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1st International Workshop on Digital Disease Detection using Social Media, DDDSM 2017, co-located with the 8th International Joint Conference on Natural Language Processing, IJCNLP 2017

作者： Wang, Chen-Kai Singh, Onkar Tang, Zhao-Li Dai, Hong-Jie Graduate Institute of Biomedical Informatics Taipei Medical University Taipei Taiwan Bioinformatics Program Taiwan International Graduate Program Institute of Information Science Academia Sinica Taipei Taiwan Institute of Biomedical Informatics National Yang-Ming University Taipei Taiwan Department of Computer Science and Information Engineering National Taitung University Taitung Taiwan Interdisciplinary Program of Green and Information Technology National Taitung University Taitung Taiwan

ISBN: (纸本)9781948087070

Traditional disease surveillance systems depend on outpatient reporting and virological test results released by hospitals. These data have valid and accurate information about emerging outbreaks but it's often not timely. In recent years the exponential growth of users getting connected to social media provides immense knowledge about epidemics by sharing related information. Social media can now flag more immediate concerns related to outbreaks in real time. In this paper we apply the long short-term memory recurrent neural network (RNN) architecture to classify tweets conveyed influenza-related information and compare its performance with baseline algorithms including support vector machine (SVM), decision tree, naive Bayes, simple logistics, and naive Bayes multinomial. The developed RNN model achieved an F-score of 0.845 on the MedWeb task test set, which outperforms the F-score of SVM without applying the synthetic minority oversampling technique by 0.08. The F-score of the RNN model is within 1% of the highest score achieved by SVM with oversampling technique. © 2017 AFNLP

关键词： Support vector machines

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Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

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Translational psychiatry 2024年第1期14卷 109页

作者： Anna H Ou Sara B Rosenthal Mazda Adli Kazufumi Akiyama Nirmala Akula Martin Alda Azmeraw T Amare Raffaella Ardau Bárbara Arias Jean-Michel Aubry Lena Backlund Michael Bauer Bernhard T Baune Frank Bellivier Antonio Benabarre Susanne Bengesser Abesh Kumar Bhattacharjee Joanna M Biernacka Pablo Cervantes Guo-Bo Chen Hsi-Chung Chen Caterina Chillotti Sven Cichon Scott R Clark Francesc Colom David A Cousins Cristiana Cruceanu Piotr M Czerski Clarissa R Dantas Alexandre Dayer Maria Del Zompo Franziska Degenhardt J Raymond DePaulo Bruno Étain Peter Falkai Frederike Tabea Fellendorf Ewa Ferensztajn-Rochowiak Andreas J Forstner Louise Frisén Mark A Frye Janice M Fullerton Sébastien Gard Julie S Garnham Fernando S Goes Maria Grigoroiu-Serbanescu Paul Grof Oliver Gruber Ryota Hashimoto Joanna Hauser Urs Heilbronner Stefan Herms Per Hoffmann Andrea Hofmann Liping Hou Stephane Jamain Esther Jiménez Jean-Pierre Kahn Layla Kassem Tadafumi Kato Sarah Kittel-Schneider Barbara König Po-Hsiu Kuo Ichiro Kusumi Nina Lackner Gonzalo Laje Mikael Landén Catharina Lavebratt Marion Leboyer Susan G Leckband Carlos A López Jaramillo Glenda MacQueen Mario Maj Mirko Manchia Cynthia Marie-Claire Lina Martinsson Manuel Mattheisen Michael J McCarthy Susan L McElroy Francis J McMahon Philip B Mitchell Marina Mitjans Francis M Mondimore Palmiero Monteleone Caroline M Nievergelt Markus M Nöthen Tomas Novák Urban Ösby Norio Ozaki Sergi Papiol Roy H Perlis Claudia Pisanu James B Potash Andrea Pfennig Daniela Reich-Erkelenz Andreas Reif Eva Z Reininghaus Marcella Rietschel Guy A Rouleau Janusz K Rybakowski Martin Schalling Peter R Schofield K Oliver Schubert Thomas G Schulze Barbara W Schweizer Florian Seemüller Giovanni Severino Tatyana Shekhtman Paul D Shilling Kazutaka Shimoda Christian Simhandl Claire M Slaney Alessio Squassina Thomas Stamm Pavla Stopkova Sarah K Tighe Alfonso Tortorella Gustavo Turecki Eduard Vieta Julia Volkert Stephanie Witt Naomi R Wray Adam Wright L Trevor Young Peter P Zandi John R Kelsoe Department of Psychiatry University of California San Diego La Jolla CA USA. Center for Computational Biology and Bioinformatics Department of Medicine University of California San Diego La Jolla CA USA. Department of Psychiatry and Psychotherapy Charité- Universitätsmedizin Berlin Campus Charité Mitte Berlin Germany. Fliedner Klinik Berlin Center for Psychiatry Psychotherapy and Psychosomatic Medicine Berlin Germany. Department of Biological Psychiatry and Neuroscience Dokkyo Medical University School of Medicine Mibu Japan. Intramural Research Program National Institute of Mental Health National Institutes of Health US Department of Health & Human Services Bethesda MD USA. Department of Psychiatry Dalhousie University Halifax NS Canada. National Institute of Mental Health Klecany Czech Republic. Discipline of Psychiatry University of Adelaide Adelaide SA Australia. Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy. Department of Evolutive Biology Ecology and Environmental Sciences Facultat de Biologia and Institut de Biomedicina (IBUB) Universitat de Barcelona Barcelona Spain. CIBER de Salud Mental ISCIII Madrid Barcelona Catalonia Spain. Department of Mental Health and Psychiatry Mood Disorders Unit-Geneva University Hospitals Geneva Switzerland. Department of Molecular Medicine and Surgery Karolinska Institutet and Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden. Department of Psychiatry and Psychotherapy University Hospital Carl Gustav Carus Medical Faculty Technische Universität Dresden Dresden Germany. Department of Psychiatry University of Münster Münster Germany. INSERM UMR-S 1144-Université Paris Cité Département de Psychiatrie et de Médecine Addictologique AP-HP Groupe Hospitalier Lariboisière-F Widal Paris France. Bipolar and Depressive Disorders Unit Institute of Neuroscience Hospital Clinic University of Barcelona IDIBAPS CIBERSAM ISCIII Barcelona Catalonia Spa

Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

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Evaluating drug targets through human loss-of-function genetic variation (vol 581, pg 459, 2020)

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NATURE 2021年第7846期590卷 E56-E56页

作者： Minikel, Eric Vallabh Karczewski, Konrad J. Martin, Hilary C. Cummings, Beryl B. Whiffin, Nicola Rhodes, Daniel Alfoldi, Jessica Trembath, Richard C. van Heel, David A. Daly, Mark J. Schreiber, Stuart L. MacArthur, Daniel G. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA Chemical Biology and Therapeutics Science Program Broad Institute of MIT and Harvard Cambridge MA USA Analytical and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Program in Biological and Biomedical Sciences Harvard Medical School Boston MA USA Henry and Allison McCance Center for Brain Health Massachusetts General Hospital Boston MA USA Department of Neurology Massachusetts General Hospital Boston MA USA Prion Alliance Cambridge MA USA National Heart and Lung Institute and MRC London Institute of Medical Sciences Imperial College London London UK National Heart & Lung Institute and MRC London Institute of Medical Sciences Imperial College London London UK Cardiovascular Research Centre Royal Brompton & Harefield Hospitals NHS Trust London UK European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge UK Center for Genomic Medicine Massachusetts General Hospital Boston MA USA Program in Bioinformatics and Integrative Genomics Harvard Medical School Boston MA USA Broad Genomics Broad Institute of MIT and Harvard Cambridge MA USA Division of Genetics and Genomics Boston Children’s Hospital Boston MA USA Department of Pediatrics Harvard Medical School Boston MA USA Cardiac Arrhythmia Service and Cardiovascular Research Center Massachusetts General Hospital Boston MA USA Estonian Genome Center Institute of Genomics University of Tartu Tartu Estonia Department of Medicine Harvard Medical School Boston MA USA Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA USA Centre for Population Genomics Garvan Institute of Medical Research and UNSW Sydney Sydney Australia Centre for Population Genomics Murdoch Children’s Research Institute Melbourne Australia Divi

