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American journal of epidemiology 2017年第5期186卷 625-626页

作者： Annah B Wyss Mia Hashibe Yuan-Chin Amy Lee Shu-Chun Chuang Joshua Muscat Chu Chen Stephen M Schwartz Elaine Smith Zuo-Feng Zhang Hal Morgenstern Qingyi Wei Guojun Li Karl T Kelsey Deborah M Winn Maura L Gillison Jose P Zevallos Paolo Boffetta Andrew F Olshan Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill North Carolina. Epidemiology Branch National Institute of Environmental Health Sciences Research Triangle Park North Carolina. Department of Family and Preventive Medicine School of Medicine University of Utah Salt Lake City Utah. Huntsman Cancer Institute Salt Lake City Utah. Institute of Population Health Sciences National Health Research Institutes Miaoli Taiwan. Department of Public Health Sciences College of Medicine Penn State College of Medicine Hershey Pennsylvania. Department of Epidemiology School of Public Health University of Washington Seattle Washington. Program in Epidemiology Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington. Department of Epidemiology College of Public Health University of Iowa Iowa City Iowa. Department of Epidemiology School of Public Health University of California Los Angeles Los Angeles California. Departments of Epidemiology and Environmental Health Sciences School of Public Health University of Michigan Ann Arbor Michigan. Comprehensive Cancer Center University of Michigan Ann Arbor Michigan. Duke Cancer Center Duke University Medical Center Durham North Carolina. Department of Epidemiology Division of Cancer Prevention and Population Sciences University of Texas MD Anderson Cancer Center Houston Texas. Department of Head and Neck Surgery Division of Surgery University of Texas MD Anderson Cancer Center Houston Texas. Department of Epidemiology School of Public Health Brown University Providence Rhode Island. Division of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland. Department of Internal Medicine Wexner Medical Center Ohio State University Columbus Ohio. Department of Otolaryngology/Head and Neck Surgery School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina. Tisch Can

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Corrigendum to "Spumaretroviruses: Updated taxonomy and nomenclature" [Virology 516 (2018) 158-164]

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Virology 2019年 528卷 208-208页

作者： Arifa S Khan Jochen Bodem Florence Buseyne Antoine Gessain Welkin Johnson Jens H Kuhn Jacek Kuzmak Dirk Lindemann Maxine L Linial Martin Löchelt Magdalena Materniak-Kornas Marcelo A Soares William M Switzer Laboratory of Retroviruses US Food and Drug Administration Silver Spring MD 20993 USA. Electronic address: arifa.khan@fda.hhs.gov. Institut für Virologie und Immunbiologie Universität Würzburg Würzburg Germany. Unit of Epidemiology and Physiopathology of Oncogenic Viruses Institut Pasteur Paris France Centre National de la Recherche Scientifique CNRS UMR3569 Paris France. Biology Department Boston College Chestnut Hill MA 02467 USA. Integrated Research Facility at Fort Detrick National Institute of Allergy and Infectious Diseases National Institutes of Health Frederick MD 21702 USA. Department of Biochemistry National Veterinary Research Institute Puławy Poland. Institute of Virology Technische Universität Dresden Dresden Germany. Division of Basic Sciences Fred Hutchinson Cancer Research Center Seattle WA 98109 USA. Research Program Infection Inflammation and Cancer German Cancer Research Center (DFKZ) Heidelberg Germany. Instituto Nacional de Câncer and Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil. Laboratory Branch Division of HIV/AIDS Prevention Centers for Disease Control and Prevention Atlanta GA 30329 USA.

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Risk Model for Colorectal cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study (vol 7, 43263, 2017)

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SCIENTIFIC REPORTS 2017年第1期7卷 43263-43263页

