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Miniaturized Microarray-Format Digital ELISA Enabled by Lithographic Protein Patterning

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SSRN

SSRN 2023年

作者： Stephens, Andrew D. Song, Yujing McClellan, Brandon L. Su, Shiuan-Haur Xu, Sonnet Chen, Kevin Castro, Maria G. Singer, Benjamin H. Kurabayashi, Katsuo Department of Mechanical Engineering University of Michigan Ann ArborMI48109 United States Department of Neurosurgery University of Michigan Medical School Ann ArborMI48109 United States Department of Cell and Developmental Biology University of Michigan Medical School Ann ArborMI48109 United States Graduate Program in Immunology University of Michigan Medical School Ann ArborMI48109 United States Department of Biomedical Engineering University of Michigan Ann ArborMI48109 United States Rogel Cancer Center University of Michigan Ann ArborMI48109 United States Department of Internal Medicine Division of Pulmonary and Critical Care Medicine University of Michigan Ann ArborMI48109 United States Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109 United States Weil Institute for Critical Care Research and Innovation University of Michigan Ann ArborMI48109 United States

The search for reliable protein biomarker candidates is critical for early disease detection and treatment. However, current immunoassay technologies are failing to meet increasing demands for sensitivity and multiplexing. Here, the authors have created a highly sensitive protein microarray using the principle of single-molecule counting for signal amplification, capable of simultaneously detecting a panel of cancer biomarkers at sub-pg/mL levels. To enable this amplification strategy, the authors introduce a novel method of protein patterning using photolithography to subdivide addressable arrays of capture antibody spots into hundreds of thousands of individual microwells. This allows for the total sensor area to be miniaturized, increasing the total possible multiplex capacity. With the immunoassay realized on a standard 75x25 mm form factor glass substrate, sample volume consumption is minimized to © 2023, The Authors. All rights reserved.

关键词： Biomarkers

Phase transitions in the frustrated Ising ladder with stoquastic and nonstoquastic catalysts

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Physical Review Research 2021年第4期3卷 043013-043013页

作者： Kabuki Takada Shigetoshi Sota Seiji Yunoki Bibek Pokharel Hidetoshi Nishimori Daniel A. Lidar Department of Physics Tokyo Institute of Technology Yokohama Kanagawa 226-8503 Japan Computational Materials Science Research Team RIKEN Center for Computational Science (R-CCS) Kobe Hyogo 650-0047 Japan Computational Condensed Matter Physics Laboratory RIKEN Cluster for Pioneering Research (CPR) Wako Saitama 351-0198 Japan Computational Quantum Matter Research Team RIKEN Center for Emergent Matter Science (CEMS) Wako Saitama 351-0198 Japan Department of Physics University of Southern California Los Angeles California 90089 USA Center for Quantum Information Science & Technology University of Southern California Los Angeles California 90089 USA Institute of Innovative Research Tokyo Institute of Technology Yokohama Kanagawa 226-8503 Japan Graduate School of Information Sciences Tohoku University Sendai Miyagi 980-8579 Japan RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS) Wako Saitama 351-0198 Japan Department of Electrical & Computer Engineering and Department of Chemistry University of Southern California Los Angeles California 90089 USA

The role of nonstoquasticity in the field of quantum annealing and adiabatic quantum computing is an actively debated topic. We study a strongly-frustrated quasi-one-dimensional quantum Ising model on a two-leg ladder to elucidate how a first-order phase transition with a topological origin is affected by interactions of the ±XX-type. Such interactions are sometimes known as stoquastic (negative sign) and nonstoquastic (positive sign) “catalysts”. Carrying out a symmetry-preserving real-space renormalization group analysis and extensive density-matrix renormalization group computations, we show that the phase diagrams obtained by these two methods are in qualitative agreement with each other and reveal that the first-order quantum phase transition of a topological nature remains stable against the introduction of both XX-type catalysts. This is the first study of the effects of nonstoquasticity on a first-order phase transition between topologically distinct phases. Our results indicate that nonstoquastic catalysts are generally insufficient for removing topological obstacles in quantum annealing and adiabatic quantum computing.

