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Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach

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Emerging Contaminants 2024年第2期10卷 76-82页

作者： Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun Kim Department of Biology Jeju National UniversityJeju63243South Korea Department of Interdisciplinary Program in Biomedical Science Graduate SchoolSoonchunhyang UniversityAsanChungcheongnam-doSouth Korea Department of Laboratory Medicine Soonchunhyang University Seoul HospitalSeoul04401South Korea

Chromium(III)oxide nanoparticles(NPs)have a wide range of industrial applications,particularly in the production of lithium-ion batteries;however,the toxicity of these NPs has not been studied *** phytotoxicity and genotoxicity of chromium(III)oxide NPs have not been assessed,and only one study reported their cytotoxicity,underscoring the need to perform comprehensive toxicity studies on these ***,we showed that chromium(III)oxide NPs had no effect on germination rates,and only decreased root elongation in *** as determined by root elongation and biomass ***(III)oxide NPs had no phytotoxic effects under environmental realistic conditions,whereas they had cytotoxic effects against HK-2 and Raw 264.7 cells in ***,the cytotoxicity of chromium(III)oxide NPs did not occur under environmentally realistic *** genotoxicity of chromium(III)oxide NPs was not significant in HK-2 cells,suggesting that the potential environmental cytotoxicity of chromium(III)oxide NPs is *** study proposes comprehensive phytotoxicity,cytotoxicity,and genotoxicity testing tools that would be easy,safe,and effective for evaluating the toxicity of *** integrated testing system could be an accurate and stable method for evaluating the toxicity of other nanomaterials.

关键词： Nanoparticle Plant growth Cell viability Chromium(III)oxide Nephrotoxicity

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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

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Bioactive Materials 2024年第10期40卷 306-317页

作者： Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul08826South Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826South Korea Department of Biomedical Engineering Dongguk UniversitySeoul10326South Korea Soonchunhyang Institute of Medi-bio Science(SIMS) Soonchunhyang UniversityCheonan31151South Korea Department of Integrated Biomedical Science Soonchunhyang UniversityAsan31538South Korea Department of Orthopaedic Surgery Konkuk University Chungju HospitalKonkuk University School of MedicineChungju27376South Korea BioMAX Institute Seoul National UniversitySeoul08826South Korea

Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage *** or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect *** this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with ***,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage ***,we incorporated whitlockite(WH),a Mg^(2+)-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic *** is the first study to use WH to produce hypertrophic ***-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone ***,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage *** the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair.

关键词： Bioceramic Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair

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Correction: Recent progress in DNA data storage based on high-throughput DNA synthesis

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biomedical engineering letters 2024年第5期14卷 1147-1152页

作者： Seokwoo Jo Haewon Shin Sung-Yune Joe David Baek Chaewon Park Honggu Chun Department of Biomedical Engineering Korea University 466 Hana Science Hall Seoul 02841 Korea. Interdisciplinary Program in Precision Public Health Korea University 466 Hana Science Hall Seoul 02841 Korea.

[This corrects the article DOI: 10.1007/s13534-024-00386-z.].

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O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine (vol 13, 2904, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 2904页

作者： Kim, Kibum Yoo, Hee Chan Kim, Byung Gyu Kim, Sulhee Sung, Yulseung Yoon, Ina Yu, Ya Chun Park, Seung Joon Kim, Jong Hyun Myung, Kyungjae Hwang, Kwang Yeon Kim, Sunghoon Han, Jung Min Interdisciplinary Program of Integrated OMICS for Biomedical Science Graduate School Yonsei University Seoul 03722 South Korea. Yonsei Institute of Pharmaceutical Sciences College of Pharmacy Yonsei University Incheon 21983 South Korea. Center for Genomic Integrity Institute for Basic Science Ulsan 44919 South Korea. Department of Biotechnology College of Life Sciences and Biotechnology Korea University Seoul 02841 South Korea. Department of Biochemistry School of Medicine Catholic University of Daegu Daegu 42472 South Korea. Interdisciplinary Program of Integrated OMICS for Biomedical Science Graduate School Yonsei University Seoul 03722 South Korea. jhan74@yonsei.ac.kr.

