to modeling stochasticity considers a dynamical system driven by Gaussian white noise. Here, we propose an alternative hybrid formulation, in which continuous dynamics is interspersed with noise...
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The canonical approach to modeling stochasticity considers a dynamical system driven by Gaussian white noise. Here, we propose an alternative hybrid formulation, in which continuous dynamics is interspersed with noise injection events that occur at discrete times. The time interval between two successive events is drawn from an arbitrary, positively-valued continuous distribution. Although the hybrid approach converges to the classical stochastic differential equation when events occur sufficiently fast, the hybrid formulation captures a wider range of stochastic phenomena that deviate from Gaussian statistics when events occur at slower timescales. These deviations are mathematically captured by exact analytical expressions for higher-order moments, such as skewness and kurtosis of the state space. We illustrate this approach using the example of a nanosensor impacted by collisions from surrounding molecules. Our results provide an important generalization to capture the stochastic dynamics of physical, biological, and engineering systems and reveal a novel approach for exploiting higher-order moments to infer parameters that are not observable in lower-order moments.
Inter-Turn faults (ITFs) rapidly evolve into catastrophic failures of induction motors, thereby needing continuous monitoring. In this regard, methods based on localizing ITF-related harmonics in the line current are ...
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Wireless communication via unmanned aerial vehicles (UAVs) has drawn a great deal of attention due to its flexibility in establishing line-of-sight (LoS) communications. However, in complex urban and dynamic environme...
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The hemodynamic sources of glymphatic flow are typically measured using MRI. In this work, we demonstrate the feasibility of measuring cerebral hemodynamics through NIRS toward the goal of estimating glymphatic flux i...
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Phase transition in vanadium dioxide (VO2) from insulation to metallic phase, makes it an attractive candidate for the realization of electro-absorption modulators. In this paper, we investigate and design a high-perf...
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Redox polymers are a class of high-capacity, low-cost electrode materials for electrochemical energy storage, butthe mechanisms governing their cycling stability are not well understood. Here we investigate the effect...
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Redox polymers are a class of high-capacity, low-cost electrode materials for electrochemical energy storage, butthe mechanisms governing their cycling stability are not well understood. Here we investigate the effect of anionson the longevity of a p-dopable polymer through comparing two aqueous zinc-based electrolytes. Galvanostaticcycling studies reveal the polymer has better capacity retention in the presence of triflate anions than that withsulfate anions. Based on electrode microstructural analysis and evolution profiles of the cell stacking pressure, theorigin of capacity decay is ascribed to mechanical fractures induced by volume change of the polymer activematerials during repeated cycling. The volume change of the polymer with the triflate anion is 61% less than thatwith the sulfate anion, resulting in fewer cracks in the electrodes. The difference is related to the different anionsolvation structures—the triflate anion has fewer solvated water molecules compared with the sulfate anion,leading to smaller volume expansion. This work highlights that anions with low solvation degree are preferablefor long-term cycling.
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