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Correction to: CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study

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Respiratory Research 2022年第1期23卷 1-1页

作者： K. C. Gribben P. A. Farazi T. D. LeVan A. B. Wyss S. J. London J. A. Poole C. Wichman M. Richards-Barber D. M. Umbach L. E. Beane Freeman P. K. Henneberger Department of Epidemiology University of Nebraska Medical Center Omaha NE 68198 USA Department of Internal Medicine Division of Pulmonary Critical Care and Sleep University of Nebraska Medical Center Omaha NE 68198 USA Epidemiology Branch Department of Health and Human Services National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park NC USA Department of Internal Medicine Division of Allergy and Immunology University of Nebraska Medical Center Omaha NE 68198 USA Department of Biostatistics University of Nebraska Medical Center Omaha NE 68198 USA Westat Durham NC USA Biostatistics and Computational Biology Branch Department of Health and Human Services National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park NC USA Occupational and Environmental Epidemiology Branch National Cancer Institute Bethesda MD USA Respiratory Health Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Morgantown WV USA

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Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

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Nature communications 2025年第1期16卷 4852页

作者： Maria Zanti Denise G O'Mahony Michael T Parsons Leila Dorling Joe Dennis Nicholas J Boddicker Wenan Chen Chunling Hu Marc Naven Kristia Yiangou Thomas U Ahearn Christine B Ambrosone Irene L Andrulis Antonis C Antoniou Paul L Auer Caroline Baynes Clara Bodelon Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Kristen D Brantley Nicola J Camp Archie Campbell Jose E Castelao Melissa H Cessna Jenny Chang-Claude Fei Chen Georgia Chenevix-Trench Don M Conroy Kamila Czene Arcangela De Nicolo Susan M Domchek Thilo Dörk Alison M Dunning A Heather Eliassen D Gareth Evans Peter A Fasching Jonine D Figueroa Henrik Flyger Manuela Gago-Dominguez Montserrat García-Closas Gord Glendon Anna González-Neira Felix Grassmann Andreas Hadjisavvas Christopher A Haiman Ute Hamann Steven N Hart Mikael B A Hartman Weang-Kee Ho James M Hodge Reiner Hoppe Sacha J Howell Anna Jakubowska Elza K Khusnutdinova Yon-Dschun Ko Peter Kraft Vessela N Kristensen James V Lacey Jingmei Li Geok Hoon Lim Sara Lindström Artitaya Lophatananon Craig Luccarini Arto Mannermaa Maria Elena Martinez Dimitrios Mavroudis Roger L Milne Kenneth Muir Katherine L Nathanson Rocio Nuñez-Torres Nadia Obi Janet E Olson Julie R Palmer Mihalis I Panayiotidis Alpa V Patel Paul D P Pharoah Eric C Polley Muhammad U Rashid Kathryn J Ruddy Emmanouil Saloustros Elinor J Sawyer Marjanka K Schmidt Melissa C Southey Veronique Kiak-Mien Tan Soo Hwang Teo Lauren R Teras Diana Torres Amy Trentham-Dietz Thérèse Truong Celine M Vachon Qin Wang Jeffrey N Weitzel Siddhartha Yadav Song Yao Gary R Zirpoli Melissa S Cline Peter Devilee Sean V Tavtigian David E Goldgar Fergus J Couch Douglas F Easton Amanda B Spurdle Kyriaki Michailidou Biostatistics Unit The Cyprus Institute of Neurology & Genetics Nicosia Cyprus. Department of Medical Genetics Oslo University Hospital Oslo Norway. Population Health Program QIMR Berghofer Medical Research Institute Brisbane Queensland Australia. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Cambridge UK. Department of Quantitative Health Sciences Division of Computational Biology Mayo Clinic Rochester MN USA. Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda MD USA. Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Institute Buffalo NY USA. Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Toronto Ontario Canada. Department of Molecular Genetics University of Toronto Toronto Ontario Canada. Division of Biostatistics Data Science Institute and Cancer Center Medical College of Wisconsin Milwaukee WI USA. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK. Department of Population Science American Cancer Society Atlanta GA USA. Radiation Oncology Research Unit Hannover Medical School Hannover Germany. Copenhagen General Population Study Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark. Department of Clinical Biochemistry Herlev and Gentofte Hospital Copenhagen University Hospital Herlev Denmark. Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark. Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA. Department of Internal Medicine and Huntsman Cancer Institute University of Utah Salt Lake City UT USA. Centre for Genomic and Experimental Medicine Institute of Genetics & Cancer The University of Ed

