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International Forum on Medical Imaging in Asia 2021, IFMIA 2021

作者： Huang, Chao-Jung Wu, Brian Li, Xiaodong Han, Yongxia Zhang, Yaqi Hao, Shiying Ling, Xuefeng B. National Taiwan University-Stanford Joint Program Office of AI in Biotechnology Ministry of Science and Technology Joint Research Center for Artificial Intelligence Technology and All Vista Healthcare Taipei Taiwan Clinical Research University of California San Diego San DiegoCA92093 United States School of Computer Science and Technology Hangzhou Dianzi University Hangzhou China School of Electrical Power Engineering South China University of Technology Guangzhou China Department of Surgery Stanford University StanfordCA94305 United States Department of Cardiothoracic Surgery Stanford University StanfordCA94305 United States Clinical and Translational Research Program Betty Irene Moore Children's Heart Center Lucile Packard Children's Hospital Palo AltoCA94305 United States

ISBN: (数字)9781510644212

ISBN: (纸本)9781510644205

Acute kidney injury (AKI) is associated with increased morbidity and mortality in intensive care units (ICU). The sudden episode of kidney failure may lead to end-stage renal disease (ESRD) or deaths, and has been related to significantly increasing costs of ICU admissions and treatments. Early prediction of AKI inpatient mortality will help decision-making, and benefit resource allocation in ICU. Therefore, it is crucial to develop an early warning system for AKI prediction. We aimed to create a more comprehensive predictive model for 1-year AKI mortality. A cohort of 2,247 patients with AKI was assembled, of which the in-hospital mortality was 36.67%. Longitudinal data of each patient were collected from the Medical Information Mart for Intensive Care III (MIMIC-III) dataset. An interpretable XGBoost risk model was developed and validated by 10-fold cross validation. Model predictors included 11 routinely collected AKI-related laboratory measurements, 8 complications of AKI, and demographic data. An artificial neural network (ANN) model was also developed in parallel for comparison. The XGBoost model demonstrated an area under the receiver-operating characteristic curve (AUC) of 0.83, which was superior to ANN (AUC = 0.79). Our model was able to predict mortality of AKI in ICU with high accuracy. Our model can predict 1-year AKI mortality. Furthermore, it had great potential for identifying at-risk patients in ICU. These findings indicated that our approach might offer opportunities for better resource utilization and better administration of AKI. © 2021 SPIE.

关键词： Neural networks

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Efficient Breast Cancer Diagnosis from Complex Mammographic Images Using Deep Convolutional Neural Network

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Computational intelligence and neuroscience 2023年第1期2023卷 7717712页

作者： Hameedur Rahman Tanvir Fatima Naik Bukht Rozilawati Ahmad Ahmad Almadhor Abdul Rehman Javed Department of Computer Games Development Faculty of Computing and AI Air University E9 Islamabad Pakistan. Department of Computer Science Faculty of Computing and AI Air University E9 Islamabad Pakistan. Diagnostic Imaging and Radiotherapy Program Therapeutic and Investigation Studies Faculty of Health Sciences University Kebangsaan Malaysia Kuala Lumpur Malaysia. Department of Computer Engineering and Networks College of Computer and Information Sciences Jouf University Sakaka 72388 Saudi Arabia. Department of Cyber Security Air University Islamabad Pakistan. Department of Electrical and Computer Engineering Lebanese American University Byblos Lebanon.

Medical image analysis places a significant focus on breast cancer, which poses a significant threat to women's health and contributes to many fatalities. An early and precise diagnosis of breast cancer through digital mammograms can significantly improve the accuracy of disease detection. computer-aided diagnosis (CAD) systems must analyze the medical imagery and perform detection, segmentation, and classification processes to assist radiologists with accurately detecting breast lesions. However, early-stage mammography cancer detection is certainly difficult. The deep convolutional neural network has demonstrated exceptional results and is considered a highly effective tool in the field. This study proposes a computational framework for diagnosing breast cancer using a ResNet-50 convolutional neural network to classify mammogram images. To train and classify the INbreast dataset into benign or malignant categories, the framework utilizes transfer learning from the pretrained ResNet-50 CNN on ImageNet. The results revealed that the proposed framework achieved an outstanding classification accuracy of 93%, surpassing other models trained on the same dataset. This novel approach facilitates early diagnosis and classification of malignant and benign breast cancer, potentially saving lives and resources. These outcomes highlight that deep convolutional neural network algorithms can be trained to achieve highly accurate results in various mammograms, along with the capacity to enhance medical tools by reducing the error rate in screening mammograms.