作者： Ibanez-Sanz, Gemma Diez-Villanueva, Anna Henar Alonso, M. Rodriguez-Moranta, Francisco Perez-Gomez, Beatriz Bustamante, Mariona Martin, Vicente Llorca, Javier Amiano, Pilar Ardanaz, Eva Tardon, Adonina Jimenez-Moleon, Jose J. Peiro, Rosana Alguacil, Juan Navarro, Carmen Guino, Elisabet Binefa, Gemma Fernandez-Navarro, Pablo Espinosa, Anna Davila-Batista, Veronica Molina, Antonio Jose Palazuelos, Camilo Castano-Vinyals, Gemma Aragones, Nuria Kogevinas, Manolis Pollan, Marina Moreno, Victor Cancer Prevention and Control Program Catalan Institute of Oncology-IDIBELL L’Hospitalet de Llobregat Spain Cancer Prevention and Control Program Catalan Institute of Oncology-IDIBELL L’Hospitalet de Llobregat Spain Cancer Prevention and Control Program Catalan Institute of Oncology-IDIBELL L’Hospitalet de Llobregat Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Gastroenterology Department Bellvitge University Hospital-IDIBELL L’Hospitalet de Llobregat Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Environmental and Cancer Epidemiology Department National Center of Epidemiology - Instituto de Salud Carlos III Madrid Spain Oncology and Hematology Area IIS Puerta De Hierro Cancer Epidemiology Research Group Madrid Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain ISGlobal Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Instituto de Biomedicina (IBIOMED). Grupo de investigación en interacciones gen ambiente y salud. Universidad de León León Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Universidad de Cantabria - IDIVAL Santander Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Public Health Division of Gipuzkoa Biodonostia Research Institute San Sebastian Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Navarra Public Health Institute Navarra Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain University Institute of Oncology of Asturias (IUOPA) Universidad de Oviedo Oviedo Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA) Hospitales Universitarios de Granada Granada Spain CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Va

Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5^th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1^st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.

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Author Correction: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

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Nature communications 2019年第1期10卷 5617页

作者： Jiyuan An Puya Gharahkhani Matthew H Law Jue-Sheng Ong Xikun Han Catherine M Olsen Rachel E Neale John Lai Tom L Vaughan Ines Gockel René Thieme Anne C Böhmer Janusz Jankowski Rebecca C Fitzgerald Johannes Schumacher Claire Palles David C Whiteman Stuart MacGregor Statistical Genetics QIMR Berghofer Medical Research Institute Brisbane QLD Australia. Cancer Control QIMR Berghofer Medical Research Institute Brisbane QLD Australia. Cancer Aetiology and Prevention QIMR Berghofer Medical Research Institute Brisbane QLD Australia. School of Public Health The University of Queensland Brisbane QLD Australia. School of Public Health and Social Work the Queensland University of Technology Brisbane QLD Australia. Centre for Epidemiology and Biostatistics The University of Melbourne Melbourne VIC Australia. Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA USA. Department of Visceral Transplant Thoracic and Vascular Surgery University Hospital of Leipzig Leipzig Germany. Institute of Human Genetics University of Bonn School of Medicine & University Hospital Bonn Bonn Germany. Department of Genomics Life & Brain Center University of Bonn Bonn Germany. Royal College of Surgeons in Ireland Dublin Ireland. Medical Research Council (MRC) Cancer Unit Hutchison-MRC Research Centre and University of Cambridge Cambridge UK. Center for Human Genetics University Hospital of Marburg Marburg Germany. Institute of Cancer and Genomic Sciences University of Birmingham Birmingham UK. Statistical Genetics QIMR Berghofer Medical Research Institute Brisbane QLD Australia. stuart.macgregor@qimrberghofer.edu.au.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Preliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women

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Scientific Reports 2016年第1期6卷 1-10页

作者： Huang, Yubei Dai, Hongji Song, Fengju Li, Haixin Yan, Ye Yang, Zhenhua Ye, Zhaoxiang Zhang, Sheng Liu, Hong Cao, Yali Xiong, Li Luo, Yahong Pan, Tie Ma, Xiangjun Wang, Jie Song, Xiuling Leng, Ling Zhang, Yeping Sun, Jie Wang, Jialin Ma, Hengmin Kong, Lingzhi Lei, Zhenglong Wang, Yaogang Peishan, Wang Han, Jiali Hao, Xishan Chen, Kexin Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China Department of Radiology National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China 3rd Department of Breast Cancer National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China 2nd Department of Breast Cancer National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China Prevention and Cure Center of Breast Disease Third Hospital of Nanchang Nanchang China Department of Medical Image Liaoning Cancer Institute and Hospital Shenyang China Department of Cancer Prevention and Control Liaoning Cancer Institute and Hospital Shenyang China Center for Breast Disease Haidian Maternal and Child Health Hospital Beijing China People's Hospital of Feicheng City Taian China Shandong Tumor Hospital and Institute Jinan China Chinese Ministry of Health Beijing China Department of Health Service Management School of Public Health Tianjin Medical University Tianjin China Department of Epidemiology Fairbanks School of Public Health Indiana University Indianapolis IN United States Chinese Anti-Cancer Association Tianjin China