Clinical genetic testing identifies variants causal for hereditary cancer, information that is used for risk assessment and clinical management. Unfortunately, some variants identified are of uncertain clinical significance (VUS), complicating patient management. Case-control data is one evidence type used to classify VUS. As an initiative of the Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Analytical Working Group we analyze germline sequencing data of BRCA1 and BRCA2 from 96,691 female breast cancer cases and 302,116 controls from three studies: the BRIDGES study of the Breast cancer Association Consortium, the cancer Risk Estimates Related to Susceptibility consortium, and the UK Biobank. We observe 11,207 BRCA1 and BRCA2 variants, with 6909 being coding, covering 23.4% of BRCA1 and BRCA2 VUS in ClinVar and 19.2% of ClinVar curated (likely) benign or pathogenic variants. Case-control likelihood ratio (ccLR) evidence is highly consistent with ClinVar assertions for (likely) benign or pathogenic variants; exhibiting 99.1% sensitivity and 95.3% specificity for BRCA1 and 93.3% sensitivity and 86.6% specificity for BRCA2. This approach provides case-control evidence for 787 unclassified variants; these include 579 with strong or moderate benign evidence and 10 with strong pathogenic evidence for which ccLR evidence is sufficient to alter clinical classification.

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Reply to V Gianfredi et al

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Advances in nutrition (Bethesda, Md.) 2022年第2期13卷 685-686页

作者： Wolfgang Marx Nicola Veronese Jaimon Kelly Sam Collins Gina L Trakman Alexandra Wade Melissa Lane Hajara Aslam Adrienne O'Neil James R Hebert Lauren Blekkenhorst Michael Berk Felice Jacka From Deakin University The Institute for Mental and Physical Health and Clinical Translation (IMPACT) Food & Mood Centre School of Medicine Barwon Health Geelong Victoria Australia. Electronic address: wolf.marx@deakin.edu.au. Aging Branch Neuroscience Institute National Research Council Padova Italy. Centre of Applied Health Economics Griffith University Brisbane Queensland Australia Menzies Health Institute Queensland Griffith University Gold Coast Queensland Australia. From Deakin University The Institute for Mental and Physical Health and Clinical Translation (IMPACT) Food & Mood Centre School of Medicine Barwon Health Geelong Victoria Australia. Department of Dietetics Nutrition and Sport La Trobe University Melbourne Victoria Australia. Alliance for Research in Exercise Nutrition and Activity Allied Health and Human Performance University of South Australia Adelaide South Australia Australia. Melbourne School of Population & Global Health University of Melbourne Melbourne Victoria Australia. Department of Epidemiology and Biostatistics and Cancer Prevention and Control Program Arnold School of Public Health University of South Carolina Columbia SC USA Department of Nutrition Connecting Health Innovations LLC Columbia SC USA. School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia Medical School The University of Western Australia Perth Western Australia Australia. Black Dog Institute Sydney New South Wales Australia James Cook University Townsville Queensland Australia Centre for Adolescent Health Murdoch Children's Research Institute Melbourne Victoria Australia.