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Author Correction: aiVariant: a deep learning-based somatic variant detector for highly contaminated tumor samples

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Experimental & molecular medicine 2025年第1期57卷 284页

作者： Hyeonseong Jeon Junhak Ahn Byunggook Na Soona Hong Lee Sael Sun Kim Sungroh Yoon Daehyun Baek Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Genome4me Inc. Seoul Republic of Korea. School of Biological Sciences Seoul National University Seoul Republic of Korea. Department of Electrical and Computer Engineering Seoul National University Seoul Republic of Korea. AIGENDRUG Co. Ltd. Seoul Republic of Korea. Department of Software and Computer Engineering Ajou University Suwon Republic of Korea. Department of Computer Science and Engineering Seoul National University Seoul Republic of Korea. Interdisciplinary Program in Artificial Intelligence Seoul National University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. baek@snu.ac.kr. Genome4me Inc. Seoul Republic of Korea. baek@snu.ac.kr. School of Biological Sciences Seoul National University Seoul Republic of Korea. baek@snu.ac.kr. Interdisciplinary Program in Artificial Intelligence Seoul National University Seoul Republic of Korea. baek@snu.ac.kr.

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Scientific discovery in the age of artificial intelligence

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NATURE 2023年第7978期621卷 E33-E33页

作者： Wang, Hanchen Fu, Tianfan Du, Yuanqi Gao, Wenhao Huang, Kexin Liu, Ziming Chandak, Payal Liu, Shengchao Van Katwyk, Peter Deac, Andreea Anandkumar, Anima Bergen, Karianne Gomes, Carla P. Ho, Shirley Kohli, Pushmeet Lasenby, Joan Leskovec, Jure Liu, Tie-Yan Manrai, Arjun Marks, Debora Ramsundar, Bharath Song, Le Sun, Jimeng Tang, Jian Velickovic, Petar Welling, Max Zhang, Linfeng Coley, Connor W. Bengio, Yoshua Zitnik, Marinka Department of Engineering University of Cambridge Cambridge UK Department of Computing and Mathematical Sciences California Institute of Technology Pasadena CA USA NVIDIA Santa Clara CA USA Department of Computational Science and Engineering Georgia Institute of Technology Atlanta GA USA Department of Computer Science Cornell University Ithaca NY USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA USA Department of Computer Science Stanford University Stanford CA USA Department of Physics Massachusetts Institute of Technology Cambridge MA USA Harvard-MIT Program in Health Sciences and Technology Cambridge MA USA Mila – Quebec AI Institute Montreal Quebec Canada Université de Montréal Montreal Quebec Canada HEC Montréal Montreal Quebec Canada CIFAR AI Chair Toronto Ontario Canada Department of Earth Environmental and Planetary Sciences Brown University Providence RI USA Data Science Institute Brown University Providence RI USA Center for Computational Astrophysics Flatiron Institute New York NY USA Department of Astrophysical Sciences Princeton University Princeton NJ USA Department of Physics Carnegie Mellon University Pittsburgh PA USA Department of Physics and Center for Data Science New York University New York NY USA Google DeepMind London UK Department of Computer Science and Technology University of Cambridge Cambridge UK Microsoft Research Beijing China Department of Biomedical Informatics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Harvard Data Science Initiative Cambridge MA USA Kempner Institute for the Study of Natural and Artificial Intelligence Harvard University Cambridge MA USA Department of Systems Biology Harvard Medical School Boston MA USA Deep Forest Sciences Palo Alto CA USA BioMap Beijing China Mo

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Abnormal association between neural activity and genetic expressions of impulsivity in attention deficit hyperactivity disorder: an Adolescent Brain Cognitive Development study

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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2025年

作者： Soohyun Jeon Jae-eon Kang Jundong Hwang Vince D. Calhoun Jong-Hwan Lee Department of Brain and Cognitive Engineering Korea University Seoul South Korea Center for Translational Research in Neuroimaging and Data Science (TReNDS): Georgia State University Georgia Institute of Technology and Emory University Atlanta USA Department of Electrical and Computer Engineering Georgia Institute of Technology Atlanta USA Interdisciplinary Program in Precision Public Health Korea University Seoul South Korea McGovern Institute for Brain Research Massachusetts Institute of Technology Boston MA

