检索结果-内蒙古大学图书馆

Molecular insight of dissolved organic matter and chlorinated disinfection by-products in reclaimed water during chlorination with permanganate preoxidation

引用

Chemosphere 2024年 349卷 140807页

作者： Hu, Wei Niu, Xi-Zhi Chen, Huan Ye, Bei Liang, Jun-Kun Guan, Yun-Tao Wu, Qian-Yuan Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety Institute of Environment and Ecology Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Environmental Engineering and Science Program Department of Chemical and Environmental Engineering University of Cincinnati CincinnatiOH45221 United States Department of Environmental Engineering and Earth Science Clemson University SC29634 United States

Permanganate is a common preoxidant applied in water treatment to remove organic pollutants and to reduce the formation of disinfection by-products. However, the effect of permanganate preoxidation on the transformation of dissolved effluent organic matter (dEfOM) and on the formation of unknown chlorinated disinfection by-products (Cl-DBPs) during chlorination remains unknown at molecular level. In this work, the molecular changes of dEfOM during permanganate preoxidation and subsequent chlorination were characterized using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Permanganate preoxidation was found to decrease the DBE (double bond equivalent) and AImod (modified aromaticity index) of the dEfOM. The identity and fate of over 400 unknown Cl-DBPs during KMnO4-chlorine treatment were investigated. Most Cl-DBPs and the precursors were found to be highly unsaturated aliphatic and phenolic compounds. The Cl-DBPs precursors with lower H/C and lower O/C were preferentially removed by permanganate preoxidation. Additionally, permanganate preoxidation decreased the number of unknown Cl-DBPs by 30% and intensity of unknown Cl-DBPs by 25%. One-chlorine-containing DBPs were the major Cl-DBPs and had more CH2 groups and higher DBEw than Cl-DBPs containing two and three chlorine atoms. 60% of the Cl-DBPs formation was attributed to substitution reactions (i.e., +Cl–H, +2Cl–2H, +3Cl–3H, +ClO–H, +Cl2O3–2H). This work provides detailed molecular level information on the efficacy of permanganate preoxidation on the control of overall Cl-DBPs formation during chlorination. © 2023 Elsevier Ltd

关键词： Chlorination

来源：评论

学校读者我要写书评

暂无评论

Enhanced carbon tetrachloride degradation by hydroxylamine in ferrous ion activated calcium peroxide in the presence of formic acid

引用

Frontiers of environmental Science & Engineering 2020年第2期14卷 75-85页

作者： Wenchao Jiang Ping Tang Zhen Liu Huan He Qian Sui Shuguang Lyu State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China Environmental Engineering and Science Program Department of Chemical and Environmental EngineeringUniversity of CincinnatiCincinnatiOH 45221-0071USA

Hydroxyl radicals(HO*)show low reactivity with perchlorinated hydrocarbons,such as carbon tetrachloride(CT),in conventional Fenton reactions,therefore,the generation of reductive radicals has attracted increasing *** study investigated the enhancement of CT degradation by the synergistic effects of hydroxylamine(HA)and formic acid(FA)(initial[CT]=0.13 mmol/L)in a Fe(il)activated calcium peroxide(CP)fenton *** degradation increased from 56.6%to 99.9%with the addition of 0.78 mmol/L HA to the CP/Fe(II)/FA/CT process in a molar ratio o f 12/6/12/*** results also showed that the presence of HA enhanced the regeneration of Fe(II)from Fe(III),and the production of HO*increased one-fold when employing benzoic acid as the HO****,FA slightly improves the production of HO*.A study of the mechanism confirmed that the carbon dioxide radical(C02·),a strong reductant generated by the reaction between FA and HO*,was the dominant radical responsible for CT *** complete CT dechlorination was achieved in the *** presence of humic acid and chloride ion slightly decreased CT removal,while high doses of bicarbonate and high pH inhibited CT *** study helps us to better understand the synergistic roles of FA and HA for HO·and C02·^-generation and the removal of perchlorinated hydrocarbons in modified Fenton systems.

