Modern optical technologies encompass classical light phenomena and non-linear effects, crucial for biomedical imaging and therapies. Despite substantial interest and many experimental studies, non-linear optical effe...
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In synthetic aperture (SA) ultrasound imaging, whether monostatic or multistatic, all elements of the transducer array are used in turn one-by-one during the transmission phase. However, during reception, the monostat...
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We present visible Fourier-reweighted stimulated Raman scattering (VFR-SRS), a vibrational imaging scheme that achieves sub-100 nm resolution by computationally amplifying high spatial frequency components, enabling l...
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Microscale electroporation devices are mostly restricted to in vitro experiments(i.e.,microchannel and microcapillary).Novel fiber-based microprobes enable in vivo microscale electroporation and arbitrarily select the...
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Microscale electroporation devices are mostly restricted to in vitro experiments(i.e.,microchannel and microcapillary).Novel fiber-based microprobes enable in vivo microscale electroporation and arbitrarily select the cell groups of interest to *** developed a flexible,fiber-based microscale electroporation device through a thermal drawing process and femtosecond laser micromachining *** fiber consists of four copper electrodes(80μm),one microfluidic channel(30μm),and has an overall diameter of 400μ*** dimensions of the exposed electrodes and channel were customizable through a delicate femtosecond laser *** feasibility of the fiber probe was validated through numerical simulations and in vitro *** reversible and irreversible microscale electroporation was observed in a 3D collagen scaffold(seeded with U251 human glioma cells)using fluorescent *** ablation regions were estimated by performing the covariance error ellipse method and compared with the numerical *** computational and experimental results of the working fiber-based microprobe suggest the feasibility of in vivo microscale electroporation in space-sensitive areas,such as the deep brain.
Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while ...
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Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.
In this paper, an analysis to detect broken rotor bars while the motor is operating in closed loop control is presented. Due to changes in the supply frequency, which occur to keep the speed constant, a time-frequency...
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In this research, LiDAR sensor technology introduces a new representation of point cloud data for tasks in 3D object recognition. Point clouds provide rich information that can be utilized to predict the orientation p...
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We report the application of widefield birefringence microscopy for 3D rendering of sparse myelinated fibers in human brain gray matter. This inexpensive and simple method offers the potential to inform studies of the...
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We demonstrate mode-division multiplexing at visible wavelengths (473 nm) for the first time using adiabatic mode couplers. We measure less than -15 dB and -20 dB crosstalk for TE2 and TE3 higher-order mode couplers, ...
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We demonstrate mode-division multiplexing at visible wavelengths (473 nm) for the first time using adiabatic mode couplers. We measure less than -15 dB and -20 dB crosstalk for TE2 and TE3 higher-order mode couplers, ...
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