关键词： Adiabatic quantum optimization Phase transitions by order Quantum spin models Density matrix renormalization group Renormalization group

Self-Awareness for Autonomous Systems

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PROCEEDINGS OF THE IEEE 2020年第7期108卷 971-975页

作者： Dutt, Nikil Regazzoni, Carlo S. Rinner, Bernhard Yao, Xin Nikil Dutt (Fellow IEEE) received the Ph.D. degree from the University of Illinois at Urbana–Champaign Champaign IL USA in 1989.""He is currently a Distinguished Professor of computer science (CS) cognitive sciences and electrical engineering and computer sciences (EECS) with the University of California at Irvine Irvine CA USA. He is a coauthor of seven books. His research interests include embedded systems electronic design automation (EDA) computer architecture distributed systems healthcare Internet of Things (IoT) and brain-inspired architectures and computing.""Dr. Dutt is a Fellow of ACM. He was a recipient of the IFIP Silver Core Award. He has received numerous best paper awards. He serves as the Steering Committee Chair of the IEEE/ACM Embedded Systems Week (ESWEEK). He is also on the steering organizing and program committees of several premier EDA and embedded system design conferences and workshops. He has served on the Editorial Boards for the IEEE Transactions on Very Large Scale Integration (VLSI) Systems and the ACM Transactions on Embedded Computing Systems and also previously served as the Editor-in-Chief (EiC) for the ACM Transactions on Design Automation of Electronic Systems. He served on the Advisory Boards of the IEEE Embedded Systems Letters the ACM Special Interest Group on Embedded Systems the ACM Special Interest Group on Design Automationt and the ACM Transactions on Embedded Computing Systems. Carlo S. Regazzoni (Senior Member IEEE) received the M.S. and Ph.D. degrees in electronic and telecommunications engineering from the University of Genoa Genoa Italy in 1987 and 1992 respectively.""He is currently a Full Professor of cognitive telecommunications systems with the Department of Electrical Electronics and Telecommunication Engineering and Naval Architecture (DITEN) University of Genoa and a Co-Ordinator of the Joint Doctorate on Interactive and Cognitive Environments (JDICE) international Ph.D. course started initially as EU Erasmus Mundus Project and

Autonomous systems are able to make decisions and potentially take actions without direct human intervention, which requires some knowledge about the system and its environment as well as goal-oriented reasoning. In computer systems, one can derive such behavior from the concept of a rational agent with autonomy (“control over its own actions”), reactivity (“react to events from the environment”), proactivity (“act on its own initiative”), and sociality (“interact with other agents”) as fundamental properties \n[1]\n. Autonomous systems will undoubtedly pervade into our everyday lives, and we will find them in a variety of domains and applications including robotics, transportation, health care, communications, and entertainment to name a few. \nThe articles in this month’s special issue cover concepts and fundamentals, architectures and techniques, and applications and case studies in the exciting area of self-awareness in autonomous systems.

关键词： Special issues and sections Autonomous systems Self-aware Robot sensing systems Computational modeling

Cavity-mediated superthermal phonon correlations in the ultrastrong coupling regime

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arXiv 2024年

作者： Kim, Dasom Hou, Jin Lee, Geon Agrawal, Ayush Kim, Sunghwan Zhang, Hao Bao, Di Baydin, Andrey Wu, Wenjing Tay, Fuyang Huang, Shengxi Chia, Elbert E.M. Kim, Dai-Sik Seo, Minah Mohite, Aditya D. Hagenmüller, David Kono, Junichiro Applied Physics Graduate Program Smalley–Curl Institute Rice University HoustonTX77005 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Sensor System Research Center Korea Institute of Science and Technology Seoul02792 Korea Republic of Department of Physics and Astronomy Seoul National University Seoul08826 Korea Republic of Department of Chemical and Biomolecular Engineering Rice University Houston77005 United States Ulsan44919 Korea Republic of Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore Smalley–Curl Institute Rice University HoustonTX77005 United States Rice Advanced Materials Institute Rice University HoustonTX77005 United States KU–KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Université de Strasbourg CNRS Strasbourg67200 France Department of Physics and Astronomy Rice University HoustonTX77005 United States

Phonons, or vibrational quanta, are behind some of the most fundamental physical phenomena in solids, including superconductivity, Raman processes, and broken-symmetry phases. It is therefore of fundamental importance to find ways to harness phonons for controlling these phenomena and developing novel quantum technologies. However, the majority of current phonon control techniques rely on the use of intense external driving fields or strong anharmonicities, which restricts their range of applications. Here, we present a scheme for controlling the intensity fluctuations in phonon emission at room temperature based on multimode ultrastrong light–matter coupling. The multimode ultrastrong coupling regime is achieved by coupling two optical phonon modes in lead halide perovskites to an array of nanoslots, which operates as a single-mode cavity. The extremely small mode volume of the nanoslots enables unprecedented coupling strengths in a cavity phonon-polariton system. In the far-detuned, low-cavity-frequency regime, we demonstrate that the nanoslot resonator mediates an effective coupling between the phonon modes, resulting in superthermal phonon bunching in thermal equilibrium, both within the same mode and between different modes. Experimental results are in good agreement with a multimode Hopfield model. Our work paves the way for the tailoring of phonons to modify charge and energy transport in perovskite materials, with potential applications in light-collecting or emitting devices. Copyright © 2024, The Authors. All rights reserved.

