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Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters

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Nature chemical biology 2018年第9期14卷 901-901页

作者： Kiryl D Piatkevich Erica E Jung Christoph Straub Changyang Linghu Demian Park HoJun Suk Daniel R Hochbaum Daniel Goodwin Eftychios Pnevmatikakis Nikita Pak Takashi Kawashima ChaoTsung Yang Jeffrey L Rhoades Or Shemesh Shoh Asano YoungGyu Yoon Limor Freifeld Jessica L Saulnier Clemens Riegler Florian Engert Thom Hughes Mikhail Drobizhev Balint Szabo Misha B Ahrens Steven W Flavell Bernardo L Sabatini Edward S Boyden Media Lab Massachusetts Institute of Technology (MIT) Cambridge MA USA. Howard Hughes Medical Institute Department of Neurobiology Harvard Medical School Boston MA USA. Department of Electrical Engineering and Computer Science MIT Cambridge MA USA. Harvard-MIT Division of Health Sciences and Technology MIT Cambridge MA USA. Simons Center Data Analysis Simons Foundation New York NY USA. Department of Mechanical Engineering MIT Cambridge MA USA. Janelia Research Campus Howard Hughes Medical Institute Ashburn Virginia USA. Picower Institute for Learning & Memory and Department of Brain & Cognitive Sciences MIT Cambridge MA USA. Department of Molecular and Cellular Biology and Center for Brain Science Harvard University Cambridge MA USA. Department of Neurobiology Faculty of Life Sciences University of Vienna Wien Austria. Department of Cell Biology and Neuroscience Montana State University Bozeman Montana USA. Department of Biological Physics Eotvos University Budapest Hungary. Media Lab Massachusetts Institute of Technology (MIT) Cambridge MA USA. esb@media.mit.edu. Department of Biological Engineering MIT Cambridge MA USA. esb@media.mit.edu. MIT Center for Neurobiological Engineering MIT Cambridge MA USA. esb@media.mit.edu. Department of Brain and Cognitive Sciences MIT Cambridge MA USA. esb@media.mit.edu. MIT McGovern Institute for Brain Research MIT Cambridge MA USA. esb@media.mit.edu.

In the version of this article originally published, the bottom of Figure 4f,g was partially truncated in the PDF. The error has been corrected in the PDF version of this article.

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Search for B−L R-parity-violating top squarks in s=13 TeV pp collisions with the ATLAS experiment

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Physical Review D 2018年第3期97卷 032003-032003页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder Y. Afik T. Agatonovic-Jovin C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka H. Akerstedt T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. C. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos S. Amoroso G. Amundsen C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov N. Anjos A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay K. Augsten G. Avolio B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker P. J. Bakker E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Center for High Energy Physics University of Oregon Eugene Oregon USA Department of Physics Stockholm University Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Institute of Physics University of Belgrade Belgrade Serbia Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas—LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Italy Dipartimento di Fisica Univ

A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb−1 of proton-proton collisions at a center-of-mass energy of s=13 TeV, collected in 2015 and 2016 by the ATLAS detector at the LHC. No significant excess is observed over the Standard Model background, and exclusion limits are set on stop pair production at a 95% confidence level. Lower limits on the stop mass are set between 600 GeV and 1.5 TeV for branching ratios above 10% for decays to an electron or muon and a b-quark.

关键词： Supersymmetric models Baryon & lepton number symmetries Supersymmetry

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Search for squarks and gluinos in final states with jets and missing transverse momentum using 36 fb−1 of s=13 TeV pp collision data with the ATLAS detector

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Physical Review D 2018年第11期97卷 112001-112001页

作者： M. Aaboud G. Aad B. Abbott O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder T. Agatonovic-Jovin C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka H. Akerstedt T. P. A. Åkesson E. Akilli A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini S. C. Alderweireldt M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. I. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos A. Amorim S. Amoroso G. Amundsen C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov N. Anjos A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay K. Augsten G. Avolio B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes M. Backhaus P. Bagnaia M. Bahmani H. Bahrasemani J. T. Baines M. Bajic O. K. Baker E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas A. Bandyopadhyay Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits J. T. Barkeloo T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Center for High Energy Physics University of Oregon Eugene Oregon USA Department of Physics Stockholm University Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Institute of Physics University of Belgrade Belgrade Serbia Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas - LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos Universidad de Granada Granada Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN Sezione di Roma Tor Vergata Italy Dipartimento di Fisi