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Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

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Leukemia 2023年第10期37卷 2142页

作者： Sonja I Berndt Joseph Vijai Yolanda Benavente Nicola J Camp Alexandra Nieters Zhaoming Wang Karin E Smedby Geffen Kleinstern Henrik Hjalgrim Caroline Besson Christine F Skibola Lindsay M Morton Angela R Brooks-Wilson Lauren R Teras Charles Breeze Joshua Arias Hans-Olov Adami Demetrius Albanes Kenneth C Anderson Stephen M Ansell Bryan Bassig Nikolaus Becker Parveen Bhatti Brenda M Birmann Paolo Boffetta Paige M Bracci Paul Brennan Elizabeth E Brown Laurie Burdett Lisa A Cannon-Albright Ellen T Chang Brian C H Chiu Charles C Chung Jacqueline Clavel Pierluigi Cocco Graham Colditz Lucia Conde David V Conti David G Cox Karen Curtin Delphine Casabonne Immaculata De Vivo Arjan Diepstra W Ryan Diver Ahmet Dogan Christopher K Edlund Lenka Foretova Joseph F Fraumeni Attilio Gabbas Hervé Ghesquières Graham G Giles Sally Glaser Martha Glenn Bengt Glimelius Jian Gu Thomas M Habermann Christopher A Haiman Corinne Haioun Jonathan N Hofmann Theodore R Holford Elizabeth A Holly Amy Hutchinson Aalin Izhar Rebecca D Jackson Ruth F Jarrett Rudolph Kaaks Eleanor Kane Laurence N Kolonel Yinfei Kong Peter Kraft Anne Kricker Annette Lake Qing Lan Charles Lawrence Dalin Li Mark Liebow Brian K Link Corrado Magnani Marc Maynadie James McKay Mads Melbye Lucia Miligi Roger L Milne Thierry J Molina Alain Monnereau Rebecca Montalvan Kari E North Anne J Novak Kenan Onel Mark P Purdue Kristin A Rand Elio Riboli Jacques Riby Eve Roman Gilles Salles Douglas W Sborov Richard K Severson Tait D Shanafelt Martyn T Smith Alexandra Smith Kevin W Song Lei Song Melissa C Southey John J Spinelli Anthony Staines Deborah Stephens Heather J Sutherland Kaitlyn Tkachuk Carrie A Thompson Hervé Tilly Lesley F Tinker Ruth C Travis Jenny Turner Celine M Vachon Claire M Vajdic Anke Van Den Berg David J Van Den Berg Roel C H Vermeulen Paolo Vineis Sophia S Wang Elisabete Weiderpass George J Weiner Stephanie Weinstein Nicole Wong Doo Yuanqing Ye Meredith Yeager Kai Yu Anne Zeleniuch-Jacquotte Yawei Zhang Tongzhang Zheng Elad Ziv Joshua Sampson Nilanjan Chatterjee Kenn Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Md USA. berndts@mail.nih.gov. Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA. Cancer Epidemiology Research Programme Catalan Institute of Oncology-IDIBELL L'Hospitalet de Llobregat Barcelona Spain. CIBER de Epidemiología y Salud Pública (CIBERESP) Barcelona Spain. Department of Internal Medicine and Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City UT USA. Institute for Immunodeficiency University Medical Center Freiburg Freiburg Germany. Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis TN USA. Laboratory of Translational Genomics Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Department of Medicine Solna Karolinska Institutet Stockholm Sweden. Hematology Center Karolinska University Hospital Stockholm Sweden. School of Public Health University of Haifa Haifa Israel. Department of Epidemiology Research Division of Health Surveillance and Research Statens Serum Institut Copenhagen Denmark. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark. Department of Haematology Rigshospitalet Copenhagen Denmark. Danish Cancer Society Research Center Danish Cancer Society Copenhagen Denmark. Centre Hospitalier de Versailles Le Chesnay France. Université Paris-Saclay UVSQ Inserm Équipe "Exposome et Hérédité" CESP Villejuif France. Department of Hematology and Medical Oncology Emory University School of Medicine Atlanta GA USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Md USA. Genome Sciences Centre BC Cancer Agency Vancouver BC Canada. Department of Biomedical Physiology and Kinesiology Simon Fraser University Burnaby BC Canada. Department of Population Science American Cancer Society Atlanta GA USA. Department of Medical Epidemiology and Biostatistics Karolinska In

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Fatal police violence by race and state in the USA, 1980–2019: a network meta-regression

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The Lancet 2021年第10307期398卷 1239-1255页