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Gut microbiota composition can reflect immune responses of latent tuberculosis infection in patients with poorly controlled diabetes

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Respiratory research 2023年第1期24卷 11页

作者： Hung-Ling Huang Yong-Chun Luo Po-Liang Lu Cheng-Hsieh Huang Kun-Der Lin Meng-Rui Lee Meng-Hsuan Cheng Yao-Tsung Yeh Cheng-Yuan Kao Jann-Yuan Wang Jinn-Moon Yang Inn-Wen Chong Division of Pulmonary and Critical Care Medicine Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Internal Medicine Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital 68 Jhonghua 3rd Rd Cianjin District Kaohsiung 80145 Taiwan. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University 1001 University Road Hsinchu 30010 Taiwan. Center for Liquid Biopsy and Cohort Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Aging and Disease Prevention Research Center Fooyin University 151 Jinxue Rd. Daliao Dist. Kaohsiung 83102 Taiwan. Ph. D. Program in Environmental and Occupational Medicine Kaohsiung Medical University 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Medical Laboratory Science and Biotechnology Fooyin University 151 Jinxue Rd. Daliao Dist. Kaohsiung 83102 Taiwan. Division of Endocrinology and Metabolism Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Department of Internal Medicine National Taiwan University Hospital 7 Chung-Shan South Rd. Zhongzheng Dist. Taipei 100225 Taiwan. Department of Respiratory Therapy Kaohsiung Medical University Hospital 100 Shih-Chuan 1st Road Kaohsiung 80708 Taiwan. Immunology Research Center National Health Research Institutes 35 Keyan Road Zhunan Town Miaoli 35053 Taiwan. Department of Internal Medicine National Taiwan University Hospital 7 Chung-Shan South Rd. Zhongzheng Dist. Taipei 100225 Taiwan. jywang@ntu.edu.tw. Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University 1001 University Road Hsinchu 30010 Taiwan. moon@faculty.nctu.edu.tw. Department of Biologica

BACKGROUND:Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB). Evidence has linked the DM-related dysbiosis of gut microbiota to modifiable host immunity to Mycobacterium tuberculosis infection. However, the crosslinks between gut microbiota composition and immunological effects on the development of latent TB infection (LTBI) in DM patients remain uncertain. METHODS:We prospectively obtained stool, blood samples, and medical records from 130 patients with poorly-controlled DM (pDM), defined as ever having an HbA1c > 9.0% within previous 1 year. Among them, 43 had LTBI, as determined by QuantiFERON-TB Gold in-Tube assay. The differences in the taxonomic diversity of gut microbiota between LTBI and non-LTBI groups were investigated using 16S ribosomal RNA sequencing, and a predictive algorithm was established using a random forest model. Serum cytokine levels were measured to determine their correlations with gut microbiota. RESULTS:Compared with non-LTBI group, the microbiota in LTBI group displayed a similar alpha-diversity but different beta-diversity, featuring decrease of Prevotella_9, Streptococcus, and Actinomyces and increase of Bacteroides, Alistipes, and Blautia at the genus level. The accuracy was 0.872 for the LTBI prediction model using the aforementioned 6 microbiome-based biomarkers. Compared with the non-LTBI group, the LTBI group had a significantly lower serum levels of IL-17F (p = 0.025) and TNF-α (p = 0.038), which were correlated with the abundance of the aforementioned 6 taxa. CONCLUSIONS:The study results suggest that gut microbiome composition maybe associated with host immunity relevant to TB status, and gut microbial signature might be helpful for the diagnosis of LTBI.

