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Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

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The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, Muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun Mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, Muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

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Tea, coffee, and head and neck cancer risk in a multicenter study in east Asia

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Oral cancer 2018年第1期2卷 57-65页

作者： Li, Shuang Lee, Yuan-Chin Amy Li, Qian Chen, Chien-Jen Hsu, Wan-Lun Lou, Pen-Jen Zhu, Cairong Pan, Jian Shen, Hongbing Ma, Hongxia Cai, Lin He, Baochang Wang, Yu Zhou, Xiaoyan Ji, Qinghai Zhou, Baosen Wu, Wei Ma, Jie Boffetta, Paolo Zhang, Zuo-Feng Dai, Min Hashibe, Mia Division of Public Health Department of Family and Preventive Medicine and Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City USA Departments of Preventive Medicine Icahn School of Medicine at Mount Sinai New York USA Genomics Research Center Academia Sinica Taipei Taiwan Graduate Institute of Epidemiology and Preventive Medicine National Taiwan University Taipei Taiwan Department of Otolaryngology National Taiwan University Hospital Taipei Taiwan Department of Epidemiology and Biostatistics West China School of Public Health Sichuan University Chengdu China Department of Oral Surgery West China Hospital of Stomatology Sichuan University Sichuan China Department of Epidemiology and Biostatistics Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine School of Public Health Nanjing Medical University Nanjing China Department of Epidemiology and Biostatistics School of Public Health Fujian Medical University Fujian China Department of Head and Neck Surgery Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Shanghai Medical College Fudan University Shanghai China Department of Pathology Fudan University Shanghai Cancer Center Shanghai China Department of Epidemiology School of Public Health China Medical University Liaoning China Department of Head and Neck Oncology Henan Cancer Hospital Henan China Tisch Cancer Institute Icahn School of Medicine Mount Sinai New York City USA Department of Epidemiology and Center for Environmental Genomics UCLA Fielding School of Public Health Los Angeles USA National Office of Cancer Prevention and Control Cancer Institute and Hospital and Chinese Academy of Medical Sciences Beijing China

The role of tea or coffee on head and neck cancer (HNC) risk has not been consistent, especially in Asian populations. The aim of the study was to investigate whether tea or coffee is associated with HNC risks in a Chinese population. Our case–control study included 921 head and neck cancer cases and 806 controls. We obtained information on tea and coffee consumption frequency, duration, age at start, strength, and types. Unconditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (95% CIs). No association between tea drinking and HNC risk was observed after adjusting for potential confounders. Coffee drinking was inversely associated with oral cavity cancer risk with dose–response trends for both frequency (p for trend = 0.0149) and the duration (p for trend = 0.0167) of intake. When stratified by age, sex, and cigarette smoking, coffee drinking was not clearly associated with head and neck cancer risk in terms of frequency or duration. Coffee consumption was associated with a decreased risk of oral cavity cancer. Further investigations with more specific tea consumption-related factors are warranted to examine the relationship between tea drinking and HNC risks.

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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

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The Lancet Global Health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

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Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

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Human genetics 2019年第7期138卷 789-791页

