Goal of this work is to show how the developmental conditions of in vitro neuronal networks influence the effect of drug delivery. The proposed experimental neuronal model consists of dissociated cortical neurons plat...
Goal of this work is to show how the developmental conditions of in vitro neuronal networks influence the effect of drug delivery. The proposed experimental neuronal model consists of dissociated cortical neurons plated to Micro-Electrode Arrays (MEAs) and grown according to different conditions (i.e., by varying both the adopted culture medium and the number of days needed to let the network grow before performing the chemical modulation). We delivered rising amount of bicuculline (BIC), a competitive antagonist of GABAA receptors, and we computed the firing rate dose-response curve for each culture. We found that networks matured in BrainPhys for 18 days in vitro exhibited a decreasing firing trend as a function of the BIC concentration, quantified by an average IC50 (i.e., half maximal inhibitory concentration) of 4.64 ± 4.02 µM. On the other hand, both cultures grown in the same medium for 11 days, and ones matured in Neurobasal for 18 days displayed an increasing firing rate when rising amounts of BIC were delivered, characterized by average EC50 values (i.e., half maximal excitatory concentration) of 0.24 ± 0.05 µM and 0.59 ± 0.46 µM, *** Relevance— This research proves the relevance of the experimental factors that can influence the network development as key variables when developing a neuronal model to conduct drug delivery in vitro, simulating the in vivo environment. Our findings suggest that not considering the consequences of the chosen growing conditions when performing in vitro pharmacological studies could lead to incomplete predictions of the chemically induced alterations.
This paper formalizes a multi-level optimization problem for a distribution power grid. The grid is set up with Electrical Vehicles (EVs) to minimize the total energy cost and satisfy different loads distributed in th...
This paper formalizes a multi-level optimization problem for a distribution power grid. The grid is set up with Electrical Vehicles (EVs) to minimize the total energy cost and satisfy different loads distributed in the grid. At the higher level, the Distribution System Operator (DSO) must deal with a Balancing Market to minimize costs. Instead, at a lower level, Electrical Vehicle Aggregators (EVAs) aim at controlling the charging and discharging of Electrical Vehicles (EVs) maximizing their profit. The optimization problem of EVAs is solved analytically through KKT (Karush-Khun-Tucker) conditions and inserted into the DSO optimization problem. The complete optimization model has been implemented and tested in the IEEE 13-bus system. The results show that the proposed bi-level model significantly reduced the variation of peak consumption by 64.56% and the power cost by 3.07%.
In a system of systems, a system can be modelled as a set of interacting subsystems. When each subsystem can be separately controlled, a distributed algorithm can be applied to manage the control. In this work, we pro...
In a system of systems, a system can be modelled as a set of interacting subsystems. When each subsystem can be separately controlled, a distributed algorithm can be applied to manage the control. In this work, we propose a distributed approach, the Alternating Direction Method of Multipliers (ADMM), based on a distributed Linear Quadratic Regulator (LQR) approach to manage the achievement of a common goal cooperatively. The proposed approach can work with different agents with a limited observation of the system of systems state. The method is demonstrated on a natural system including four interconnected water tanks (quad tank system) whose level can be controlled by two pumps. The results show the behaviour of the proposed algorithm when the tanks have to reach a constant set point and when they must agree on a time-varying set point.
The Capacitated Vehicle Routing Problem (CVRP) has gained significant attention in both academic and industrial circles due to its pivotal role in optimizing logistic systems. In the context of evolving distributor co...
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The Capacitated Vehicle Routing Problem (CVRP) has gained significant attention in both academic and industrial circles due to its pivotal role in optimizing logistic systems. In the context of evolving distributor companies and the growing integration of logistics with broader societal concerns such as climate considerations, this paper delves into a CVRP variant that includes time windows and split deliveries. Real-world assumptions are incorporated to enhance the practical applicability of the study. A mathematical model is proposed to minimize both economic costs and pollutant emissions. Given the unavailability of cost information for all possible routes, a cost function is estimated through multiple linear regression, considering both distance and time factors simultaneously, in order to associate to each link costs and emissions. To validate the effectiveness of the proposed model, a real-world case study involving an industrial distribution company is investigated. The results demonstrate a significant improvement compared to the company’s current operational procedures.
We foresee robots that bootstrap knowledge representations and use them for classifying relevant situations and making decisions based on future observations. Particularly for assistive robots, the bootstrapping mecha...
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We present a symbolic learning framework inspired by cognitive-like memory functionalities (i.e., storing, retrieving, consolidating and forgetting) to generate task representations to support high-level task planning...
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The flexibility and range of motion in human hands play a crucial role in human interaction with the environment and have been studied across different fields. Researchers explored various technological solutions for ...
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This paper presents a stochastic optimization approach for the operational management of sustainable energy districts and polygeneration microgrids. Stochastic operation optimization allows for an uncertain approach t...
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This paper presents a stochastic optimization approach for the operational management of sustainable energy districts and polygeneration microgrids. Stochastic operation optimization allows for an uncertain approach to deal with imprecise variables. A new approach is here presented for generating scenarios based on Ant Colony Optimization (ACO) to assess the uncertainties related to inexact data, renewable energy sources and power demand. In fact, due to the uncertainties related to forecasting loads and renewables, it is necessary to analyze the probability of occurrence of the prediction and the different scenarios that could be faced. Then, based on the generated scenarios and probabilities, a scenario-based two-stage stochastic optimization approach has been formulated to optimize the operation strategies of the various technologies and solve the unit commitment problem under uncertainty. The developed models have been applied to the Savona Campus Smart Polygeneration Microgrid, and historical data from 2018 have been used.
The paper tackles the issue of mapping logic axioms formalised in the Ontology Web Language (OWL) within the Object-Oriented Programming (OOP) paradigm. The issues of mapping OWL axioms hierarchies and OOP objects hie...
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