To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35-69 years first received clinical breast examinations. Urban women with suspected cancer received mammography followed by breast ultrasound (BUS), while rural suspected women underwent BUS followed by mammography. After one-year follow-up, 223 and 431 breast cancers were detected among urban and rural women (respectively), with overall detection rates of 0.56/1000 and 0.52/1000. Higher detection rates were significantly associated with older age at screening for both urban and rural women;additionally, urban women were at significantly higher risk if they had no job, no insurance, or were obese;additional risk factors specific to rural women included Han nationality, higher income, being unmarried, and having a family history of cancer (all P values < 0.05). Among screening-detected breast cancers in urban vs. rural women, 46.2% and 38.8% (respectively) were early stage, 62.5% and 66.3% were ≤2 centimeters, 38.0% and 47.3% included lymph-node involvement, and 14.0% and 6.0% were identified as carcinoma in situ. All abovementioned cancer characteristics were significantly better than clinic-detected cancers (all P values < 0.001). In conclusion, several important differences were found between urban and rural women in screening effectiveness and patterns of cancer distribution. © The Author(s) 2016.

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Designing emails aimed at increasing family physicians’ use of a web-based audit and feedback tool to improve cancer screening rates: Cocreation process

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JMIR Human Factors 2018年第3期5卷 e25页

作者： Bravo, Caroline A. Llovet, Diego Witteman, Holly O. Desveaux, Laura Presseau, Justin Saragosa, Marianne Vaisson, Gratianne Umar, Shama Tinmouth, Jill Ivers, Noah M. Prevention and Cancer Control Cancer Care Ontario Toronto ON Canada Institute of Health Policy Management and Evaluation University of Toronto Toronto ON Canada Department of Family and Emergency Medicine Faculty of Medicine Laval University Quebec City QC Canada Office of Education and Professional Development Faculty of Medicine Laval University Quebec City QC Canada Research Centre of the CHU de Québec Quebec City QC Canada Women’s College Research Institute Women’s College Hospital Toronto ON Canada Institute for Health System Solutions and Virtual Care Women's College Hospital 76 Grenville Street Toronto M5S 1B2 ON Canada Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa ON Canada School of Epidemiology and Public Health Faculty of Medicine University of Ottawa Ottawa ON Canada School of Psychology Faculty of Social Sciences University of Ottawa Ottawa ON Canada Family Practice Health Centre Women's College Hospital Toronto ON Canada Institute for Clinical Evaluative Sciences Toronto ON Canada Department of Medicine Faculty of Medicine University of Toronto Toronto ON Canada Sunnybrook Research Institute Toronto ON Canada Department of Family and Community Medicine Faculty of Medicine University of Toronto Toronto ON Canada

Background: Providing clinical performance data to health professionals, a process known as audit and feedback, can play an important role in health system improvement. However, audit and feedback tools can only be effective if the targeted health professionals access and actively review their data. Email is used by cancer Care Ontario, a provincial cancer agency, to promote access to a Web-based audit and feedback tool called the Screening Activity Report (SAR);however, current emails that lack behavior change content have been ineffective at encouraging log-in to the SAR. Objective: The objective of our study was to describe the process and experience of developing email content that incorporates user input and behavior change techniques (BCTs) to promote the use of the SAR among Ontario primary care providers. Methods: Our interdisciplinary research team first identified BCTs shown to be effective in other settings that could be adapted to promote use of the SAR. We then developed draft BCT-informed email content. Next, we conducted cocreation workshops with physicians who had logged in to the SAR more than once over the past year. Participants provided reactions to researcher-developed BCT-informed content and helped to develop an email that they believed would prompt their colleagues to use the SAR. Content from cocreation workshops was brought to focus groups with physicians who had not used the SAR in the past year. We analyzed notes from the cocreation workshops and focus groups to inform decisions about content. Finally, 8 emails were created to test BCT-informed content in a 2×2×2 factorial randomized experiment. Results: We identified 3 key tensions during the development of the email that required us to balance user input with scientific evidence, organizational policies, and our scientific objectives, which are as follows: conflict between user preference and scientific evidence, privacy constraints around personalizing unencrypted emails with performan

关键词： Audit and feedback Behavior change Clinical audit Co-creation Email Physician engagement User design

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Publisher Correction: Shared heritability and functional enrichment across six solid cancers

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Nature communications 2019年第1期10卷 4386页