作者： Stephanie A Bien Yu-Ru Su David V Conti Tabitha A Harrison Conghui Qu Xingyi Guo Yingchang Lu Demetrius Albanes Paul L Auer Barbara L Banbury Sonja I Berndt Stéphane Bézieau Hermann Brenner Daniel D Buchanan Bette J Caan Peter T Campbell Christopher S Carlson Andrew T Chan Jenny Chang-Claude Sai Chen Charles M Connolly Douglas F Easton Edith J M Feskens Steven Gallinger Graham G Giles Marc J Gunter Jochen Hampe Jeroen R Huyghe Michael Hoffmeister Thomas J Hudson Eric J Jacobs Mark A Jenkins Ellen Kampman Hyun Min Kang Tilman Kühn Sébastien Küry Flavio Lejbkowicz Loic Le Marchand Roger L Milne Li Li Christopher I Li Annika Lindblom Noralane M Lindor Vicente Martín Caroline E McNeil Marilena Melas Victor Moreno Polly A Newcomb Kenneth Offit Paul D P Pharaoh John D Potter Chenxu Qu Elio Riboli Gad Rennert Núria Sala Clemens Schafmayer Peter C Scacheri Stephanie L Schmit Gianluca Severi Martha L Slattery Joshua D Smith Antonia Trichopoulou Rosario Tumino Cornelia M Ulrich Fränzel J B van Duijnhoven Bethany Van Guelpen Stephanie J Weinstein Emily White Alicja Wolk Michael O Woods Anna H Wu Goncalo R Abeçasis Graham Casey Deborah A Nickerson Stephen B Gruber Li Hsu Wei Zheng Ulrike Peters Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. sbien@***. Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. USC Norris Comprehensive Cancer Center University of Southern California Los Angeles CA 90089 USA. Department of Preventive Medicine Keck School of Medicine University of Southern California Los Angeles CA 90033 USA. Division of Epidemiology Vanderbilt University School of Medicine Nashville TN 37232 USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD 20892 USA. Joseph J. Zilber School of Public Health University of Wisconsin-Milwaukee Milwaukee WI 53205 USA. Centre Hospitalier Universitaire Hotel-Dieu 44093 Nantes France. Service de Génétique Médicale Centre Hospitalier Universitaire (CHU) 44093 Nantes France. Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) 69120 Heidelberg Germany. German Cancer Consortium (DKTK) 69120 Heidelberg Germany. Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Parkville VIC 3010 Australia. Colorectal Oncogenomics Group Department of Pathology University of Melbourne Melbourne VIC 3010 Australia. Genetic Medicine and Familial Cancer Centre The Royal Melbourne Hospital Parkville VIC 3010 Australia. Division of Research Kaiser Permanente Medical Care Program of Northern California Oakland CA 94612 USA. Epidemiology Research Program American Cancer Society Atlanta GA 30329-4251 USA. Division of Gastroenterology Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA. Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA 02115 USA. Unit of Genetic Epi

Every author has erroneously been assigned to the affiliation "62". The affiliation 62 belongs to the author Graham Casey.

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Gene Abnormalities in Transplant Associated-Thrombotic Microangiopathy: Comparison between Recipient and Donor's DNA

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Thrombosis and Haemostasis 2021年第7期122卷 1247-1250页

作者： Evangeline Millicent Rodrigues Gianluigi Ardissino Giulia Pintarelli Valentina Capone Jacopo Mariotti Marta Verna Maria Ester Bernardo Maura Faraci Monica Tozzi Alessandro Bucalossi Elisabetta Schiavello Veronica Biassoni Anna Guidetti Alessandra Carotti Luca Facchini Elisabetta Terruzzi Fabio Giglio Marco Zecca Francesco Onida Leonardo Caroti Simone Cesaro Dario Consonni Massimo Cugno Luigi Porcaro Center for HUS Control Prevention and Management Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy Laboratory of Medical Genetics Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy Bone Marrow Transplant Unit Hematology-Oncology Department Humanitas Cancer Center Rozzano Italy Paediatric Foundation MBBM San Gerardo Hospital Monza Italy Paediatric Immunohaematology and Bone Marrow Transplantation Unit San Raffaele Scientific Institute Vita Salute San Raffaele University Milan Italy Hematopoietic Stem Cell Unit Department of Hematology-Oncology IRCCS Istituto G. Gaslini Genova Italy Cellular Therapy Unit Azienda Ospedaliera Universitaria Senese Siena Italy Paediatric Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy Hematology Division Hemato-Oncology Department Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy HST Program Hematology Immunology Department University Hospital Perugia Italy Haematology Department Azienda USL IRCCS Reggio Emilia Italy Division of Hematology and CTA San Gerardo Hospital Monza Italy Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute Milan Italy Paediatric Hematoloy/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy Hematology-BMT Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico University of Milan Milan Italy Nephrology and Dialysis Unit Azienda Ospedaliero-Universitaria Careggi Florence Italy Oncoematologia Pediatrica Azienda Ospedaliera Universitaria Integrata Verona Italy Unit of Epidemiology in Public Health Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy

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A national survey of primary care physicians: Perceptions and practices of low-dose CT lung cancer screening

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Preventive Medicine Reports 2018年 11卷 93-99页

作者： Eberth, Jan M. McDonnell, Karen Kane Sercy, Erica Khan, Samira Strayer, Scott M. Dievendorf, Amy C. Munden, Reginald F. Vernon, Sally W. Department of Epidemiology and Biostatistics Arnold School of Public Health University of South Carolina Columbia SC United States Statewide Cancer Prevention and Control Program Arnold School of Public Health University of South Carolina Columbia SC United States South Carolina Rural Health Research Center Arnold School of Public Health University of South Carolina Columbia SC United States College of Nursing University of South Carolina Columbia SC United States Department of Family and Preventive Medicine School of Medicine University of South Carolina Columbia SC United States Department of Radiology Wake Forest Baptist Medical Center Winston Salem NC United States Department of Health Promotion & Behavioral Sciences School of Public Health University of Texas Health Sciences Center at Houston Houston TX United States