A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded in 2015 and 2016 by the ATLAS experiment in s=13 TeV proton-proton collisions at the Large Hadron Collider, corresponding to an integrated luminosity of 36.1 fb−1. The results are interpreted in the context of various models where squarks and gluinos are pair produced and the neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 2.03 TeV for a simplified model incorporating only a gluino and the lightest neutralino, assuming the lightest neutralino is massless. For a simplified model involving the strong production of mass-degenerate first- and second-generation squarks, squark masses below 1.55 TeV are excluded if the lightest neutralino is massless. These limits substantially extend the region of supersymmetric parameter space previously excluded by searches with the ATLAS detector.

关键词： Hadron-hadron interactions Supersymmetric models Particle data analysis

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Measurements of integrated and differential cross sections for isolated photon pair production in pp collisions at s=8 TeV with the ATLAS detector

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Physical Review D 2017年第11期95卷 112005-112005页

作者： M. Aaboud G. Aad B. Abbott J. Abdallah O. Abdinov B. Abeloos S. H. Abidi O. S. AbouZeid N. L. Abraham H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya S. Adachi L. Adamczyk J. Adelman M. Adersberger T. Adye A. A. Affolder T. Agatonovic-Jovin C. Agheorghiesei J. A. Aguilar-Saavedra S. P. Ahlen F. Ahmadov G. Aielli S. Akatsuka H. Akerstedt T. P. A. Åkesson A. V. Akimov G. L. Alberghi J. Albert P. Albicocco M. J. Alconada Verzini M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander T. Alexopoulos M. Alhroob B. Ali M. Aliev G. Alimonti J. Alison S. P. Alkire B. M. M. Allbrooke B. W. Allen P. P. Allport A. Aloisio A. Alonso F. Alonso C. Alpigiani A. A. Alshehri M. Alstaty B. Alvarez Gonzalez D. Álvarez Piqueras M. G. Alviggi B. T. Amadio Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos A. Amorim S. Amoroso G. Amundsen C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders J. K. Anders K. J. Anderson A. Andreazza V. Andrei S. Angelidakis I. Angelozzi A. Angerami A. V. Anisenkov N. Anjos A. Annovi C. Antel M. Antonelli A. Antonov D. J. Antrim F. Anulli M. Aoki L. Aperio Bella G. Arabidze Y. Arai J. P. Araque V. Araujo Ferraz A. T. H. Arce R. E. Ardell F. A. Arduh J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster L. J. Armitage O. Arnaez H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Artz S. Asai N. Asbah A. Ashkenazi L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay K. Augsten G. Avolio B. Axen M. K. Ayoub G. Azuelos A. E. Baas M. J. Baca H. Bachacou K. Bachas M. Backes M. Backhaus P. Bagnaia H. Bahrasemani J. T. Baines M. Bajic O. K. Baker E. M. Baldin P. Balek F. Balli W. K. Balunas E. Banas Sw. Banerjee A. A. E. Bannoura L. Barak E. L. Barberio D. Barberis M. Barbero T. Barillari M-S Barisits T. Barklow N. Barlow S. L. Barnes B. M. Barnett R. M. Barnett Z. Barnovska-Blenessy A. Baroncelli G. Barone A. J. Barr L. Barranco Navarro F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos A. Basalaev A. Bassalat R. L. Bates S. J. Batista J. R. Batley M. Faculté des Sciences Université Mohamed Premier and LPTPM Oujda Morocco CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman Oklahoma USA Department of Physics The University of Texas at Arlington Arlington Texas USA Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan LAL Univ. Paris-Sud CNRS/IN2P3 Université Paris-Saclay Orsay France Department of Physics University of Toronto Toronto Ontario Canada Santa Cruz Institute for Particle Physics University of California Santa Cruz Santa Cruz California USA Department of Physics and Astronomy University of Sussex Brighton United Kingdom Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel Center for High Energy Physics University of Oregon Eugene Oregon USA Department of Physics Stockholm University Stockholm Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy International Center for Elementary Particle Physics and Department of Physics The University of Tokyo Tokyo Japan AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Department of Physics Northern Illinois University DeKalb Illinois USA Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Institute of Physics University of Belgrade Belgrade Serbia Department of Physics Alexandru Ioan Cuza University of Iasi Iasi Romania Laboratório de Instrumentação e Física Experimental de Partículas - LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada Granada Portugal Department of Physics Boston University Boston Massachusetts USA Joint Institute for Nuclear