All living organisms have the ability to sense nutrient levels to coordinate cellular metabolism. Despite the importance of nutrient-sensing pathways that detect the levels of amino acids and glucose, how the availability of these two types of nutrients is integrated is unclear. Here, we show that glucose availability regulates the central nutrient effector mTORC1 through intracellular leucine sensor leucyl-tRNA synthetase 1 (LARS1). Glucose starvation results in O-GlcNAcylation of LARS1 on residue S1042. This modification inhibits the interaction of LARS1 with RagD GTPase and reduces the affinity of LARS1 for leucine by promoting phosphorylation of its leucine-binding site by the autophagy-activating kinase ULK1, decreasing mTORC1 activity. The lack of LARS1 O-GlcNAcylation constitutively activates mTORC1, supporting its ability to sense leucine, and deregulates protein synthesis and leucine catabolism under glucose starvation. This work demonstrates that LARS1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.

关键词： Glycobiology Metabolism Nutrient signalling Post-translational modifications

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Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4983-4998页

作者： Yongho Jang Jeehun Park Pilsu Kim Eun-Joo Park Hyungjin Sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea Research Institute of Advanced Materials(RIAM) Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea Department of Electronic Engineering Sogang UniversitySeoul 04107Republic of Korea Biomedical Research Institute&Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Engineering Research Bio-MAX InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Biomedical Engineering Sogang UniversitySeoul 04107Republic of Korea

Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery ***,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active *** exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original *** this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into *** a result,the stability of Exo-MBs is improved over the conventional *** the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug *** higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell *** have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy.

关键词： Exosomes Microbubbles Photodynamic therapy Ultrasound Sonoporation Cancer immunotherapy Drug delivery

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Transferrin-Mediated Nanophotosensitizer to Enhance Phototherapy with Photoacoustic Imaging Under Hypoxia

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CCS Chemistry 2025年第4期7卷 1127-1141页

作者： Mengyao Yang Yunyoung Nah Donghyeon Oh Xingshu Li Heejeong Kim Sinyoung Park Junha Lim Aibing Chen Chulhong Kim Won Jong Kim Juyoung Yoon College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018 Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul 03760 Department of Chemistry POSTECH-Catholic Biomedical Engineering InstitutePOSTECHPohang 37673 Department of Electrical Engineering Convergence IT EngineeringMechanical Engineeringand Medical Science and EngineeringMedical Device Innovation CenterPOSTECHPohang 37673 Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350108 School of Interdisciplinary Bioscience and Bioengineering POSTECHPohang 37673 Graduate Program in Innovative Biomaterials Convergence Ewha Womans UniversitySeoul 03760

Various obstacles[poor tissue penetration,hypoxic tumor microenvironment,and reactive oxygen species(ROS)production quenching due to aggregation]obstruct imaging-guided high-efficiency phototherapy targeting ***,nanophthalocyanine(ZnPcN4-TF)is elaborately designed based on a synthetic phthalocyanine derivative(ZnPcN4)and nonimmunogenic transferrin(TF)through multiple noncovalent interactions for photoacoustic(PA)imaging-guided *** conjugating electron-rich amino groups effectively suppressed fluorescence and ROS generation due to the strong photoinduced electron transfer effect,ZnPcN4 became an ideal photothermal and PA imaging ***4-TF not only effectively targeted tumor sites and accumulated there,but also,surprisingly,facilitated the enhancement of ROS production via a type I process in an aggregate compared to ZnPcN4 itself,potentially due to accelerated electron ***,ZnPcN4-TF had a substantially more powerful photothermal effect than ZnPcN4 ***,this design effectively overcomes the obstacles to photodynamic therapy(aggregation-related ROS generation quenching in a hypoxic environment).Furthermore,PA imaging solves the tissue penetration challenge in optical *** study provides a broader base for designing novel photosensitizers to improve phototherapy under hypoxia.

关键词： photoacoustic imaging type I reactive oxygen species photothermal effect tumor accumulation self-assembly

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Time-dependent reduction of somatic variants in lichen striatus as evidence for the clearance of mutated skin cells

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Journal of the American Academy of Dermatology 2025年第6期92卷 1377-1379页

作者： Lee, Byunghyuk Lim, Dong Min Shin, Kihyuk Lee, Hyun Jung Lee, Jungsoo Kim, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Kihun Kim, Won Kyu Kang, Junho Ko, Hyun-Chang Kim, Yun Hak Department of Dermatology College of Medicine Pusan National University Yangsan South Korea Interdisciplinary Program of Genomic Data Science Pusan National University Yangsan South Korea Department of Dermatology Pusan National University Yangsan Hospital Yangsan South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan South Korea Department of Pathology School of Medicine Pusan National University Yangsan South Korea Department of Biomedical Informatics School of Medicine Pusan National University Yangsan South Korea Department of Anatomy School of Medicine Pusan National University Yangsan South Korea Natural Product Research Center Korea Institute of Science and Technology Gangneung South Korea Department of Research Keimyung University Dongsan Medical Center Daegu South Korea

