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International Conference on Complex, Intelligent and Software Intensive systems, CISIS

作者： Marco Gaudina Simone Schiappacasse Luca Lagomarsino Edoardo Bellanti Gianni Vercelli Circle Garage Start-up Innovativa S.R.L. Genoa Italy Department of Informatics Bioengineering Robotics and System Engineering University of Genoa Genoa Italy

Holographic interactivity is nowadays a promising research topic within HCI field, mainly due to recent technological improvements. Moreover, low-cost off-the shelf components are widely availables, with respect to the last century situation for traditional human-machine interaction paradigms. The way of displaying information and data communication are now much more robust and solid than in the past, allowing better user experiences (Ux) than before in terms of presence and immersion. The paper presents a novel interaction system based on holographic and multi-touch technologies well suited for shows and interactive talks. The performer/presenter operates behind a vertical touch enabled transparent holographic panel where multimedia contents are projected and directly manipulated. This type of communication is much more cogent and immersive than any other, since both the presenter and the public interact facing each other with the possibility of focusing their attention on the same interspersed interactive elements. Furthermore, the system relies on a web based cross-platform framework allowing both proximal and remote interaction and visualization on smartphones, tablets and internet enabled devices in general. Preliminary interviews have underlined the goodness of this new interaction paradigm suggesting that this could be a strong base of a much larger platform for many and different uses.

关键词： Three-dimensional displays Software Tactile sensors Business Multimedia communication Internet

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Change over time of infants’ movements based on motion analysis: comparison with changes in general movements and the body sway

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Physiotherapy 2015年 101卷 e1388-e1388页

作者： K. Shimatani T. Shibanoki K. Shima Y. Kurita A. Otsuka M. Casadio P. Giannoni P. Moretti P. Morasso T. Tsuji Prefectural University of Hiroshima Department of Physical Therapy Mihara Japan Ibaraki University Department of Computer and Information Sciences Hitachi Japan Yokohama National University Graduate School of Engineering Yokohama Japan Hiroshima University Graduate School of Engineering Higashihiroshima Japan University of Genova Department of Informatics Bioengineering Robotics and Systems Engineering Genova Italy ART Education and Rehabilitation Centre Genova Italy Institute of Giannina Gaslini Children's Hospital Department of Physical Medicine and Rehabilitation Genova Italy Italian Institute of Technology Department of Robotics Brain and Cognitive Sciences Genova Italy

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Quantifying performance and variability in reward-based motor skill learning

Quantifying performance and variability in reward-based moto...

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5th International Symposium on Measurement, Analysis and Modelling of Human Functions, ISHF 2013

作者： Tamagnone, Irene Casadio, Maura Sanguineti, Vittorio Dept. Informatics Bioengineering Robotics and Systems Engineering University of Genoa Italy

ISBN: (纸本)9781632660251

This study investigates motor skill learning in a specific situation in which the only information provided on performance consists of a reward signal. Subjects performed a point-to-point movement. After the end of the movement we displayed a score based on the distance from a hidden via-point - the maximum score corresponds to the via-point belonging to the trajectory path. The score was the sole information available on task performance and subjects got no additional clues of how to make it high. The task is highly redundant, as infinite trajectories are compatible with the maximum score. We specifically looked at how subjects explore the task space and how they exploit task redundancy to maximize their performance. We also compared the experimental data with the solution predicted by an optimal feedback control model. The main findings were that (i) movement outcomes are largely determined by the subject-specific history of exploration;(ii) during learning, path variability gradually decreased;(iii) for the majority of subjects the point of minimum variability gradually gets closer to the point at minimum distance from the hidden via-point;and (iv) overall, subjects don't converge to the 'optimal control' solution.