A measurement of the production cross section for two isolated photons in proton-proton collisions at a center-of-mass energy of s=8 TeV is presented. The results are based on an integrated luminosity of 20.2 fb−1 recorded by the ATLAS detector at the Large Hadron Collider. The measurement considers photons with pseudorapidities satisfying |ηγ|<1.37 or 1.56<|ηγ|<2.37 and transverse energies of respectively ET,1γ>40 GeV and ET,2γ>30 GeV for the two leading photons ordered in transverse energy produced in the interaction. The background due to hadronic jets and electrons is subtracted using data-driven techniques. The fiducial cross sections are corrected for detector effects and measured differentially as a function of six kinematic observables. The measured cross section integrated within the fiducial volume is 16.8±0.8 pb. The data are compared to fixed-order QCD calculations at next-to-leading-order and next-to-next-to-leading-order accuracy as well as next-to-leading-order computations including resummation of initial-state gluon radiation at next-to-next-to-leading logarithm or matched to a parton shower, with relative uncertainties varying from 5% to 20%.

关键词： Quantum chromodynamics Photons

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Persistent and occasional: searching for the variable population of the ZTF/4MOST sky using ZTF data release 11

arXiv

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arXiv 2023年

作者： Sánchez-Sáez, P. Arredondo, J. Bayo, A. Arévalo, P. Bauer, F.E. Cabrera-Vives, G. Catelan, M. Coppi, P. Estévez, P.A. Förster, F. Hernández-García, L. Huijse, P. Kurtev, R. Lira, P. Arancibia, A.M. Muñoz Pignata, G. European Southern Observatory Karl-Schwarzschild-Strasse 2 Garching bei München85748 Germany Nuncio Monseñor Sotero Sanz 100 Of. 104 Providencia Santiago Chile Departamento de Ingeniería Informática Universidad de Santiago de Chile Av. Ecuador Santiago3659 Chile Instituto de Física y Astronomía Facultad de Ciencias Universidad de Valparaíso Gran Bretaña No. 1111 Playa Ancha Valparaíso Chile Instituto de Astrofísica Facultad de Física Pontificia Universidad Católica de Chile Casilla 306 Santiago22 Chile Centro de Astroingeniería Pontificia Universidad Católica de Chile Av. Vicuña Mackenna 4860 Macul Santiago7820436 Chile Space Science Institute 4750 Walnut Street Suite 205 BoulderCO80301 United States Department of Computer Science Universidad de Concepción Chile Data Science Unit Universidad de Concepción Edmundo Larenas 310 Concepción Chile Department of Astronomy Yale University P.O. Box 208101 New HavenCT06520-8101 United States Department of Electrical Engineering Universidad de Chile Av. Tupper 2007 Santiago8320000 Chile University of Chile Santiago Chile Universidad de Chile Beauchef 851 Santiago8320000 Chile Instituto de Informática Facultad de Ciencias de la Ingeniería Universidad Austral de Chile General Lagos 2086 Valdivia Chile Departamento de Astronomía Universidad de Chile Casilla 36D Santiago Chile Departamento de Ciencias Fisícas Universidad Andres Bello Avda. Republica 252 Santiago Chile