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

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Injectable Platelet Lysate–Thai Silk Fibroin Hydrogel for Canine Intervertebral Disc Repair: A Minimally Invasive Strategy for Sustained Growth Factor Release

SSRN

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SSRN 2025年

作者： Ratanavaraporn, Juthamas Chayatup, Kannika Boonkruephan, Sarinthorn Keeratihattayakorn, Saran Wangdee, Chalika Interdisciplinary Program of Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok Thailand Biomedical Engineering Research Center Faculty of Engineering Chulalongkorn University Bangkok Thailand Research Unit Chulalongkorn University Bangkok10330 Thailand Department of Veterinary Surgery Faculty of Veterinary Science Chulalongkorn University Bangkok Thailand

Canine intervertebral disc degeneration (IVDD) is a progressive spinal disorder that compromises mobility, induces chronic pain, and reduces quality of life. Existing treatments provide only symptomatic relief and do not halt disease progression or restore disc integrity. This study aims to develop and characterize an injectable platelet lysate–Thai silk fibroin (PL–TSF) hydrogel as a minimally invasive platform for localized and sustained growth factor delivery in canine IVDD treatment. The hydrogel was formulated using PL from expired canine platelet concentrates and TSF extracted from cocoons of Thai-bred Bombyx mori silkworms. Fabricated via sonication-induced gelation, it exhibited tunable gelation kinetics and injectability through a 27-gauge spinal needle, supporting clinical feasibility for minimally invasive delivery. PL incorporation enhanced the hydrogel’s elasticity and mechanical resilience without compromising scaffold integrity. The system demonstrated biphasic degradation over 35 days. TGF-β1 release kinetics exhibited an initial burst followed by sustained release over 28 days, consistent with diffusion-controlled delivery suitable for IVD repair. Cytotoxicity testing confirmed good biocompatibility and supported the viability of canine chondrocytes. By combining mechanical support with prolonged growth factor availability, PL–TSF hydrogels address key limitations of conventional platelet-based therapies and represent a promising strategy for early-stage IVDD intervention. Further in vivo studies are warranted to confirm long-term regenerative efficacy and facilitate clinical translation in veterinary medicine. © 2025, The Authors. All rights reserved.

关键词： Gelation

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COIN: Confidence Score-Guided Distillation for Annotation-Free Cell Segmentation

arXiv

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arXiv 2025年

作者： Jo, Sanghyun Lee, Seo Jin Lee, Seungwoo Hong, Seohyung Seo, Hyungseok Kim, Kyungsu OGQ Seoul Korea Republic of Laboratory of Cell & Gene Therapy Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University Korea Republic of Department of Biomedical Science and Medical Research Center College of Pharmacy Seoul National University Korea Republic of School of Transdisciplinary Innovations Interdisciplinary Program in Bioengineering Interdisciplinary Program in Artificial Intelligence Seoul National University Korea Republic of

Cell instance segmentation (CIS) is crucial for identifying individual cell morphologies in histopathological images, providing valuable insights for biological and medical research. While unsupervised CIS (UCIS) models aim to reduce the heavy reliance on labor-intensive image annotations, they fail to accurately capture cell boundaries, causing missed detections and poor performance. Recognizing the absence of error-free instances as a key limitation, we present COIN (COnfidence score-guided INstance distillation), a novel annotation-free framework with three key steps: (1) Increasing the sensitivity for the presence of error-free instances via unsupervised semantic segmentation with optimal transport, leveraging its ability to discriminate spatially minor instances, (2) Instance-level confidence scoring to measure the consistency between model prediction and refined mask and identify highly confident instances, offering an alternative to ground truth annotations, and (3) Progressive expansion of confidence with recursive self-distillation. Extensive experiments across six datasets show COIN outperforming existing UCIS methods, even surpassing semi- and weakly-supervised approaches across all metrics on the MoNuSeg and TNBC datasets. The code is available at https://***/shjo-april/COIN. © 2025, CC BY.

关键词： Semantic Segmentation

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