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11th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2021

作者： Basher, Abdur Rahman M. A. Hallam, Steven J. Graduate Program in Bioinformatics University of British Columbia VancouverBCV5Z 4S6 Canada Department of Microbiology & Immunology University of British Columbia VancouverBCV6T 1Z3 Canada

ISBN: (纸本)9783031175305

Metabolic pathway inference from genomic sequence information is an integral scientific problem with wide ranging applications in the life sciences. As sequencing throughput increases, scalable and performative methods for pathway prediction at different levels of genome complexity and completion become compulsory. In this paper, we present reMap (relabeling metabolic pathway data with groups) a simple, and yet, generic framework, that performs relabeling examples to a different set of labels, characterized as groups. A pathway group is comprised of a subset of statistically correlated pathways that can be further distributed between multiple pathway groups. This has important implications for pathway prediction, where a learning algorithm can revisit a pathway multiple times across groups to improve sensitivity. The relabeling process in reMap is achieved through an alternating feedback process. In the first feed-forward phase, a minimal subset of pathway groups is picked to label each example. In the second feed-backward phase, reMap’s internal parameters are updated to increase the accuracy of mapping examples to pathway groups. The resulting pathway group dataset is then be used to train a multi-label learning algorithm. reMap’s effectiveness was evaluated on metabolic pathway prediction where resulting performance metrics equaled or exceeded other prediction methods on organismal genomes. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Forecasting

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ConvNeXt Model for Breast Cancer Image Classification

ConvNeXt Model for Breast Cancer Image Classification

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International Conference on Cybernetics and Intelligent System (ICORIS)

作者： Devin Setiawan Andrea Stevens Karnyoto Indo Intan Bens Pardamean Department of Electrical Engineering and Computer Science University of Kansas Lawrence United States Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia Department of Informatics Engineering Universitas Dipa Makassar Makassar Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Program Bina Nusantara University Jakarta Indonesia

ISBN: (数字)9798331539603

ISBN: (纸本)9798331539610

Breast cancer is an occurrence of cancer that attacks breast tissue and is the most common cancer among women worldwide, affecting one in eight women. In this modern world, breast cancer image classification simplifies the process of analyzing, providing objective and accurate results. By leveraging machine learning algorithms and computer vision techniques, we developed breast cancer detection. The dataset is histopathology dataset from BreakHis and UNHAS Hospital. We chose the ConvNeXt-Tiny model then modified the classifier head as the proposed method. Before the dataset is processed by the model, we augment the images by applying random horizontal and vertical flips, adjustments to brightness, contrast, saturation, and hue using color jitter. The augmentation process simulates real-world variance and enhances the model's ability to generalize to unseen data. Our proposed model gained better performance (accuracy, F1-Score) results compared two other techniques to VGG16 and SVM. According to our experiments, the F1-Score for the ConvNeXt-Tiny model with classifier head modification is higher at 0.9516, than the gain for VGG16 at 0.9292, and the gain for the SVM at 0.83.

关键词： Support vector machines Accuracy Head Computational modeling Transfer learning Breast cancer Magnetic heads Data models Reliability Image classification

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Repurposing transfer learning strategy of computer vision for owl sound classification 7

Repurposing transfer learning strategy of computer vision fo...

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7th International Conference on Computer Science and Computational Intelligence, CSCI 2022

作者： Gunawan, Kevin William Hidayat, Alam Ahmad Cenggoro, Tjeng Wawan Pardamean, Bens Computer Science Department BINUS Graduate Program-Master of Computer Science Bina Nusantara University Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia

Accurately predicting an owl species based on its sound can be helpful for owl conservation. To build an accurate model for owl sound classification, deep learning is currently the most preferred algorithm, due to its excellent performance for modeling audio data. However, deep learning is generally underperformed for a small dataset, which is the case for recognizing scops owl sound. To overcome the issue, we proposed a transfer learning strategy, which is common for computer vision tasks, that can alleviate overfitting in a deep learning model for the owl sound classification. In our approach, we propose a neural network architecture consisting of the backbone of a EfficientNet model pre-Trained on the massive ImageNet database. The model takes the sound input that has been converted as two image representations: Spectrogram and Mel Frequency Cepstral Coefficients. Our strategy enables the use of a relatively small size of pre-Trained image classification model, which is widely available, for transfer learning in owl sound classification. Deploying the lightweight model in an automatic sound classifier provides a fast and accurate tool for various owl conservation purposes. © 2022 Elsevier B.V.. All rights reserved.

关键词： Deep learning

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BERT-based Topic Modeling Approach for Malaria Research Publication 4

BERT-based Topic Modeling Approach for Malaria Research Publ...

