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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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Group Method of Data Handling for Modeling Magnetorheological Dampers

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Intelligent Control and Automation 2013年第1期4卷 70-79页

作者： Khaled Assaleh Tamer Shanableh Yasmin Abu Kheil Department of Computer Science and Engineering American University of Sharjah Sharjah United Arab Emirates Department of Electrical Engineering American University of Sharjah Sharjah United Arab Emirates Mechatronics Graduate Program American University of Sharjah Sharjah United Arab Emirates

This paper proposes the use of Group Method of Data Handling (GMDH) technique for modeling Magneto-Rheological (MR) dampers in the context of system identification. GMDH is a multilayer network of quadratic neurons that offers an effective solution to modeling non-linear systems. As such, we propose the use of GMDH to approximate the forward and inverse dynamic behaviors of MR dampers. We also introduce two enhanced GMDH-based solutions. Firstly, a two-tier architecture is proposed whereby an enhanced GMD model is generated by the aid of a feedback scheme. Secondly, stepwise regression is used as a feature selection method prior to GMDH modeling. The proposed enhancements to GMDH are found to offer improved prediction results in terms of reducing the root-mean-squared error by around 40%.

关键词： System Identification Magneto-Rheological Dampers Group Method of Data Handling Polynomial Classifier

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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A Data Management in a Private Cloud Storage Environment Utilizing High Performance Distributed File Systems

A Data Management in a Private Cloud Storage Environment Uti...

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IEEE International Workshops on Enabling Technologies: Infrastructure for Collaborative Enterprises

作者： Tiago S. Soares M. A. R. Dantas Douglas D. J. de Macedo Michael A. Bauer Informatics and Statistic Department (INE) Federal University of Santa Catarina (UFSC) Post-Graduate Program of Knowledge Engineering and Management Federal University of Santa Catarina (UFSC) Computer Science Department (CSD) University of Western Ontario (UWO)

ISBN: (纸本)9781479904051

The new trend in the process of data-intensive management indicates the importance of a distributed file system for both Internet large scale services and cloud computing environments. I/O latency and application buffering sizes are two of a number of issues that are essential to be analysed on different class of distributed file systems. In this paper, it is presented a research work comparing four different high performance distributed file systems. Those systems were employed to support a medical image server application in a private storage environment. Experimental results highlight the importance of an appropriate distributed file system to provide a differential level of performance considering application specific characteristics.

关键词： Distributed File System DICOM HDF5 Telemedicine

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Hardware-based parallel firefly algorithm for embedded applications

Hardware-based parallel firefly algorithm for embedded appli...

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NASA/ESA Conference on Adaptive Hardware and Systems (AHS)

作者： Daniel M. Muñoz Carlos H. Llanos Leandro dos Santos Coelho Mauricio Ayala-Rincón Electronics Engineering Graduate Program Faculty of Gama University of Brasilia Brasilia DF Brazil Department of Mechanical Engineering University of Brasilia Brasilia DF Brazil Industrial and Systems Engineering Graduate Program LAS/PPGEPS Pontifical Catholic University of Parana Curitiba Parana Brazil Departments of Computer Science and Mathematics University of Brasilia Brasilia DF Brazil

ISBN: (纸本)9781467363822

The firefly algorithm (FA) is a new population-based metaheuristic bioinspired on the behavior of the flashing characteristics of fireflies. As a population-based algorithm, the FA suffers from large execution times specifically for embedded optimization problems with computational limitations. For reducing execution times we propose a hardware parallel architecture of the FA algorithm that facilitates the implementation in Field programmable Gate Arrays (FPGAs). In addition, this work proposes the application of the opposition-based learning (OBL) approach to the FA algorithm. The respective hardware implementation (HPOFA) was mapped into a Virtex5 FPGA device and numerical experiments using four well-known benchmark problems demonstrate that the opposition-based approach allows the FA algorithm to improve its functionality, preserving the swarm diversity and avoiding the premature convergence problem. Synthesis results point out that the HPOFA architecture is effectively mapped in hardware and is suitable for embedded applications.

关键词： Hardware computer architecture Optimization Equations Random access memory Field programmable gate arrays Search problems

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Photonic crystal biosensor with in-situ synthesized DNA probes for enhanced sensitivity

Photonic crystal biosensor with in-situ synthesized DNA prob...

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IEEE Photonics Conference (IPC)

作者： S. Hu Y. Zhao S. T. Retterer I. I. Kravchenko S. M. Weiss Department of Physics and Astronomy Vanderbilt University Nashville TN USA Interdisciplinary Graduate Program in Materials Science Vanderbilt University Nashville TN USA Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge TN USA Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN USA

We report on a nearly 8-fold increase in multi-hole defect photonic crystal biosensor response by incorporating insitu synthesis of DNA probes, as compared to the conventional functionalization method employing pre-sy... 详细信息

关键词： Probes Biosensors Photonic crystals DNA Optical surface waves Magnetohydrodynamics Silicon

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Impact response measurement of contact lenses 5

Impact response measurement of contact lenses

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5th International Conference on Advanced Micro-Device Engineering, AMDE 2013