Aims. We present a variability, color and morphology based classifier, designed to identify multiple classes of transients, persistently variable, and non-variable sources, from the Zwicky Transient Facility (ZTF) data Release 11 (DR11) light curves of extended and point sources. The main motivation to develop this model was to identify active galactic nuclei (AGN) at different redshift ranges to be observed by the 4MOST Chilean AGN/Galaxy Evolution Survey (ChANGES). Still, it serves as a more general time-domain astronomy study. Methods. The model uses nine colors computed from CatWISE and PanSTARRS1 (PS1), a morphology score from PS1, and 61 single-band variability features computed from the ZTF DR11 g and r light curves. We trained two versions of the model, one for each ZTF band, since ZTF DR11 treats independently the light curves observed in a particular combination of field, filter, and CCD-quadrant. We used a hierarchical local classifier per parent node approach, where each node was composed of a balanced random forest model. We adopted a 17-class taxonomy, including non-variable stars and galaxies, three transients (SNIa, SN-other, and CV/Nova), five classes of stochastic variables (lowz-AGN, midz-AGN, highz-AGN, Blazar, and YSO), and seven classes of periodic variables (LPV, EA, EB/EW, DSCT, RRL, CEP, and Periodic-other). Results. The macro averaged precision, recall and F1-score are 0.61, 0.75, and 0.62 for the g-band model, and 0.60, 0.74, and 0.61, for the r-band model. When grouping the four AGN classes (lowz-AGN, midz-AGN, highz-AGN, and Blazar) into one single class, its precision, recall, and F1-score are 1.00, 0.95, and 0.97, respectively, for both the g and r bands. This demonstrates the good performance of the model classifying AGN candidates. We applied the model to all the sources in the ZTF/4MOST overlapping sky (−28 ≤ dec ≤ 8.5), avoiding ZTF fields covering the Galactic bulge (|gal_b| ≤ 9 and gal_l ≤ 50). This area includes 86,576,577 light

关键词： Population statistics

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Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

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Angewandte Chemie 2022年第48期134卷

作者： Xia Peng Mario Urso Jan Balvan Michal Masarik Martin Pumera Future Energy and Innovation Laboratory Central European Institute of Technology Brno University of Technology Purkynova 123 61200 Brno Czech Republic Contribution: Data curation (lead) Department of Physiology Faculty of Medicine Masaryk University Kamenice 5 62500 Brno Czech Republic Department of Pathological Physiology Faculty of Medicine Masaryk University Kamenice 5 62500 Brno Czech Republic BIOCEV First Faculty of Medicine Charles University Prumyslova 595 25250 Vestec Czech Republic Department of Chemistry and Biochemistry Mendel University Zemedelska 1 61300 Brno Czech Republic Department of Medical Research China Medical University Hospital China Medical University No. 91 Hsueh-Shih Road 40402 Taichung Taiwan Faculty of Electrical Engineering and Computer Science VSB Technical University of Ostrava 17. listopadu 2172/15 70800 Ostrava Czech Republic Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Korea

Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

关键词： Cargo Transportation Micromachines Micromotors Photocatalysis Tumor Cells

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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells

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Nature biotechnology 2024年第3期42卷 529页

作者： Hui Kwon Kim Goosang Yu Jinman Park Seonwoo Min Sungtae Lee Sungroh Yoon Hyongbum Henry Kim Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. Electrical and Computer Engineering Seoul National University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Graduate School of Data Science Seoul National University Seoul Republic of Korea. Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac. Severance Biomedical Science Institute Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of NanoScience and Technology Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac.

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Author Correction: Bridging the literacy gap for surgical consents: an AI-human expert collaborative approach

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NPJ digital medicine 2024年第1期7卷 93页

作者： Rohaid Ali Ian D Connolly Oliver Y Tang Fatima N Mirza Benjamin Johnston Hael F Abdulrazeq Rachel K Lim Paul F Galamaga Tiffany J Libby Neel R Sodha Michael W Groff Ziya L Gokaslan Albert E Telfeian John H Shin Wael F Asaad James Zou Curtis E Doberstein Department of Neurosurgery Rhode Island Hospital and The Warren Alpert Medical School of Brown University Providence RI USA. ali.rohaid@***. Norman Prince Neurosciences Institute Providence RI USA. ali.rohaid@***. Department of Neurosurgery Massachusetts General Hospital Boston MA USA. Department of Neurosurgery Rhode Island Hospital and The Warren Alpert Medical School of Brown University Providence RI USA. Department of Dermatology The Warren Alpert Medical School of Brown University Providence RI USA. Department of Neurosurgery Brigham and Women's Hospital Boston MA USA. Norman Prince Neurosciences Institute Providence RI USA. Department of Surgery & Division of Cardiothoracic Surgery Rhode Island Hospital and The Warren Alpert Medical School of Brown University Providence RI USA. Ratcliffe Harten Galamaga LLP Providence RI USA. Departments of Electrical Engineering Biomedical Data Science and Computer Science Stanford University Stanford CA USA. Chan Zuckerberg Biohub San Francisco CA USA.

