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Acalabrutinib in High-Risk Chronic Lymphocytic Leukemia Patients Naïve or Previous Treated. a Multicenter Retrospective Observational Real-Life Experience

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Blood 2024年 144卷 6798-6798页

作者： Idanna Innocenti Annamaria Tomasso Diana Giannarelli Lydia Scarfo Roberta Murru Andrea Visentin Anna Maria Frustaci Francesca Morelli Candida Vitale Antonio Mosca Alessandro Sanna Giuliana Farina Roberta Laureana Massimo Gentile Andrea Galitzia Raffaella Pasquale Francesco Autore Jacopo Olivieri Azzurra Anna Romeo Marina Deodato Luca Laurenti Department of Laboratory and Haematological Sciences Haematology Area Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of Sacred Heart Roma Italy Catholic University of Sacred Heart Hematology Section Department of Radiological and Hematological Sciences Rome Italy Facility of Epidemiology and Biostatistics GSTeP Fondazione Policlinico Universitario Agostino Gemelli IRCCS Roma Italy Strategic Research Program on CLL IRCCS Ospedale San Raffaele Milano Italy Medical School Università Vita-Salute San Raffaele Milano Italy Hematology and Stem Cell Transplantation Unit Ospedale Oncologico A. Businco ARNAS “G. Brotzu” Cagliari Italy Hematology Unit Department of Medicine - DIMED University of Padua Padova Italy Department of Hematology Niguarda Cancer Center ASST Grande Ospedale Metropolitano Niguarda Milano Italy Department of Hematology University of Florence Firenze Italy Department of Molecular Biotechnology and Health Sciences University of Torino and Division of Hematology University Hospital (A.O.U.) Città della Salute e della Scienza di Torino Torino Italy Hematology Section Department of Radiological and Hematological Sciences Catholic University of Sacred Heart Rome Italy Hematology Department of Oncology AOU Careggi Firenze Italy Hematology and Medical Oncology AORN Sant'Anna e San Sebastiano Caserta Italy Hematology Department of Biomedicine and Prevention University of Rome Tor Vergata Rome Italy Hematology Section Cosenza Hospital Cosenza Italy Hematology and Stem Cell Transplantation Unit Ospedale San Francesco Hematology and Stem Cell Transplantation Unit Ospedale San Francesco Nuoro Italy SOC Clinica Ematologia Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) Udine Italy Hematology Section Department of Radiological and Hematological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy Hematology and Stem Cell transplantation Unit S.M. Goretti Hospital Polo Universitario Pontino

In recent years, treatment of chronic lymphocytic leukemia(CLL) has changed considerably, in favor of a tailored and chemo-free approach, with the introduction of target drugs, such as BTK inhibitors (BTKi). Continuous BTKi, thanks to a prolonged disease control and low hematological toxicities, improved therapeutic results and responses close to eradicationeven in patients with an unfavorable risk profile [del(17p), TP53 m, unmutated IGHV genes (uIGHV)]. Acalabrutinib, a covalent second-generation BTKi, demonstrated similar progression free survival (PFS) and overall survival (OS) of Ibrutinib, the first in class BTKi, in pts carrying del(17p) and/or del(11q), while showing a lower rate of treatment discontinuation for adverse events (AE) due to a more favorable toxicity profile. Despite these data, in clinical practice it's still unclear whether there's a difference of efficacy of Acalabrutinib in other high-risk (HR) subgroups ( TP53 m, uIGVH) and whether there might be a subgroup that could be a better candidate for treatment with Acalabrutinib. The primary aim of the study was to evaluate the efficacy of Acalabrutinib in pts with HR CLL and to identify which subgroup may benefit the most from its use. The secondary aims were to describe clinical-biological features of pts with HR CLL candidates to Acalabrutinib in real life and to assess its tolerability profile. A retrospective analysis was conducted on 129 pts with HR CLL [del(17p), TP53 m and/or uIGHV], who started Acalabrutinib between June 2021 and June 2023, from 14 Italian centers. Pts were divided into two groups: the treatment-naïve (TN) group (n = 98) and the relapsed/refractory (RR) group (n = 31). Median ages were 70 and 75 years for TN and RR pts, respectively. For both, we analyzed survival data by stratifying pts into further subgroups according to HR biological features [10 TN and 2 RR pts with del(17p) and/or TP53 m only, 68 TN and 18 RR with uIGHV only, 18 TN and 9 RR with uIGHV with del(17p)

