检索结果-内蒙古大学图书馆

arXiv 2018年

作者： Lu, Chao Bu, Yi Wang, Jie Ding, Ying Torvik, Vetle Schnaars, Matthew Zhang, Chengzhi School of Economics and Management Nanjing University of Science and Technology Nanjing Jiangsu China School of Informatics Computing and Engineering Indiana University BloomingtonIN United States Center for Complex Networks and Systems Research School of Informatics Computing and Engineering Indiana University BloomingtonIN United States School of Information Management Nanjing University Nanjing Jiangsu China School of Information Management Wuhan University Wuhan Hubei China School of Information Sciences University of Illinois UrbanaIL United States Jiangsu Key Laboratory of Data Engineering and Knowledge Service Nanjing University Nanjing Jiangsu China

Publishing articles in high-impact English journals is difficult for scholars around the world, especially for non-native English-speaking scholars (NNESs), most of whom struggle with proficiency in English. In order to uncover the differences in English scientific writing between native English-speaking scholars (NESs) and NNESs, we collected a large-scale data set containing more than 150,000 full-text articles published in PLoS between 2006 and 2015. We divided these articles into three groups according to the ethnic backgrounds of the first and corresponding authors, obtained by Ethnea, and examined the scientific writing styles in English from a two-fold perspective of linguistic complexity: (1) syntactic complexity, including measurements of sentence length and sentence complexity;and (2) lexical complexity, including measurements of lexical diversity, lexical density, and lexical sophistication. The observations suggest marginal differences between groups in syntactical and lexical complexity. Copyright © 2018, The Authors. All rights reserved.

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Combining noise-to-image and image-to-image GANs: Brain MR image augmentation for tumor detection

arXiv

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arXiv 2019年

作者： Han, Changhee Rundo, Leonardo Araki, Ryosuke Nagano, Yudai Furukawa, Yujiro Mauri, Giancarlo Nakayama, Hideki Hayashi, Hideaki Machine Perception Group Graduate School of Information Science and Technology University of Tokyo Tokyo113-8657 Japan Research Center for Medical Big Data National Institute of Informatics Tokyo100-0003 Japan Department of Radiology University of Cambridge CambridgeCB2 0QQ United Kingdom Cancer Research UK Cambridge Centre CambridgeCB2 0RE United Kingdom Department of Informatics Systems and Communication University of Milano-Bicocca Milan20126 Italy Machine Perception and Robotics Group Graduate School of Engineering Chubu University Aichi487-8501 Japan Department of Psychiatry Jikei University School of Medicine Tokyo105-8461 Japan Human Interface Laboratory Department of Advanced Information Technology Kyushu University Fukuoka819-0395 Japan

Convolutional Neural Networks (CNNs) can achieve excellent computer-assisted diagnosis performance, relying on sufficient annotated training data. Unfortunately, most medical imaging datasets, often collected from various scanners, are small and fragmented. In this context, as a data Augmentation (DA) technique, Generative Adversarial Networks (GANs) can synthesize realistic/diverse additional training images to fill the data lack in the real image distribution;researchers have improved classification by augmenting images with noise-to-image (e.g., random noise samples to diverse pathological images) or image-to-image GANs (e.g., a benign image to a malignant one). Yet, no research has reported results combining (i) noise-to-image GANs and image-to-image GANs or (ii) GANs and other deep generative models, for further performance boost. Therefore, to maximize the DA effect with the GAN combinations, we propose a two-step GAN-based DA that generates and refines brain MR images with/without tumors separately: (i) Progressive Growing of GANs (PGGANs), multi-stage noise-to-image GAN for highresolution image generation, first generates realistic/diverse 256 256 images-even a physician cannot accurately distinguish them from real ones via Visual Turing Test;(ii) UNsupervised Image-to-image Translation or SimGAN, image-to-image GAN combining GANs/Variational AutoEncoders or using a GAN loss for DA, further refines the texture/shape of the PGGAN-generated images similarly to the real *** thoroughly investigate CNN-based tumor classification results, also considering the influence of pre-training on ImageNet and discarding weird-looking GAN-generated images. The results show that, when combined with classic DA, our two-step GAN-based DA can significantly outperform the classic DA alone, in tumor detection (i.e., boosting sensitivity from 93:63% to 97:53%) and also in other medical imaging tasks. Copyright © 2019, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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How China Deals with Big data