Background Impulsivity in highly heritable attention deficit hyperactivity disorder (ADHD) has been studied using neural activity via fMRI or genetic data, but rarely with multivariate methods linking both. We investigated coupled neural activity and gene expression signatures, using parallel independent component analysis (pICA) and Adolescent Brain Cognitive Development data. Methods Children with ADHD ( n = 394; 63% males) and healthy controls ( n = 1,000; 47% males) of European ancestry were included. The subjects were randomly divided into 80% discovery and 20% replication datasets with demographic stratification. We analyzed neural activity and gene expressions from the discovery datasets using pICA and extracted paired independent components (pICs). The loading coefficients of the pICs were utilized to predict behavioral and cognitive data for stop signal task (SST) in replication datasets. Results We identified three pICs estimated from gene expression in the cortex, cerebellum, and nucleus accumbens. Significant neural activity was mainly localized to the orbital/inferior/middle frontal gyri, rectal gyrus, precuneus, inferior temporal gyrus, inferior parietal lobule, and cerebellum. Significant gene components were associated with immunoglobulin, taste receptor, and immunity-related terms and were overlapped with ADHD-related genes. The extracted fMRI-/Gene-ICs were significantly correlated with mean reaction time, stop signal reaction time of SST, and behavioral inhibition with a large boost in sensitivity when both the paired fMRI-/Gene-ICs and their interaction were used in a multimodal regression analysis. Conclusion We reported biologically plausible pairs of neural activity and gene sets using pICA, which were significantly associated with ADHD impulsivity-related behavioral and cognitive data.

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Investigation of the Electronic, Magnetic, Exchange Interactions, and Magnetocaloric Properties in Orthotitanate Oxides Rtio3 (R = Er, Ho)

SSRN

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SSRN 2023年

作者： Jmal, Sohail ait Tamerd, Mohamed ait Mounkachi, Omar Salvestrini, Jean Paul Balli, Mohamed AMEEC Team LERMA International University of Rabat Parc Technopolis Rocade de Rabat- Salé 11100 Morocco Laboratory of Condensed Matter and Interdisciplinary Sciences Department of Physics Faculty of Sciences Mohammed V University in Rabat PO Box 1014 Rabat Morocco Modeling Simulation & Data Analysis Program Mohammed VI Polytechnic University Ben Guerir43150 Morocco Institute of Applied Physics Mohammed VI Polytechnic University Lot 660 Hay Moulay Rachid BP 43150 Ben Guerir Morocco CNRS IRL 2958 Georgia Tech CNRS 2 rue Marconi Metz57070 France Georgia Institute of Technology School of Electrical and Computer Engineering AtlantaGA30332-0250 United States

Strong correlated materials are emerging materials in low magnetocaloric cooling applications. The development of these fields necessitates materials with appealing magnetic, and magnetocaloric features. In this context, Density Functional Theory (DFT) combined with Monte Carlo simulations (MCs) are performed to comprehensively examine various physical, and magnetic features of the orthorhombic perovskite-type RTiO3. A metallic behavior of (Ho, Er)TiO3 has been found via the density of state using GGA+U approach. X-ray magnetic circular dichroism (XMCD) was carried out to identify the magnetic contributions of Ho, Er, and Ti atoms in HoTiO3, and ErTiO3 compounds. The spin-orbit coupling was added in our calculations to study and evaluate the magnetocrystalline anisotropies of RTiO3 with (R= Ho, Er). We noticed an easy magnetization axis along the b-direction for HoTiO3, and along the c-direction for ErTiO3. Low magnetocrystalline anisotropy energies were found compared to other perovskite oxides such as RVO3, and RMnO3indicating that a weak rotating magnetocaloric effect (RMCE) is expected in (Ho, Er)TiO3. Moreover, the exchange coupling interactions were calculated using Ising model, the (Ti-Ti) interaction coupling is ferromagnetic, and larger than the other exchange interactions in (Ho, Er)TiO3. Furthermore, these exchange coupling interactions were utilized within the Heisenberg model for MCs, allowing us to understand the driving mechanisms underlying magnetocaloric and magnetic behaviors in (Ho, Er)TiO3. © 2023, The Authors. All rights reserved.