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Lammi, Vilma Nakanishi, Tomoko Jones, Samuel E. Andrews, Shea J. Karjalainen, Juha Cortés, Beatriz O’Brien, Heath E. Ochoa-Guzman, Ana Fulton-Howard, Brian E. Broberg, Martin Haapaniemi, Hele H. Kanai, Masahiro Pirinen, Matti Schmidt, Axel Mitchell, Ruth E. Mousas, Abdou Mangino, Massimo Huerta-Chagoya, Alicia Sinnott-Armstrong, Nasa Cirulli, Elizabeth T. Vaudel, Marc Kwong, Alex S. F. Maiti, Amit K. Marttila, Minttu M. Posner, Daniel C. Rodriguez, Alexis A. Batini, Chiara Minnai, Francesca Dearman, Anna R. Warmerdam, C. A. Robert Sequeros, Celia B. Winkler, Thomas W. Jordan, Daniel M. Rešcenko, Raimonds Miano, Lorenzo Lane, Jacqueline M. Chung, Ryan K. Guillen-Guio, Beatriz Leavy, Olivia C. Carvajal-Silva, Laura Aguilar-Valdés, Kevin Frangione, Erika Guare, Lindsay Vergasova, Ekaterina Marouli, Eirini Striano, Pasquale Zainulabid, Ummu Afeera Kumar, Ashutosh Ahmad, Hajar Fauzan Edahiro, Ryuya Azekawa, Shuhei Maj, Carlo Pensel, Max C. Miller, Abigail Nöthen, Markus M. Behzad, Pari Schultz, Sonja Heggemann, Julia Balla, Daniella Morrison, David R. Mooser, Vincent Perley, Danielle Ragoussis, Jiannis Rousseau, Simon Shi, Fangyi Lathrop, G. Mark Yanishevsky, Solomia Laurent, Laetitia Auld, Daniel Bertrand, Mylene Boisclair, Ariane Bourque, Guillaume Bujold, David Durand, Madeleine Adra, Darin St-Cyr, Janick Niemi, Mari E. K. Iyengar, Sudha K. Cai, Tianxi Cho, Kelly Sarvadhavabhatla, Sannidhi Donaire, Maria Sophia Valenzuela-Jorquera, Héctor Lamoza, Eduardo Arévalo, Tamara V. Retamales-Ortega, Rocío Sanhueza, Sergio Selman, Carolina S. Silva, Andrea X. Alarcon, Teresa A. Martínez, Matías F. Quiroga, Romina Zuñiga-Pacheco, Paula Zapata-Contreras, Daniela Yáñez, Cristian E. Quiñones, Luis A. Tobar-Calfucoy, Eduardo A. Monardes-Ramírez, Virginia A. Signore, Iskra A. Guajardo, Lissette G. Figueroa, Alvaro Oróstica, Karen Y. Muñoz, Christian A. Fuentes-Guajardo, Macarena Bocchieri, Pamela Cabrera, Camilo Echeverria, Cesar A. Cerpa, Leslie C. Donoso, Gerardo Gutiérrez-Richards, Scarlett Nova-Lamperti, Estefania Saez Hidalgo Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal QC Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal QC Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Department of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco CA United States Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA United States Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA United States Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA United States Genomes for Life-GCAT Lab CORE Program Germans Trias i Pujol Research Institute (IGTP) Badalona Spain Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) Barcelona Spain Sano Genetics Limited London United Kingdom Unidad de Biología Molecular y Medicina Genómica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City NY United States Broad Institute Cambridge MA United States Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany MRC Integrat

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. © The Author(s) 2025.