关键词： Perovskite

Electrochemical biosensor based on an atomic layered composite of graphene oxide/graphene as an electrode material towards selective and sensitive detection of miRNA-21

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Microchemical Journal 2024年 199卷

作者： Huang, Min-Shin Govindasamy, Mani Chinnapaiyan, Sathishkumar Lin, Yi-Ting Lu, Shao-Yang Samukawa, Seiji Huang, Chi-Hsien Department of Materials Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai-602105 Tamil Nadu India Institute of Fluid Science Tohoku University Sendai 980-8577 Japan College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan City 33305 Taiwan College of Engineering Chang Gung University Taoyuan City 33302 Taiwan

Development of an efficient technique towards the detection of miRNAs is highly significant for the timely diagnosis and prognosis of cancers. In this study, we utilized the chemical vapor deposition (CVD) technique to grow bilayer graphene (BLG) on copper foil and subsequently transferred the BLG to fluorine doped tin oxide (FTO) substrate via a facile wet transfer technique. The upper layer of the BLG was modified to graphene oxide (GO) with a low damage plasma treatment (LDPT) process to serve as a biomolecule receiving layer and the lower graphene layer (G) serves as an electron transport layer. The developed GO/G/FTO platform offers superior sensing ability towards the miRNA-21. The results demonstrated that the proposed GO/G/FTO substrate detect the miRNA-21 with a wide linear range (10 fM ∼ 1 nM), low limit of detection (3.18 fM), high sensitivity (0.6 mApM⁻¹cm⁻²), selectivity and stability via the differential pulse voltammetry method. Additionally, the sensors can efficiently discriminate the target miRNA-21 from its complementary base mismatched counterparts. The proposed approach serves as an excellent tool for the early diagnosis of diseases. © 2024 Elsevier B.V.

关键词： Atomic layer oxidation Biosensor Cancer biomarkers Electrochemical Graphene oxide Plasma treatment

Chiral Phonons with Giant Magnetic Moments in a Topological Crystalline Insulator

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arXiv 2022年

作者： Hernandez, Felix G.G. Baydin, Andrey Chaudhary, Swati Tay, Fuyang Katayama, Ikufumi Takeda, Jun Nojiri, Hiroyuki Okazaki, Anderson K. Rappl, Paulo H.O. Abramof, Eduardo Rodriguez-Vega, Martin Fiete, Gregory A. Kono, Junichiro Instituto de Física Universidade de São Paulo SP São Paulo05508-090 Brazil Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics The University of Texas at Austin AustinTX78712 United States Department of Physics Northeastern University BostonMA02115 United States Department of Physics Massachusetts Institute of Technology CambridgeMA02139 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics Graduate School of Engineering Science Yokohama National University Yokohama240-8501 Japan Institute for Materials Research Tohoku University Sendai980-8577 Japan Instituto Nacional de Pesquisas Espaciais SP São José dos Campos12201-970 Brazil Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Material Science and NanoEngineering Rice University HoustonTX77005 United States

We have studied the magnetic response of transverse optical phonons in Pb1−xSnxTe films. Polarization-dependent terahertz magnetospectroscopy measurements revealed Zeeman splittings and diamagnetic shifts, demonstrating that these phonon modes become chiral in magnetic fields. Films in the topological crystalline insulator phase (x > 0.32) exhibited magnetic moment values that are larger than those for topologically trivial films (x Copyright © 2022, The Authors. All rights reserved.

关键词： Phonons

Breakdown of the weak coupling limit in quantum annealing

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arXiv 2021年

作者： Bando, Yuki Yip, Ka-Wa Chen, Huo Lidar, Daniel A. Nishimori, Hidetoshi Institute of Innovative Research Tokyo Institute of Technology Kanagawa Yokohama226-8503 Japan Center for Quantum Information Science & Technology University of Southern California Los AngelesCA90089 United States Department of Physics & Astronomy University of Southern California Los AngelesCA90089 United States Department of Electrical & Computer Engineering University of Southern California Los AngelesCA90089 United States Department of Chemistry University of Southern California Los AngelesCA90089 United States International Research Frontiers Initiative Tokyo Institute of Technology Kanagawa Yokohama226-8503 Japan Graduate School of Information Sciences Tohoku University Miyagi Sendai980-8579 Japan Saitama Wako351-0198 Japan

Reverse annealing is a variant of quantum annealing, in which the system is prepared in a classical state, reverse-annealed to an inversion point, and then forward-annealed. We report on reverse annealing experiments using the D-Wave 2000Q device, with a focus on the p = 2 p-spin problem, which undergoes a second order quantum phase transition with a gap that closes polynomially in the number of spins. We concentrate on the total and partial success probabilities, the latter being the probabilities of finding each of two degenerate ground states of all spins up or all spins down, the former being their sum. The empirical partial success probabilities exhibit a strong asymmetry between the two degenerate ground states, depending on the initial state of the reverse anneal. To explain these results, we perform open-system simulations using master equations in the limits of weak and strong coupling to the bath. The former, known as the adiabatic master equation (AME), with decoherence in the instantaneous energy eigenbasis, predicts perfect symmetry between the two degenerate ground states, thus failing to agree with the experiment. In contrast, the latter, known as the polaron transformed Redfield equation (PTRE), is in close agreement with experiment. Thus our results present a challenge to the sufficiency of the weak system-bath coupling limit in describing the dynamics of current experimental quantum annealers, at least for reverse annealing on timescales of a μsec or longer. © 2021, CC BY.