作者： Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Ch Program in Genetic Epidemiology and Statistical Genetics Harvard T.H. Chan School of Public Health 677 Huntington Ave Boston MA 02115 USA. xiajiang@hsph.harvard.edu. Unit of Cardiovascular Epidemiology Institute of Environmental Medicine Karolinska Institutet Nobels vagen 13 17177 Stockholm Sweden. xiajiang@hsph.harvard.edu. Department of Epidemiology Harvard T.H. Chan School of Public Health 677 Huntington Ave Boston MA 02115 USA. Program in Medical and Population Genetics Broad Institute of MIT and Harvard 75 Ames St Cambridge MA 02142 USA. Department of Population and Quantitative Health Sciences Case Western Reserve University 10900 Eucid Avenue Cleveland OH 44106 USA. Seidman Cancer Center University Hospitals Cleveland OH 44106 USA. Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Dr. MRC-CANCONT Tampa FL 33612 USA. Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Dr. MRC-CANCONT Tampa FL 33612 USA. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge 2 Worts' Causeway Cambridge CB1 8RN UK. Department of Biomedical Data Science The Geisel School of Medicine at Dartmouth 1 Medical Center Drive Lebanon NH 03756 USA. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge 2 Worts' Causeway Cambridge CB1 8RN UK. Department of Electron Microscopy/Molecular Pathology The Cyprus Institute of Neurology and Genetics 1683 Nicosia Cyprus. Genetic Epidemiology Group International Agency for Research on Cancer 150 Cours Albert Thomas 69008 Lyon France. Section of Genetics International Agency for Research on Cancer 150 cours Albert Thomas 69008 Lyon France. Division of Psychiatry University College London Maple House 149 Tottenham Court Road London W1T 7NF UK. UCL Genetics Institute University College London Gower Street London WC1E 6BT UK.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

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Nature communications 2021年第1期12卷 3001页

作者： Cathrine Axfors Andreas M Schmitt Perrine Janiaud Janneke Van't Hooft Sherief Abd-Elsalam Ehab F Abdo Benjamin S Abella Javed Akram Ravi K Amaravadi Derek C Angus Yaseen M Arabi Shehnoor Azhar Lindsey R Baden Arthur W Baker Leila Belkhir Thomas Benfield Marvin A H Berrevoets Cheng-Pin Chen Tsung-Chia Chen Shu-Hsing Cheng Chien-Yu Cheng Wei-Sheng Chung Yehuda Z Cohen Lisa N Cowan Olav Dalgard Fernando F de Almeida E Val Marcus V G de Lacerda Gisely C de Melo Lennie Derde Vincent Dubee Anissa Elfakir Anthony C Gordon Carmen M Hernandez-Cardenas Thomas Hills Andy I M Hoepelman Yi-Wen Huang Bruno Igau Ronghua Jin Felipe Jurado-Camacho Khalid S Khan Peter G Kremsner Benno Kreuels Cheng-Yu Kuo Thuy Le Yi-Chun Lin Wu-Pu Lin Tse-Hung Lin Magnus Nakrem Lyngbakken Colin McArthur Bryan J McVerry Patricia Meza-Meneses Wuelton M Monteiro Susan C Morpeth Ahmad Mourad Mark J Mulligan Srinivas Murthy Susanna Naggie Shanti Narayanasamy Alistair Nichol Lewis A Novack Sean M O'Brien Nwora Lance Okeke Léna Perez Rogelio Perez-Padilla Laurent Perrin Arantxa Remigio-Luna Norma E Rivera-Martinez Frank W Rockhold Sebastian Rodriguez-Llamazares Robert Rolfe Rossana Rosa Helge Røsjø Vanderson S Sampaio Todd B Seto Muhammad Shahzad Shaimaa Soliman Jason E Stout Ireri Thirion-Romero Andrea B Troxel Ting-Yu Tseng Nicholas A Turner Robert J Ulrich Stephen R Walsh Steve A Webb Jesper M Weehuizen Maria Velinova Hon-Lai Wong Rebekah Wrenn Fernando G Zampieri Wu Zhong David Moher Steven N Goodman John P A Ioannidis Lars G Hemkens Meta-Research Innovation Center at Stanford (METRICS) Stanford University Stanford CA USA. Department for Women's and Children's Health Uppsala University Uppsala Sweden. Department of Clinical Research University Hospital Basel University of Basel Basel Switzerland. Department of Medical Oncology University of Basel Basel Switzerland. Amsterdam University Medical Center Amsterdam University Amsterdam the Netherlands. Tropical Medicine and Infectious Diseases Department Faculty of Medicine Tanta University Tanta Egypt. Tropical Medicine and Gastroenterology Department Faculty of Medicine Assiut University Assiut Egypt. Department of Emergency Medicine University of Pennsylvania Philadelphia PA USA. Department of Internal Medicine Vice Chancellor University of Health Sciences Lahore Punjab Pakistan. Abramson Cancer Center and Department of Medicine University of Pennsylvania Philadelphia PA USA. Department of Critical Care Medicine The Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center University of Pittsburgh Pittsburgh PA USA. the UPMC Health System Office of Healthcare Innovation University of Pittsburgh Medical Centre Pittsburgh PA USA. Intensive Care Department King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center Riyadh Saudi Arabia. Department of Public Health University of Health Sciences Lahore Punjab Pakistan. Division of Infectious Diseases Brigham and Women's Hospital Boston MA USA. Department of Medicine Division of Infectious Diseases and International Health Duke University Medical Center Durham NC USA. Infectious Diseases Department Cliniques universitaires Saint-Luc Université Catholique de Louvain Brussels Belgium. Center of Research & Disruption of Infectious Diseases Department of Infectious Diseases Copenhagen University Hospital Amager and Hvidovre Hvidovre Denmark. Department of Internal Medicine Elisabeth-Tweesteden hospital Ti

