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3D engineered neural networks coupled to Micro-Electrode Arrays: development of an innovative in-vitro experimental model for neurophysiological studies

3D engineered neural networks coupled to Micro-Electrode Arr...

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International IEEE/EMBS Conference on Neural engineering

作者： Monica Frega Mariateresa Tedesco Paolo Massobrio Mattia Pesce Adam Williamson Andreas Schober Sergio Martinoia Department of Informatics Bioengineering Robotics System Engineering (DIBRIS) Department of Neuroscience and Brain Technologies Italian Institute of Technology Department of Nano-Biosystem Technology Ilmenau University of Technology

ISBN: (纸本)9781467319676

2D neuronal populations coupled to Micro-Electrode-Arrays (MEAs) constitute a well-established experimental in-vitro platform to study neurobiology, network electrophysiology, and basic injury-disease mechanisms. They are also widely used for neuropharmacological screening and neurotoxicity tests. Here we propose a new experimental in-vitro paradigm constituted by 3D engineered networks coupled to both planar and innovative 3D-MEAs. The advantage of such a model is clearly its improved representation of the actual in-vivo environment while maintaining some of the advantages (control, observation) of in-vitro systems. We constructed a physically connected 3D neural network and we demonstrate how the 3D network dynamic differs from the corresponding 2D model, resembling the one detected in the in-vivo situation. The obtained results suggest new avenues for the use of such 3D models for neurophysiological studies or for the development of biohybrid microsystems for in-vivo neural repair.

关键词： Neural network Three Dimensions Microelectrodes experimental model Neurotoxicity Syndromes Planar coupling

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Preface

SpringerBriefs in Computer Science

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SpringerBriefs in Computer Science 2014年第9781493921485期 v-vi页

作者： Čomić, Lidija de Floriani, Leila Magillo, Paola Iuricich, Federico Department for Fundamental Disciplines Faculty of Technical Sciences University of Novi Sad Novi Sad Serbia Department of Computer Science Bioengineering Robotics and Systems Engineering University of Genova Genova Italy Department of Computer Science University of Maryland College ParkMD United States

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Development of a System to Provide Different Fields of View to Eyes with a Function to Generate Rapid Movements

Development of a System to Provide Different Fields of View ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Fumio Mizuno Tomoaki Hayasaka Takami Yamaguchi Department of Electronics and Intelligent Systems Tohoku Institute of Technology Department of Bioengineering and Robotics Tohoku University Graduate School of Engineering Department of Biomedical Engineering Tohoku University Graduate School of Biomedical Engineering

ISBN: (纸本)9781457702150

We developed a system that provides a human user with the artificial oculomotor ability to control their eyes independently, which was named Virtual Chameleon after Chameleons. Virtual Chameleon consists of two independently controlled CCD cameras, a 3D tracking sensor system and a head-mounted display. The Virtual Chameleon control independently postures of two cameras to follow the sensors of the 3D tracking system smoothly. The successful users of the system were able to actively control visual axes by manipulating 3D sensors held by their both hands, to watch independent view fields presented to the left and right eyes, and to look around as chameleons do. Although it is thought that those independent fields of view the user of Virtual Chameleon corresponds to smooth movements on human eye movements, the system did not have functions to control angles of cameras rapidly in way corresponding to saccadic eye movements and compensatory movements as numerous animals including human do. In this paper, we implemented functions to control angles camera rapidly corresponding to saccadic eye movements in Virtual Chameleon, and we performed fundamental experiments to evaluate effects on the user's visual capabilities.

关键词： Chameleons Eye Movements Saccades Eye field of view Chamaeleonidae Function View Virtual optical coherence tomography angiography device system parameter Movements Cameras Angle

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Towards energy-aware intrusion detection systems on mobile devices

Towards energy-aware intrusion detection systems on mobile d...

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International Conference on High Performance Computing & Simulation (HPCS)

作者： Monica Curti Alessio Merlo Mauro Migliardi Simone Schiappacasse Department of Informatics Bioengineering Robotics and System Engineering (DIBRIS) University of Genova Genova Italy Department of Engineering - E-Campus University 22060 Novedrate (Italy) Department of Information Engineering (DEI) University of Padova Padova Italy

This paper investigates the correlations between the energy consumption of Android devices and the presence of threats (e.g. battery-drain attacks). In particular, this paper proposes a model for the energy consumption of single hardware components of a mobile device during normal usage and under attack. The model has been implemented in a kernel module and used to build up an energetic signature of both legal and malicious behaviors of WiFi hardware component in different Android devices. Such activity allows us to build a tentative database of signatures that can be used to detect attacks by means of the actual energy consumption of a mobile device. The proposed power consumption model and kernel module can be applied also to other hardware components, so to obtain very precise energetic signatures.

