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Z16b,a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia

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中国药理学报（英文版） 2022年第9期43卷 2340-2350页

作者： Jiang-fan Wan Gang Wang Fu-ying Qin Dan-ling Huang Yan Wang Ai-ling Su Hai-ping Zhang Yang Liu Shao-yin Zeng Chao-liang Wei Yong-xian Cheng Jie Liu Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhen 518000China Center for Translation Medicine Research and Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Guangdong Provincial key laboratory of South China Structure Heart Disease Department of Pediatric CardiologyGuangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China

Catecholaminergic polymorphic ventricular tachycardia(CPVT)is an inherited,lethal ventricular arrhythmia triggered by *** in genes that encode cardiac ryanodine receptor(RyR2)and proteins that regulate RyR2 activity cause enhanced diastolic Ca2+release(leak)through the RyR2 channels,resulting in *** therapies for CPVT are *** found that Z16b,a meroterpenoid isolated from Ganoderma cochlear,inhibited Ca2+spark frequency(CaSF)in R2474S/+cardiomyocytes in a dose-dependent manner,with an IC50 of 3.2 μM.Z16b also dose-dependently suppressed abnormal post-pacing Ca2+release *** injection(i.p.)of epinephrine and caffeine stimulated sustained ventricular tachycardia in all R2474S/+mice,while pretreatment with Z16b(0.5 mg/kg,i.p.)prevented ventricular arrhythmia in 9 of 10 mice,and Z16b administration immediately after the onset of VT abolished sVT in 9 of 12 *** translational significance,Z16b significantly inhibited CaSF and abnormal Ca2+release events in human CPVT ***,Z16b interacts with RyR2,enhancing the"zipping"state of the N-terminal and central domains of RyR2.A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626,His1670,and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight"zipping"*** findings support that Z16b is a novel RyR2 stabilizer that can prevent *** may also serve as a lead compound with a new scaffold for the design of safer and more efficient drugs for treating CPVT.

关键词： arrhythmia catecholaminergic polymorphic ventricular tachycardia natural product ryanodine receptor induced pluripotent stem cell-derived cardiomyocytes

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Runge-Kutta symmetric interior penalty discontinuous Galerkin methods for modified Buckley-Leverett equations

arXiv

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arXiv 2018年

作者： Zhang, Hong Guo, Yunrui Li, Weibin Zegeling, Paul Andries Department of Mathematics Faculty of Science Utrecht University Budapestlaan 6 Utrecht3584CD Netherlands State Key Laboratory of High Performance Computing National University of Defense Technology Changsha Hunan410073 China Computational Aerodynamics Institute China Aerodynamics Research and Development Center Mianyang621000 China

We present a robust and accurate numerical method to solve the modified Buckley-Leverett equation in two-phase porous media flow with dynamic capillary pressure effect. A symmetric interior penalty discontinuous Galerkin method is used to discretize the equation in the space direction. For accuracy and stability issues, the third-order strong stability preserving implicit-explicit Runge-Kutta method is adopted to solve the nonlinear semi-discrete system: the linear diffusion term is discretized implicitly while the nonlinear flux term is discretized explicitly. The spatial accuracy of the discontinuous Galerkin method depends on the limiters applied to the solution: we test a minmod-TVB limiter, a simple WENO limiter and a high-order shock-capturing moment limiter to demonstrate that a suitable shock capturing moment limiter leads to more accurate approximation of solution. A set of representative numerical experiments are presented to show the accuracy and efficiency of the proposed approach. The results indicate that the moment limiter proposed by Moe et al. [Arxiv:1507.03024, 2015] is the most suitable one to be used in solving the modified Buckley-Leverett equation, and high order schemes perform much better than lower order schemes. Our simulation results are consistent with the previous results in Kao et al.[J. Sci. Comput., 64(3) (2015), 837-857], Zhang and Zegeling [J. Comput. Phys., 345 (2017), 510-527 and Commun. Comput. Phys., 22(4) (2017), 935-964]. Copyright © 2018, The Authors. All rights reserved.

关键词： Galerkin methods

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Electronic voting scheme

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Ruan Jian Xue Bao/Journal of Software 2005年第10期16卷 1805-1810页

作者： Li, Yan-Jiang Ma, Chuan-Gui Huang, Liu-Sheng Department of Computer Science and Technology University of Science and Technology of China Hefei 230027 China Department of Applied Mathematics PLA Information Engineering University Zhengzhou 450002 China Anhui Province-MOST Co-Key Laboratory of High Performance Computing and Application Hefei 230027 China

A dynamic multi-secrets sharing threshold scheme is presented to apply to a large scale electronic voting system with many talliers (tallying authorities). Even if there exists adaptive adversaries, this scheme can guard the ballot's producing, encrypting, transmitting, decrypting and final tallying in spite of the adversaries's attack, so the scheme guarantees robustness. In this paper, the verifiability of the voters' qualification and talliers' identification will be solved by a dynamic multi-secret sharing scheme without invoking more zero knowledge proof to maintain privacy, universal verifiability, and anonymity of ballots. It holds more communication efficiency and more security than the proposed schemes in early time.