关键词： Perovskite

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Human-like active learning: Machines simulating the human learning process

arXiv

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arXiv 2020年

作者： Lim, Jaeseo Jo, Hwiyeol Zhang, Byoung-Tak Park, Jooyong Interdisciplinary Program in Cognitive Science Seoul National University Korea Republic of Institute of Computer Technology Seoul National University Korea Republic of Department of Computer Science and Engineering Seoul National University Korea Republic of SNU AI Institute Seoul National University Korea Republic of Department of Psychology Seoul National University Korea Republic of

Although the use of active learning to increase learners’ engagement has recently been introduced in a variety of methods, empirical experiments are lacking. In this study, we attempted to align two experiments in order to (1) make a hypothesis for machine and (2) empirically confirm the effect of active learning on learning. In Experiment 1,we compared the effect of a passive form of learning to active form of learning. The results showed that active learning had a greater learning outcomes than passive learning. In the machine experiment based on the human result, we imitated the human active learning as a form of knowledge distillation. The active learning framework performed better than the passive learning framework. In the end, we showed not only that we can make build better machine training framework through the human experiment result, but also empirically confirm the result of human experiment through imitated machine experiments;human-like active learning have crucial effect on learning performance. Copyright © 2020, The Authors. All rights reserved.

关键词： Distillation

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Bulk-plasmon-mediated free-electron radiation beyond the conventional formation time

arXiv

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arXiv 2022年

作者： Tay, Fuyang Lin, Xiao Shi, Xihang Chen, Hongsheng Kaminer, Ido Zhang, Baile Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation ZJUHangzhou Global Science and Technology Innovation Center College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley–Curl Institute Rice University HoustonTX77005 United States International Joint Innovation Center The Electromagnetics Academy Zhejiang University Zhejiang University Haining314400 China Department of Electrical Engineering Technion-Israel Institute of Technology Haifa32000 Israel Jinhua Institute of Zhejiang University Zhejiang University Jinhua321099 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore Centre for Disruptive Photonic Technologies Nanyang Technological University 637371 Singapore

Free-electron radiation is a fundamental photon emission process that is induced by fast-moving electrons interacting with optical media. Historically, it has been understood that, just like any other photon emission process, free-electron radiation must be constrained within a finite time interval known as the "formation time", whose concept is applicable to both Cherenkov radiation and transition radiation, the two basic mechanisms describing radiation from a bulk medium and from an interface, respectively. Here we reveal an alternative mechanism of free-electron radiation far beyond the previously defined formation time. It occurs when a fast electron crosses the interface between vacuum and a plasmonic medium supporting bulk plasmons. While emitted continuously from the crossing point on the interface — thus consistent with the features of transition radiation — the extra radiation beyond the conventional formation time is supported by a long tail of bulk plasmons following the electron’s trajectory deep into the plasmonic medium. Such a plasmonic tail mixes surface and bulk effects, and provides a sustained channel for electron-interface interaction. These results also settle the historical debate in Ferrell radiation, regarding whether it is a surface or bulk effect, from transition radiation or plasmonic oscillation. Copyright © 2022, The Authors. All rights reserved.

关键词： Plasmonics

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Opportunities and challenges for monitoring terrestrial biodiversity in the robotics age

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Nature Ecology and Evolution 2025年第6期9卷 1031-1042页