关键词： Diabetic mellitus Gut microbiota Immunity Latent tuberculosis infection

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Transcript expression-aware annotation improves rare variant interpretation (vol 581, pg 452, 2020)

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NATURE 2021年第7846期590卷 E54-E54页

作者： Cummings, Beryl B. Karczewski, Konrad J. Kosmicki, Jack A. Seaby, Eleanor G. Watts, Nicholas A. Singer-Berk, Moriel Mudge, Jonathan M. Karjalainen, Juha Satterstrom, F. Kyle O'Donnell-Luria, Anne H. Poterba, Timothy Seed, Cotton Solomonson, Matthew Alfoldi, Jessica Daly, Mark J. MacArthur, Daniel G. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Analytical and Translational Genetics Unit Massachusetts General Hospital Boston MA USA Program in Biological and Biomedical Sciences Harvard Medical School Boston MA USA Program in Bioinformatics and Integrative Genomics Harvard Medical School Boston MA USA Genomic Informatics Group University Hospital Southampton Southampton UK Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA Division of Genetics and Genomics Boston Children’s Hospital Boston MA USA Department of Pediatrics Harvard Medical School Boston MA USA European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge UK Center for Genomic Medicine Massachusetts General Hospital Boston MA USA Broad Genomics Broad Institute of MIT and Harvard Cambridge MA USA National Heart & Lung Institute and MRC London Institute of Medical Sciences Imperial College London London UK Cardiovascular Research Centre Royal Brompton & Harefield Hospitals NHS Trust London UK Cardiac Arrhythmia Service and Cardiovascular Research Center Massachusetts General Hospital Boston MA USA Estonian Genome Center Institute of Genomics University of Tartu Tartu Estonia Department of Medicine Harvard Medical School Boston MA USA Cardiac Arrhythmia Service Massachusetts General Hospital Boston MA USA Division of General Internal Medicine Massachusetts General Hospital Boston MA USA Institute for Molecular Medicine FIMM University of Helsinki Helsinki Finland Department of Public Health Faculty of Medicine University of Helsinki Helsinki Finland Department of Genetics Harvard Medical School Boston MA USA Data Sciences Platform Broad Institute of MIT and Harvard Cambridge MA USA Genomics Platform Broad Institute of MIT and Harvard Cambridge MA USA Wellcome Sanger Institute Hinxton Cambridgeshire UK Unidad de Investigaci

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Correction to: Genome-wide sequencing as a first-tier screening test for short tandem repeat expansions

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Genome medicine 2021年第1期13卷 151页

作者： Indhu-Shree Rajan-Babu Junran J Peng Readman Chiu Chenkai Li Arezoo Mohajeri Egor Dolzhenko Michael A Eberle Inanc Birol Jan M Friedman Department of Medical Genetics University of British Columbia and Children's & Women's Hospital Vancouver BC V6H3N1 Canada. indhu.babu@bcchr.ca. Department of Medical and Molecular Genetics King's College London Strand London WC2R 2LS UK. indhu.babu@bcchr.ca. Department of Medical Genetics University of British Columbia and Children's & Women's Hospital Vancouver BC V6H3N1 Canada. Canada's Michael Smith Genome Sciences Centre BC Cancer Agency Vancouver BC V5Z4S6 Canada. Bioinformatics Graduate Program University of British Columbia Vancouver BC V6T1Z4 Canada. Illumina Inc. San Diego CA 92121 USA.

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Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan

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European journal of medical research 2024年第1期29卷 286页