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Rural populations facilitated early SARS-CoV-2 evolution and transmission in Missouri, USA

Npj viruses

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Npj viruses 2023年第1期1卷 7-7页

作者： Cynthia Y Tang Tao Li Tricia A Haynes Jane A McElroy Detlef Ritter Richard D Hammer Christopher Sampson Richard Webby Jun Hang Xiu-Feng Wan Center for Influenza and Emerging Infectious Diseases University of Missouri Columbia MO USA. Molecular Microbiology and Immunology School of Medicine University of Missouri Columbia MO USA. Bond Life Sciences Center University of Missouri Columbia MO USA. Institute for Data Science and Informatics University of Missouri Columbia MO USA. These authors contributed equally: Cynthia Y. Tang Tao Li. Viral Diseases Branch Walter Reed Army Institute of Research Silver Spring MD USA. Family and Community Medicine University of Missouriś Columbia MO USA. Anatomic Pathology & Clinical Pathology University of Missouri Columbia MO USA. Emergency Medicine University of Missouri Columbia MO USA. Infectious Diseases St. Jude Children's Research Hospital Memphis TN USA. Department of Electrical Engineering & Computer Science College of Engineering University of Missouri Columbia MO USA.

In the United States, rural populations comprise 60 million individuals and suffered from high COVID-19 disease burdens. Despite this, surveillance efforts are biased toward urban centers. Consequently, how rurally circulating SARS-CoV-2 viruses contribute toward emerging variants remains poorly understood. In this study, we aim to investigate the role of rural communities in the evolution and transmission of SARS-CoV-2 during the early pandemic. We collected 544 urban and 435 rural COVID-19-positive respiratory specimens from an overall vaccine-naïve population in Southwest Missouri between July and December 2020. Genomic analyses revealed 53 SARS-CoV-2 Pango lineages in our study samples, with 14 of these lineages identified only in rural samples. Phylodynamic analyses showed that frequent bi-directional diffusions occurred between rural and urban communities in Southwest Missouri, and that four out of seven Missouri rural-origin lineages spread globally. Further analyses revealed that the nucleocapsid protein (N):R203K/G204R paired substitutions, which were detected disproportionately across multiple Pango lineages, were more associated with urban than rural sequences. Positive selection was detected at N:204 among rural samples but was not evident in urban samples, suggesting that viruses may encounter distinct selection pressures in rural versus urban communities. This study demonstrates that rural communities may be a crucial source of SARS-CoV-2 evolution and transmission, highlighting the need to expand surveillance and resources to rural populations for COVID-19 mitigation.

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Erratum: Towards a muon collider

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The European Physical Journal C 2024年第1期84卷 1-4页

