检索结果-内蒙古大学图书馆

Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis (vol 14, 3750, 2023)

引用

NATURE COMMUNICATIONS 2023年第1期14卷 1-16页

作者： Takada, Hitomi Sasagawa, Yohei Yoshimura, Mika Tanaka, Kaori Iwayama, Yoshimi Hayashi, Tetsutaro Isomura-Matoba, Ayako Nikaido, Itoshi Kurisaki, Akira Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan Master’s/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan

Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the mechanisms underlying the multilineage differentiation of gastric progenitor cells during healthy homeostasis remain poorly understood. Here, using a single-cell RNA sequencing method, Quartz-Seq2, we analyzed the gene expression dynamics of progenitor cell differentiation toward pit cell, neck cell, and parietal cell lineages in healthy adult mouse corpus tissues. Enrichment analysis of pseudotime-dependent genes and a gastric organoid assay revealed that EGFR-ERK signaling promotes pit cell differentiation, whereas NF-κB signaling maintains gastric progenitor cells in an undifferentiated state. In addition, pharmacological inhibition of EGFR in vivo resulted in a decreased number of pit cells. Although activation of EGFR signaling in gastric progenitor cells has been suggested as one of the major inducers of gastric cancers, our findings unexpectedly identified that EGFR signaling exerts a differentiation-promoting function, not a mitogenic function, in normal gastric homeostasis.

关键词： Adult stem cells Stem-cell differentiation Stem-cell niche

来源：评论

学校读者我要写书评

暂无评论

Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer

引用

Signal Transduction and Targeted Therapy 2023年第9期8卷 4365-4379页

作者： Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong Department of Urology Guangzhou First People’s HospitalSouth China University of Technology510180 GuangzhouGuangdongChina Urology Key Laboratory of Guangdong Province The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical University510230 GuangzhouGuangdongChina Guangzhou National Laboratory No.9 XingDaoHuanBei RoadGuangzhou International Bio Island510005 GuangzhouGuangdongChina Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92507USA Graduate Program in Genetics Genomics&BioinformaticsUniversity of CaliforniaRiversideCA 92507USA State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyTaipa999078 MacaoChina

The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical *** treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to drug ***,the underlying mechanism is still *** this study,we found evidences that metformin resistance in PCa cells may be linked to cell cycle ***-enhancers(SEs),crucial regulatory elements,have been shown to be associated with drug resistance in various *** analysis of SEs in metformin-resistant(MetR)PCa cells revealed a correlation with Prostaglandin Reductase 1(PTGR1)expression,which was identified as significantly increased in a cluster of cells with metformin resistance through single-cell transcriptome *** functional experiments showed that PTGR1 overexpression accelerated cell cycle progression by promoting progression from the G0/G1 to the S and G2/M phases,resulting in reduced sensitivity to ***,we identified key transcription factors that significantly increase PTGR1 expression,such as SRF and RUNX3,providing potential new targets to address metformin resistance in *** conclusion,our study sheds new light on the cellular mechanism underlying metformin resistance and the regulation of the SE-TFs-PTGR1 axis,offering potential avenues to enhance metformin’s therapeutic efficacy in PCa.

关键词： RUNX3 cancer offering

来源：评论

学校读者我要写书评

暂无评论

A Diversity Inventory Monitoring System of Riparian Vegetation 4

A Diversity Inventory Monitoring System of Riparian Vegetati...

引用

4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Putra, Dian Pratama Nugraha, Nanda Satya Suparyanto, Teddy Hidayat, Alam Ahmad Sudigyo, Digdo Pardamean, Bens STIPER Agricultural Institute Faculty of Agricultural Technology Yogyakarta55282 Indonesia STIPER Agricultural Institute Yogyakarta Faculty of Agricultural Technology Faculty of Forestry Yogyakarta55282 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia Bina Nusantara University BINUS Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

To strengthen conservation efforts for preserving biodiversity in a conservation area, forest inventory is important to understand the natural succession process in the area and to establish a monitoring strategy. Further, tree inventory aims to monitor the output yielded in the area. More specifically, the tree inventory in the watershed area plays a key role to achieve Sustainable Development Goals (SDG), especially in riparian zones which are also vital parts of green zones in forests. However, the traditional inventory approach is time-consuming and laborious therefore the development of an expert system to assist in inventory monitoring is required. In this study, we develop a monitoring system via a mobile application to collect, analyze and visualize tree inventory data. The application includes algorithms required to compute tree biodiversity, distribution, and richness for the given input of the data of all tree species in a conservation area. For the model validation stage, we compare the traditional inventory approach with our proposed application-based approach to compute diversity inventory in two riparian locations: Klaten Conservation Park and Wonosobo Conservation Park. After the three-day data collection in the areas, we obtain that the accuracy of reading data of our proposed system can achieve more than 90% in comparison with the manual approach. This demonstrates that the system can assist forestry workers to perform more efficient tree inventories in different locations. © 2022 IEEE.