Soon after the National Lung Screening Trial, organizations began to endorse low-dose computed tomography (LCDT) screening for lung cancer in high-risk patients. Concerns about the risks versus benefits of screening, as well as the logistics of identifying and referring eligible patients, remained among physicians. This study aimed to examine primary care physicians' knowledge, attitudes, referral practices, and associated barriers regarding LDCT screening. We administered a national survey of primary care physicians in the United States between September 2016 and April 2017. Physicians received up to 3 mailings, 1 follow-up email, and received varying incentives to complete the survey. Overall, 293 physicians participated, for a response rate of 13%. We used weighted descriptive statistics to characterize participants and their responses. Over half of the respondents correctly reported that the US Preventive Services Task Force recommends LDCT screening for high-risk patients. Screening recommendations for patients not meeting high-risk criteria varied. Although 75% agreed that the benefits of LDCT screening outweigh the risks, fewer agreed that there is substantial evidence that screening reduces mortality (50%). The most commonly reported barriers to ordering screening included prior authorization requirements (57%), lack of insurance coverage (53%), and coverage denials (31%). The most frequently cited barrier to conducting LDCT screening shared decision making was patients' competing health priorities (42%). Given the impact of physician recommendations on cancer screening utilization, further understanding of physicians' LDCT screening attitudes and shared decision-making practices is needed. Clinical practice and policy changes are also needed to engage more patients in screening discussions. © 2018

关键词： Computed tomography Early detection of cancer Lung cancer Mass screening Physicians

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Acalabrutinib in High-Risk Chronic Lymphocytic Leukemia Patients Naïve or Previous Treated. a Multicenter Retrospective Observational Real-Life Experience

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Blood 2024年 144卷 6798-6798页

作者： Idanna Innocenti Annamaria Tomasso Diana Giannarelli Lydia Scarfo Roberta Murru Andrea Visentin Anna Maria Frustaci Francesca Morelli Candida Vitale Antonio Mosca Alessandro Sanna Giuliana Farina Roberta Laureana Massimo Gentile Andrea Galitzia Raffaella Pasquale Francesco Autore Jacopo Olivieri Azzurra Anna Romeo Marina Deodato Luca Laurenti Department of Laboratory and Haematological Sciences Haematology Area Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of Sacred Heart Roma Italy Catholic University of Sacred Heart Hematology Section Department of Radiological and Hematological Sciences Rome Italy Facility of Epidemiology and Biostatistics GSTeP Fondazione Policlinico Universitario Agostino Gemelli IRCCS Roma Italy Strategic Research Program on CLL IRCCS Ospedale San Raffaele Milano Italy Medical School Università Vita-Salute San Raffaele Milano Italy Hematology and Stem Cell Transplantation Unit Ospedale Oncologico A. Businco ARNAS “G. Brotzu” Cagliari Italy Hematology Unit Department of Medicine - DIMED University of Padua Padova Italy Department of Hematology Niguarda Cancer Center ASST Grande Ospedale Metropolitano Niguarda Milano Italy Department of Hematology University of Florence Firenze Italy Department of Molecular Biotechnology and Health Sciences University of Torino and Division of Hematology University Hospital (A.O.U.) Città della Salute e della Scienza di Torino Torino Italy Hematology Section Department of Radiological and Hematological Sciences Catholic University of Sacred Heart Rome Italy Hematology Department of Oncology AOU Careggi Firenze Italy Hematology and Medical Oncology AORN Sant'Anna e San Sebastiano Caserta Italy Hematology Department of Biomedicine and Prevention University of Rome Tor Vergata Rome Italy Hematology Section Cosenza Hospital Cosenza Italy Hematology and Stem Cell Transplantation Unit Ospedale San Francesco Hematology and Stem Cell Transplantation Unit Ospedale San Francesco Nuoro Italy SOC Clinica Ematologia Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) Udine Italy Hematology Section Department of Radiological and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy Hematology and Stem Cell transplantation Unit S.M. Goretti Hospital Polo Universitario Pontino