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Publisher Correction: Early-onset colorectal cancer: initial clues and current views

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Nature reviews. Gastroenterology & hepatology 2020年第8期17卷 517页

作者： Lorne J Hofseth James R Hebert Anindya Chanda Hexin Chen Bryan L Love Maria M Pena E Angela Murphy Mathew Sajish Amit Sheth Phillip J Buckhaults Franklin G Berger Center for Colon Cancer Research University of South Carolina Columbia SC USA. hofseth@cop.sc.edu. Cancer Prevention and Control Program University of South Carolina Columbia SC USA. hofseth@cop.sc.edu. Department of Drug Discovery and Biomedical Sciences College of Pharmacy University of South Carolina Columbia SC USA. hofseth@cop.sc.edu. Center for Colon Cancer Research University of South Carolina Columbia SC USA. Cancer Prevention and Control Program University of South Carolina Columbia SC USA. Department of Epidemiology & Biostatistics University of South Carolina Columbia SC USA. Department of Environmental Health Sciences Arnold School of Public Health University of South Carolina Columbia SC USA. Department of Biology College of Arts and Sciences University of South Carolina Columbia SC USA. Department of Clinical Pharmacy and Outcomes Sciences College of Pharmacy University of South Carolina Columbia SC USA. Department of Pathology Microbiology & Immunology School of Medicine University of South Carolina Columbia SC USA. Department of Drug Discovery and Biomedical Sciences College of Pharmacy University of South Carolina Columbia SC USA. Department of Computer Science and Engineering College of Engineering University of South Carolina Columbia SC USA.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Iran in transition (vol 393, pg 1984, 2019)

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LANCET 2019年第10186期393卷 2124-2124页

作者： Danaei, G. Farzadfar, F. Kelishadi, R. [a]Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA Department of Global Health and Population and Department of Epidemiology Harvard T H Chan School of Public Health Boston MA USA [b]Scientific Association for Public Health in Iran Boston MA USA Scientific Association for Public Health in Iran Boston MA USA [c]Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran [d]Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran [e]Diabetes Research Center Tehran University of Medical Sciences Tehran Iran Diabetes Research Center Tehran University of Medical Sciences Tehran Iran [f]Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Clinical Sciences Institute Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran [g]Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran Department of Global Health and Public Policy Tehran University of Medical Sciences Tehran Iran [h]Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran [i]School of Public Health Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran [j]Faculty of Medicine Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Te

Summary Being the second-largest country in the Middle East, Iran has a long history of civilisation during which several dynasties have been overthrown and established and health-related structures have been reorganised. Iran has had the replacement of traditional practices with modern medical treatments, emergence of multiple pioneer scientists and physicians with great contributions to the advancement of science, environmental and ecological changes in addition to large-scale natural disasters, epidemics of multiple communicable diseases, and the shift towards non-communicable diseases in recent decades. Given the lessons learnt from political instabilities in the past centuries and the approaches undertaken to overcome health challenges at the time, Iran has emerged as it is today. Iran is now a country with a population exceeding 80 million, mainly inhabiting urban regions, and has an increasing burden of non-communicable diseases, including cardiovascular diseases, hypertension, diabetes, malignancies, mental disorders, substance abuse, and road injuries.

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)

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NATURE GENETICS 2021年第5期53卷 762-762页