关键词： Electronic communities

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Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types

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细胞研究（英文版） 2018年第5期28卷 601-604页

作者： Yanan Cao Weiwei Zhou Lin Li Jiaqian Wang Zhibo Gao Yiran Jiang Xiuli Jiang Aijing Shan Matthew H. Bailey Kuan-lin Huang Sam Q. Sun Michael D. McLellan Beifang Niu Weiqing Wang Li Ding Guang Ning Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Key Laboratory for Endocrine Tumors Rui-Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Laboratory of Endocrinology and Metabolism Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Key Laboratory for Endocrine Tumors Rui-Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China YuceBio Shenzhen China McDonnell Genome Institute Washington University St Louis MO USA Department of Medicine Division of Oncology Washington University St Louis MO USA McDonnell Genome Institute Washington University St Louis MO USA McDonnell Genome Institute Washington University St Louis MO USA Department of High-Performance Computing Technology and Application Development Computer Network Information Center Chinese Academy of Sciences Beijing China McDonnell Genome Institute Washington University St Louis MO USA Department of Medicine Division of Oncology Washington University St Louis MO USA Siteman Cancer Center Washington University St. Louis MO USA

Dear Editor,Neuroendocrine tumors (NETs) comprise a heterogeneous spectrum of neoplasms originating from neuroendocrine cells in various organs — most commonly in the endocrine glands and the gastrointestinal tract.1 The molecular and etiological features of NETs arising from different organs are still far from clarified. Therefore, systematic analysis of genomic alternations and their contribution to core pathways in NETs is urgently needed for the development of novel diagnostic, therapeutic strategies and personalized management of patients. Here, we investigated somatic mutations across 21 NET types through pan-cancer analysis and identified 86 candidate driver genes. Further analysis of druggability and panel sequencing of these genes provide potential diagnostic and therapeutic targets for NETs.

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Stress Detection Using Multimodal Physiological Signals With Machine Learning From Wearable Devices

Stress Detection Using Multimodal Physiological Signals With...

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IEEE Symposium on Computers and Communications (ISCC)

作者： Pranita Subhash Shedage Seyedamin Pouriyeh Reza M. Parizi Meng Han Giovanna Sannino Nasrin Dehbozorgi Department of Information and Technology Kennesaw State University Marietta GA USA Decentralized Science Lab Kennesaw State University Marietta GA USA College of Computer Science and Technology Zhejiang University Hangzhou China Binjiang Institute of Zhejiang University Hangzhou China Institute for High-Performance Computing and Networking (ICAR) National Research Council (CNR) Naples Italy Department of Software and Game Development Kennesaw State University Marietta GA USA

ISBN: (数字)9798350354232

ISBN: (纸本)9798350354249

Stress is considered one of the most prevalent concerns among individuals. Studies have shown that experiencing long-term stress can cause severe health issues such as cardiovascular diseases, hypertension, depression, etc. Preventative measures, such as early stress detection, can help individuals mitigate these health issues. When a person gets stressed, physiological values like blood volume pulse, temperature, and electrodermal activity signals get affected. Machine Learning techniques can be utilized to identify stress by analyzing these physiological signals. This paper presents a machine learning method for detecting stress levels of an individual using the publicly available dataset called "Wearable Stress and Affect Detection"(WESAD), which has physiological data collected from the wrist-worn and chest-worn sensors attached to 15 different subjects. We used physiological signals, including Blood Volume Pulse(BVP), Body Temperature(TEMP), and Electrodermal Activity(EDA) signals, collected from wrist-worn sensors to detect the state of the mind. For the implementation, we used different Machine Learning models, like Logistic Regression, Decision Tree, Random Forest, and Stacking Ensemble Learning technique. During the investigation, personalized models, utilizing individual subject data, and generalized models, amalgamating all subject data, were developed. Evaluation reveals accuracy values reaching up to 99% and 91% for individual subject data and combined data, respectively.

关键词： Temperature measurement Radio frequency Accuracy Machine learning Physiology Data models Wearable devices Stress Wearable sensors Blood

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A finite-volume upstream-flux-splitting scheme for flow simulations in the pool-type fishways

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Journal of the Chinese Institute of Civil and Hydraulic Engineering 2010年第2期22卷 167-178页

作者： Guo, Wen-Dar Lai, Jihn-Sung Kuo, Yao-Chi Lin, Gwo-Fong Chang, Wen-Yi Hu, Tung-Jer Hydrotech Research Institute National Taiwan University Taipei 10617 Taiwan Department of Civil Engineering National Taiwan University Taipei 10617 Taiwan National Center for High-Performance Computing Hsinchu 30076 Taiwan Department of Computer Application Engineering Lan Yang Institute of Technology Ilan 26141 Taiwan