关键词： Calcium peroxide Hydroxylamine Modified Fenton Reactive oxygen species Perchlorinated hydrocarbon

来源：评论

学校读者我要写书评

暂无评论

Exposure to trace levels of metals and fluoroquinolones increases inflammation and tumorigenesis risk of zebrafish embryos

引用

environmental Science and Ecotechnology 2022年第2期10卷 12-22页

作者： Dantong Jia Ruijie Zhang Jian Shao Wei Zhang Leilei Cai Weiling Sun College of Environmental Sciences and Engineering Peking UniversityThe Key Laboratory of Water and Sediment SciencesMinistry of EducationBeijing100871China State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems International Joint Laboratory for Regional Pollution ControlMinistry of EducationBeijing100871China College of Animal Science Guizhou UniversityThe Key Laboratory of Animal GeneticsBreeding and Reproduction in the Plateau Mountainous RegionMinistry of EducationGuiyangGuizhou550025China Department of Plant Soil and Microbial SciencesEnvironmental Science and Policy ProgramMichigan State UniversityEast LansingMI48824United States College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdaoShandong266590China

Exposure to trace-level heavy metals and antibiotics may elicit metabolic disorder,alter protein expression,and then induce pathological changes in zebrafish embryos,despite negligible physiological and developmental *** study investigated the single and combined developmental toxicity of fluoroquinolones(enrofloxacin[ENR]and ciprofloxacin[CIP])(0.5 mM)and heavy metals(Cu and Cd)(0.5 mM)to zebrafish embryos,and molecular responses of zebrafish larvae upon exposure to the single pollutant(0.2 mM)or a binary metal-fluoroquinolone mixture(0.2 mM).In all single and mixture exposure groups,no developmental toxicity was observed,but oxidative stress,inflammation,and lipid depletion were found in zebrafish embryos,which was more severe in the mixture exposure groups than in the single exposure groups,probably due to increased metal bioaccumulation in the presence of ENR or *** analysis revealed the up-regulation of amino acids and down-regulation of fatty acids,corresponding to an active response to oxidative stress and the occurrence of *** up-regulation of antioxidase and immune proteins revealed by proteomics analysis further confirmed the occurrence of oxidative stress and ***,the KEGG pathway enrichment analysis showed a significant disturbance of pathways related to immunity and tumor,indicating the potential risk of tumorigenesis in zebrafish *** findings provide molecular-level insights into the adverse effects of heavy metals and antibiotics(especially in chemical mixtures)on zebrafish embryos,and highlight the potential ecotoxicological risks of trace-level heavy metals and antibiotics in the environment.

关键词： Fluoroquinolone Metal Inflammation Tumor Oxidative stress

来源：评论

学校读者我要写书评

暂无评论

Accelerating environmental Research to Achieve Sustainable Development Goals

引用

environmental SCIENCE & TECHNOLOGY LETTERS 2023年第11期10卷 961-962页

作者： Mihelcic, James R. Barra, Ricardo O. Brooks, Bryan W. Diamond, Miriam L. Eckelman, Matthew J. Gibson, Jacqueline MacDonald Guidotti, Sunny Ikeda-Araki, Atsuko Kumar, Manish Maiga, Ynoussa McConville, Jennifer Miller, Shelly L. Pizarro, Valeria Rosario-Ortiz, Fernando Wang, Shuxiao Zimmerman, Julie B. Department of Civil & Environmental Engineering University of South Florida 4202 E Fowler Ave ENG 030 Tampa Florida 33620 United States Faculty of Environmental Sciences and EULA Chile Centre University of Concepcion Barrio Universitario s/n Concepción 4070386 Chile Department of Environmental Science Baylor University One Bear Place #97266 Waco Texas 76798-7266 United States Department of Earth Sciences and School of the Environment University of Toronto Toronto M5S 1A1 ON Canada College of Engineering Northeastern University Boston Massachusetts 02115 United States Department of Civil Construction and Environmental Engineering North Carolina State University Fitts-Woolard Hall Room 3253 915 Partners Way Raleigh North Carolina 27695-7908 United States UNICEF Latin America and Caribbean Regional Office Building 102 Alberto Tejada Street City of Knowledge 0843 Republic of Panama Faculty of Health Sciences Hokkaido University Kita 12 Nishi 5 Kitaku Sapporo 060-0812 Japan Sustainability Cluster School of Engineering University of Petroleum & Energy Studies Dehradun Uttarakhand 248007 India Escuela de Ingenieria y Ciencias Tecnologico de Monterrey Campus Monterey Monterrey 64849 Nuevo León Mexico Laboratory of Microbiology and Microbial Biotechnology UFR SVT University Joseph KI-ZERBO 03 BP 7021 Ouagadougou Burkina Faso Department of Energy and Technology Swedish University of Agricultural Sciences Box 7032 Uppsala SE-750 07 Sweden Department of Mechanical Engineering University of Colorado Boulder 427 UCB Boulder Colorado 80309-0427 United States Perry Institute for Marine Science Windsor School (Albany Campus) Frank Watson Boulevard Adelaide The Bahamas Department of Civil Environmental and Architectural Engineering Environmental Engineering Program University of Colorado Boulder Colorado 80309 United States State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084