作者： Surendran, Praveen Feofanova, Elena V. Lahrouchi, Najim Ntalla, Ioanna Karthikeyan, Savita Cook, James Chen, Lingyan Mifsud, Borbala Yao, Chen Kraja, Aldi T. Cartwright, James H. Hellwege, Jacklyn N. Giri, Ayush Tragante, Vinicius Thorleifsson, Gudmar Liu, Dajiang J. Prins, Bram P. Stewart, Isobel D. Cabrera, Claudia P. Eales, James M. Akbarov, Artur Auer, Paul L. Bielak, Lawrence F. Bis, Joshua C. Braithwaite, Vickie S. Brody, Jennifer A. Daw, E. Warwick Warren, Helen R. Drenos, Fotios Nielsen, Sune Fallgaard Faul, Jessica D. Fauman, Eric B. Fava, Cristiano Ferreira, Teresa Foley, Christopher N. Franceschini, Nora Gao, He Giannakopoulou, Olga Giulianini, Franco Gudbjartsson, Daniel F. Guo, Xiuqing Harris, Sarah E. Havulinna, Aki S. Helgadottir, Anna Huffman, Jennifer E. Hwang, Shih-Jen Kanoni, Stavroula Kontto, Jukka Larson, Martin G. Li-Gao, Ruifang Lindstrom, Jaana Lotta, Luca A. Lu, Yingchang Luan, Jian'an Mahajan, Anubha Malerba, Giovanni Masca, Nicholas G. D. Mei, Hao Menni, Cristina Mook-Kanamori, Dennis O. Mosen-Ansorena, David Muller-Nurasyid, Martina Pare, Guillaume Paul, Dirk S. Perola, Markus Poveda, Alaitz Rauramaa, Rainer Richard, Melissa Richardson, Tom G. Sepulveda, Nuno Sim, Xueling Smith, Albert V. Smith, Jennifer A. Staley, James R. Stanakova, Alena Sulem, Patrick Theriault, Sebastien Thorsteinsdottir, Unnur Trompet, Stella Varga, Tibor V. Velez Edwards, Digna R. Veronesi, Giovanni Weiss, Stefan Willems, Sara M. Yao, Jie Young, Robin Yu, Bing Zhang, Weihua Zhao, Jing-Hua Zhao, Wei Zhao, Wei Evangelou, Evangelos Aeschbacher, Stefanie Asllanaj, Eralda Blankenberg, Stefan Bonnycastle, Lori L. Bork-Jensen, Jette Brandslund, Ivan Braund, Peter S. Burgess, Stephen Cho, Kelly Christensen, Cramer Connell, John de Mutsert, Renee Dominiczak, Anna F. Dorr, Marcus Eiriksdottir, Gudny Farmaki, Aliki-Eleni Gaziano, J. Michael Grarup, Niels Grove, Megan L. Hallmans, Goran Hansen, Torben Have, Christian T. Heiss, Gerardo Jorgensen, Marit E. Jousilahti, Pekka Kajantie, Eero Kamat, Mihir Karajamaki, AnneMari Kar British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK British Heart Foundation Centre of Research Excellence University of Cambridge Cambridge UK Health Data Research UK Cambridge Wellcome Genome Campus and University of Cambridge Cambridge UK Rutherford Fund Fellow Department of Public Health and Primary Care University of Cambridge Cambridge UK MRC Biostatistics Unit University of Cambridge Cambridge UK National Institute for Health Research Cambridge Biomedical Research Centre University of Cambridge and Cambridge University Hospitals Cambridge UK MRC Integrative Epidemiology Unit (IEU) Population Health Sciences Bristol Medical School University of Bristol Bristol UK Robertson Centre for Biostatistics University of Glasgow Glasgow UK MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge UK Department of Immunology and Inflammation Imperial College London London UK Centre for Non-communicable Disease Research (CNCR) Dhaka Bangladesh National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge Cambridge UK Department of Human Genetics Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge UK Department of Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Non-Communicable Diseases Karachi Pakistan Department of Genetics Novo Nordisk Research Centre Oxford Oxford UK Human Genetics Center Department of Epidemiology Human Genetics and Environmental Sciences School of Public Health University of Texas Health Science Center at Houston Houston TX USA Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Cardiovascular Research Center Center for Genomic Medicine

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Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

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Nature communications 2021年第1期12卷 2986页

