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arXiv 2019年

作者： Kowsari, Kamran Sali, Rasoul Khan, Marium N. Adorno, William Asad Ali, S. Moore, Sean R. Amadi, Beatrice C. Kelly, Paul Syed, Sana Brown, Donald E. Department of Systems & Information Engineering University of Virginia CharlottesvilleVA United States School of Data Science University of Virginia CharlottesvilleVA United States Department of Pediatrics School of Medicine University of Virginia CharlottesvilleVA United States Aga Khan University Karachi Pakistan Tropical Gastroenterology and Nutrition group University of Zambia School of Medicine Lusaka Zambia Blizard Institute Barts and The London School of Medicine Queen Mary University of London London United Kingdom

Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. CD is an autoimmune disorder that is prevalent worldwide and is caused by an increased sensitivity to gluten. Gluten exposure destructs the small intestinal epithelial barrier, resulting in nutrient mal-absorption and childhood under-nutrition. EE also results in barrier dysfunction but is thought to be caused by an increased vulnerability to infections. EE has been implicated as the predominant cause of under-nutrition, oral vaccine failure, and impaired cognitive development in low-and-middle-income countries. Both conditions require a tissue biopsy for diagnosis, and a major challenge of interpreting clinical biopsy images to differentiate between these gastrointestinal diseases is striking histopathologic overlap between them. In the current study, we propose a convolutional neural network (CNN) to classify duodenal biopsy images from subjects with CD, EE, and healthy controls. We evaluated the performance of our proposed model using a large cohort containing 1000 biopsy images. Our evaluations show that the proposed model achieves an area under ROC of 0.99, 1.00, and 0.97 for CD, EE, and healthy controls, respectively. These results demonstrate the discriminative power of the proposed model in duodenal biopsies classification. Copyright © 2019, The Authors. All rights reserved.

关键词： Medical imaging

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Computational Approaches to Explainable Artificial Intelligence: Advances Intheory, Applications and Trends

SSRN

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SSRN 2023年

作者： Górriz, Juan Manuel Álvarez-Illán, I. Álvarez-Marquina, A. Arco, J.E. Atzmueller, M. Ballarini, F. Barakova, E. Bologna, G. Bonomini, P. Castellanos-Dominguez, G. Castillo-Barnes, D. Cho, S.B. Contreras, R. Cuadra, J.M. Domínguez, E. Domínguez-Mateos, F. Duro, R.J. Elizondo, D. Fernández-Caballero, A. Fernandez-Jover, E. Formoso, M.A. Gallego-Molina, N.J. Gamazo, J. García González, J. Garcia-Rodriguez, J. Garre, C. Garrigós, J. Gómez-Rodellar, A. Gómez-Vilda, P. Graña, M. Guerrero-Rodriguez, B. Hendrikse, S.C.F. Jimenez-Mesa, C. Jodra-Chuan, M. Julian, V. Kotz, G. Kutt, K. Leming, M. de Lope, J. Macas, B. Marrero-Aguiar, V. Martinez, J.J. Martinez-Murcia, F.J. Martínez-Tomás, R. Mekyska, J. Nalepa, G.J. Novais, P. Orellana, D. Ortiz, A. Palacios-Alonso, D. Palma, J. Pereira, A. Pinacho-Davidson, P. Pinninghoff, M.A. Ponticorvo, M. Psarrou, A. Ramírez, J. Rincón, M. Rodellar-Biarge, V. Rodríguez-Rodríguez, I. Roelofsma, P.H.M.P. Santos, J. Salas-Gonzalez, D. Salcedo-Lagos, P. Segovia, F. Shoeibi, A. Silva, M. Simic, D. Suckling, J. Treur, J. Tsanas, A. Varela, R. Wang, S.H. Wang, W. Zhang, Y.D. Zhu, H. Zhu, Z. Ferrández-Vicente, J.M. SiPBA at Data Science and Computational Intelligence Institute University of Granada Granada Spain University of Granada Granada Spain Dept. of Psychiatry University of Cambridge Cambridge United Kingdom Dept. of Communications Engineering University of Malaga Malaga Spain School of Computing and Mathematical Sciences University of Leicester Leicester United Kingdom Semantic Information Systems Group Osnabrück University Osnabrück Germany Osnabrück Germany Dept. of Electronics Computer Technology and Projects Universidad Politécnica de Cartagena Cartagena Spain Universitat Politècnica de València València Spain Institute of Applied Computer Science Jagiellonian University Kraków Poland Dept. of Information and Communication Engineering University of Murcia Murcia Spain Dept. of Computer Science and Information Technologies University of A Coruña A Coruña Spain Dept. of Computer Science University of Oviedo Oviedo Spain Buenos Aires Argentina Buenos Aires Argentina Eindhoven University of Technology Eindhoven5612 AZ Netherlands Dept. of Computer Science University of Malaga Malaga Spain De Montfort University Leicester United Kingdom Dept. of Computer Science Faculty of Engineering Universidad de Concepción Concepción Chile Neurocognition and Emotion Research Unit Albacete Research Institute of Informatics University of Castilla-La Mancha Albacete Spain Dept. of Educational Informatics Universidad de Concepción Concepción Chile Madrid Spain Dept. of Humanistic Studies University of Naples Federico II Napoli Italy Escuela Técnica Superior de Ingeniería Informática Universidad Rey Juan Carlos Campus de Móstoles Móstoles Madrid28933 Spain Neuromorphic Speech Processing Lab Center for Biomedical Technology Universidad Politécnica de Madrid Campus de Montegancedo Pozuelo de Alarcón Madrid28223 Spain Biomedical Research Networking Center in Mental Health Instituto de Salud Carlos III Madrid28016 Spain Usher Institute Faculty o