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4th International Conference on Informatics, Multimedia, Cyber and Information System, ICIMCIS 2022

作者： Hidayat, Alam Ahmad Nirwantono, Rudi Budiarto, Arif Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia School of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia Bina Nusantara University Binus Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665473279

Malaria is a communicable disease with half of the global population at risk due to its high morbidity and mortality rates. A massive number of studies are dedicated to malaria research, so it plays a key role in formulating the proper prevention strategy and effective malaria treatment. With the overwhelming number of updated publications in the field, an unsupervised text mining approach such as topic modeling may provide an alternative method for the malaria researcher to keep pace with new insights. In this work, we collect metadata of malaria publications from the PubMed database to perform BERT-based topic modeling to find well-defined topics regarding malaria research. The method is largely based on the popular BERTopic pipeline. We compare the performance of three different language models to generate document embeddings from the data. The dimension reduction and the density-based clustering algorithm are used to cluster the embeddings. The topic representation is computed based on the semantic similarity of the class TF-IDF representation. The substance of the resulting topics is then manually annotated based on the top words of each topic. We demonstrate that by merging initial topics into larger topics using hierarchical clustering and manual content-based examination, the evaluated coherence measure can be further improved, thus enhancing the topic's interpretability. Our modeling result is able to extract ten major topics recurring in the malaria research publication published from 2017-2022. The result provides preliminary insight to understand the dynamics and patterns of malaria research over the years © 2022 IEEE.

关键词： Diseases

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Machine Learning Approach for Single Nucleotide Polymorphism Selection in Genetic Testing Results

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Procedia Computer Science 2023年 227卷 46-54页

作者： Joko Pebrianto Trinugroho Alam Ahmad Hidayat Mahmud Isnan Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta 11480 Indonesia Department of Mathematics School of Computer Science Bina Nusantara University Jakarta 11480 Indonesia Computer Science Department BINUS Graduate Program Bina Nusantara University Jakarta 11480 Indonesia

Lactose intolerance is a type of digestive problem that may threaten the population because milk and dairy products compose of nutrients that are essential for human body. Genetic tests possess a great potential to detect lactose intolerance as it can be used in children and even infants. However, a new approach to analyze the genetic test results is needed to elucidate the Single Nucleotide Polymorphisms (SNPs) that are related to lactose intolerance. In this work, we utilized the machine learning based feature selection to select the SNPs associated with lactose tolerance trait from genotyping samples of direct-to-customer (DTCG genetic tests, obtained from the public database. Recursive Feature Elimination (RFE) with XGBoost model was used to perform feature selection. We also compared three different models, such as XGBoost, support vector machine (SVM), and random forest (RF) for training the selected features. Our findings revealed that 20 SNPs (out of 3501) were chosen, with rs4394668 as the most important variables (F-score 0.009). Furthermore, when compared to the RF and SVM models, the XGBoost model had the highest accuracy (0.87). Further studies should be undertaken to elucidate how the selected SNPs may lead to the lactose intolerance trait.

关键词： lactose intolerance SNP genetic test feature selection

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The Technology behind Genomic Database 4

The Technology behind Genomic Database

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4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Trinugroho, Joko Pebrianto Perbangsa, Anzaludin Samsinga Pardamean, Bens Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia School of Information Systems Bina Nusantara University Information Systems Department Jakarta11480 Indonesia Bina Nusantara University BINUS Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

In this digital era, we are exposed to a large amount of data. This includes biological data, which stores information about living organisms, including Deoxyribonucleic acid (DNA), genes, and proteins. With the development of information technology and information system, most of available biological data are stored in an online public database. Many of the databases are free-access and easily used, which helps the users, especially researchers, to make use of the data. Among the known public biological databases are the University of California Santa Cruz (UCSC) Genome Browser Database and the Rat Genome Database (RGD). These two databases provide access to the biological data from different organisms. This paper aims to describe the technology of public biological databases. Also elucidated in this paper are the differences features between UCSC Genome Browser Database and the RGD. Our results showed that the UCSC contains much more biological data and features than the RGD. However, the genome browser of UCSC has a complex display, while the RGD has a simple display. Overall, both databases give the users the option to choose the most suitable database for them. © 2022 IEEE.

关键词： Rats

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Database Management System Design Improvement for Child Stunting Data Collection in Multiple Observation Areas 7

Database Management System Design Improvement for Child Stun...