作者： Pringle, Stephen Dallimer, Martin Goddard, Mark A. Le Goff, Léni K. Hart, Emma Langdale, Simon J. Fisher, Jessica C. Abad, Sara-Adela Ancrenaz, Marc Angeoletto, Fabio Auat Cheein, Fernando Austen, Gail E. Bailey, Joseph J. Baldock, Katherine C. R. Banin, Lindsay F. Banks-Leite, Cristina Barau, Aliyu S. Bashyal, Reshu Bates, Adam J. Bicknell, Jake E. Bielby, Jon Bosilj, Petra Bush, Emma R. Butler, Simon J. Carpenter, Dan Clements, Christopher F. Cully, Antoine Davies, Kendi F. Deere, Nicolas J. Dodd, Michael Drinkwater, Rosie Driscoll, Don A. Dutilleux, Guillaume Dyrmann, Mads Edwards, David P. Farhadinia, Mohammad S. Faruk, aisyah Field, Richard Fletcher, Robert J. Foster, Chris W. Fox, Richard Francksen, Richard M. Franco, Aldina M. A. Gainsbury, Alison M. Gardner, Charlie J. Giorgi, Ioanna Griffiths, Richard A. Hamaza, Salua Hanheide, Marc Hayward, Matt W. Hedblom, Marcus Helgason, Thorunn Heon, Sui P. Hughes, Kevin A. Hunt, Edmund R. Ingram, Daniel J. Jackson-Mills, George Jowett, Kelly Keitt, Timothy H. Kloepper, Laura N. Kramer-Schadt, Stephanie Labisko, Jim Labrosse, Frédéric Lawson, Jenna Lecomte, Nicolas de Lima, Ricardo F. Littlewood, Nick A. Marshall, Harry H. Masala, Giovanni L. Maskell, Lindsay C. Matechou, Eleni Mazzolai, Barbara McConnell, Alistair Melbourne, Brett A. Miriyev, Aslan Nana, Eric Djomo Ossola, Alessandro Papworth, Sarah Parr, Catherine L. Payo-Payo, Ana Perry, Gad Pettorelli, Nathalie Pillay, Rajeev Potts, Simon G. Prendergast-Miller, Miranda T. Qie, Lan Rolley-Parnell, Persie Rossiter, Stephen J. Rowcliffe, Marcus Rumble, Heather Sadler, Jon P. Sandom, Christopher J. Sanyal, Asiem Schrodt, Franziska Sethi, Sarab S. Shabrani, Adi Siddall, Robert Smith, Simón C. Snep, Robbert P. H. Soulsbury, Carl D. Stanley, Margaret C. Stephens, Philip A. Stephenson, P.J. Struebig, Matthew J. Studley, Matthew Svátek, Martin Tang, Gilbert Taylor, Nicholas K. Umbers, Kate D. L. Ward, Robert J. White, Patrick J. C. Whittingham, Mark J. Wich, Serge Williams, Christopher D. Yakubu, Ibrahim B. Yoh, Natalie Durrell Institute of Conservation and Ecology (DICE) School of Natural Sciences University of Kent Canterbury United Kingdom Centre for Environmental Policy Imperial College London London United Kingdom Department of Geography and Environmental Sciences Northumbria University Newcastle upon Tyne United Kingdom School of Computing Engineering and the Built Environment Edinburgh Napier University Edinburgh United Kingdom Synthotech Ltd Milner Court Hornbeam Square Harrogate United Kingdom Mechanical Engineering Department University College London London United Kingdom HUTAN SWD Kota Kinabalu Malaysia Programa de Pós-Graduação em Gestão e Tecnologia Ambiental da Universidade Federal de Rondonópolis Rondonópolis Brazil Department of Engineering Harper Adams University Newport United Kingdom Applied Ecology Research Group School of Life Sciences Anglia Ruskin University Cambridge United Kingdom Centre for Ecology and Hydrology Penicuik United Kingdom Department of Life Sciences Imperial College London Silwood Park Campus Ascot United Kingdom Department of Urban and Regional Planning Faculty of Earth and Environmental Sciences Bayero University Kano Nigeria Greenhood Nepal Kathmandu Nepal Animal Rural & Environmental Sciences Nottingham Trent University Nottinghamshire United Kingdom School of Biological and Environmental Sciences Liverpool John Moores University Liverpool United Kingdom Lincoln Centre for Autonomous Systems University of Lincoln Lincoln United Kingdom Royal Botanic Garden Edinburgh Edinburgh United Kingdom School of Biological Sciences University of East Anglia Norwich Research Park Norwich United Kingdom Digital Ecology Limited Bristol United Kingdom School of Biological Sciences University of Bristol Bristol United Kingdom Department of Computing Imperial College London London United Kingdom Department of Ecology and Evolutionary Biology University of Colorado Boulder CO United States Faculty of Science Technology Engineering

With biodiversity loss escalating globally, a step change is needed in our capacity to accurately monitor species populations across ecosystems. Robotic and autonomous systems (RAS) offer technological solutions that may substantially advance terrestrial biodiversity monitoring, but this potential is yet to be considered systematically. We used a modified Delphi technique to synthesize knowledge from 98 biodiversity experts and 31 RAS experts, who identified the major methodological barriers that currently hinder monitoring, and explored the opportunities and challenges that RAS offer in overcoming these barriers. Biodiversity experts identified four barrier categories: site access, species and individual identification, data handling and storage, and power and network availability. Robotics experts highlighted technologies that could overcome these barriers and identified the developments needed to facilitate RAS-based autonomous biodiversity monitoring. Some existing RAS could be optimized relatively easily to survey species but would require development to be suitable for monitoring of more ‘difficult’ taxa and robust enough to work under uncontrolled conditions within ecosystems. Other nascent technologies (for instance, new sensors and biodegradable robots) need accelerated research. Overall, it was felt that RAS could lead to major progress in monitoring of terrestrial biodiversity by supplementing rather than supplanting existing methods. Transdisciplinarity needs to be fostered between biodiversity and RAS experts so that future ideas and technologies can be codeveloped effectively. © The Author(s) 2025.