Groundbreaking advances in theoretical and applied Artificial Intelligence (AI). DL algorithms are groundedin non-linear and complex artificial neural systems that progressively extract higher-level features from *** is frequently compared with human-level performance in real-world tasks, such as clinical diagnostics. Itis also a turning point in solving otherwise intractable problems in the design of virtual agents or robotics;orin providing novel insight into disease progress in genomics and Neuroimaging (NI), understanding humanbrain function, the automation of industrial processes based on computer vision, and so on. In this paper, themost relevant advances from the last few years in AI and several applications to neuroscience, neuroimaging,computer vision, and robotics are presented, reviewed and discussed. In this way, we summarize the state-ofthe-art in AI methods, models and applications within a collection of works presented at the 9th InternationalConference on the Interplay between Natural and Artificial Computation (IWINAC). The works presentedin this paper are excellent examples of new scientific discoveries made in laboratories that are successfullytransferred to real-life applications. © 2023, The Authors. All rights reserved.

关键词： Neuroimaging

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BPRIM: An integrated framework for business process management and risk management

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Computers in Industry 2019年 113卷

作者： Lamine, Elyes Thabet, Rafika Sienou, Amadou Bork, Dominik Fontanili, Franck Pingaud, Herve Toulouse University ISIS Institut National Universitaire Champollion Rue Firmin-OulèsCastres81104 France Toulouse University IMT Mines Albi Department of Industrial Engineering Route de Teillet Albi Cedex 981013 France abamix Consulting – Business Information Systems Unit Stuttgart Germany MARS Laboratory University of Sousse ISITCom Hammam Sousse Tunisia University of Vienna Faculty of Computer Science Research Group Knowledge Engineering Währingerstrasse 29 Vienna1090 Austria Toulouse University CNRS LGC Toulouse Cedex 04F-31432 France

Enterprise engineering deals with the design of processes which aim to improve the structure and efficiency of business organizations. It develops approaches based on modeling techniques, particularly on business process modeling, to ensure the quality and the global consistency of enterprise strategies and expectations. Nowadays, risk consideration in enterprise engineering is a growing concern since the business environment is becoming more and more competitive, complex, and unpredictable. To face this concern, a paradigm named risk-aware business process management (R-BPM) has recently emerged. It seeks to integrate the two traditionally isolated fields of risk management and business process management. Despite the significant benefits that can arise from the use of R-BPM, it suffers from a lack of solid scientific foundations and dedicated tooling. This present research work contributes to bridging that gap in a twofold way: (i) by establishing the BPRIM business process-risk integrated method framework, and (ii) by designing a dedicated tool, named ADOBPRIM which supports the efficient application of the BPRIM framework. This paper first comprehensively presents the foundation of BPRIM which is based on three main components and, secondly, its dedicated tool ADOBPRIM which was designed using the ADOxx meta-modeling platform. An evaluation with a real case study in the health care domain shows the relevance of the methodological framework. © 2019 Elsevier B.V.

关键词： Risk management

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Image schemas and conceptual dependency primitives: A comparison

Image schemas and conceptual dependency primitives: A compar...