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Association entre un score mesurant le potentiel pro/anti-inflammatoire de l’alimentation (le DII) et la mortalité : modulation par une supplémentation en antioxydants dans l’essai randomisé ***

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Nutrition Clinique et Métabolisme 2017年第1期31卷 63-64页

作者： L. Graffouillère M. Deschasaux F. Mariotti L. Neufcourt N. Shivappa J. Hébert M. Wirth P. Latino-Martel S. Hercberg P. Galan C. Julia E. Kesse-Guyot M. Touvier Équipe de recherche en épidémiologie nutritionnelle (Éren) centre de recherche en épidémiologie et statistique Sorbonne Paris Cité U1153 Inserm U1125 Inra Cnam université Paris 13 Bobigny France UMR 914 physiologie de la nutrition et du comportement alimentaire AgroParisTech CRNH-IdF UMR 914 physiologie de la nutrition et du comportement alimentaire Inra CRNH-IdF Paris France Department of Epidemiology and Biostatistics Arnold School of Public Health Cancer Prevention and Control Program University of South Carolina Columbia États-Unis Département de santé publique hôpital Avicenne Bobigny France

Introduction et but de l’étude L’inflammation chronique est un mécanisme central impliqué dans quatre causes majeures de décès : les maladies cardiovasculaires, les cancers, le diab...

Introduction et but de l’étude L’inflammation chronique est un mécanisme central impliqué dans quatre causes majeures de décès : les maladies cardiovasculaires, les cancers, le diabète et les maladies respiratoires chroniques. L’alimentation est une source majeure de composés bioactifs pro- et anti-inflammatoires. Le Dietary Inflammatory Index (DII) a été conçu pour estimer le potentiel inflammatoire de l’alimentation. Notre objectif était, pour la première fois, d’étudier les associations entre le DII et la mortalité et d’investiguer si une supplémentation en antioxydants était susceptible de moduler cette relation. Matériel et méthodes L’étude *** est un essai randomisé en double-aveugle durant lequel les participants ont reçu des antioxydants à dose nutritionnelle ou un placebo entre 1994 et 2002. Cette étude prospective observationnelle incluait 7 997 participants suivis entre 1994 et 2007 (suivi médian de 12,4 ans). Le DII a été calculé à partir d’enregistrements alimentaires de 24 h répétés ; un score plus élevé correspondant à un régime alimentaire plus pro-inflammatoire. Au cours du suivi, 184 décès ont été enregistrés dont 102 dus à un cancer et 41 à une maladie cardiovasculaire. Les associations ont été caractérisées par des modèles multivariés de Cox à risques proportionnels. Résultats et analyse statistique Les tertiles de DII sexe-spécifiques étaient positivement associés à la mortalité par cancers et maladies cardiovasculaires (RR T3 vs T1 = 1,53 [1,01–2,33], p = 0,04) et par cancer uniquement (RR T3 vs T1 = 1,84 [1,12–3,00], p = 0,01). La p -value correspondante pour toutes causes de mortalité était de 0,07. Le DII était significativement associé à une augmentation de la mortalité dans le groupe placebo de l’essai *** (RR T3 vs T1 = 2,11 [1,15–3,85], p = 0,02), mais pas dans le groupe supplémenté en antioxydants ( p = 0,8 ; P-interaction = 0,1). Conclusion Ces résultats suggèrent qu’une alimentation pro-in

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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