来源：评论

学校读者我要写书评

暂无评论

Enhancing Diagnostic and Patient Safety in Healthcare Systems: Key Insights from the World Patient Safety Day 2024 Commemoration in Uganda

引用

Drug, healthcare and patient safety 2025年 17卷 135-143页

作者： Munanura Turyasiima Prima Maria Niwampeire Martin Ssendyona Balbina Gillian Akot Miriam Acheng Simon Peter Katongole Joseph Okware Juliet Tumwikirize Kenneth Mutesasira Joshua Atepo Robinah Kaitiritimba Joshua Epuitai Benson Tuhwezeine Tumwesigye Gaston Turinawe Robert Mutumba Martin Ndifuna Geofrey Musinguzi Denise Asaba Kemigisa Department of Standards Compliance Accreditation and Patient Protection Ministry of Health Kampala Uganda. Department of Pediatrics and Child Health Kampala International University Kampala Uganda. The Aids Support Organization Kampala Uganda. Division of Health Information Management Ministry of Health Kampala Uganda. Uganda Martyrs University Kampala Uganda. Quality Improvement Office World Health Organization Kampala Uganda. The Uganda National Health Consumers' Organization Kampala Uganda. Department of Nursing Faculty of Health Services Busitema University Mbale Uganda. STD/AIDS Control Program Ministry of Health Kampala Uganda. Johns Hopkins Program for International Education in Gynecology and Obstetrics (Jhpeigo) Kampala Uganda. Department of Disease Control and Environmental Health Makerere University School of Public Health Kampala Uganda.

Background:The 4th World Patient Safety Day (WPSD) 2024 commemoration in Uganda, themed "Improving Diagnosis for Patient Safety", highlighted critical challenges and opportunities in reducing diagnostic errors within healthcare systems. This review synthesizes key insights from the event, focusing on factors contributing to diagnostic inaccuracies, systemic gaps, and actionable strategies for improvement. Methods:Using a qualitative synthesis approach guided by the Consolidated Criteria for Reporting Qualitative Research (COREQ), we analyzed data from a hybrid webinar (210 participants) and a four-day medical camp (600+ patients served). Thematic analysis identified four key areas: (i) factors influencing diagnostic errors, (ii) the role of laboratory and imaging services in diagnosis error prevention, (iii) existing health system interventions, and (iv) patient empowerment in the diagnostic process. Results:Diagnostic errors in Uganda stem from cognitive biases, systemic inefficiencies (eg, understaffing, inadequate equipment), and financial barriers in private healthcare. Strengthening laboratory capacity, digitizing health records, and enhancing provider-patient communication emerged as pivotal solutions. The Ministry of Health's initiatives such as laboratory accreditation, the 5S quality improvement framework, and patient feedback mechanisms demonstrate progress but require scaling. Recommendations:We propose a multi-level approach: (1) national policies for error reporting and patient safety frameworks, (2) expanded supportive supervision and digitization (eg, EHRs with decision support), (3) stricter regulation of private healthcare, and (4) community engagement to improve health literacy and early care-seeking. Conclusion:Reducing diagnostic errors demands systemic reforms, technological integration, and collaborative stakeholder engagement. Uganda's WPSD 2024 insights offer a model for similar low-resource settings to enhance diagnostic accuracy and patient

关键词： Uganda diagnostic errors healthcare quality patient safety world patient safety day

来源：评论

学校读者我要写书评

暂无评论

Comparison of ZnO Doped Different Phases TiO2 Nanoparticles in Terms of Toxicity Using Zebrafish (Danio Rerio)