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2017 Joint Ontology Workshops Episode 3: The Tyrolean Autumn of Ontology, JOWO 2017

作者： Macbeth, Jamie C. Gromann, Dagmar Hedblom, Maria M. Department of Electrical and Computer Systems Engineering Fairfield University FairfieldCT06824 United States Bellaterra Spain Research Center for Knowledge and Data Free University of Bozen-Bolzano Italy

A major challenge in natural language understanding research in artificial intelligence (AI) has been and still is the grounding of symbols in a representation that allows for rich semantic interpretation, inference, and deduction. Across cognitive linguistics and other disciplines, a number of principled methods for meaning representation of natural language have been proposed that aim to emulate capacities of human cognition. However, little cross-fertilization among those methods has taken place. A joint effort of human-level meaning representation from AI research and from cognitive linguistics holds the potential of contributing new insights to this profound challenge. To this end, this paper presents a first comparison of image schemas to an AI meaning representation system called Conceptual Dependency (CD). Restricting our study to the domain of physical and spatial conceptual primitives, we find connections and mappings from a set of action primitives in CD to a remarkably similar set of image schemas. We also discuss important implications of this connection, from formalizing image schemas to improving meaning representation systems in AI. © 2017 CEUR-WS. All rights reserved.

关键词： Image enhancement

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Aesthetic Attributes Assessment of Images

arXiv

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arXiv 2019年

作者： Jin, Xin Wu, Le Zhao, Geng Li, Xiaodong Zhang, Xiaokun Ge, Shiming Zou, Dongqing Zhou, Bin Zhou, Xinghui Department of Cyber Security Beijing Electronic Science and Technology Institute Beijing100070 China Cetc Big Data Research Institute Co. Ltd. Guiyang Guizhou550018 China Institute of Information Engineering Chinese Academy of Sciences Beijing100093 China SenseTime Research Beijing100084 China State Key Laboratory of Virtual Reality Technology and Systems Beihang University Peng Cheng Laboratory Beijing100191 China

Image aesthetic quality assessment has been a relatively hot topic during the last decade. Most recently, comments type assessment (aesthetic captions) has been proposed to describe the general aesthetic impression of an image using text. In this paper, we propose Aesthetic Attributes Assessment of Images, which means the aesthetic attributes captioning. This is a newformula of image aesthetic assessment, which predicts aesthetic attributes captions together with the aesthetic score of each attribute. We introduce a new dataset named DPC-Captions which contains comments of up to 5 aesthetic attributes of one image through knowledge transfer from a full-annotated small-scale dataset. Then, we propose Aesthetic Multi-Attribute Network (AMAN), which is trained on a mixture of fully-annotated small-scale PCCD dataset and weakly-annotated large-scale DPC-Captions dataset. Our AMAN makes full use of transfer learning and attention model in a single framework. The experimental results on our DPC-Captions and PCCD dataset reveal that our method can predict captions of 5 aesthetic attributes together with numerical score assessment of each attribute. We use the evaluation criteria used in image captions to prove that our specially designed AMAN model outperforms traditional CNN-LSTM model and modern SCA-CNN model of image captions. Copyright © 2019, The Authors. All rights reserved.

关键词： Long short-term memory

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Author Correction: Community assessment of methods to deconvolve cellular composition from bulk gene expression

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Nature communications 2024年第1期15卷 9783页

作者： Brian S White Aurélien de Reyniès Aaron M Newman Joshua J Waterfall Andrew Lamb Florent Petitprez Yating Lin Rongshan Yu Martin E Guerrero-Gimenez Sergii Domanskyi Gianni Monaco Verena Chung Jineta Banerjee Daniel Derrick Alberto Valdeolivas Haojun Li Xu Xiao Shun Wang Frank Zheng Wenxian Yang Carlos A Catania Benjamin J Lang Thomas J Bertus Carlo Piermarocchi Francesca P Caruso Michele Ceccarelli Thomas Yu Xindi Guo Julie Bletz John Coller Holden Maecker Caroline Duault Vida Shokoohi Shailja Patel Joanna E Liliental Stockard Simon Julio Saez-Rodriguez Laura M Heiser Justin Guinney Andrew J Gentles Sage Bionetworks Seattle WA USA. The Jackson Laboratory for Genomic Medicine Farmington CT USA. Centre de Recherche des Cordeliers INSERM U1138 Université Paris Cité Paris France. Institute for Stem Cell Biology and Regenerative Medicine Stanford University Stanford CA USA. Department of Biomedical Data Science Stanford University Stanford CA USA. INSERM U830 and Translational Research Department Institut Curie PSL Research University Paris France. Programme Cartes d'Identité des Tumeurs Ligue Nationale Contre le Cancer Paris France. MRC Centre for Reproductive Health the Queen's Medical Research Institute University of Edinburgh Edinburgh United Kingdom. Xiamen University Xiamen Fujian China. Institute of Biochemistry and Biotechnology School of Medicine National University of Cuyo Mendoza Argentina. Michigan State University East Lansing MI USA. BIOGEM Institute of Molecular Biology and Genetics Ariano Irpino AV Italy. Department of Biomedical Engineering Knight Cancer Institute Oregon Health & Science University Portland OR USA. Heidelberg University Faculty of Medicine Heidelberg Germany. Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany. Aginome Scientific Xiamen Fujian China. Department of Pathology Cancer Hospital Chinese Aacdemy of Medical Science Beijing China. AmoyDx Xiamen Fujian China. Laboratory of Intelligent Systems (LABSIN) Engineering School National University of Cuyo Mendoza Argentina. Department of Radiation Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA. Department of Electrical Engineering and Information Technology (DIETI) University of Naples "Federico II" Ariano Irpino AV Italy. Sylvester Comprehensive Cancer Center Department of Public Health Sciences University of Miami Miller School of Medicine Miami Florida USA. Stanford Functional Genomics Facility Stanford University School of Medicine Stanford CA USA. Institute fo