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Annals of data Science 2017年第4期4卷 433-440页

作者： Shi, Yong Shan, Zhiguang Li, Jianping Fang, Yufei School of Economics and Management University of Chinese Academy of Sciences Beijing100190 China Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing China Informatization Research Department State Information Center Beijing100045 China Institute of Policy and Management Chinese Academy of Sciences Beijing100190 China School of Computer and Communication Engineering University of Science and Technology Beijing100083 China Informatization Research Department State Information Center Beijing100045 China

On September 5, 2015, the State Council of Chinese Government, China’s cabinet formally announced its Action Framework for Promoting Big data (***, 2015). This is the milestone for China to catch up the global wave of big data. Since 2012 big data became a hot issue for scientific communities as well as the governments of many countries (Lazer et al. in Science 343:1203–1205, 2014;Einav et al. in Science 345:715, 2014;Cate in Science 346:818, 2014;Khoury and Ioannidis in Science 346:1054–1055, 2014). At the 2013 G8 Summit, the leaders of Canada, France, Germany, Italy, Japan, Russia, U.S.A. and United Kingdom agreed on an "open government plan" (***/government/publications/open-data-charter/g8-open-data-charter-and-technical-annex, 2013). China’s framework, however, mainly emphasizes the integration of all trans-departmental data and establishes a number of government-driven national big data platforms so as to provide big data services to research, public and enterprises. The framework not only demonstrates a strong commitment of the Chinese government on big data, but also covers a wide range of governmental branches, enterprises and institutions far more than that of other countries. In addition, the framework shows an interpretation of big data that differs from other countries. If its objective is achieved, China would become a strong "big data country". © 2017, Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Big data

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Highly ionized clumps shooting out from a quasar at relativistic speeds