In recent years, treatment of chronic lymphocytic leukemia(CLL) has changed considerably, in favor of a tailored and chemo-free approach, with the introduction of target drugs, such as BTK inhibitors (BTKi). Continuous BTKi, thanks to a prolonged disease control and low hematological toxicities, improved therapeutic results and responses close to eradicationeven in patients with an unfavorable risk profile [del(17p), TP53 m, unmutated IGHV genes (uIGHV)]. Acalabrutinib, a covalent second-generation BTKi, demonstrated similar progression free survival (PFS) and overall survival (OS) of Ibrutinib, the first in class BTKi, in pts carrying del(17p) and/or del(11q), while showing a lower rate of treatment discontinuation for adverse events (AE) due to a more favorable toxicity profile. Despite these data, in clinical practice it's still unclear whether there's a difference of efficacy of Acalabrutinib in other high-risk (HR) subgroups ( TP53 m, uIGVH) and whether there might be a subgroup that could be a better candidate for treatment with Acalabrutinib. The primary aim of the study was to evaluate the efficacy of Acalabrutinib in pts with HR CLL and to identify which subgroup may benefit the most from its use. The secondary aims were to describe clinical-biological features of pts with HR CLL candidates to Acalabrutinib in real life and to assess its tolerability profile. A retrospective analysis was conducted on 129 pts with HR CLL [del(17p), TP53 m and/or uIGHV], who started Acalabrutinib between June 2021 and June 2023, from 14 Italian centers. Pts were divided into two groups: the treatment-naïve (TN) group (n = 98) and the relapsed/refractory (RR) group (n = 31). Median ages were 70 and 75 years for TN and RR pts, respectively. For both, we analyzed survival data by stratifying pts into further subgroups according to HR biological features [10 TN and 2 RR pts with del(17p) and/or TP53 m only, 68 TN and 18 RR with uIGHV only, 18 TN and 9 RR with uIGHV with del(17p)

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Publisher Correction: Early-onset colorectal cancer: initial clues and current views

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Nature reviews. Gastroenterology & hepatology 2020年第8期17卷 517页

作者： Lorne J Hofseth James R Hebert Anindya Chanda Hexin Chen Bryan L Love Maria M Pena E Angela Murphy Mathew Sajish Amit Sheth Phillip J Buckhaults Franklin G Berger Center for Colon Cancer Research University of South Carolina Columbia SC USA. hofseth@cop.sc.edu. Cancer Prevention and Control Program University of South Carolina Columbia SC USA. hofseth@cop.sc.edu. Department of Drug Discovery and Biomedical Sciences College of Pharmacy University of South Carolina Columbia SC USA. hofseth@cop.sc.edu. Center for Colon Cancer Research University of South Carolina Columbia SC USA. Cancer Prevention and Control Program University of South Carolina Columbia SC USA. Department of Epidemiology & Biostatistics University of South Carolina Columbia SC USA. Department of Environmental Health Sciences Arnold School of Public Health University of South Carolina Columbia SC USA. Department of Biology College of Arts and Sciences University of South Carolina Columbia SC USA. Department of Clinical Pharmacy and Outcomes Sciences College of Pharmacy University of South Carolina Columbia SC USA. Department of Pathology Microbiology & Immunology School of Medicine University of South Carolina Columbia SC USA. Department of Drug Discovery and Biomedical Sciences College of Pharmacy University of South Carolina Columbia SC USA. Department of Computer Science and Engineering College of Engineering University of South Carolina Columbia SC USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Iran in transition (vol 393, pg 1984, 2019)

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LANCET 2019年第10186期393卷 2124-2124页

作者： Danaei, G. Farzadfar, F. Kelishadi, R. [a]Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA [b]Scientific Association for Public Health in Iran Boston MA USA Scientific Association for Public Health in Iran Boston MA USA [c]Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran [d]Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran [e]Diabetes Research Center Tehran University of Medical Sciences Tehran Iran Diabetes Research Center Tehran University of Medical Sciences Tehran Iran [f]Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran [g]Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran [h]Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran [i]School of Public Health Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran [j]Faculty of Medicine Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Te

Summary Being the second-largest country in the Middle East, Iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. Iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades. Given the lessons learnt from political instabilities in the past centuries and the approaches undertaken to overcome health challenges at the time, Iran has emerged as it is today. Iran is now a country with a population exceeding 80 million, mainly inhabiting urban regions, and has an increasing burden of non-communicable diseases, including cardiovascular diseases, hypertension, diabetes, malignancies, mental disorders, substance abuse, and road injuries.