关键词： Energy consumption Hardware Batteries IEEE 802.11 Standards Energy measurement Mobile handsets Androids

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Leader neurons drive spontaneous and evoked activation patterns in cortical networks

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BMC Neurosci 2013年第SUPPL 1期14卷 P64-P64页

作者： Valentina Pasquale Sergio Martinoia Michela Chiappalone Department of Neuroscience and Brain Technologies - NTECH Istituto Italiano di Tecnologia Via Morego 30 Genova 16163 Italy Department of Informatics Bioengineering Robotics System Engineering (DIBRIS) University of Genova Genova 16145 Italy

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Hyperstaticity for ergonomie design of a wrist exoskeleton

Hyperstaticity for ergonomie design of a wrist exoskeleton

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2013 IEEE 13th International Conference on Rehabilitation robotics, ICORR 2013

作者： Esmaeili, Mohammad Jarrassé, Nathanael Dailey, Wayne Burdet, Etienne Campolo, Domenico School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639798 Singapore Institute of Intelligent Systems and Robotics CNRS - UMR 7222 University Pierre et Marie Curie Paris France Department of Bioengineering Imperial College of Science Technology and Medicine London SW7 2AZ United Kingdom

ISBN: (纸本)9781467360241

Increasing the level of transparency in rehabilitation devices has been one of the main goals in robot-aided neurorehabilitation for the past two decades. This issue is particularly important to robotic structures that mimic the human counterpart's morphology and attach directly to the limb. Problems arise for complex joints such as the human wrist, which cannot be accurately matched with a traditional mechanical joint. In such cases, mechanical differences between human and robotic joint cause hyperstaticity (i.e. overconstraint) which, coupled with kinematic misalignments, leads to uncontrolled force/torque at the joint. This paper focuses on the prono-supination (PS) degree of freedom of the forearm. The overall force and torque in the wrist PS rotation is quantified by means of a wrist robot. A practical solution to avoid hyperstaticity and reduce the level of undesired force/torque in the wrist is presented, which is shown to reduce 75% of the force and 68% of the torque. © 2013 IEEE.

关键词： Exoskeleton (robotics)

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An Overview of a Multiagent-Based Simulation System for Dynamic Management of Risk Related to Dangerous Goods Transport

An Overview of a Multiagent-Based Simulation System for Dyna...

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IEEE International systems Conference

作者： Mohamed Haitam Laarabi Claudio Roncoli Roberto Sacile Azedine Boulmakoul Emmanuel Garbolino Department of Computer science Bioengineering Robotics and Systems engineering University of Genoa LIM/IST Lab. Computer Sciences Department Mohammedia Faculty of Sciences and Technologies (FSTM) Mines ParisTech CRC

ISBN: (纸本)9781467331074

Transportation engineering, and especially of Dangerous Goods (DG), is one of the areas in which technological development is crucial. Logistic control systems, routing and scheduling algorithms, supply chain management have been applied in this aspect so as to improve the cost-effectiveness ratio and to reduce risks. Unfortunately, most of these works remain theoretical since tests on real case scenario sometimes proves difficult to achieve especially when we are dealing with Dangerous Goods Transport (DGT). In this paper, an architecture of a visual DGT simulation system has been introduced. It provides entries for testing these works and produces results close to real experiments. Applications on serious games, financial market, engineering are evidence of success of the visual simulation system. Thus, the challenge consists on how to design a system that represents real-world systems with an appropriate degree of complexity and dynamics. Several researchers have already suggested solutions since the 50s. These solutions have been classified in three levels: microscopic, mesoscopic and macroscopic simulation. It has been decided to use a microscopic approach using an agent-based model. It allows the representation of systems at different levels of complexity, a System of systems (SoS), through the use of autonomous, goal-driven and interacting entities. The system is implemented using the software MATSim (). The main actors of the system stand for the DG Carriers Operator (CO) agent that manages a fleet of DG Carriers agents, taking logistic decisions on their behalf. The COs collaborate with the National Authority (NA), which is an agent concerned by the safety shipment of goods at regional and national level. The paper focus on the Multi-Agent System (MAS) architecture and introduces its key components as well as the means on interaction.

