We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,inc...
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We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including *** examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 *** conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain *** confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-β*** expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed ***,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated *** radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by *** res
This paper presents the design of a standalone hybrid renewable energy system (HRES) for a hospital in Lafayette, Indiana, USA, to enhance energy reliability and reduce costs. The proposed system integrates photovolta...
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ISBN:
(数字)9798350379884
ISBN:
(纸本)9798350379891
This paper presents the design of a standalone hybrid renewable energy system (HRES) for a hospital in Lafayette, Indiana, USA, to enhance energy reliability and reduce costs. The proposed system integrates photovoltaic (PV) panels, wind turbines, batteries, and a backup diesel generator. Using Hybrid Optimization Model for Electric Renewables (HOMER) software, the system is optimized for cost-effectiveness and sustainability, while electrical Transient Analyzer program (ETAP) software is employed to ensure a safe operation under varying conditions. Results verify that the developed HRES meets the hospital’s energy needs, significantly reduces operational costs, and minimizes carbon emissions, offering a sustainable model for healthcare facilities.
This work presents a workflow to simplify the design process, simulation effort and verification scheme, to generate a signal with desired power, polarization and controlled higher-order modes required for aeronautica...
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This work presents a workflow to simplify the design process, simulation effort and verification scheme, to generate a signal with desired power, polarization and controlled higher-order modes required for aeronautical tracking systems. This workflow is especially suitable for the simulation and analysis of complex antenna feed systems with multimode monopulse tracking capabilities through the emulation of real operation. The presented scheme is based on S-parameters obtained from literature or full-wave simulations and linear techniques, transforming a CAD-FEM problem into a circuital one, that can be easily implemented analytically and processed in commercial schematic simulation tools. The proposed approach is applied to the analysis of an antenna feed system with a resonant TE21 tracking coupler, commonly used in tracking systems today and can be easily adapted and/or extended to more complex feed systems working with different tracking couplers and/or high-order modes. Different polarizations and feed settings are analyzed, obtaining useful information on the operation and best configuration of these complex systems.
AI Safety has become a vital front-line concern of many scientists within and outside the AI community. There are many immediate and long term anticipated risks that range from existential risk to human existence to d...
Miniaturized two-photon (2P) imaging devices enable real-time in vivo and in situ imaging at subcellular resolution, highly valuable for clinical applications and basic research (such as neuroscience). However, achiev...
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Miniaturized two-photon (2P) imaging devices enable real-time in vivo and in situ imaging at subcellular resolution, highly valuable for clinical applications and basic research (such as neuroscience). However, achieving high-quality volumetric imaging at varying depths remains challenging. In this study, we demonstrated a 2P fiberscope capable of three-dimensional (3D) imaging over a cylindrical volume of a 350 μm diameter and a 400 μm depth. Depth scanning was achieved by incorporating a miniature electrowetting-based varioptic lens (VL) into a two-dimensional (2D) scanning 2P fiberscope, whose focus was tuned by modulating the VL drive voltage. The performance of the fiberscope was demonstrated by ex vivo imaging of fluorescently stained convallaria and GFP mouse brain sections, as well as in vivo dynamic GCaMP-based calcium imaging of cortical neurons in an awake mouse.
We report a simple, vacuum-compatible fiber attach process for in situ study of grating-coupled photonic devices. The robustness of this technique is demonstrated on grating-coupled waveguides exposed to multiple X-ra...
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The existence of fine-grained image classification supporting smart retail provides effectiveness in recognizing products with high similarity. However, the generic classification method performs poorly in identifying...
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Domain data can be shifted in any direction so it will be shared in different distributions to its original domain. This could be a problem since the model was trained with different distributions. It is found that ad...
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This paper reports on the development of nanostructure-electrode-based electrochemical sensors for detecting lactate dehydrogenase (LDH). Using an ultrathin nanopore template, gold nanostructured electrodes were fabri...
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