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Ensuring data confidentiality via plausibly cdeniable encryption and secure deletion-a survey

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网络空间安全科学与技术（英文版） 2018年第1期1卷 25-44页

作者： Qionglu Zhang Shijie Jia Bing Chang Bo Chen Data Assurance and Communication Security Research Center Chinese Academy of Sciences Beijing China State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of SciencesBeijing China School of Cyber Security University of Chinese Academy of Sciences Beijing China Data Assurance and Communication Security Research Center Chinese Academy of Sciences Beijing China State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of SciencesBeijing China School of Information Systems Singapore Management University Singapore Singapore Department of Computer Science Michigan Technological University Houghton USA

Ensuring confidentiality of sensitive data is of paramount importance,since data leakage may not only endanger data owners' privacy,but also ruin reputation of businesses as well as violate various regulations like HIPPA and Sarbanes-Oxley *** provide confidentiality guarantee,the data should be protected when they are preserved in the personal computing devices (i.e.,confidentiality during theirlifetime);and also,they should be rendered irrecoverable after they are removed from the devices (i.e.,confidentiality after their lifetime).Encryption and secure deletion are used to ensure data confidentiality during and after their lifetime,*** work aims to perform a thorough literature review on the techniques being used to protect confidentiality of the data in personal computing devices,including both encryption and secure *** for encryption,we mainly focus on the novel plausibly deniable encryption (PDE),which can ensure data confidentiality against both a coercive (i.e.,the attacker can coerce the data owner for the decryption key) and a non-coercive attacker.

关键词： data confidentiality Plausibly deniable encryption Secure deletion

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MultiFarm: A Benchmark for Multilingual Ontology Matching

SSRN

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SSRN 2018年

作者： Meilicke, Christian García-Castro, Raúl Freitas, Fred van Hage, Willem Robert Montiel-Ponsoda, Elena de Azevedo, Ryan Ribeiro Stuckenschmidt, Heiner Šváb-Zamazal, Ondřej Svátek, Vojtěch Tamilin, Andrei Trojahn, Cássia Wang, Shenghui Universidade Federal de Pernambuco University of Mannheim Universidad Politécnica de Madrid Web & Media Group Ontology Engineering Group Data and Web Science Group Department of Information and Knowledge Engineering Fondazione Bruno Kessler Grenoble - Rhône-Alpes VU University Amsterdam

In this paper we present the MultiFarm dataset, which has been designed as a benchmark for multilingual ontology matching. The MultiFarm dataset is composed of a set of ontologies translated in different languages and the corresponding alignments between these ontologies. It is based on the OntoFarm dataset, which has been used successfully for several years in the Ontology Alignment Evaluation Initiative (OAEI). By translating the ontologies of the OntoFarm dataset into eight different languages – Chinese, Czech, Dutch, French, German, Portuguese, Russian, and Spanish - we created a comprehensive set of realistic test cases. Based on these test cases, it is possible to evaluate and compare the performance of matching approaches with a special focus on multilingualism. © 2018, The Authors. All rights reserved.