关键词： Ground state

Terahertz chiral photonic-crystal cavities with broken time-reversal symmetry

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arXiv 2024年

作者： Tay, Fuyang Sanders, Stephen Baydin, Andrey Song, Zhigang Welakuh, Davis M. Alabastri, Alessandro Rokaj, Vasil Dag, Ceren B. Kono, Junichiro Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley–Curl Institute Rice University HoustonTX77005 United States Smalley–Curl Institute Rice University HoustonTX77005 United States John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA02139 United States Max Planck Institute for The Structure and Dynamics of Matter Luruper Chaussee 149 Hamburg22761 Germany ITAMP Harvard-Smithsonian Center for Astrophysics CambridgeMA02138 United States Department of Physics Harvard University CambridgeMA02138 United States Department of Physics Villanova University VillanovaPA19085 United States Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

Strong coupling between matter and vacuum electromagnetic fields in a cavity can induce novel quantum phases in thermal equilibrium via symmetry breaking. Particularly, coupling with circularly polarized fields can break time-reversal symmetry, leading to topological modifications in the band structure. Therefore, chiral optical cavities that host chiral vacuum fields are being sought, especially in the terahertz (THz) frequency range, where various large-oscillator-strength resonances exist. Here, we present a novel approach to achieving THz chiral photonic-crystal cavities (PCCs) with high-quality factors (>400) using a magnetoplasma in a lightly doped semiconductor. Numerical simulations of an optimized structure based on InSb in a small perpendicular magnetic field (∼0.2 T) show chiral cavity resonances with near-perfect ellipticity at the surfaces of the central dielectric layer, where one can place atomically thin materials like monolayer graphene. We theoretically estimate an energy gap on the order of 1 meV in graphene when coupled to our proposed chiral cavity, which is potentially measurable in experiments. These THz chiral PCCs offer a promising platform for exploring new phases in cavity-dressed condensed matter with broken time-reversal symmetry. Copyright © 2024, The Authors. All rights reserved.

关键词： Crystal symmetry

Windows computer laboratory as a tutorial for undergraduate electromagnetics

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computer Applications in engineering Education 1995年第3期3卷 183-183页

作者： McCulloch, J. Keddy, W.A. Stuchly, M.A. University of Victoria Department of Electrical and Computer Engineering University of Victoria Victoria British Columbia Canada Janet McCulloch:is a native of Toronto Canada where she briefly attended both York University and the University of Toronto before she set off on a year-long adventure through the Middle East and North Africa. When she returned to Canada she relocated to California. She spent a number of years living both in Los Angeles and coastal Northern California interspersed with several extended trips through the United States Mexico and Central America. Ms. McCulloch moved to Victoria British Columbia in 1989 and a year later registered in the cooperative education program in Electrical Engineering at the University of Victoria. She is presently in the fifth and final year of the program and has her sights set on graduate school. Besides the work described in this article she has been very much involved in the use of technology to assist in the delivery of curriculum at the senior secondary level. She lives on a country property a half-hour from the University with her husband her horse and three cats. W. Alfred Keddy:is an applications programmer/analyst for the Department of Electrical and Computer Engineering at the University of Victoria. He received a BEng (1988) in Electrical Engineering and an MASc (1994) from the University of Victoria. His research interests include distributed systems image processing local area networks VLSI and DSP system design for computation and communication and human–computer interface design. Maria A. Stuchly:received an MSc in Electrical Engineering in 1962 from Warsaw Technical University and a PhD in Electrical Engineering from the Polish Academy of Sciences in 1970. Between the years of 1962 and 1970 she was with the Warsaw Technical University an Institute of the Polish Academy of Sciences. After immigrating to Canada during 1970 her first position was with the University of Manitoba. In 1976 she became employed by the Bureau of Radi

Contents and implementation of a computer laboratory for undergraduate electromagnetics are described. The laboratory consists of four 3-hour sessions covering vector calculus, Maxwell's equations (integral and differential forms), wave propagation in materials, and wave behavior at planar interfaces. Each session contains theory (in the Help file), animations (where relevant) and a quiz. The program runs on IBM compatible 486-based PCs in a Windows environment and uses the Borland C ++ 4.0 compiler.

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