作者： Sharara, Fablina Wool, Eve E. Bertolacci, Gregory J. Weaver, Nicole Davis Balassyano, Shelly Watson, Alexandrea Dippenaar, Ilse N. Cunningham, Matthew Fuller, John E. Marczak, Laurie B. Johnson, Catherine Owens Roth, Gregory A. Abedi, Aidin Acuna, Juan Manuel Advani, Shailesh M. Agasthi, Pradyumna Alahdab, Fares Al-Aly, Ziyad Antony, Catherine M. Assari, Shervin Awan, Asma Tahir Basu, Sanjay Bell, Arielle Wilder Braithwaite, Dejana Burkart, Katrin Chew, Adrienne Cho, Daniel Youngwhan Chowdhury, Mohiuddin Ahsanul Kabir Dai, Xiaochen Daoud, Farah Dharmaratne, Samath Dhamminda Dwyer-Lindgren, Laura Elgendy, Islam Y. Fares, Jawad Farwati, Medhat Fisher, James L. Gholamrezanezhad, Ali Gopalani, Sameer Vali Grada, Ayman Guha, Avirup Hafezi-Nejad, Nima Haider, Mohammad Rifat Hay, Simon I. Hossain, Md Mahbub Ikuta, Kevin S. Islam, Jessica Y. Jabbarinejad, Roxana Khatab, Khaled Khubchandani, Jagdish Kim, Daniel Kimokoti, Ruth W. Kisa, Adnan Krishnamoorthy, Vijay Krohn, Kris J. Lawrence, Wayne R. LeGrand, Kate E. Lim, Stephen S. Lin, Ziqiang Liu, Xuefeng Mahmoudi, Morteza Martinez-Piedra, Ramon Mehta, Kala M. Miller, Ted R. Moitra, Modhurima Mokdad, Ali H. Morrison, Shane Douglas Murray, Christopher J.L. Nápoles, Anna María Nsoesie, Elaine Okanyene Odell, Christopher M. Pawar, Shrikant Perez-Stable, Eliseo J. Pilz, Tessa M. Ram, Pradhum Reiner, Robert C. Roberts, Nicholas L.S. Salehi, Sana Sanabria, Juan Schwebel, David C. Sheikh, Aziz Sigfusdottir, Inga Dora Singh, Jasvinder A. Spurlock, Emma Elizabeth Sykes, Bryan L. Tadbiri, Hooman Tleyjeh, Imad I. Tsai, Alexander C. Vos, Theo Wu, Chenkai Yandrapalli, Srikanth Yunusa, Ismaeel Zand, Ramin Zhang, Wangjian Naghavi, Mohsen Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Division of Cardiology University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Plastic Surgery University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Anesthesiology & Pain Medicine University of Washington Seattle WA United States Department of Orthopaedic Surgery University of Southern California Los Angeles CA United States Department of Radiology University of Southern California Los Angeles CA United States Department of Epidemiology and Population Health Khalifa University Abu Dhabi United Arab Emirates FIU Robert Stempel College of Public Health & Social Work Florida International University Miami FL United States Terasaki Institute for Biomedical Innovation Los Angeles CA United States School of Medicine Georgetown University Washington DC United States Department of Cardiovascular Medicine Mayo Clinic Scottsdale AZ United States Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T Milliken Department of Internal Medicine Washington University in St Louis St Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Department of Family Medicine Charles R Drew University of Medicine and Science Los Angeles CA United States School of Nursing and Health Sciences Capella University Minneapolis MN United States Continuing Education Grant Writing Academy University of Nevada Las Vegas NV United States Center for Primary Care Harvard University Boston MA United States Department of Global Health and Social Medicine Harvard University Boston MA United States Division of Cardiology Harvard University Bos