SSRN

引用

SSRN 2022年

作者： Sezer, Selda Yücel, Ayşegül Turan, Duygu Özhan Emre, Fatma Bilge Sarikaya, Musa Malatya Turgut Ozal University Akcadag Vocational School Laboratory and Veterinary Health Program Akcadag Malatya Turkey Iskenderun Technical University Iskenderun Vocational School Environmental Protection and Control Program Hatay Iskenderun Turkey Inonu University Faculty of Engineering Department of Mining Engineering Malatya Turkey Inonu University Faculty of Arts and Science Department of Biology Malatya Turkey Inonu University Faculty of Education Department of Science Teaching Malatya Turkey

Titanium dioxide is used in many commercial and industrial areas such as paint, paper, cosmetics, textiles, and surface coating. The reasons for its use in such a wide area are its anti-corrosion and high stability. Although TiO2 is considered to be a low toxicity material, research has been further expanded following the recognition of the possible carcinogenic effects of TiO2 in humans by the International Agency for Research on Cancer (IARC). The aim of this study is to compare the toxicity of TiO2 used in many fields in different phases. In the study anatase TiO2 synthesized by hydrothermal method and dual phase TiO2 (anatase and rutile phase) structures obtained by thermal conditioning were used and compared with commercially available TiO2. ZnO which has similar uses like TiO2 was also used and compared with 1% doped TiO2 in different phases in terms of toxicity. Zebrafish (Danio rerio, D. rerio), a freshwater fish, which is widely used in toxicity assessments was preferred in this study due to its small size, fast reproduction rate, low cost, physiological and molecular similarity with humans, and genetic predisposition. Experimental investigations showed that the highest death occurred in the low concentrations of (10 ppm) ZnO doped rutile phase. 39% of the embryos died in the ZnO nanoparticle solutions prepared at low concentrations. The highest mortality at medium (100 ppm) and high (1000 ppm) concentrations were observed in the ZnO-doped rutile phase after 96 hours. Similarly, the highest malformation was detected in the ZnO-doped rutile phase during the same period. © 2022, The Authors. All rights reserved.

关键词： Titanium dioxide

来源：评论

学校读者我要写书评

暂无评论

Novel Dopamine-Derived Carbon Modified Fe-Based Metal-Organic Framework Enhanced Aptasensor Rendering Ultrasensitive Electrochemical Detection of Oxytetracycline

SSRN

引用

SSRN 2024年

作者： Song, Jialing Fan, Xiaoxuan Ee, Liang Ying Lin, Xuanhao Li, Sam Fong Yau Huang, Manhong Singapore Donghua University China Shanghai University College of Science Department of Chemistry International Joint Laboratory Catalyst Chemistry Shanghai200444 China College of Environmental Science and Engineering State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry Donghua University Shanghai201620 China National University of Singapore Department of Chemistry 3 Science Drive 3 Singapore117543 Singapore Advanced Membranes and Porous Materials Center Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia Chemical Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal23955-6900 Saudi Arabia National University of Singapore Environmental Research Institute T Lab Building 5A Engineering Drive 1 Singapore117411 Singapore

In the present work, an aptasensor with dual binding sites based on Au NPs modified with self-polymerized polydopamine (PDA) and Fe-MOF is successfully constructed. In terms of standard electron transfer, the cyclic voltammetry (CV) analysis showcases a rate constant (ks) of 96.0 s-1, signifying an exceptional electron transfer rate of oxytetracycline at the sensor interface of Apt/Au@PDA@NH2-MIL-101(Fe)/GCE. Further deepening the investigation into electrochemical kinetics using chronoamperometry (CA), we investigated the electrocatalytic parameters (Kcat) of Au@PDA@NH2-MIL-101(Fe) in relation to oxytetracycline. The results divulged an impressive average Kcat value of 3.06×105 M-1 S-1. This evidence robustly suggests the superior electrocatalytic activity of Au@PDA@NH2-MIL-101(Fe) when it comes to oxytetracycline oxidation. A custom-designed portable rapid detection platform was developed, achieving detection limits of 6.88 nM under static water flow conditions and 5.56 nM under dynamic conditions. Remarkably, the self-polymerization of PDA on Au NPs not only refines their size but also boosts their interaction with biomolecules, thereby promising excellent biocompatibility. Moreover, the abundance of -COOH groups and unsaturated Fe3+ sites on the NH2-MIL-101(Fe) surface furnishes a considerable number of grafting sites for the aptamer. More importantly, the redox interplay between Au@PDA and NH2-MIL-101(Fe) accelerates electron movement, thus amplifying the electrochemical signal and the detection sensitivity for oxytetracycline. © 2024, The Authors. All rights reserved.