作者： Watanabe, Kazuhide Miyashita, Naoki Bin, Du Hong Irisa, Kyohei Takita, Akihiro Yamaguchi, Takao Carcasona, Edwin Mitatha, Somsak Fujii, Yusaku Education Program of Electronics and Infomatics Mathematics and Physics Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Department of Electronics Faculty of Engineering Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Education Program of Mechanical Science and Technology School of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Department of Electronics Graduate School of Engineering Gunma University 1-5-1 Tenjin-cho Kiryu376-8515 Japan Division of Mechanical Science and Technology Faculty of Science and Technology Gunma University 1-5-1 Tenjin-cho Kiryu Gunma376-8515 Japan Department of Mechanical Engineering University of San Carlos Cebu City230-0100 Philippines Hybrid Computing Research Laboratory School of Computer Engineering Faculty of Engineering King Mongkut's Institute of Technology Ladkrabang Chalongkrung Road Bangkok Thailand

ISBN: (纸本)9783038354659

Impact response of contact lenses is measured using the Levitation Mass Method (LMM). In the LMM, a small mass collides with contact lenses and the impact force is measured with high accuracy as the inertial force of the moving part. A pneumatic linear bearing is used to achieve linear motion with sufficiently small friction acting on the moving part. Hysteresis loop and consumed energy as mechanical characteristics of contact lenses are also calculated.. © (2015) Trans Tech Publications, Switzerland.

关键词： Contact lenses

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Proactive repair redundancy algorithms for distributed storage in P2P networks

Proactive repair redundancy algorithms for distributed stora...

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2012 26th Queen's Biennial Symposium on Communications, QBSC 2012

作者： Herrera, Octavio Znati, Taieb Graduate Telecommunications Program School of Information Science United States Computer Science Department School of Arts and Sciences University of Pittsburgh United States

ISBN: (纸本)9781467311137

Distributed storage systems frequently use erasure coding based redundancy or replication to improve availability. Traditional erasure coding based approaches to redundancy are optimal in terms of their storage overhead-reliability tradeoff, but are expensive to repair. In this paper, we propose Proactive Repair (PR), a novel hybrid redundancy scheme. We discuss the implementation of the proposed scheme and discuss an emulated-based experimental study to evaluate PR's performance. The results show that PR outperforms exact-repair Minimum Bandwidth Regenerating (exact-MBR) network coding in terms of complexity and repair traffic overhead. Content availability when the system uses PR exhibits higher ability to dynamically adapt to changing failures rates, caused by nodes leaving the network. © 2012 IEEE.

关键词： Redundancy

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Performance of redundancy methods in P2P networks under churn

Performance of redundancy methods in P2P networks under chur...

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2012 International Conference on Computing, Networking and Communications, ICNC'12

作者： Herrera-Ruiz, Octavio Znati, Taieb Graduate Telecommunications Program School of Information Science United States Computer Science Department School of Arts and Sciences University of Pittsburgh United States

ISBN: (纸本)9781467300094

Peer-to-Peer (P2P) networks organize large amounts of resources distributed across the Internet for user access. However, the availability of these resources is hindered by the participants' transient connectivity. Redundancy can be used to deal with this problem, but the redundancy repair traffic must be controlled to prevent performance degradation. In this paper, we present a comprehensive analytical formulation for erasure code redundancy methods in P2P networks, focused on fragments availability and redundancy repair cost. We use this model to evaluate the effectiveness of a proposed new redundancy scheme (PR) that outperforms other methods. Our results provide important insights for the design and construction of automated content availability mechanisms for P2P overlays under churn. Our evaluation framework allows us to determine at which point substituting a traditional erasure coding method (MDS) with other schemes is viable. For instance, e-MBR network coding performs worst than MDS for average fragment availabilities below 0.52. In addition, our experimental results indicate that adaptive repair strategies with elastic maintenance intervals can produce significant bandwidth savings compared with reactive and periodic redundancy repair strategies. In our experimental evaluation, an adaptive repair strategy consumes up to 49% less bandwidth than its periodic counterpart. © 2012 IEEE.

关键词： Redundancy

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Smart environmental architecture for node localization in a wireless sensor network

Smart environmental architecture for node localization in a ...

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8th International Conference on Intelligent Environments, IE 2012

作者： Jauregui-Ortiz, Salvador Siller, Mario Ramos, Felix Scalabrin, Edson Electrical Engineering and Computer Science Department Center of Research and Advanced Studies Guadalajara Jalisco Mexico Graduate Program in Computer Science Pontifical Catholic University Parana Brazil Curitiba Parana Brazil

ISBN: (纸本)9780769547411

As far as we know, there is not a Node Localization Algorithm (NLA) that presents the same accuracy for all possible scenarios. We believe that a NLA should be able to interpret the dynamic information of the environment. In this sense, simple NLAs are rather focused and might perform well for specific scenarios and applications. Therefore, information fusion and context awareness seems to be an appropriate approach to address this issue. We propose the Smart Environmental Architecture for Node Localization (SEA-NL), which is composed by two main elements: (i) the Smart Beacon Nodes (SBNs) and (ii) the Logical Position of Nodes (LPN). In (i) the obstruction level indicator is estimated and can improve the estimation of distances among nodes. In (ii) environment information and a one to one relation between a node and an object are used and can also improve location estimation. Via simulation, our architecture was tested indoors and outdoors considering three localization algorithms: the Weighed Centroid Localization (WCL), the Centroid Localization, and the Triangular Centroid Localization. Finally, we present an accuracy comparison among NLAs used in isolated way, and by using the SBNs, the LPN, and the SEA-NL, where our architecture improves WCL up to ~30.88%. © 2012 IEEE.

关键词： Information fusion

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