作者： Juliette Coignard Michael Lush Jonathan Beesley Tracy A O'Mara Joe Dennis Jonathan P Tyrer Daniel R Barnes Lesley McGuffog Goska Leslie Manjeet K Bolla Muriel A Adank Simona Agata Thomas Ahearn Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Volker Arndt Norbert Arnold Kristan J Aronson Banu K Arun Annelie Augustinsson Jacopo Azzollini Daniel Barrowdale Caroline Baynes Heko Becher Marina Bermisheva Leslie Bernstein Katarzyna Białkowska Carl Blomqvist Stig E Bojesen Bernardo Bonanni Ake Borg Hiltrud Brauch Hermann Brenner Barbara Burwinkel Saundra S Buys Trinidad Caldés Maria A Caligo Daniele Campa Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Wendy K Chung Kathleen B M Claes Christine L Clarke J Margriet Collée Don M Conroy Kamila Czene Mary B Daly Peter Devilee Orland Diez Yuan Chun Ding Susan M Domchek Thilo Dörk Isabel Dos-Santos-Silva Alison M Dunning Miriam Dwek Diana M Eccles A Heather Eliassen Christoph Engel Mikael Eriksson D Gareth Evans Peter A Fasching Henrik Flyger Florentia Fostira Eitan Friedman Lin Fritschi Debra Frost Manuela Gago-Dominguez Susan M Gapstur Judy Garber Vanesa Garcia-Barberan Montserrat García-Closas José A García-Sáenz Mia M Gaudet Simon A Gayther Andrea Gehrig Vassilios Georgoulias Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Per Hall Ute Hamann Patricia A Harrington Steven N Hart Wei He Frans B L Hogervorst Antoinette Hollestelle John L Hopper Darling J Horcasitas Peter J Hulick David J Hunter Evgeny N Imyanitov Agnes Jager Anna Jakubowska Paul A James Uffe Birk Jensen Esther M John Michael E Jones Rudolf Kaaks Pooja Middha Kapoor Beth Y Karlan Renske Keeman Elza Khusnutdinova Johanna I Kiiski Yon-Dschun Ko Veli-Matti Kosma Peter Kraft Allison W Kurian Yael Laitman Diether Lambrechts Loic Le Marchand Jenny Lester Fabienne Lesueur Tricia Lindstrom Adria Lopez-Fernández Jennifer T Loud Craig Luccarini Arto Mannermaa Siranou Genetic Epidemiology of Cancer team Inserm U900 Paris France. Institut Curie Paris Paris France. Mines ParisTech Fontainebleau Paris France. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Cambridge UK. PSL University Paris Paris France. Paris Sud University Orsay France. Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane QLD Australia. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK. Family Cancer Clinic The Netherlands Cancer Institute Antoni van Leeuwenhoek hospital Amsterdam The Netherlands. Immunology and Molecular Oncology Unit Veneto Institute of Oncology IOV - IRCCS Padua Italy. Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda MD USA. Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki Finland. Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Toronto ON Canada. Department of Molecular Genetics University of Toronto Toronto ON Canada. Department of Epidemiology Genetic Epidemiology Research Institute University of California Irvine Irvine CA USA. Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany. Department of Gynaecology and Obstetrics University Hospital of Schleswig-Holstein Campus Kiel Christian-Albrechts University Kiel Kiel Germany. Institute of Clinical Molecular Biology University Hospital of Schleswig-Holstein Campus Kiel Christian-Albrechts University Kiel Kiel Germany. Department of Public Health Sciences and Cancer Research Institute Queen's University Kingston ON Canada. Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston TX USA. Department of Cancer Epidemiology Clinical Sciences

A Correction to this paper has been published: https://***/10.1038/s41467-021-23162-4.

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci (vol 50, pg 928, 2018)

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NATURE GENETICS 2019年第2期51卷 363-363页