关键词： Rate constants

来源：评论

学校读者我要写书评

暂无评论

Polyvinyl chloride microplastics and drought co-exposure alter rice growth by affecting metabolomics and proteomics

引用

Science of the Total Environment 2024年 955卷 177002页

作者： Khan, Kiran Yasmin Ali, Barkat Ghani, Hafiz Usman Cui, Xiaoqiang Luo, Xiaohan Ali, Zeshan Ahmed, Waqar Tan, Jinglu Lysenko, Vladimir Guo, Ya Key Laboratory of Advanced Process Control for Light Industry Ministry of Education Jiangnan University Wuxi214122 China Food Science Research Institute National Agricultural Research Centre Islamabad44000 Pakistan Hebei Medical University Shijiazhuang050000 China School of Environmental Science and Engineering/Tianjin Key Lab of Biomass Waste Utilization Tianjin University Tianjin300072 China Ecotoxicology Research Program Institute of Plant and Environmental Protection National Agriculture Research Center Islamabad44000 Pakistan Department of Biomedical Biological & Chemical Engineering University of Missouri ColumbiaMO65211 United States Southern Federal University Academy of Biology and Biotechnology Rostov-on-Don344041 Russia International Joint Research Center for Intelligent Optical Sensing and Applications at Jiangnan University Wuxi214122 China

Microplastics, interacting with drought stress, have become threat to crops by altering soil environment. Currently, the effect of combined microplastic and drought stress on crop growth remain poorly understood. In this work, the mechanism of multi-stress responses was investigated under the exposure of polvinylchloride microplastic (PV) and drought (D) individually and in combination (DPV) on rice varieties Hanyou73 and Q280 through proteomics and metabolomic analysis. All treatments negatively affect chlorophyll content, antioxidant enzyme activities, rice grain composition, metabolome and proteomic profiling of both rice varieties. Full rice grain yield was decreased under all treatments except PV treatment in which it was increased in both rice varieties. DPV treatment shows the lowest grain yield and more adverse effects on metabolome by affecting glycerophospholipid metabolism, tryptophan metabolism and alanine, aspartate and glutamate metabolism. Soluble sugar contents were decreased in H73 but in Q280 increased by 159 % under DPV and 123 % in PV treatment, compared to their control group. The results from metabolomics illustrate that glycerophospholipid metabolism is commonly altered in both rice types under all treatments. PV and drought alone and in combination induce extensive alterations in proteomics of rice leaves especially impacting proteins related to binding, translation and photosynthetic process. The results reveal that PV and DPV treatments highly distort the abundance of metabolites and proteins in both rice types, demonstrating that microplastic toxicity effects on rice plants become more severe when combined with drought stress. © 2024 Elsevier B.V.

关键词： Drought Metabolite Polyvinyl chloride microplastic Protein Rice

来源：评论

学校读者我要写书评

暂无评论

Suspect Screening and Chemical Profile Analysis of Stormwater Runoff Following 2017 Wildfires in Northern California

SSRN

引用

SSRN 2022年

作者： Wang, Miaomiao Kinyua, Juliet Jiang, Ting Sedlak, Meg McKee, Lester J. Fadness, Richard Sutton, Rebecca Park, June-Soo California Department of Toxic Substances Control California Environmental Protection Agency 700 Heinz Ave. BerkeleyCA94710 United States Section of Forensic Chemistry Dept. of Forensic Medicine Faculty of Health and Medical Sciences University of Copenhagen Frederik V's vej 11 Copenhagen2100 Denmark San Francisco Estuary Institute 4911 Central Ave RichmondCA94804 United States North Coast Regional Water Quality Control Board 5550 Skylane Blvd Ste A Santa RosaCA95403 United States Program on Reproductive Health and the Environment Department of Obstetrics Gynecology and Reproductive Sciences University of California-San Francisco San FranciscoCA94143 United States