Background: The burden of fatal police violence is an urgent public health crisis in the USA. Mounting evidence shows that deaths at the hands of the police disproportionately impact people of certain races and ethnicities, pointing to systemic racism in policing. Recent high-profile killings by police in the USA have prompted calls for more extensive and public data reporting on police violence. This study examines the presence and extent of under-reporting of police violence in US Government-run vital registration data, offers a method for correcting under-reporting in these datasets, and presents revised estimates of deaths due to police violence in the USA. Methods: We compared data from the USA National Vital Statistics System (NVSS) to three non-governmental, open-source databases on police violence: Fatal Encounters, Mapping Police Violence, and The Counted. We extracted and standardised the age, sex, US state of death registration, year of death, and race and ethnicity (non-Hispanic White, non-Hispanic Black, non-Hispanic of other races, and Hispanic of any race) of each decedent for all data sources and used a network meta-regression to quantify the rate of under-reporting within the NVSS. Using these rates to inform correction factors, we provide adjusted estimates of deaths due to police violence for all states, ages, sexes, and racial and ethnic groups from 1980 to 2019 across the USA. Findings: Across all races and states in the USA, we estimate 30 800 deaths (95% uncertainty interval [UI] 30 300–31 300) from police violence between 1980 and 2018;this represents 17 100 more deaths (16 600–17 600) than reported by the NVSS. Over this time period, the age-standardised mortality rate due to police violence was highest in non-Hispanic Black people (0·69 [95% UI 0·67–0·71] per 100 000), followed by Hispanic people of any race (0·35 [0·34–0·36]), non-Hispanic White people (0·20 [0·19–0·20]), and non-Hispanic people of other races (0·15 [0·14– 0·16]). This var

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Corrigendum to 'Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and cancer': [Annals of Oncology Volume 31, Issue 1, January 2020, Pages 103-114]

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Annals of oncology : official journal of the European Society for Medical Oncology 2021年第9期32卷 1201页

作者： J M Genkinger K Wu M Wang D Albanes A Black P A van den Brandt K A Burke M B Cook S M Gapstur G G Giles E Giovannucci G G Goodman P J Goodman N Håkansson T J Key S Männistö L Le Marchand L M Liao R J MacInnis M L Neuhouser E A Platz N Sawada J M Schenk V L Stevens R C Travis S Tsugane K Visvanathan L R Wilkens A Wolk S A Smith-Warner Department of Epidemiology Mailman School of Public Health Columbia University Medical Center New York USA Cancer Epidemiology Program Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York USA. Electronic address: jg3081@columbia.edu. Department of Nutrition Harvard TH Chan School of Public Health Boston USA. Department of Epidemiology Harvard TH Chan School of Public Health Boston USA Department of Biostatistics Harvard TH Chan School of Public Health Boston USA Department of Medicine Harvard Medical School Boston USA. Division of Cancer Epidemiology and Genetics National Cancer Institute NIH DHHS Bethesda USA. Department of Epidemiology GROW-School for Oncology and Developmental Biology Maastricht University Maastricht The Netherlands. Department of Epidemiology Mailman School of Public Health Columbia University Medical Center New York USA. Behavioral and Epidemiology Research Group American Cancer Society Atlanta USA. Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne Australia Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health University of Melbourne Melbourne Australia. Department of Nutrition Harvard TH Chan School of Public Health Boston USA Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle USA. SWOG Statistical Center Seattle USA. Division of Nutritional Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden. Cancer Epidemiology Unit Nuffield Department of Population Health University of Oxford Oxford UK. Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland. Epidemiology Program University of Hawaii Cancer Center Honolulu USA. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore USA. Epidemiology and Prevention Group Center for Public Health Sciences National Cancer Center Tokyo Japan. Division

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The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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Nature Communications 2022年第1期13卷 1-14页