关键词： Biodiversity

来源：评论

学校读者我要写书评

暂无评论

Determining Variables Associated with Annual Oil Palm Yield: An Explainable Gradient Boosting Approach

引用

Procedia Computer Science 2023年 227卷 262-271页

作者： Gregorius Natanael Elwirehardja Teddy Suparyanto Miftakhurrokhmat Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480 Computer Science Department School of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Faculty of Agricultural Technology Institute of Agriculture STIPER Yogyakarta Indonesia 55282 Faculty of Industrial Technology Universitas Islam Indonesia Yogyakarta Indonesia 55584 Computer Science Department BINUS Graduate Program – Master of Computer Science Program Bina Nusantara University Jakarta Indonesia 11480

With the growing demands for Precision Agriculture (PA) in Indonesia, researchers have evaluated the utilization of Machine Learning for predicting oil palm yields and determining variables affecting them. Previous studies showed that meteorological variables, including rainfalls and wind speed, are associated with oil palm yields. In this research, the Extreme Gradient Boosting (XGBoost) model and the Shapley Additive exPlanations (SHAP) were deployed for analyzing the importance of 15 agrometeorological variables in predicting oil palm yield. The best model attained 1.911 RMSE and 0.855 R2. By analyzing the weights and gains of the XGBoost model along with the SHAP values, it was found that the yield in the previous year, the age and number of plants, the area of peat lands, and meteorological parameters such as rainfall rates and the number of rainy days in the previous three years were considered important. The previous year's yield in particular possesses the greatest weight and gain values according to the model, and the highest SHAP value among all input variables. However, the meteorological data used in this research are only limited to rainfall rates and the number of rainy days. In the future, more diverse variables can be analyzed.

关键词： Oil Palm Yield Machine Learning XGBoost XAI SHAP

来源：评论

学校读者我要写书评

暂无评论

Characterizing the mechanical response of metallic glasses to uniaxial tension using a spring network model

引用

Physical Review Materials 2023年第7期7卷 073605-073605页

作者： Aya Nawano Weiwei Jin Jan Schroers Mark D. Shattuck Corey S. O'Hern Department of Mechanical Engineering and Materials Science Yale University New Haven Connecticut 06520 USA Benjamin Levich Institute and Physics Department The City College of New York New York New York 10031 USA Department of Physics Yale University New Haven Connecticut 06520 USA Department of Applied Physics Yale University New Haven Connecticut 06520 USA Graduate Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA

A coarse-grained spring network model is proposed for the prediction of the mechanical response of metallic glasses as a function of the microstructure prior to loading. This model describes the mechanical response of metallic glasses using a network of parallel springs that can break and reform, mimicking atomic rearrangements during deformation. We compare predictions of the spring network model for stress versus strain to results from numerical simulations of athermal quasistatic, uniaxial tensile deformation of Cu50Zr50 metallic glasses using Lennard-Jones (LJ) and embedded atom method (EAM) atomic interactions. We show that both the LJ and EAM models possess qualitatively similar stress σ versus strain γ curves. By specifying five parameters [ultimate strength, strain at ultimate strength, slopes of σ(γ) at γ=0 and at large strain, and strain at fracture where σ=0], we demonstrate that the spring network model can accurately describe the form of the stress-strain curves during uniaxial tension for the computational studies of Cu50Zr50, as well as recent experimental studies of several Zr-based metallic glasses.

关键词： Alloys Amorphous materials Glasses Packing & jamming problems Molecular dynamics

来源：评论

学校读者我要写书评

暂无评论

Pyramid Scene Parsing Net Model for Automated Paddy Field Map using SPOT 6 Satellite Images 5

Pyramid Scene Parsing Net Model for Automated Paddy Field Ma...

引用

5th IEEE Asia-Pacific Conference on Geoscience, Electronics and Remote Sensing Technology, AGERS 2022

作者： Heryadi, Yaya Irwansyah, Edy Miranda, Eka Soeparno, Haryono Herlawati Hashimoto, Kiyota Bina Nusantara University Binus Graduate Program-Doctor of Computer Science Computer Science Department Jakarta11480 Indonesia School of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia School of Information Systems Bina Nusantara University Information Systems Department Jakarta11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Prince of Songkla University Faculty of Technology and Environment Phuket83120 Thailand

ISBN: (纸本)9798350398212

Food sustainability is still one of the main priorities for many countries as it contributes to the economy and stability of the nation. For government in many countries whose peoples consumes rice as its staple food, food self-sufficiency initiatives highly depend on accurate prediction of paddy field map. Mapping paddy field task is a challenging problem which cannot be handled manually especially when the paddy fields are spread out in very wide geographical areas such as those in Indonesia. Fortunately, wide availability of satellite imagery and the advent of deep learning technology in the past ten years have made it possible to improve efficiency of most parts of those manual works involving image semantic segmentation tasks. However, satellite image-based semantic segmentation is a challenging task. High object complexity, cloud partial occlusion, larger image size than a computer memory can stored can hinder accuracy of the image segmentation results. This paper presents a method for paddy field map generating using semantic image segmentation approach in which Pyramid Scene Parsing Net model is used for segmenting satellite imagery. The generated paddy map can be used as a basis for decision-making, especially in the agricultural sector. Analysis of local land use/land cover dynamics. The results of his experiments using SPOT 6 satellite imagery from the Pahung region of Central Kalimantan achieved average training accuracy, best training accuracy and test accuracy of 0.85, 0.86 and 0.89 respectively. These results indicated that the semantic segmentation model is suitable for addressing the same task in different crops. © 2022 IEEE.