This paper deals with applications of a finite volume scheme to the flow simulations in the pool-typed fishways. The scheme is based on the finite volume method with the upstream flux-splitting algorithm for solving the two-dimensional shallow water equations. The scheme is then applied to simulate flows in two different types of pool fishways, namely the vertical-slot-typed fishway and waterfall-typed fishway. The simulated results by the presented scheme are compared with those by the experiments. Based on the average energy dissipation rate per unit volume in the pool, the burst swimming speed of fish and the maximum velocity in flow of fishway, the maximum discharges per unit width are numerically estimated for five species of fishes, including Varicorhinus barbatulus, Acrossocheilus paradoxus, Zacco barbata, Zacco pachycephalus, and Zacco platypus. Maximum acceptable discharges for fish migration would be helpful for fishway design in the future.

关键词： Lakes

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0305 Can We Rely on Wearable Sleep-Tracker Devices for Fatigue Management?

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Sleep 2024年第Supplement_1期47卷 A131–A132页

作者： Reifman, Jaques Priezjev, Nikolei Vital-Lopez, Francisco Department of Defense Biotechnology High Performance Computing Software Applications Institute Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Development Command

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可持续发展情景下丝绸之路沿线国家土地利用及其对陆地碳库影响

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Science Bulletin 2023年第7期68卷 740-749页

作者：曹敏田雅吴凯陈旻陈玉胡雪孙中昶左丽君林键骆磊朱瑞许振赐 Temenoujka Bandrova Milan Konecny 袁文平郭华东林珲闾国年 Key Laboratory of Virtual Geographic Environment Ministry of EducationNanjing Normal UniversityNanjing 210023China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China School of Geography and Environment Jiangxi Normal UniversityNanchang 330022China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China The Key Laboratory of Urban Land Resources Monitoring and Simulation Ministry of Natural ResourcesShenzhen 518034China Sierra Nevada Research Institute University of CaliforniaMerced CA 95348USA Institute of High Performance Computing Agency for ScienceTechnology and ResearchSingapore 138632Singapore Department of Geography the University of Hong KongHong Kong 999077China Laboratory on Cartography University of ArchitectureCivil Engineering and GeodesySofia 1164Bulgaria Laboratory on Geoinformatics and Cartography Institute of GeographyMasaryk UniversityBrno 60177Czech Republic School of Atmospheric Sciences Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityZhuhai 519082China Key Laboratory of Poyang Lake Wetland and Watershed Research Ministry of EducationJiangxi Normal UniversityNanchang 330022China

可持续发展目标(SDGs)呼吁全世界共同采取行动,促进繁荣并保护地球.本研究面向SDGs构建了环境、粮食和经济等可持续发展情景,预测2020~2030年丝绸之路沿线国家的土地利用变化,并分析其对陆地碳库的影响。研究表明:未来土地利用变化及其... 详细信息

可持续发展目标(SDGs)呼吁全世界共同采取行动,促进繁荣并保护地球.本研究面向SDGs构建了环境、粮食和经济等可持续发展情景,预测2020~2030年丝绸之路沿线国家的土地利用变化,并分析其对陆地碳库的影响。研究表明:未来土地利用变化及其对陆地碳库的影响在不同情景下存在显著差异。在可持续环境情景下,林地得到了有效保护,相较于2020年中国林地碳储量增加了约0.60%;在可持续粮食情景下,耕地流失得到了缓解,尤其在南亚及东南亚地区的耕地面积呈现上升趋势:在可持续经济情景下,城市扩张速度加快,引起的碳损失量最多这项研究有助于推进丝绸之路沿线甚至全球可持续发展进程,为探寻可持续发展路径提供了科学依据。

关键词： Sustainable development goals(SDGs) Land-use projection Carbon pool Scenarios System dynamics model Cellular automata

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0171 EEG Markers from Routine Sleep Discriminate Individuals Who Are Vulnerable or Resilient to Sleep Loss

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Sleep 2024年第Supplement_1期47卷 A74–A74页

作者： Subramaniyan, Mannivannan Vital-Lopez, Francisco Hughes, John Doty, Tracy Reifman, Jaques Department of Defense Biotechnology High Performance Computing Software Applications Institute Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Development Command Behavioral Biology Branch Walter Reed Army Institute of Research

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0151 Personalized Caffeine Recommendations to Achieve Optimal Alertness Levels

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Sleep 2024年第Supplement_1期47卷 A66–A66页

作者： Vital-Lopez, Francisco Doty, Tracy Anlap, Ian Killgore, William Reifman, Jaques Department of Defense Biotechnology High Performance Computing Software Applications Institute Telemedicine and Advanced Technology Research Center U.S. Army Medical Research and Development Command Behavioral Biology Branch Walter Reed Army Institute of Research University of Arizona College of Medicine

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