作者： Schumacher, Fredrick R. Al Olama, Ali Amin Berndt, Sonja I. Benlloch, Sara Ahmed, Mahbubl Saunders, Edward J. Dadaev, Tokhir Leongamornlert, Daniel Anokian, Ezequiel Cieza-Borrella, Clara Goh, Chee Brook, Mark N. Sheng, Xin Fachal, Laura Dennis, Joe Tyrer, Jonathan Muir, Kenneth Lophatananon, Artitaya Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M., Jr. Batra, Jyotsna Chambers, Suzanne Moya, Leire Clements, Judith Horvath, Lisa Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Nordstrom, Tobias Pharoah, Paul Pashayan, Nora Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Albanes, Demetrius Weinstein, Stephanie Wolk, Alicja Hakansson, Niclas West, Catharine M. L. Dunning, Alison M. Burnet, Neil Mucci, Lorelei A. Giovannucci, Edward Andriole, Gerald L. Cussenot, Olivier Cancel-Tassin, Geraldine Koutros, Stella Freeman, Laura E. Beane Sorensen, Karina Dalsgaard Orntoft, Torben Falck Borre, Michael Maehle, Lovise Grindedal, Eli Marie Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Travis, Ruth C. Key, Tim J. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Ingles, Sue Ann Stern, Mariana C. Rosenstein, Barry S. Kerns, Sarah L. Ostrer, Harry Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Guo, Xin Wang, Guomin Sun, Zan Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. FitzGerald, Liesel M. Kibel, Adam S. Drake, Bettina F. Vega, Ana Gomez-Caamano, Antonio Szulkin, Robert Eklund, Martin Kogevinas, Manolis Llorca, Javier Castano-Vinyals, Gemma Penney, Kathryn L. Stampfer, Meir Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Stanford, Janet L. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Ostrander, Elaine A. Geybels, Milan S. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bisbjerg, Rasmus Roder, Martin Andreas Iversen, Peter Brenner, Hermann Cuk, Katarina Holleczek, Bernd Maier, Christiane Luedeke, Manuel Schnoeller, Thomas Kim, Jeri Logothetis, Christopher J. John, E Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland USA Seidman Cancer Center University Hospitals Cleveland USA Royal Marsden NHS Foundation Trust London UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology University of Cambridge Strangeways Research Laboratory Cambridge UK Department of Clinical Neurosciences University of Cambridge Cambridge UK Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Bethesda USA Institute of Cancer Research London UK Department of Preventive Medicine Keck School of Medicine University of Southern California/Norris Comprehensive Cancer Center Los Angeles USA Fundación Pública Galega de Medicina Xenómica–SERGAS Grupo de Medicina Xenómica CIBERER IDIS Santiago de Compostela Spain Department of Oncology Centre for Cancer Genetic Epidemiology Strangeways Laboratory University of Cambridge Cambridge UK Division of Population Health Health Services Research and Primary Care University of Manchester Manchester UK Warwick Medical School University of Warwick Coventry UK Epidemiology Research Program American Cancer Society Atlanta USA SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle USA CHRISTUS Santa Rosa Hospital–Medical Center San Antonio USA Institute of Health and Biomedical Innovation and School of Biomedical Sciences Queensland University of Technology Brisbane Australia Australian Prostate Cancer Research Centre–Qld Translational Research Institute Brisbane Australia Menzies Health Institute of Queensland Griffith University Nathan Australia Cancer Council Queensland Fortitude Valley Australia Chris O’Brien Lifehouse (COBLH) Camperdown Australia Garvan Institute of Medical Research Sydney Australia Dame Roma Mitchell Cancer Research Centre University of Adelaide Adelaide Australia Monash Biomedicine Discovery Institute Cancer Program Prostate Cancer Research Program Department of Anatom

In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.

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Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a ***,multicenter,cross-sectional survey

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Chinese Journal of cancer 2017年第8期36卷 352-366页

作者： Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai Program Office for Cancer Screening in Urban China National Cancer Center/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical College17 South Panjiayuan LaneChaoyang DistrictBeijing 100021P.R.China Department of Cancer Epidemiology Henan Cancer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenan 450008P.R.China Institute of Epidemiology and Health Statistics Lanzhou UniversityLanzhouGansu 730000P.R.China Hunan Office for Cancer Control and Research Hunan Provincial Cancer HospitalChangshaHunan 410006P.R.China Department of Health Economics School of Health ManagementHarbin Medical UniversityHarbinHeilongjiang 150081P.R.China Public Health Information Research Office Institute of Medical InformationChinese Academy of Medical SciencesBeijing 100020P.R.China Center for Health Management and Policy Key Lab of Health Economics and PolicyShandong UniversityJinanShandong 250012P.R.China Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical UniversityHarbinHeilongjiang 150081P.R.China Zhejiang Office for Cancer Control and Research Zhejiang Cancer HospitalHangzhouZhejiang 310022P.R.China Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical UniversityürümqiXinjiang 830011P.R.China Science and Education Department of Public Health Division Shandong Tumor HospitalJinanShandong 250117P.R.China Chongqing Office for Cancer Control and Research Chongqing Cancer HospitalChongqing 400030P.R.China Cancer Epidemiology Research Center Gansu Provincial Cancer HospitalLanzhouGansu 730050P.R.China Department of Health Policy and Economic Research Guangdong Provincial Institute of Public HealthGuangzhouGuangdong 511430P.R.China Department of Institute of Tumor Research Henan Cancer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenan 450008P.R.China Institute of Chronic Disease Prevention and Control Harbin Center for Disease Control and PreventionHarbinHei

Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in ***: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall ***: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 *** overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagno

关键词： Colorectal neoplasms Direct expenditure Financial burden China

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Medical expenditure for esophageal cancer in China:a 10-year multicenter retrospective survey(2002-2011)

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Chinese Journal of cancer 2017年第11期36卷 548-559页

作者： Lan-Wei Guo Hui-Yao Huang Ju-Fang Shi Li-Hong Lv Ya-Na Bai A-Yan Mao Xian-Zhen Liao Guo-Xiang Liu Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Jin-Yi Zhou Ji-Yong Gong Qi Zhou Lin Zhu Yu-Qin Liu Bing-Bing Song Ling-Bin Du Xiao-Jing Xing Pei-An Lou Xiao-Hua Sun Xiao Qi Shou-Ling Wu Rong Cao Li Lan Ying Ren Kai Zhang Jie He Jian.Gong Zhang Min Dai Department of Cancer Epidemiology Henan Office for Cancer Control and Research The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital No. 127 Dongming Road Zhengzhou 450008 Henan P. R China Program Office for Cancer Screening in Urban China Cancer Hospital Chinese Academy of Medical Sciences (CAMS) Peking Union Medical College National Cancer Center of China No. 17 Panjiayuannanli Chaoyang District Beijing 100021 P. R. China Department of Human Resources The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou 450008 Henan P. R. China Institute of Epidemiology and Health Statistics Lanzhou University Lanzhou 730000 Gansu P. R. China Public Health Information Research Office Institute of Medical Information Chinese Academy of Medical Sciences (CAMS) Beijing 100020 P. R. China Hunan Office for Cancer Control and Research Hunan Provincial Cancer Hospital Changsha 410006 Hunan P. R. China Department of Health Economics School of Health Management Harbin Medical University Harbin 150081 Heilongjiang P. R. China Center for Health Management and Policy Key Lab of Health Economics and Policy Shandong University Jinan 250012 Shandong P. R. China Institute of Chronic Non.Communicable Diseases Prevention and Control Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009 Jiangsu P. R. China Science and Education Department Public Health Division Shandong Tumor Hospital Jinan 250117 Shandong P. R. China Chongqing Office for Cancer Control and Research Chongqing Cancer Hospital Chongqing 400030 P. R. China Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical University ürümqi 830011 Xinjiang P. R. China Cancer Epidemiology Research Center Gansu Provincial Cancer Hospital Lanzhou 730050 Gansu P. R. China Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University Harbin 150081 Heilongjiang P R. China Zhejiang Office for Cancer

Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated ***: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the cancer Screening program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan(CNY; 1 CNY = 0.155 USD) based on the2011 value and inflated using the year-specific health care consumer price index for ***: A total of 14,967 esophageal cancer patients were included in the analysis. It was estimated that the overall average expenditure per patient was 38,666 CNY, and an average annual increase of 6.27% was observed from 2002(25,111 CNY) to 2011(46,124 CNY). The average expenditures were 34,460 CNY for stage Ⅰ,39,302 CNY for stage Ⅱ,40,353 CNY for stage Ⅲ, and 37,432 CNY for stage IV diseases(P < 0.01). The expenditure also differed by the therapy type, which was 38,492 CNY for surgery, 27,933 CNY for radiotherapy, and 27,805 CNY for chemotherapy(P < 0.05).Drugs contributed to 45.02% of the overall ***: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure.

关键词： Esophageal neoplasms Medical expenditure Diagnosis and treatment China

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

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Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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