Meta-heuristics are efficient techniques for solving large scale optimization problems in which traditional mathematical techniques are impractical or provide sub-optimal solutions. The Shuffled Frog Leaping algorithm...
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The recent advance in SNP genotyping has made a significant contribution to reduction of the costs for large-scale genotyping. The development also has dramatically increased the size of the SNP genotype data. The inc...
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The recent advance in SNP genotyping has made a significant contribution to reduction of the costs for large-scale genotyping. The development also has dramatically increased the size of the SNP genotype data. The increase of the volume of the data, however, has posed a huge obstacle to the conventional analysis techniques that are typically vulnerable to the high-dimensionality problem. To address the issue, we propose a method that exploits two well-tested models: the document-term model and the transaction analysis model. The proposed method consists of two phases. In the first phase, we reduce the dimensions of the SNP genotype data by extracting significant SNPs through transformation of the data in lieu of the document-term model. In the second phase, we discover the association rules that signify the relations between the SNPs and the traits, through the application of the transactional analysis in the reduced-dimension genotype data. We validated the discovered rules through the literature survey. Experiments were also carried out using the HGDP panel data provided by the Foundation Jean Dausset-CEPH, which prove the validity of our new method for identifying appropriate dimensional reduction and associations of multiple SNPs and traits.
Glutamine synthetase (GS) is a key enzyme in nitrogen metabolism in plants. One of the GS isoforms in plants, GS1, is transcriptionally regulated. Our recent studies show that a soybean GS1, Gmglnβ 1, gene is posttra...
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ISBN:
(纸本)9781617381119
Glutamine synthetase (GS) is a key enzyme in nitrogen metabolism in plants. One of the GS isoforms in plants, GS1, is transcriptionally regulated. Our recent studies show that a soybean GS1, Gmglnβ 1, gene is posttranscriptionally regulated by its 3′UTR. It is of interest to know if the 3′UTR-mediated posttranscriptional regulation of GS1 genes is a universal phenomenon or is it limited to Gmglnβ 1 gene only. The 3′UTR-mediated posttranscriptional regulation of alfalfa GS1 genes (MsGS100 and MsGS13) was investigated using both computational and biological approaches. For our first set of study, we used CisFind, a software tool that identifies unextendable common patterns among sequences, to analyze the 3′UTRs of GS1 genes. CisFind analysis of the 3′UTRs showed that the 3′UTR of MsGS100 shared common putative cis-element motifs with the Gmglnβ 1 3′UTR whereas these elements were absent in the 3′UTR of MsGS13 gene. The computational results were verified using transgenic approach, and the results confirmed the computational analysis. The 3′UTR of MsGS 100 plays a similar role as the 3′UTR of Gmglnβ 1 gene in posttranscriptional regulation of a reporter gene while the 3′UTR of the MsGS13 does not. CisFind, was also used in analyzing the region in the 3′UTR of MsGS13 that could be responsible for its nodule enhanced expression (by detecting putative cis-elements that are overrepresented in the 3′UTR of nodule-enhanced GS1 genes).
An important problem in Wireless Sensor Networks (WSN) is the occurrence of failures that lead to the disconnection of parts of the network, compromising the final results achieved by the WSN operation. A way to overc...
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Errors in diagnosing the disease is a critical risk that must be faced by any person giving treatment to the hospital. Medical treatment can not always be done with perfect accuracy. Lung cancer is one of the most dea...
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Errors in diagnosing the disease is a critical risk that must be faced by any person giving treatment to the hospital. Medical treatment can not always be done with perfect accuracy. Lung cancer is one of the most deadly disease that prone to misdiagnose. In general, some practitioners tend to “read” cancer in x-ray rontgen image as tumor this could be fatal. To generate a diagnose, a general practitioner use three kind of examination i.e : patient History, Radio logic examination, phisical examination. In this paper, Gray color for image indexing and retrieval are investigated. The features are derived based on the statistical distribution of Harralick feature from image sample. By utilizing the proposed invariant features, the similarity measure between query and database images provides reliable retrieval results.
A well know problem in the Wireless Sensor Network (WSN) research area is the usage of appropriate strategies to setup the sensor nodes such that they may accomplish sensing missions. This problem refers to the select...
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Particle Swarm Optimization (PSO) algorithms have been proposed to solve engineering problems that require to find an optimal point of operation. There are several embedded applications which requires to solve online ...
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Photonic crystal cavities with tunable surface area via multiple-hole defects were investigated for increased resonance wavelength shifts upon exposure to variable-index analytes. Sensitivity was improved by 10% compa...
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Photonic crystal cavities with tunable surface area via multiple-hole defects were investigated for increased resonance wavelength shins upon exposure to variable-index analytes. Sensitivity was improved by 10% compar...
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Pure ZnO, pure MgO and 5 wt%MgO/ZnO nanocomposites were produced by flame spray pyrolysis (FSP) in a single step using zinc naphthenate and magnesium acetate tetrahydrate as Zn and Mg precursors. The particle properti...
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