作者： Reiner, Robert C. Welgan, Catherine A. Troeger, Christopher E. Baumann, Mathew M. Weiss, Daniel J. Deshpande, Aniruddha Blacker, Brigette F. Miller-Petrie, Molly K. Earl, Lucas Bhatt, Samir Abolhassani, Hassan Abosetugn, Akine Eshete Abu-Gharbieh, Eman Adekanmbi, Victor Adetokunboh, Olatunji O. Aghaali, Mohammad Aji, Budi Alahdab, Fares Al-Aly, Ziyad Alhassan, Robert Kaba Ali, Saqib Alizade, Hesam Aljunid, Syed Mohamed Almasi-Hashiani, Amir Al-Mekhlafi, Hesham M. Altirkawi, Khalid A. Alvis-Guzman, Nelson Amare, Azmeraw T. Amini, Saeed Amugsi, Dickson A. Ancuceanu, Robert Andrei, Catalina Liliana Ansari, Fereshteh Anvari, Davood Appiah, Seth Christopher Yaw Arabloo, Jalal Aremu, Olatunde Atout, Maha Moh’d Wahbi Ausloos, Marcel Ausloos, Floriane Ayanore, Martin Amogre Aynalem, Yared Asmare Azene, Zelalem Nigussie Badawi, Alaa Baig, Atif Amin Banach, Maciej Bedi, Neeraj Bhagavathula, Akshaya Srikanth Bhandari, Dinesh Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bijani, Ali Birhanu, Tesega Tesega Mengistu Bitew, Zebenay Workneh Boloor, Archith Brady, Oliver J. Butt, Zahid A. Car, Josip Carvalho, Felix Casey, Daniel C. Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Coelho, Camila H. Cook, Aubrey J. Damiani, Giovanni Daoud, Farah Gela, Jiregna Darega Darwish, Amira Hamed Daryani, Ahmad Das, Jai K. Davis Weaver, Nicole Deribe, Kebede Desalew, Assefa Dharmaratne, Samath Dhamminda Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Dorostkar, Fariba Dubljanin, Eleonora Duko, Bereket Dwyer-Lindgren, Laura Effiong, Andem El Sayed Zaki, Maysaa El Tantawi, Maha Enany, Shymaa Fattahi, Nazir Feigin, Valery L. Fernandes, Eduarda Ferrara, Pietro Fischer, Florian Foigt, Nataliya A. Folayan, Morenike Oluwatoyin Foroutan, Masoud Frostad, Joseph Jon Fukumoto, Takeshi Gaidhane, Abhay Motiramji Gebrekrstos, Hailemikael Gebrekidan G. K. Gebremeskel, Leake Gebreslassie, Assefa Ayalew Gething, Peter W. Gezae, Kebede Embaye Ghadiri, Keyghobad Ghashghaee, Ahmad Golechha, Mahaveer Gubar Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Malaria Atlas Project University of Oxford Oxford United Kingdom Imperial College London London United Kingdom Department of Laboratory Medicine Karolinska University Hospital Huddinge Sweden Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Debre Berhan University Debre Berhan Ethiopia Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Population Health Sciences King’s College London London United Kingdom Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Stellenbosch South Africa Department of Global Health Stellenbosch University Cape Town South Africa Department of Epidemiology and Biostatistics Qom University of Medical Sciences Qom Iran Faculty of Medicine and Public Health Jenderal Soedirman University Purwokerto Indonesia Mayo Evidence-based Practice Center Mayo Clinic Foundation for Medical Education and Research Rochester MN United States John T. Milliken Department of Internal Medicine Washington University in St. Louis St. Louis MO United States Clinical Epidemiology Center Department of Veterans Affairs St Louis MO United States Institute of Health Research University of Health and Allied Sciences Ho Ghana Department of Information Systems College of Economics and Political Science Sultan Qaboos University Muscat Oman Infectious and Tropical Disease Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Health Policy and Management Kuwait University Safat Kuwait International Centre for Casemix and Clinical Coding National University of Malaysia Bandar Tun Razak Malaysia Department of Epidemiology Arak University of Medical Sciences Arak Iran Medical Research Center

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).