arXiv

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arXiv 2025年

作者： Audard, Marc Awaki, Hisamitsu Ballhausen, Ralf Bamba, Aya Behar, Ehud Boissay-Malaquin, Rozenn Brenneman, Laura Brown, Gregory V. Corrales, Lia Costantini, Elisa Cumbee, Renata Trigo, María Díaz Done, Chris Dotani, Tadayasu Ebisawa, Ken Eckart, Megan Eckert, Dominique Enoto, Teruaki Eguchi, Satoshi Ezoe, Yuichiro Foster, Adam Fujimoto, Ryuichi Fujita, Yutaka Fukazawa, Yasushi Fukushima, Kotaro Furuzawa, Akihiro Gallo, Luigi García, Javier A. Gu, Liyi Guainazzi, Matteo Hagino, Kouichi Hamaguchi, Kenji Hatsukade, Isamu Hayashi, Katsuhiro Hayashi, Takayuki Hell, Natalie Hodges-Kluck, Edmund Hornschemeier, Ann Ichinohe, Yuto Ishida, Manabu Ishikawa, Kumi Ishisaki, Yoshitaka Kaastra, Jelle Kallman, Timothy Kara, Erin Katsuda, Satoru Kanemaru, Yoshiaki Kelley, Richard Kilbourne, Caroline Kitamoto, Shunji Kobayashi, Shogo Kohmura, Takayoshi Kubota, Aya Leutenegger, Maurice Loewenstein, Michael Maeda, Yoshitomo Markevitch, Maxim Matsumoto, Hironori Matsushita, Kyoko McCammon, Dan McNamara, Brian Mernier, François Miller, Eric D. Miller, Jon M. Mitsuishi, Ikuyuki Mizumoto, Misaki Mizuno, Tsunefumi Mori, Koji Mukai, Koji Murakami, Hiroshi Mushotzky, Richard Nakajima, Hiroshi Nakazawa, Kazuhiro Ness, Jan-Uwe Nobukawa, Kumiko Nobukawa, Masayoshi Noda, Hirofumi Odaka, Hirokazu Ogawa, Shoji Ogorzalek, Anna Okajima, Takashi Ota, Naomi Paltani, Stephane Petre, Robert Plucinsky, Paul Porter, Frederick Scott Pottschmidt, Katja Sato, Kosuke Sato, Toshiki Sawada, Makoto Seta, Hiromi Shidatsu, Megumi Simionescu, Aurora Smith, Randall Suzuki, Hiromasa Szymkowiak, Andrew Takahashi, Hiromitsu Takeo, Mai Tamagawa, Toru Tamura, Keisuke Tanaka, Takaaki Tanimoto, Atsushi Tashiro, Makoto Terada, Yukikatsu Terashima, Yuichi Tsuboi, Yohko Tsujimoto, Masahiro Tsunemi, Hiroshi Tsuru, Takeshi G. Uchida, Hiroyuki Uchida, Nagomi Uchida, Yuusuke Uchiyama, Hideki Ueda, Yoshihiro Uno, Shinichiro Vink, Jacco Watanabe, Shin Williams, Brian J. Yamada, Satoshi Yamada, Shinya Yamaguchi, Hiroya Yamaoka, Kazutaka Yamasaki, Noriko Yamauchi, Makoto Yamauchi, S Department of Astronomy University of Geneva VersoixCH-1290 Switzerland Department of Physics Ehime University Ehime790-8577 Japan Department of Astronomy University of Maryland College ParkMD20742 United States NASA / Goddard Space Flight Center GreenbeltMD20771 United States Center for Research and Exploration in Space Science and Technology NASA / GSFC CRESST II GreenbeltMD20771 United States Department of Physics University of Tokyo Tokyo113-0033 Japan Department of Physics Technion Technion City Haifa3200003 Israel BaltimoreMD21250 United States Center for Astrophysics — Harvard-Smithsonian MA02138 United States Lawrence Livermore National Laboratory CA94550 United States Department of Astronomy University of Michigan MI48109 United States SRON Netherlands Institute for Space Research Leiden Netherlands ESO Karl-Schwarzschild-Strasse 2 Garching bei München85748 Germany Centre for Extragalactic Astronomy Department of Physics University of Durham South Road DurhamDH1 3LE United Kingdom Kanagawa252-5210 Japan Department of Physics Kyoto University Kyoto606-8502 Japan Department of Economics Kumamoto Gakuen University Kumamoto862-8680 Japan Department of Physics Tokyo Metropolitan University Tokyo192-0397 Japan Department of Physics Hiroshima University Hiroshima739-8526 Japan Department of Physics Fujita Health University Aichi470-1192 Japan Department of Astronomy and Physics Saint Mary’s University NSB3H 3C3 Canada Cahill Center for Astronomy and Astrophysics California Institute of Technology PasadenaCA91125 United States Noordwijk2200 AG Netherlands Faculty of Engineering University of Miyazaki Miyazaki889-2192 Japan RIKEN Nishina Center Saitama351-0198 Japan Leiden Observatory University of Leiden P.O. Box 9513 LeidenNL-2300 RA Netherlands Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology MA02139 United States Department of Physics Saitama University Sai

Evidence indicates that supermassive black holes exist at the centers of virtually all galaxies. Their mass correlates with the galactic bulge mass1, suggesting a co-evolution with their host galaxies2, most likely through powerful outflows/winds3. X-ray observations have revealed the presence of highly ionized winds outflowing at sub-relativistic speeds from the accretion disks around supermassive black holes4,5. However, the limited spectral resolution of current X-ray instruments has left the physical structure of the winds poorly understood, as well as their location, both of which are essential for estimating the wind kinetic power6,7. Here, the first XRISM observation of the luminous quasar, PDS 456, is reported. The high-resolution spectrometer Resolve onboard XRISM enabled the discovery of five discrete velocity components outflowing at 20–30% of the speed of light. This demonstrates that the wind structure is highly inhomogeneous, which is inferred to consist of up to a million clumps of size (0.2–1.2) × 1015 cm located (2–4) × 1016 cm away from the X-ray source. The mass outflow rate is estimated to be 60–170 solar masses per year. Subsequently, the wind kinetic power is more than 1047 erg s−1, exceeding the Eddington luminosity limit. This is more than enough to significantly impact the galaxy. Copyright © 2025, The Authors. All rights reserved.