关键词： Ontology

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The Brain Tumor Sequence Registration (BraTS-Reg) Challenge: Establishing Correspondence Between Pre-Operative and Follow-up MRI Scans of Diffuse Glioma Patients

arXiv

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arXiv 2021年

作者： Baheti, Bhakti Chakrabarty, Satrajit Akbari, Hamed Bilello, Michel Wiestler, Benedikt Schwarting, Julian Calabrese, Evan Rudie, Jeffrey Abidi, Syed Mousa, Mina Villanueva-Meyer, Javier Fields, Brandon K.K. Kofler, Florian Shinohara, Russell Takeshi Iglesias, Juan Eugenio Mok, Tony C.W. Chung, Albert C.S. Wodzinski, Marek Jurgas, Artur Marini, Niccolò Atzori, Manfredo Müller, Henning Grosbröhmer, Christoph Siebert, Hanna Hansen, Lasse Heinrich, Mattias P. Canalini, Luca Klein, Jan Gerken, Annika Heldmann, Stefan Hering, Alessa Hahn, Horst K. Meng, Mingyuan Bi, Lei Feng, Dagan Kim, Jinman Zeineldinal, Ramy A. Karar, Mohamed E. Mathis-Ullrich, Franziska Burgert, Oliver Abderezaei, Javid Pionteck, Aymeric Chopra, Agamdeep Kurt, Mehmet Yan, Kewei Yan, Yonghong Tang, Zhe Ma, Jianqiang Nasser, Sahar Almahfouz Kurian, Nikhil Cherian Meena, Mohit Shamsi, Saqib Sethi, Amit Tustison, Nicholas J. Avants, Brian B. Cook, Philip Gee, James C. Tian, Lin Greer, Hastings Niethammer, Marc Hoopesar, Andrew Hoffmannas, Malte Dalcaar, Adrian V. Christodoulidis, Stergios Estiene, Théo Vakalopoulou, Maria Paragios, Nikos Marcus, Daniel S. Davatzikos, Christos Sotiras, Aristeidis Menze, Bjoern Bakas, Spyridon Waldmannstetter, Diana Division of Computational Pathology Department of Pathology and Laboratory Medicine Indiana University School of Medicine IndianapolisIN United States Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO United States GE HealthCare San RamonCA United States University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Mallinckrodt Institute of Radiology Washington University School of Medicine St. LouisMO United States Institute for Informatics Data Science & Biostatistics Washington University School of Medicine St. LouisMO United States Department of Bioengineering Santa Clara University Santa ClaraCA United States Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Computer Science TUM School of Computation Information and Technology Technical University of Munich Munich Germany Department of Diagnostic and Interventional Neuroradiology School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany Department of Nuclear Medicine University Hospital Regensburg Regensburg Germany University Hospital Regensburg Regensburg Germany Department of Radiology & Biomedical Imaging University of California San FranciscoCA United States Department of Radiology Duke University Medical Center DurhamNC United States Department of Radiology University of California San DiegoCA United States Helmholtz AI Helmholtz Munich Neuherberg Germany Penn Statistics in Imaging and Visualization Center Department of Biostatistics Epidemiology and Informatics University of Pennsylvania Philadelphia United States Massachusetts General Hospital Harvard Medical School United States Centre for Medical Imaging Computing University College London United Kingdom The Hong Kong University of Science and Technology Hong Kong University of Applied Sciences West

Registration of longitudinal brain Magnetic Resonance Imaging (MRI) scans containing pathologies is challenging due to dramatic changes in tissue appearance. Although there has been considerable progress in developing general-purpose medical image registration techniques, they have not yet attained the requisite precision and reliability for this task, highlighting its inherent complexity. Here we describe the Brain Tumor Sequence Registration (BraTS-Reg) challenge, as the first public benchmark environment for deformable registration algorithms focusing on estimating correspondences between pre-operative and follow-up scans of the same patient diagnosed with a diffuse brain glioma. The challenge was conducted in conjunction with both the IEEE International Symposium on Biomedical Imaging (ISBI) 2022 and the International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2022. The BraTS-Reg data comprise de-identified multi-institutional multi-parametric MRI (mpMRI) scans, curated for size and resolution according to a canonical anatomical template, and divided into training, validation, and testing sets. Clinical experts annotated ground truth (GT) landmark points of anatomical locations distinct across the temporal domain. The training data with their GT annotations, were publicly released to enable the development of registration algorithms. The validation data, without their GT annotations, were also released to allow for algorithmic evaluation prior to the testing phase, which only allowed submission of containerized algorithms for evaluation on hidden hold-out testing data. Quantitative evaluation and ranking was based on the Median Euclidean Error (MEE), Robustness, and the determinant of the Jacobian of the displacement field. The top-ranked methodologies yielded similar performance across all evaluation metrics and shared several methodological commonalities, including pre-alignment, deep neural networks, inverse consistency

关键词： Magnetic resonance imaging

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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