关键词： Multiagent systems Intelligent agents System of systems Simulation System Transport engineering Dangerous Goods Transport

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Enhanced poromechanical properties of tissue engineered cartilage via swelling induced collagen remodelling

Enhanced poromechanical properties of tissue engineered cart...

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5th Biot Conference on Poromechanics, BIOT 2013

作者： Nagel, Thomas Kolditz, Olaf Kelly, Daniel J. Department of Environmental Informatics Helmholtz Centre for Environmental Research - UFZ Permoserstr. 15 04318 Leipzig Germany Applied Environmental Systems Analysis Dresden University of Technology Germany Trinity Centre for Bioengineering Trinity Biomedical Sciences Institute Trinity College 152-160 Pearse Street Dublin 2 Ireland Department of Mechanical and Manufacturing Engineering School of Engineering Trinity College College Green Dublin 2 Ireland

ISBN: (纸本)9780784412992

Mechanical loading and changes in culture media are both applied in bioreactors to improve the functionality of engineered cartilage tissue. The mechanical properties of articular cartilage are in part determined by its collagen architecture. It was previously shown that mechanical loading can alter structural characteristics of the collagen network. In this study, the influence of culture medium osmolarity and proteoglycan depletion on the collagen network in free swelling hydrogels was investigated with a remodelling algorithm. The driving force for remodelling was the balance between osmotic swelling pressures and tensile stresses in the collagen network as well as the hydrogel scaffold. A finite deformation biphasic model was used to describe the hydrogel and the tissue engineered cartilage. It was demonstrated that proteoglycan digestion at discrete time points during culture and culture in a hypertonic medium can improve the functionality of the collagen network. The positive changes manifested themselves as elevated stiffness values, lower permeabilities and an overall more compact tissue. © 2013 American Society of Civil Engineers.

关键词： Collagen

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Toward a Hybrid Approach to Generate Software Product Line Portfolios

Toward a Hybrid Approach to Generate Software Product Line P...

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IEEE Congress on Evolutionary Computation

作者： Jonathas Cruz Pedro Santos Neto Ricardo Britto Ricardo Rabelo Werney Ayala Thiago Soares Mauricio Mota Software Engineering and Industrial Informatics (EASII) Computer Science Department (DC) Federal University of Piaui (UFPI) LABoratory of Intelligent Robotics Automation and Systems (LABIRAS) State University of Piaui (UESPI)

ISBN: (纸本)9781479904532

Software Product Line (SPL) development is a new approach to software engineering that aims at the development of a whole range of products. One of the problems which hinders the adoption of that approach is related with the management of the products of the line. Additionally, the scope of a software product line is determined by the bounds of the capabilities provided by the collection of products in the product line. This introduces new challenges related to the scope problem. One of the main three different forms of scoping is the Product Portfolio Scoping (PPS). PPS aims at defining the products that should be developed as well as their key features. While this has an impact on the actual reuse opportunities, it is usually driven from marketing aspects. Defining a product portfolio by considering costumers satisfaction and cost aspects is a NP-hard problem. This work presents a hybrid approach, which combines fuzzy inference systems and the multi-objective metaheuristics NSGA-II to support product management by generating portfolios of products, based in segments of users and the development cost of the assets of the SPL. Fuzzy inference systems are used to generate development cost of an asset by using coupling, number of code lines and cyclomatic complexity and also to estimate the quality of the products generated by the optimization module of our approach. The NSGA-II metaheuristic is used to search for products minimizing the cost and maximizing the relevance of the candidate products. The results show that the proposed approach is effective in proposing the best products in terms of relevance and cost of the assets.

关键词： Portfolios Correlation Fuzzy logic Indexes Optimization Couplings Complexity theory

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Hyperstaticity for ergonomie design of a wrist exoskeleton

Hyperstaticity for ergonomie design of a wrist exoskeleton

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IEEE International Conference on Rehabilitation robotics (ICORR)

作者： Mohammad Esmaeili Nathanaël Jarrassé Wayne Dailey Etienne Bürdet Domenico Campolo School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore Institute of Intelligent Systems and Robotics University Pierre et Marie Curie Paris France Department of Bioengineering Imperial College of Science London UK

关键词： Torque Force Wrist Joints Robot sensing systems Robot kinematics

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