关键词： Image enhancement

来源：评论

学校读者我要写书评

暂无评论

The gene dose makes the disease

引用

四川生理科学杂志 2022年第8期44卷 1430-1430页

作者： Corrine Smolen Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Bioinformatics and Genomics Graduate Program The Huck Institutes of the Life Sciences University Park PA 16802 USA

A long-standing challenge in genomics has been to identify causal genes within rare copy-number variant regions that are intolerant to altered *** this issue,Collins et *** a meta-analysis of almost a million individu... 详细信息

关键词： dosage al. rare

来源：评论

学校读者我要写书评

暂无评论

Enhancing Label Consistency on Document-level Named Entity Recognition

arXiv

引用

arXiv 2022年

作者： Jeong, Minbyul Kang, Jaewoo Department of Computer Science and Engineering Korea University Seoul02841 Korea Republic of Interdisciplinary Graduate Program in Bioinformatics Korea University Seoul Korea Republic of AIGEN Sciences Seoul04778 Korea Republic of

Summary: Named entity recognition (NER) is a fundamental part of extracting information from documents in biomedical applications. A notable advantage of NER is its consistency in extracting biomedical entities in a document context. Although existing document NER models show consistent predictions, they still do not meet our expectations. We investigated whether the adjectives and prepositions within an entity cause a low label consistency, which results in inconsistent predictions. In this paper, we present our method, ConNER, which enhances the label dependency of modifiers (e.g., adjectives and prepositions) to achieve higher label agreement. ConNER refines the draft labels of the modifiers to improve the output representations of biomedical entities. The effectiveness of our method is demonstrated on four popular biomedical NER datasets;in particular, its efficacy is proved on two datasets with 7.5–8.6% absolute improvements in the F1 score. We interpret that our ConNER method is effective on datasets that have intrinsically low label consistency. In the qualitative analysis, we demonstrate how our approach makes the NER model generate consistent predictions. © 2022, CC BY-SA.

关键词： Forecasting

来源：评论

学校读者我要写书评

暂无评论

Automatic Smart Crawling on Twitter for Weather Information in Indonesia

引用

Procedia Computer Science 2023年 227卷 795-804页

作者： Kartika Purwandari Reza Bayu Perdana Join W.C. Sigalingging Reza Rahutomo Bens Pardamean Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta 11480 Indonesia Database Center Division of BMKG Meteorological Climatological and Geophysical Agency Jakarta 10720 Indonesia Information Systems Department School of Information Systems Bina Nusantara University Jakarta 11480 Indonesia Computer Science Department BINUS Graduate Program – Master of Computer Science Bina Nusantara University Jakarta 11480 Indonesia

Although Twitter is a popular platform for social interaction analysis and text data mining, it faces challenges with geolocation automation. To address this problem, the researchers propose the utilization of a Support Vector Machine (SVM) model to develop an automated Twitter crawling system. The system aims to collect data related to weather in Indonesia by employing Twin, a Python-based Twitter scraping software. To overcome null geolocations, the study incorporates aliases created based on the common practice of Indonesian users mentioning the country's location in tweets. The results demonstrate that the SVM model, combined with automated smart crawling, achieves an 85% accuracy rate.

关键词： Social media Twitter SVM smart crawling weather

来源：评论

学校读者我要写书评

暂无评论

Lightweight Pedestrian Detection through Guided Filtering and Deep Learning 10

Lightweight Pedestrian Detection through Guided Filtering an...

引用

10th IEEE Global Conference on Consumer Electronics, GCCE 2021

作者： Muchtar, Kahlil Saddami, Khairun Bintang, Akhyar Cenggoro, Tjeng Wawan Pardamean, Bens Lin, Chih-Yang Ernita, Tia Universitas Syiah Kuala Department of Electrical And Computer Engineering Aceh Indonesia Universitas Syiah Kuala Department of Electrical And Computer Engineering Aceh Indonesia Bina Nusantara University School of Computer Science Bina Nusantara University Bioinformatics And Data Science Research Center Computer Science Department Jakarta Indonesia Bina Nusantara University BINUS Graduate Program-Master of Computer Science Program Bina Nusantara University Bioinformatics And Data Science Research Center Computer Science Department Jakarta Indonesia Yuan-Ze University Department of Electrical And Engineering Taoyuan Taiwan

ISBN: (纸本)9781665436762

In this paper, we propose a novel approach to locate and detect moving pedestrians in a video. Our proposed method first locates the region of interest (ROI) using a background subtraction algorithm based on guided filtering. This novel background subtraction algorithm allows our method to also filter unexpected noises at the same time, which could benefit the performance of our proposed method. Subsequently, the pedestrians are detected using YOLOv3 within the provided ROI. Our experiments showed that the proposed method has a competitive performance in the CDNET2014 dataset with a fast-processing time. © 2021 IEEE.

关键词： Convolutional neural networks

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：