关键词： Redundancy

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Body machine interfaces for neuromotor rehabilitation: A case study

Body machine interfaces for neuromotor rehabilitation: A cas...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Camilla Pierella Farnaz Abdollahi Ali Farshchiansadegh Jessica Pedersen David Chen Ferdinando A. Mussa-Ivaldi Maura Casadio Department of Physiology Northwestern University Evanston IL Department of Informatics Bioengineering Robotics and Systems Engineering University of Genoa Genoa Italy Sensory Motor Performance Program Rehabilitation Institute of Chicago Chicago IL 60611 Department of Biomedical Engineering Northwestern University Evanston IL Rehabilitation Institute of Chicago Chicago Illinois

High-level spinal cord injury (SCI) survivors face every day two related problems: recovering motor skills and regaining functional independence. Body machine interfaces (BoMIs) empower people with sever motor disabilities with the ability to control an external device, but they also offer the opportunity to focus concurrently on achieving rehabilitative goals. In this study we developed a portable, and low-cost BoMI that addresses both problems. The BoMI remaps the user's residual upper body mobility to the two coordinates of a cursor on a computer monitor. By controlling the cursor, the user can perform functional tasks, such as entering text and playing games. This framework also allows the mapping between the body and the cursor space to be modified, gradually challenging the user to exercise more impaired movements. With this approach, we were able to change the behavior of our SCI subject, who initially used almost exclusively his less impaired degrees of freedom - on the left side - for controlling the BoMI. At the end of the few practice sessions he had restored symmetry between left and right side of the body, with an increase of mobility and strength of all the degrees of freedom involved in the control of the interface. This is the first proof of concept that our BoMI can be used to control assistive devices and reach specific rehabilitative goals simultaneously.

关键词： Sensors Shoulder Training Aerospace electronics Wireless communication Standards Spinal cord injury

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Laparoscopic skills simulator: A gradual structured training program for acquiring laparoscopic abilities

Laparoscopic skills simulator: A gradual structured training...

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25th European Modeling and Simulation Symposium, EMSS 2013

作者： Frascio, M. Sguanci, M. Mandolfino, F. Gaudina, M. Bellanti, E. Department of General Surgery DISC United States Department of Informatics Bioengineering Robotics and Systems Engineering DIBRIS United States

ISBN: (纸本)9788897999225

Aim of this study is to investigate the importance of acquiring basic and avdanced laparoscopic skills with a virtual reality low cost simulator in laparoscopic general surgery. We considered six basic skills and five advanced skills. The first exercises are related to the acquisition of tasks which allow students to reach basic gestures competences. In the second phase students will perform complex drills acquiring a correct gesture in the use of specific instruments. We developed a standardized, graduated and evidencebased curriculum. The team designed a new software able to handle the training task, creating a virtual interface based on the concept "student - exercise - evaluation". The results are "attended results" because the data analysis will be possible only after a period of testing of the simulator on different samples of students. Referring to experience from other scientific groups, we expect significant results in terms of: reduction of learning time, better dexterity and ability to intervention in case of procedural errors. © 2013 DIME UNIVERSITÀ DI GENOVA.

关键词： Simulators

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An effect of meshing on coupling simulation of left ventricular wall motion

Transactions of Japanese Society for Medical and Biological ...

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Transactions of Japanese Society for Medical and Biological engineering 2014年 52卷 O-186-O-187页

作者： Ogawa, Takafumi Shimayoshi, Takao Kida, Naoki Adachi, Taiji Matsuda, Tetsuya Department of Systems Science Graduate School of Informatics Kyoto University Japan Department of Mechanical Science and Bioengineering Graduate School of Engineering Science Osaka University Japan Department of Biomechanics Institute for Frontier Medical Sciences Kyoto University Japan

In standard finite element analysis in structural dynamics, meshing can affect computation results. However, there have been no detailed report about effects of meshing on results of coupling simulation of left ventricular wall motion which involves myocardial spontaneous contractile force and fiber orientation. In this study, we examined an effect of meshing on simulation of left ventricular wall motion, which couples precise ventricular myocyte model and myocardial fiber orientation. We compared two shape models;spheroid mesh divided along graticule and spheroid mesh subdivided from a semi-regular polyhedron. The comparison results show significant differences between two models around the ventricular apex, which are mainly caused by the contractile force and the fiber orientation. © 2014, Japan Soc. of Med. Electronics and Biol. engineering. All rights reserved.