关键词： Biogeography epidemiology Infectious diseases Malaria

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Association between the inflammatory potential of diet and stress relative to inflammatory markers among female college students

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Clinical Nutrition ESPEN 2020年 40卷 530-530页

作者： Alfreeh, L. Abulmeaty, M. Alam, I. Shivappa, N. Hebert, J. Aljuraiban, G. Department of Community Health Sciences College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia Medical Physiology Department Faculty of Medicine Zagazig University Zagazig Egypt Department of Epidemiology & Biostatistics United States Department of Cancer Prevention and Control Program University of South Carolina Columbia United States

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

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Nature communications 2023年第1期14卷 3043页

作者： Jianxin Shi Kouya Shiraishi Jiyeon Choi Keitaro Matsuo Tzu-Yu Chen Juncheng Dai Rayjean J Hung Kexin Chen Xiao-Ou Shu Young Tae Kim Maria Teresa Landi Dongxin Lin Wei Zheng Zhihua Yin Baosen Zhou Bao Song Jiucun Wang Wei Jie Seow Lei Song I-Shou Chang Wei Hu Li-Hsin Chien Qiuyin Cai Yun-Chul Hong Hee Nam Kim Yi-Long Wu Maria Pik Wong Brian Douglas Richardson Karen M Funderburk Shilan Li Tongwu Zhang Charles Breeze Zhaoming Wang Batel Blechter Bryan A Bassig Jin Hee Kim Demetrius Albanes Jason Y Y Wong Min-Ho Shin Lap Ping Chung Yang Yang She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young-Chul Kim Neil E Caporaso Jiang Chang James Chung Man Ho Michiaki Kubo Yataro Daigo Minsun Song Yukihide Momozawa Yoichiro Kamatani Masashi Kobayashi Kenichi Okubo Takayuki Honda Dean H Hosgood Hideo Kunitoh Harsh Patel Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Hidehito Horinouchi Masahiro Tsuboi Ryuji Hamamoto Koichi Goto Yuichiro Ohe Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Megumi Hara Yuichiro Nishida Kenji Takeuchi Kenji Wakai Koichi Matsuda Yoshinori Murakami Kimihiro Shimizu Hiroyuki Suzuki Motonobu Saito Yoichi Ohtaki Kazumi Tanaka Tangchun Wu Fusheng Wei Hongji Dai Mitchell J Machiela Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Gee-Chen Chang Ying-Huang Tsai Kuan-Yu Chen Ming-Shyan Huang Wu-Chou Su Yuh-Min Chen Adeline Seow Jae Yong Park Sun-Seog Kweon Kun-Chieh Chen Yu-Tang Gao Biyun Qian Chen Wu Daru Lu Jianjun Liu Ann G Schwartz Richard Houlston Margaret R Spitz Ivan P Gorlov Xifeng Wu Ping Yang Stephen Lam Adonina Tardon Chu Chen Stig E Bojesen Mattias Johansson Angela Risch Heike Bickeböller Bu-Tian Ji H-Erich Wichmann David C Christiani Gadi Rennert Susanne Arnold Paul Brennan James McKay John K Field Sanjay S Shete Loic Le Marchand Geoffrey Liu Angeline Andrew Lambertus A Kiemeney Shan Zienolddiny-Narui Kjell Grankvist Mikael Johansson Angela Cox Fiona Taylor Jian-Min Yuan Philip Lazarus Matthew B Schabath Melinda C Aldrich Hyo-Sung Jeon Shih Sheng Jiang Jae Sook Sung C Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. jianxin.shi@nih.gov. Division of Genome Biology National Cancer Research Institute Tokyo Japan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China. Prosserman Centre for Population Health Research Lunenfeld-Tanenbaum Research Institute Sinai Health Toronto ON Canada. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Tianjin China. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Epidemiology School of Public Health China Medical University Shenyang China. Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang China. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China. S

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

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880Dietary inflammatory index and the risk of adult depression symptoms

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International Journal of epidemiology 2021年第SUPPLEMENT_1期50卷

作者： Shakya, Prem Melaku, Yohannes Adama Page, Amanda J Adams, Robert J Shivappa, Nitin Hébert, James R Gill, Tiffany K Vagal Afferent Research Group University of Adelaide Adelaide Australia Nutrition Diabetes and Metabolism Lifelong Health South Australian Health and Medical Research Institute (SAHMRI) Adelaide Australia Adelaide Institute for Sleep Health (AISH) Flinders University Bedford Park Australia Adelaide Medical School University of Adelaide Adelaide Australia Cancer Prevention and Control Program University of South Carolina Columbia USA Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia USA

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