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7th International Conference on Information Management and Technology, ICIMTech 2022

作者： Rahutomo, Reza Elwirehardja, Gregorius Natanael Dominic, Nicholas Caesario, Benedict Pardamean, Bens School of Information Systems Bina Nusantara University Information Systems Department Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia BINUS Graduate Program - Master of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia

ISBN: (数字)9781665450904

ISBN: (纸本)9781665450904

The launch of StuntingDB is believed to enliven the role of database management systems (DBMS) in Indonesia's stunting research. However, a novelty in stunting data management that enables parallel project activation in multiple observation areas is necessary. Several improved functionalities in StuntingDB must be designed to prevent the high demand for accessibility in the middle of stunting research. Connolly and Begg's principle of database design is adopted along with Software Development Life Cycle's Waterfall model for creating a continuous development of the system. This research produces a new database design in the form of Entity Relationship Diagram (ERD) and Use Case Diagram to help system developers realizing a new version of StuntingDB for stunting research in several observation areas. © 2022 IEEE.

关键词： Database systems

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Systematic Literature Review of Transformer Model Implementations in Detecting Depression

Systematic Literature Review of Transformer Model Implementa...

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International Conference of Computer and Informatics Engineering (IC2IE)

作者： Kenjovan Nanggala Gregorius Natanael Elwirehardja Bens Pardamean Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia

This systematic literature review explores the application of transformer models in early detection of human depression, encompassing text, audio, and video data modalities. Transformer architectures, notably BERT for text, have proven adept at capturing crucial contextual and linguistic patterns associated with depression. For audio and video data, hybrid approaches that combine transformer models with other architectures are prevalent. Key features considered include eye gaze, head pose, facial muscle movements, and audio characteristics such as MFCC and Log-mel Spectrogram, along with text embeddings. Performance comparisons underscore the superiority of text-based data in consistently delivering the most promising results, followed by audio and video modalities when utilizing transformer models. The fusion of multiple modalities emerges as an effective strategy for enhancing predictive accuracy, with the amalgamation of audio, video, and text data yielding the most precise outcomes. However, it is noteworthy that unimodal approaches also exhibit potential, with text data exhibiting superior performance over audio and video data. Nevertheless, several challenges persist in this research domain, including imbalanced datasets, the limited availability of comprehensive and diverse samples, and the inherent complexities in interpreting visual cues. Addressing these challenges remains imperative for the continued advancement of depression detection using transformer-based models across various modalities.

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Pap Smear Medical Image Classification Using Deep Learning: A Systematic Review

Pap Smear Medical Image Classification Using Deep Learning: ...

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International Conference of Computer and Informatics Engineering (IC2IE)

作者： Elvan Selvano Gregorius Natanael Elwirehardja Bens Pardamean Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia

Cervical cancer has been known as one of the most prevalent medical disorders globally and a leading cause of death. Early detection, particularly through Pap tests, plays a vital role in its prevention. Previous studies have leveraged machine learning and deep learning techniques to classify the medical images obtained from Pap tests. In this study, a Systematic Literature Review methodology was used to examine 15 relevant papers that have been filtered from queries to Google Scholar which have gone through 4 stages of filtering that include: identification, screening, eligibility, and inclusion. This study addresses two research questions regarding the datasets and deep learning techniques for classifying pap smear images in recent years. The performance of the models was analyzed and potential areas for improvements are suggested. The findings of this study reveal that the Herlev University Hospital and SIPaKMed datasets are the most used. The methodologies used by researchers range from machine learning techniques, transfer learning using Convolutional Neural Networks, and utilize state-of-the-art models with novel optimizing methodology. While there are exciting opportunities in the field, challenges include model generalization and interpretability.

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A Systematic Literature Review of Deep Learning Application in Multiclass Anomaly Detection for Chest Medical Imaging

A Systematic Literature Review of Deep Learning Application ...

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International Conference of Computer and Informatics Engineering (IC2IE)

作者： Philips Bens Pardamean Gregorius Natanael Elwirehardja Mahmud Isnan Computer Science Department BINUS Graduate Program - Master of Compuer Science Bina Nusantara University Jakarta Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia

Medical imaging abnormality detection is challenging, but deep learning approaches have shown promise. This paper reviews the current state of the art in deep learning approaches for detecting abnormalities in chest medical imaging. To discover the trends, opportunities, and challenges associated with this field, 18 studies were selected from Google Scholar based on their titles, abstracts, and contents for extensive review to answer two research questions. The study found that the National Institutes of Health (NIH) Chest X-ray 14 dataset is the most used dataset for this task. Most research uses a single-modal approach, considering only image data as input, with X-ray being the more popular instrument. There are 8 out of 18 studies leverage the transfer learning approach, with ResN et50 being the most popular network. MobileNetV2 has demonstrated competitive results compared to more robust networks. Preprocessing techniques such as image enhancement and data augmentation are leveraged by 61.1 % of the reviewed studies and are shown to improve model performance.

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