作者： Accettura, Carlotta Adams, Dean Agarwal, Rohit Ahdida, Claudia Aimè, Chiara Amapane, Nicola Amorim, David Andreetto, Paolo Anulli, Fabio Appleby, Robert Apresyan, Artur Apyan, Aram Arsenyev, Sergey Asadi, Pouya Mahmoud, Mohammed Attia Azatov, Aleksandr Back, John Balconi, Lorenzo Bandiera, Laura Barlow, Roger Bartosik, Nazar Barzi, Emanuela Batsch, Fabian Bauce, Matteo Berg, J. Scott Bersani, Andrea Bertarelli, Alessandro Bertolin, Alessandro Black, Kevin Boattini, Fulvio Bogacz, Alex Bonesini, Maurizio Bordini, Bernardo Bottaro, Salvatore Bottura, Luca Braghieri, Alessandro Breschi, Marco Bruhwiler, Natalie Buffat, Xavier Buonincontri, Laura Burrows, Philip N. Burt, Graeme Buttazzo, Dario Caiffi, Barbara Calviani, Marco Calzaferri, Simone Calzolari, Daniele Capdevilla, Rodolfo Carli, Christian Casaburo, Fausto Casarsa, Massimo Castelli, Luca Catanesi, Maria Gabriella Cavallucci, Lorenzo Cavoto, Gianluca Celiberto, Francesco Giovanni Celona, Luigi Cerri, Alessandro Cesarini, Gianmario Cesarotti, Cari Chachamis, Grigorios Chance, Antoine Chen, Siyu Chien, Yang-Ting Chiesa, Mauro Colaleo, Anna Collamati, Francesco Collazuol, Gianmaria Costa, Marco Craig, Nathaniel Curatolo, Camilla Curtin, David Da Molin, Giacomo Dam, Magnus Damerau, Heiko Dasu, Sridhara de Blas, Jorge De Curtis, Stefania De Matteis, Ernesto De Rosa, Stefania Delahaye, Jean-Pierre Denisov, Dmitri Denizli, Haluk Densham, Christopher Dermisek, Radovan Di Luzio, Luca Di Meco, Elisa Di Micco, Biagio Dienes, Keith Diociaiuti, Eleonora Dorigo, Tommaso Dudarev, Alexey Edgecock, Robert Errico, Filippo Fabbrichesi, Marco Farinon, Stefania Ferrari, Anna Somoza, Jose Antonio Ferreira Filthaut, Frank Fiorina, Davide Fol, Elena Forslund, Matthew Franceschini, Roberto Ximenes, Rui Franqueira Gabrielli, Emidio Gallinaro, Michele Garosi, Francesco Giambastiani, Luca Gianelle, Alessio Gilardoni, Simone Giove, Dario Augusto Giraldin, Carlo Glioti, Alfredo Greco, Mario Greljo, Admir Groeber, Ramona Grojean, Christophe Grudiev, Alexej Gu, Jiayin Han, Chengcheng Han, T Organisation Européenne pour la Recherche Nucléaire (CERN) Geneva Switzerland STFC Rutherford Appleton Laboratory (RAL) Oxford UK Computer Science Department University of California (UC) Berkeley USA Dipartimento di Fisica Università di Pavia Pavia Italy INFN Sezione di Pavia Pavia Italy INFN Sezione di Torino Turin Italy Dipartimento di Fisica Università di Torino Turin Italy INFN Sezione di Padova Padua Italy INFN Sezione di Roma Rome Italy School of Physics and Astronomy University of Manchester Manchester UK Fermi National Accelerator Laboratory Batavia USA Department of Physics Brandeis University Waltham USA IRFU CEA University Paris-Saclay Gif-sur-Yvette France Center for Theoretical Physics Massachusetts Institute of Technology Cambridge USA Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt SISSA International School for Advanced Studies Trieste Italy INFN Sezione di Trieste Trieste Italy Department of Physics University of Warwick Coventry UK Dipartimento di Fisica Università di Milano Milan Italy INFN Laboratori Acceleratori e Superconduttività Applicata (LASA) Milan Italy INFN Sezione di Ferrara Ferrara Italy School of Computing and Engineering The University of Huddersfield Huddersfield UK Ohio State University Columbus USA Brookhaven National Laboratory Upton USA INFN Sezione di Genova Genoa Italy University of Wisconsin Wisconsin USA Center for Advanced Studies of Accelerators Jefferson Lab Newport News USA INFN Sezione di Milano Bicocca Milan Italy Dipartimento di Fisica Università di Milano Bicocca Milan Italy Scuola Normale Superiore Pisa Italy INFN Sezione di Pisa Pisa Italy Dipartimento di Ingegneria dell’Energia Elettrica e dell’Informazione Università di Bologna Bologna Italy INFN Sezione di Bologna Bologna Italy Department of Physics University of California (UC) Berkeley USA Dipartimento di Fisica e Astronomia Università di Padova Padoa Italy John Adams Institute University of O

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