The combustion of structures, household materials, pesticides, and firefighting materials during wildfires leads to releases of potentially hazardous chemicals directly onto the landscape. Subsequent rainfall and stormwater runoff events can transport wildfire-related contaminants to downstream receiving waters where they may pose water quality concerns. To evaluate the environmental hazards of recent Northern California fires on the types of contaminants in stormwater, and the resulting potential ecological impact in San Francisco Bay and the coastal marine environment, we analyzed stormwater collected after the Northern California wildfires (October 2017) using a non-targeted analytical (NTA) approach. Liquid chromatography quadrupole time-of-flight mass spectrometric (LC-QTOF-MS) analysis was completed on stormwater samples (n=20) collected from Napa County (impacted by Atlas and Nuns fires), the City of Santa Rosa, and Sonoma County (Nuns and Tubbs fire) during storm events that occurred on November 2017 and January 2018. The NTA approach enabled us to establish profiles of contaminants based on raw peak intensities and chemical categories found in the stormwater samples, and to prioritize significant chemicals within these profiles possibly attributed to the wildfire. The results demonstrated the presence of a wide range of contaminants in the stormwater, including surfactants, per and polyfluoroalkyl substances (PFAS), certain common chemicals from personal care products (PCPs), pesticides, and chemicals from other consumer products. Homologues of polyethylene glycol (PEGs) were found to be the major contributor to the contaminants, followed by other widely used surfactants. Nonylphenol ethoxylates (NPEs), typically used as surfactants, were also detected and were much higher in samples collected after storm event 1 comparing with storm event 2. The current study provides a comprehensive approach for examining wildfire-impacted stormwater contamination of rela

关键词： Water quality

来源：评论

学校读者我要写书评

暂无评论

Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccines (the PSERENADE project): a global surveillance analysis

引用

The Lancet Infectious Diseases 2025年第4期25卷 445-456页

作者： Garcia Quesada, Maria Peterson, Meagan E Bennett, Julia C Hayford, Kyla Zeger, Scott L Yang, Yangyupei Hetrich, Marissa K Feikin, Daniel R Cohen, Adam L von Gottberg, Anne van der Linden, Mark van Sorge, Nina M de Oliveira, Lucia H de Miguel, Sara Yildirim, Inci Vestrheim, Didrik F Verani, Jennifer R Varon, Emmanuelle Valentiner-Branth, Palle Tzanakaki, Georgina Sinkovec Zorko, Nadja Setchanova, Lena P Serhan, Fatima Scott, Kevin J Scott, J Anthony Savulescu, Camelia Savrasova, Larisa Reyburn, Rita Oishi, Kazunori Nuorti, J Pekka Napoli, Daniela Mwenda, Jason M Muñoz-Almagro, Carmen Morfeldt, Eva McMahon, Kimberley McGeer, Allison Mackenzie, Grant A Eugenia León, Maria Ladhani, Shamez N Kristinsson, Karl G Kozakova, Jana Kleynhans, Jackie Klein, Nicola P Kellner, James D Jayasinghe, Sanjay Ho, Pak-Leung Hilty, Markus Harker-Jones, Marcella A Hammitt, Laura L Grgic-Vitek, Marta Gilkison, Charlotte Gierke, Ryan French, Neil Diawara, Idrissa Desmet, Stefanie De Wals, Philippe Dalby, Tine Dagan, Ron Corcoran, Mary Colzani, Edoardo Chanto Chacón, Grettel Castilla, Jesús Camilli, Romina Ang, Michelle Ampofo, Krow Almeida, Samanta C G Alarcon, Pedro Deloria Knoll, Maria Pennington, Kate Krause, Vicki Brandileone, Maria-Cristina Ricketson, Leah Deceuninck, Geneviève Lefebvre, Brigitte Díaz, Janepsy Puentes, Rodrigo Krizova, Pavla Rafai, Eric Toropainen, Maija Viriot, Delphine Ploy, Marie-Cecile Hossain, Ilias Georgakopoulou, Theano Magaziotou, Ioanna Chow, Kin-Hung Erlendsdottir, Helga Mereckiene, Jolita Del Manso, Martina Suga, Shigeru Bigogo, Godfrey Dimina, Elina Swarthout, Todd Nzoyikorera, Néhémie Steens, Anneke Galloway, Yvonne Winje, Brita Chan, Guanhao Thoon, Koh Cheng Avdičová, Mária de Gouveia, Linda du Plessis, Mignon Ciruela, Pilar Sanz, Juan Carlos Guevara, Marcela Lepp, Tiia Amin-Chowdhury, Zahin Macdonald, Laura Pilishvili, Tamara Kobayashi, Miwako Bruden, Dana Pelton, Stephen Sutcliffe, Catherine Aukes, Laurie Byington, Carrie Zintgraff, Jonathan Chamorro, Gustavo Kawabata, Aníbal Celentano, Lucia Rey-Ben Johns Hopkins Bloomberg School of Public Health Baltimore MD United States WHO Geneva Switzerland Centre for Respiratory Diseases and Meningitis National Institute for Communicable Diseases of the National Health Laboratory Service Johannesburg South Africa School of Pathology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa School of Public Health Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa Reference Laboratory for Streptococci Department of Medical Microbiology University Hospital RWTH Aachen Aachen Germany Medical Microbiology and Infection Prevention Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam UMC University of Amsterdam Amsterdam Netherlands Pan American Health Organization WHO Washington DC United States CIBER de Enfermedades Respiratorias Madrid Spain Epidemiology Department Dirección General de Salud Pública Madrid Spain Department of Pediatrics Yale New Haven Children's Hospital New Haven CT United States Department of Public Health Ministry of Health and Care Services Oslo Norway Division of Global Health Protection Center for Global Health Centers for Disease Control and Prevention Nairobi Kenya Division of Bacterial Diseases National Center for Immunizations and Respiratory Diseases US Centers for Disease Control and Prevention Atlanta GA United States National Reference Centre for Pneumococci Data Research Department Intercommunal Hospital of Créteil Créteil France Infectious Disease Epidemiology and Prevention Statens Serum Institut Copenhagen Denmark National Meningitis Reference Laboratory Department of Public Health Policy School of Public Health University of West Attica Athens Greece Communicable Diseases Centre National Institute of Public Health Ljubljana Slovenia University Multiprofile Hospital for Active Treatment Saint Ivan Rilski Clinical Microbiology Laboratory Sofia Bulgaria Bacterial Respiratory Infection Service Scot