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)

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NATURE GENETICS 2021年第5期53卷 762-762页

作者： Surendran, Praveen Feofanova, Elena V. Lahrouchi, Najim Ntalla, Ioanna Karthikeyan, Savita Cook, James Chen, Lingyan Mifsud, Borbala Yao, Chen Kraja, Aldi T. Cartwright, James H. Hellwege, Jacklyn N. Giri, Ayush Tragante, Vinicius Thorleifsson, Gudmar Liu, Dajiang J. Prins, Bram P. Stewart, Isobel D. Cabrera, Claudia P. Eales, James M. Akbarov, Artur Auer, Paul L. Bielak, Lawrence F. Bis, Joshua C. Braithwaite, Vickie S. Brody, Jennifer A. Daw, E. Warwick Warren, Helen R. Drenos, Fotios Nielsen, Sune Fallgaard Faul, Jessica D. Fauman, Eric B. Fava, Cristiano Ferreira, Teresa Foley, Christopher N. Franceschini, Nora Gao, He Giannakopoulou, Olga Giulianini, Franco Gudbjartsson, Daniel F. Guo, Xiuqing Harris, Sarah E. Havulinna, Aki S. Helgadottir, Anna Huffman, Jennifer E. Hwang, Shih-Jen Kanoni, Stavroula Kontto, Jukka Larson, Martin G. Li-Gao, Ruifang Lindstrom, Jaana Lotta, Luca A. Lu, Yingchang Luan, Jian'an Mahajan, Anubha Malerba, Giovanni Masca, Nicholas G. D. Mei, Hao Menni, Cristina Mook-Kanamori, Dennis O. Mosen-Ansorena, David Muller-Nurasyid, Martina Pare, Guillaume Paul, Dirk S. Perola, Markus Poveda, Alaitz Rauramaa, Rainer Richard, Melissa Richardson, Tom G. Sepulveda, Nuno Sim, Xueling Smith, Albert V. Smith, Jennifer A. Staley, James R. Stanakova, Alena Sulem, Patrick Theriault, Sebastien Thorsteinsdottir, Unnur Trompet, Stella Varga, Tibor V. Velez Edwards, Digna R. Veronesi, Giovanni Weiss, Stefan Willems, Sara M. Yao, Jie Young, Robin Yu, Bing Zhang, Weihua Zhao, Jing-Hua Zhao, Wei Zhao, Wei Evangelou, Evangelos Aeschbacher, Stefanie Asllanaj, Eralda Blankenberg, Stefan Bonnycastle, Lori L. Bork-Jensen, Jette Brandslund, Ivan Braund, Peter S. Burgess, Stephen Cho, Kelly Christensen, Cramer Connell, John de Mutsert, Renee Dominiczak, Anna F. Dorr, Marcus Eiriksdottir, Gudny Farmaki, Aliki-Eleni Gaziano, J. Michael Grarup, Niels Grove, Megan L. Hallmans, Goran Hansen, Torben Have, Christian T. Heiss, Gerardo Jorgensen, Marit E. Jousilahti, Pekka Kajantie, Eero Kamat, Mihir Karajamaki, AnneMari Kar British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK British Heart Foundation Centre of Research Excellence University of Cambridge Cambridge UK Health Data Research UK Cambridge Wellcome Genome Campus and University of Cambridge Cambridge UK Rutherford Fund Fellow Department of Public Health and Primary Care University of Cambridge Cambridge UK MRC Biostatistics Unit University of Cambridge Cambridge UK National Institute for Health Research Cambridge Biomedical Research Centre University of Cambridge and Cambridge University Hospitals Cambridge UK MRC Integrative Epidemiology Unit (IEU) Population Health Sciences Bristol Medical School University of Bristol Bristol UK Robertson Centre for Biostatistics University of Glasgow Glasgow UK MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge UK Department of Immunology and Inflammation Imperial College London London UK Centre for Non-communicable Disease Research (CNCR) Dhaka Bangladesh National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge Cambridge UK Department of Human Genetics Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge UK Department of Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Non-Communicable Diseases Karachi Pakistan Department of Genetics Novo Nordisk Research Centre Oxford Oxford UK Human Genetics Center Department of Epidemiology Human Genetics and Environmental Sciences School of Public Health University of Texas Health Science Center at Houston Houston TX USA Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Cardiovascular Research Center Center for Genomic Medicine

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