作者： Wen-Chien Cheng Chia-Ling Chang Chau-Chyun Sheu Ping-Huai Wang Meng-Heng Hsieh Ming-Tsung Chen Wei-Fan Ou Yu-Feng Wei Tsung-Ming Yang Chou-Chin Lan Cheng-Yi Wang Chih-Bin Lin Ming-Shian Lin Yao-Tung Wang Ching-Hsiung Lin Shih-Feng Liu Meng-Hsuan Cheng Yen-Fu Chen Chung-Kan Peng Ming-Cheng Chan Ching-Yi Chen Lun-Yu Jao Ya-Hui Wang Chi-Jui Chen Shih-Pin Chen Yi-Hsuan Tsai Shih-Lung Cheng Horng-Chyuan Lin Jung-Yien Chien Hao-Chien Wang Wu-Huei Hsu Division of Pulmonary and Critical Care Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan. wcchengdr@***. Critical Medical Center China Medical University Hospital Taichung Taiwan. wcchengdr@***. School of Medicine College of Medicine China Medical University Taichung Taiwan. wcchengdr@***. Department of Internal Medicine National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Taiwan. Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan. Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Division of Thoracic Medicine Far Eastern Memorial Hospital Taipei Taiwan. Department of Thoracic Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. College of Medicine Chang Gung University Taoyuan Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan. Division of Chest Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Internal Medicine E-Da Cancer Hospital I-Shou University Kaohsiung Taiwan. School of Medicine for International Students College of Medicine I-Shou University Kaohsiung Taiwan. Division of Pulmonary and Critical Care Medicine Chiayi Chang Gung Memorial Hospital Chiayi Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan Republic of China. Department of Internal Medicine Cardinal Tien Hospital and School of Medicine College of Medicine Fu Jen Catholic University New Taipei City Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Hualien Tzu Chi Hospital Buddhi

BACKGROUND:Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB). METHODS:This extensive multicenter retrospective study, performed in Taiwan, concentrated on patients diagnosed with NCFB verified through high-resolution computed tomography (HRCT) scans. We not only compared the clinical features of various types of bronchiectasis (cylindrical, varicose, and cystic). Furthermore, we established relationships between the severity of clinical factors, including symptom scores, pulmonary function, pseudomonas aeruginosa colonization, exacerbation and admission rates, and HRCT parameters using modified Reiff scores. RESULTS:Data from 2,753 patients were classified based on HRCT patterns (cylindrical, varicose, and cystic) and severity, assessed by modified Reiff scores (mild, moderate, and severe). With increasing HRCT severity, a significant correlation was found with decreased forced expiratory volume in the first second (FEV1) (p < 0.001), heightened clinical symptoms (p < 0.001), elevated pathogen colonization (pseudomonas aeruginosa) (p < 0.001), and an increased annual hospitalization rate (p < 0.001). In the following multivariate analysis, elderly age, pseudomonas aeruginosa pneumonia, and hospitalizations per year emerged as the only independent predictors of mortality. CONCLUSION:Based on our large cohort study, the simplified CT scoring system (Reiff score) can serve as a useful adjunct to clinical factors in predicting disease severity and prognosis among Taiwanese patients with NCFB.

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Publisher Correction: A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

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Nature genetics 2022年第8期54卷 1259页

作者： Danny Antaki James Guevara Adam X Maihofer Marieke Klein Madhusudan Gujral Jakob Grove Caitlin E Carey Oanh Hong Maria J Arranz Amaia Hervas Christina Corsello Keith K Vaux Alysson R Muotri Lilia M Iakoucheva Eric Courchesne Karen Pierce Joseph G Gleeson Elise B Robinson Caroline M Nievergelt Jonathan Sebat Biomedical Sciences Graduate Program University of California San Diego La Jolla CA USA. Beyster Center for Psychiatric Genomics University of California San Diego La Jolla CA USA. Department of Psychiatry University of California San Diego La Jolla CA USA. Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA. Institute for Genomic Medicine University of California San Diego La Jolla CA USA. Department of Neurosciences University of California San Diego La Jolla CA USA. Department of Biomedicine Aarhus University Aarhus Denmark. The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Aarhus Denmark. Center for Genomics and Personalized Medicine and Center for Integrative Sequencing iSEQ Aarhus Denmark. Bioinformatics Research Centre Aarhus University Aarhus Denmark. Harvard T.H. Chan School of Public Health Broad Institute of the Massachusetts Institute of Technology and Harvard Cambridge MA USA. Research Laboratory Unit Fundacio Docencia i Recerca Mutua Terrassa Spain. Child and Adolescent Mental Health Unit Hospital Universitari Mútua de Terrassa Barcelona Spain. TEACCH Autism Program University of North Carolina Chapel Hill NC USA. Human Longevity Inc. San Diego CA USA. Department of Pediatrics and Department of Cellular & Molecular Medicine University of California San Diego School of Medicine Center for Academic Research and Training in Anthropogeny Archealization Center Kavli Institute for Brain and Mind La Jolla CA USA. Autism Center of Excellence University of California San Diego La Jolla CA USA. Beyster Center for Psychiatric Genomics University of California San Diego La Jolla CA USA. jsebat@ucsd.edu. Department of Psychiatry University of California San Diego La Jolla CA USA. jsebat@ucsd.edu. Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA. jsebat@ucsd.edu. Institute for Genomic Medicine University of Californi