关键词： X ray detectors

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A unified adaptive tensor approximation scheme to accelerate composite convex optimization

arXiv

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arXiv 2018年

作者： Jiang, Bo Lin, Tianyi Zhang, Shuzhong Research Institute for Interdisciplinary Sciences School of Information Management and Engineering Shanghai University of Finance and Economics Shanghai200433 China Department of Industrial Engineering and Operations Research UC Berkeley BerkeleyCA94720 United States Department of Industrial and Systems Engineering University of Minnesota MinneapolisMN55455 United States Institute of Data and Decision Analytics Chinese University of Hong Kong Shenzhen China

In this paper we propose a unified two-phase scheme to accelerate any high-order regularized tensor approximation approach on the smooth part of a composite convex optimization model. The proposed scheme has the advantage of not needing to assume any prior knowledge of the Lipschitz constants for the gradient, the Hessian and/or high-order derivatives. This is achieved by tuning the parameters used in the algorithm adaptively in its process of progression, which can be viewed as a relaxation over the existing algorithms in the literature. Under the assumption that the sub-problems can be solved approximately, we establish the overall iteration complexity bounds for three specific algorithms to obtain an ǫ-optimal solution. In general, we show that the adaptive high-order method has an iteration bound of O (1/ǫ1/(p+1)) if the first p-th order derivative information is used in the approximation, which has the same iteration complexity as in [39] where the Lipschitz constants are assumed to be known and subproblems are assumed to be solved exactly. Thus, our results answer an open problem raised by Nesterov in [39] on adaptive strategies for high-order accelerated methods. Specifically, we show that the gradient method achieves an iteration complexity in the order of O (1/ǫ1/2), which is known to be best possible (cf. [38]), while the adaptive cubic regularization methods with the exact/inexact Hessian matrix both achieve an iteration complexity in the order of O (1/ǫ1/3), which matches that of the original accelerated cubic regularization method presented in [36] assuming the availability of the exact Hessian information and the Lipschitz constants, and the global solution of the sub-problems. Our numerical experiment results show a clear effect of acceleration displayed in the adaptive Newton’s method with cubic regularization on a set of regularized logistic regression instances. Copyright © 2018, The Authors. All rights reserved.

关键词： Convex optimization

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Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

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The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, Muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun Mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, Muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

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DPHL:A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.M.Ijzermans John W.M.Martens Renske D.M.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta Mantoo Sze S.Lee Serene J.Y.Yeow Syed M.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang Man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan Meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding Ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of Medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by *** data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

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Prediction of Evaluation Value from Product Reviews and Explanations to Healthcare Products Using Network

Prediction of Evaluation Value from Product Reviews and Expl...

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2017 International MultiConference of Engineers and Computer Scientists, IMECS 2017

作者： Sakaguchi, Ayumu Nohara, Shoji Saga, Ryosuke Department of Knowledge and Information Systems School of Sustainable System Sciences Osaka Prefecture University 1-1 Gakuen-cho Naka-ku Sakai Osaka Japan Department of the Computer Science and Intelligent Systems Graduate School of Engineering Osaka Prefecture University 1-1 Gakuen-cho Naka-ku Sakai Osaka Japan

ISBN: (纸本)9789881404732

Given that reviews are difficult to score, predicting evaluation values automatically can be useful. The evaluation value depends on users who buy certain products with known information that meet expectations. Numerous studies have already predicted the evaluation value from reviews. However, many of these studies only paid attention to user reviews, and the opinions of product providers were not considered. In this paper, we will comment about the keywords of reviews and explanations, create a co-occurrence network showing keywords, and perform multiple regression analysis using the features of the network. As a result, we can acquire results of high accuracy from multiple regression analysis to predict the value of products based on the reviews and explanations to the service.

关键词： Forecasting

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