关键词： Finite element method

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A Body Machine Interface based on Inertial Sensors

A Body Machine Interface based on Inertial Sensors

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Ali Farshchiansadegh Farnaz Abdollahi David Chen Mei-Hua Lee Jessica Pedersen Camilla Pierella Elliot J. Roth Ismael Seanez Gonzalez Elias B. Thorp Ferdinando A. Mussa-Ivaldi Department of Biomedical Engineering Northwestern University Evanston IL Sensory Motor Performance Program Rehabilitation Institute of Chicago Chicago IL Rehabilitation Institute of Chicago Chicago Illinois Department of Kinesiology Michigan State University East Lansing MI Department of Physiology Northwestern University Evanston IL Department of Informatics Bioengineering Robotics and Systems Engineering University of Genoa Genoa Italy

Spinal cord injury (SCI) survivors generally retain residual motor and sensory functions, which provide them with the means to control assistive devices. A body-machine interface (BoMI) establishes a mapping from these residual body movements to control commands for an external device. In this study, we designed a BoMI to smooth the way for operating computers, powered wheelchairs and other assistive technologies after cervical spinal cord injuries. The interface design included a comprehensive training paradigm with a range of diverse functional activities to enhance motor learning and retention. Two groups of SCI survivors and healthy control subjects participated in the study. The results indicate the effectiveness of the developed system as an alternative pathway for individuals with motor disabilities to control assistive devices while engaging in functional motor activity.

关键词： Wheelchairs Training Games Aerospace electronics Spinal cord injury Injuries Sensors

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Partial correlation analysis for functional connectivity studies in cortical networks

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BMC Neuroscience 2014年第1期15卷 1-1页

作者： Daniele Poli Vito Paolo Pastore Sergio Martinoia Paolo Massobrio Department of Informatics Bioengineering Robotics and Systems Engineering (DIBRIS) University of Genova Genova 16145 Italy

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Economic analysis of a low-cost laparoscopic simulator: A descriptive study

Economic analysis of a low-cost laparoscopic simulator: A de...

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25th European Modeling and Simulation Symposium, EMSS 2013

作者： Frascio, M. Sguanci, M. Mandolfino, F. Testi, A. Parodi, M. Vercelli, G. Department of General Surgery DISC Italy Department of Economics and Quantitative Methods DIEM Italy Department of Informatics Bioengineering Robotics and Systems Engineering DIBRIS Italy

ISBN: (纸本)9788897999225

Simulation plays a basic role in medical education. At School of Medicine in Genoa a prototype of virtual reality simulator for videolaparoscopy is now in development phase. This simulation platform includes haptic interface for force feedback and autostereoscopic displays for glasses-free 3D rendering. Aim of this study is to present the simulation as a training method in medicine for laparoscopic surgery. The analysis also studies the economic impact of a market-ready, low cost, multi-user virtual reality simulation platform engineered starting from prototype currently under development. Videolaparoscopy application is analyzed. The investigation is based on 2011-2012 data obtained from queries to "Datawarehouse Sanitario" of Regione Liguria. Secondly, benefits provided by the introduction and use of prototype of a virtual reality simulation platform prospectively and quantitatively examined. The processing relates the possible reduction in total length of hospital stay due to the introduction of prototype simulator and the consequent reduction of laparotomic cholecystectomies. © 2013 DIME UNIVERSITÀ DI GENOVA.

关键词： Simulators

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FANTOM5 CAGE profiles of human and mouse samples

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Scientific Data 2017年第1期4卷 1-10页