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Roadmap on Deep Learning for Microscopy

arXiv

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arXiv 2023年

作者： Volpe, Giovanni Wählby, Carolina Tian, Lei Hecht, Michael Yakimovich, Artur Monakhova, Kristina Waller, Laura Sbalzarini, Ivo F. Metzler, Christopher A. Xie, Mingyang Zhang, Kevin Lenton, Isaac C.D. Rubinsztein-Dunlop, Halina Brunner, Daniel Bai, Bijie Ozcan, Aydogan Midtvedt, Daniel Wang, Hao Sladoje, Nataša Lindblad, Joakim Smith, Jason T. Ochoa, Marien Barroso, Margarida Intes, Xavier Qiu, Tong Yu, Li-Yu You, Sixian Liu, Yongtao Ziatdinov, Maxim A. Kalinin, Sergei V. Sheridan, Arlo Manor, Uri Nehme, Elias Goldenberg, Ofri Shechtman, Yoav Moberg, Henrik K. Langhammer, Christoph Špačková, Barbora Helgadottir, Saga Midtvedt, Benjamin Argun, Aykut Thalheim, Tobias Cichos, Frank Bo, Stefano Hubatsch, Lars Pineda, Jesus Manzo, Carlo Bachimanchi, Harshith Selander, Erik Homs-Corbera, Antoni Fränzl, Martin de Haan, Kevin Rivenson, Yair Korczak, Zofia Adiels, Caroline Beck Mijalkov, Mite Veréb, Dániel Chang, Yu-Wei Pereira, Joana B. Matuszewski, Damian Kylberg, Gustaf Sintorn, Ida-Maria Caicedo, Juan C. Cimini, Beth A. Bell, Muyinatu Lediju A. Saraiva, Bruno M. Jacquemet, Guillaume Henriques, Ricardo Ouyang, Wei Le, Trang Gómez-De-Mariscal, Estibaliz Sage, Daniel Muñoz-Barrutia, Arrate Lindqvist, Ebba Josefson Bergman, Johanna Department of Physics University of Gothenburg Gothenburg41296 Sweden Dept. IT and SciLifeLab Uppsala University Sweden Department of Electrical and Computer Engineering Boston University BostonMA02215 United States Department of Biomedical Engineering Boston University BostonMA02215 United States Görlitz Germany Department of Renal Medicine Division of Medicine University College London Royal Free Hospital Campus London United Kingdom Artificial Intelligence for Life Sciences CIC Dorset United Kingdom Roche Pharma International Informatics Roche Diagnostics GmbH Mannheim Germany Department of Electrical Engineering and Computer Sciences UC Berkeley United States Technische Universität Dresden Faculty of Computer Science Dresden Germany Max Planck Institute of Molecular Cell Biology and Genetics Center for Systems Biology Dresden Dresden Germany University of Maryland College Park United States Klosterneuburg3400 Austria School of Mathematics and Physics The University of Queensland Brisbane4072 Australia Australian Research Council Centre of Excellence for Engineered Quantum Systems The University of Queensland Brisbane4072 Australia Département d’Optique P. M. Duffieux Institut FEMTO-ST Université Franche-Comté CNRS UMR 6174 Besançon France Department of Electrical and Computer Engineering University of California Los Angeles Los AngelesCA United States Department of Information Technology Uppsala University Sweden Department of Biomedical Engineering Rensselaer Polytechnic Institute TroyNY12180 United States Elephas 1 Erdman Pl. Madison53705 United States University of Wisconsin–Madison Department of Medical Physics MadisonWI53705 United States Department of Molecular and Cellular Physiology Albany Medical College AlbanyNY12208 United States Research Laboratory of Electronics Electrical Engineering and Computer Science Massachusetts Institute of Technology BostonMA United States Center for Nanophase Materials Sciences Oak R

Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasing resolution and throughput. Artificial intelligence, deep neural networks, and machine learning are all niche terms describing computational methods that have gained a pivotal role in microscopy-based research over the past decade. This Roadmap is written collectively by prominent researchers and encompasses selected aspects of how machine learning is applied to microscopy image data, with the aim of gaining scientific knowledge by improved image quality, automated detection, segmentation, classification and tracking of objects, and efficient merging of information from multiple imaging modalities. We aim to give the reader an overview of the key developments and an understanding of possibilities and limitations of machine learning for microscopy. It will be of interest to a wide cross-disciplinary audience in the physical sciences and life sciences. Copyright © 2023, The Authors. All rights reserved.

关键词： Image enhancement

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