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Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

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Nature genetics 2023年第6期55卷 1080页

作者： Bernardo Rodriguez-Martin Eva G Alvarez Adrian Baez-Ortega Jorge Zamora Fran Supek Jonas Demeulemeester Martin Santamarina Young Seok Ju Javier Temes Daniel Garcia-Souto Harald Detering Yilong Li Jorge Rodriguez-Castro Ana Dueso-Barroso Alicia L Bruzos Stefan C Dentro Miguel G Blanco Gianmarco Contino Daniel Ardeljan Marta Tojo Nicola D Roberts Sonia Zumalave Paul A Edwards Joachim Weischenfeldt Montserrat Puiggròs Zechen Chong Ken Chen Eunjung Alice Lee Jeremiah A Wala Keiran M Raine Adam Butler Sebastian M Waszak Fabio C P Navarro Steven E Schumacher Jean Monlong Francesco Maura Niccolo Bolli Guillaume Bourque Mark Gerstein Peter J Park David C Wedge Rameen Beroukhim David Torrents Jan O Korbel Iñigo Martincorena Rebecca C Fitzgerald Peter Van Loo Haig H Kazazian Kathleen H Burns Peter J Campbell Jose M C Tubio Department of Zoology Genetics and Physical Anthropology Universidade de Santiago de Compostela Santiago de Compostela Spain. Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain. Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Transmissible Cancer Group Department of Veterinary Medicine University of Cambridge Cambridge UK. The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain. Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK. Genome Data Science Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology (BIST) Barcelona Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA) Barcelona Spain. The Francis Crick Institute London UK. Department of Human Genetics University of Leuven Leuven Belgium. Genomes and Disease Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon South Korea. Cancer Ageing and Somatic Mutation Programme Wellcome Sanger Institute Cambridge UK. Department of Biochemistry Genetics and Immunology University of Vigo Vigo Spain. Galicia Sur Health Research Institute Vigo Spain. Faculty of Science and Technology University of Vic-Central University of Catalonia (UVic-UCC) Vic Spain. Barcelona Supercomputing Center (BSC) Barcelona Spain. Experimental Cancer Genetics Wellcome Sanger Institute Cambridge UK. Oxford Big Data Institute University of Oxford Oxford UK. DNA Repair and Genome Integrity Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain. Department of Biochemistry and Molecular Biology Universidade de Santiago de Compostela Santiago de Compostela Spain. Medical R

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The Effects of Trajectory and Endpoint Errors in a Reaching Movement on the Sense of Agency

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Psychology 2017年 8卷 2321-2332页

作者： Takuro Zama Yoshiyuki Takahashi Sotaro Shimada Electrical Engineering Program Graduate School of Science and Technology Meiji University Kawasaki-shi Japan Department of Electronics and Bioinformatics School of Science and Technology Meiji University Kawasaki-shi Japan

The sense of agency (SoA) refers to the subjective feeling that an individual can control their own action with their own will. However, it is still unclear which aspects of the motor control process precisely affect the sense of agency. In this study, we investigated how the SoA is modulated by the online motor performance (trajectory error) and the outcome of the reaching movement (endpoint error). The results showed that the invalid priming and the visual feedback delay significantly increased both the trajectory and endpoint errors and that these errors significantly attenuated the SoA. The further correlation analyses showed that the decrease in SoA was significantly correlated with the trajectory error, but not with the endpoint error, when the error was explicitly noticed. We suggest that the deterioration in online motor performance, at least in a reaching movement, is the main cause of the attenuation in the SoA.

关键词： Sense of Agency Online Motor Control Error Detection

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