Background: Widespread use of pneumococcal conjugate vaccines (PCVs) has reduced vaccine-type invasive pneumococcal disease (IPD). We describe the serotype distribution of IPD after extensive use of ten-valent PCV (PCV10;Synflorix, GSK) and 13-valent PCV (PCV13;Prevenar 13, Pfizer) globally. Methods: IPD data were obtained from surveillance sites participating in the WHO-commissioned Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project that exclusively used PCV10 or PCV13 (hereafter PCV10 and PCV13 sites, respectively) in their national immunisation programmes and had primary series uptake of at least 70%. Serotype distribution was estimated for IPD cases occurring 5 years or more after PCV10 or PCV13 introduction (ie, the mature period when the serotype distribution had stabilised) using multinomial Dirichlet regression, stratified by PCV product and age group (<5 years, 5–17 years, 18–49 years, and ≥50 years). Findings: The analysis included cases occurring primarily between 2015 and 2018 from 42 PCV13 sites (63 362 cases) and 12 PCV10 sites (6806 cases) in 41 countries. Sites were mostly high income (36 [67%] of 54) and used three-dose or four-dose booster schedules (44 [81%]). At PCV10 sites, PCV10 serotypes caused 10·0% (95% CI 6·3–12·9) of IPD cases in children younger than 5 years and 15·5% (13·4–19·3) of cases in adults aged 50 years or older, while PCV13 serotypes caused 52·1% (49·2–65·4) and 45·6% (40·0–50·0), respectively. At PCV13 sites, PCV13 serotypes caused 26·4% (21·3–30·0) of IPD cases in children younger than 5 years and 29·5% (27·5–33·0) of cases in adults aged 50 years or older. The leading serotype at PCV10 sites was 19A in children younger than 5 years (30·6% [95% CI 18·2–43·1]) and adults aged 50 years or older (14·8% [11·9–17·8]). Serotype 3 was a top-ranked serotype, causing about 9% of cases in children younger than 5 years and 14% in adults aged 50 years or older at both PCV10 and PCV13 sites. Across all age an

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：