作者： Noguchi, Shuhei Arakawa, Takahiro Fukuda, Shiro Furuno, Masaaki Hasegawa, Akira Hori, Fumi Ishikawa-Kato, Sachi Kaida, Kaoru Kaiho, Ai Kanamori-Katayama, Mutsumi Kawashima, Tsugumi Kojima, Miki Kubosaki, Atsutaka Manabe, Ri-Ichiroh Murata, Mitsuyoshi Nagao-Sato, Sayaka Nakazato, Kenichi Ninomiya, Noriko Nishiyori-Sueki, Hiromi Noma, Shohei Saijyo, Eri Saka, Akiko Sakai, Mizuho Simon, Christophe Suzuki, Naoko Tagami, Michihira Watanabe, Shoko Yoshida, Shigehiro Arner, Peter Axton, Richard A. Babina, Magda Kenneth Baillie, J. Barnett, Timothy C. Beckhouse, Anthony G. Blumenthal, Antje Bodega, Beatrice Bonetti, Alessandro Briggs, James Brombacher, Frank Carlisle, Ailsa J. Clevers, Hans C. Davis, Carrie A. Detmar, Michael Dohi, Taeko Edge, B. Albert S. Edinger, Matthias Ehrlund, Anna Ekwall, Karl Endoh, Mitsuhiro Enomoto, Hideki Eslami, Afsaneh Fagiolini, Michela Fairbairn, Lynsey Farach-Carson, Mary C. Faulkner, Geoffrey J. Ferrai, Carmelo Fisher, Malcolm E. Forrester, Lesley M. Fujita, Rie Furusawa, Jun-Ichi Geijtenbeek, Teunis B. Gingeras, Thomas Goldowitz, Daniel Guhl, Sven Guler, Reto Gustincich, Stefano Ha, Thomas J. Hamaguchi, Masahide Hara, Mitsuko Hasegawa, Yuki Herlyn, Meenhard Heutink, Peter Hitchens, Kelly J. Hume, David A. Ikawa, Tomokatsu Ishizu, Yuri Kai, Chieko Kawamoto, Hiroshi Kawamura, Yuki I. Kempfle, Judith S. Kenna, Tony J. Kere, Juha Khachigian, Levon M. Kitamura, Toshio Klein, Sarah Peter Klinken, S. Knox, Alan J. Kojima, Soichi Koseki, Haruhiko Koyasu, Shigeo Lee, Weonju Lennartsson, Andreas MacKay-Sim, Alan Mejhert, Niklas Mizuno, Yosuke Morikawa, Hiromasa Morimoto, Mitsuru Moro, Kazuyo Morris, Kelly J. Motohashi, Hozumi Mummery, Christine L. Nakachi, Yutaka Nakahara, Fumio Nakamura, Toshiyuki Nakamura, Yukio Nozaki, Tadasuke Ogishima, Soichi Ohkura, Naganari Ohno, Hiroshi Ohshima, Mitsuhiro Okada-Hatakeyama, Mariko Okazaki, Yasushi Orlando, Valerio Ovchinnikov, Dmitry A. Passier, Robert Patrikakis, Margaret Pombo, Ana Pradhan-Bhatt, Swati Qin, Xian-Yang Rehli, Michael Rizzu, Patrizia Roy, S Division of Genomic Technologies RIKEN Center for Life Science Technologies Yokohama Kanagawa 230-0045 Japan RIKEN Omics Science Center Yokohama Kanagawa 230-0045 Japan Department of Medicine Karolinska Institutet Stockholm 14186 Sweden Karolinska University Hospital Center for Metabolism and Endocrinology Stockholm 14186 Sweden Scottish Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive Edinburgh EH164UU United Kingdom Department of Dermatology and Allergy Charite University Medicine Berlin Charitéplatz 1 Berlin 10117 Germany Roslin Institute and Royal School of Veterinary Studies University of Edinburgh Edinburgh EH259RG United Kingdom Australian Infectious Diseases Research Centre University of Queensland St Lucia 4072 QLD Australia School of Chemistry and Molecular Biosciences University of Queensland St Lucia 4072 QLD Australia Bio-Rad Laboratories Pty Ltd Hercules 94547 CA United States University of Queensland Diamantina Institute University of Queensland Woolloongabba 4102 QLD Australia IRCCS Fondazione Santa Lucia Via del Fosso di Fiorano 64 Rome 00143 Italy Australian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane St Lucia 4072 QLD Australia Division of Immunology Institute of Infectious Diseases and Molecular Medicine University of Cape Town Anzio Road Observatory 7925 South Africa Immunology of Infectious Diseases Faculty of Health Sciences South African Medical Research Council University of Cape Town Anzio Road 7925 South Africa International Centre for Genetic Engineering and Biotechnology Cape Town Component Anzio Road 7925 South Africa Hubrecht Institute Royal Netherlands Academy of Arts and Sciences Uppsalalaan 8 3584 Netherlands University Medical Centre Utrecht Postbus 85500 Utrecht 3508 Netherlands Genomics Cold Spring Harbor Laboratory Cold Spring Harbor New York 11797 NY United States Institute of Pharmaceutical Sciences ETH Zurich Vladi

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.

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