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Correction: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

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Journal of neuroengineering and rehabilitation 2024年第1期21卷 71页

作者： M Encarna Micó-Amigo Tecla Bonci Anisoara Paraschiv-Ionescu Martin Ullrich Cameron Kirk Abolfazl Soltani Arne Küderle Eran Gazit Francesca Salis Lisa Alcock Kamiar Aminian Clemens Becker Stefano Bertuletti Philip Brown Ellen Buckley Alma Cantu Anne-Elie Carsin Marco Caruso Brian Caulfield Andrea Cereatti Lorenzo Chiari Ilaria D'Ascanio Bjoern Eskofier Sara Fernstad Marcel Froehlich Judith Garcia-Aymerich Clint Hansen Jeffrey M Hausdorff Hugo Hiden Emily Hume Alison Keogh Felix Kluge Sarah Koch Walter Maetzler Dimitrios Megaritis Arne Mueller Martijn Niessen Luca Palmerini Lars Schwickert Kirsty Scott Basil Sharrack Henrik Sillén David Singleton Beatrix Vereijken Ioannis Vogiatzis Alison J Yarnall Lynn Rochester Claudia Mazzà Silvia Del Din Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne UK. Department of Mechanical Engineering and Insigneo Institute for in Silico Medicine The University of Sheffield Sheffield UK. Laboratory of Movement Analysis and Measurement Ecole Polytechnique Federale de Lausanne Lausanne Switzerland. Machine Learning and Data Analytics Lab Department of Artificial Intelligence in Biomedical Engineering Friedrich-Alexander-Universität Erlangen Nürnberg Erlangen Germany. Center for the Study of Movement Cognition and Mobility Neurological Institute Tel Aviv Sourasky Medical Center Tel Aviv Israel. Department of Biomedical Sciences University of Sassari Sassari Italy. Department of Electronics and Telecommunications Politecnico di Torino Turin Italy. National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC) Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK. Robert Bosch Gesellschaft für Medizinische Forschung Stuttgart Germany. The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK. School of Computing Newcastle University Newcastle Upon Tyne UK. Barcelona Institute for Global Health (ISGlobal) Barcelona Spain. Universitat Pompeu Fabra Barcelona Catalonia Spain. CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. Insight Centre for Data Analytics University College Dublin Dublin Ireland. School of Public Health Physiotherapy and Sports Science University College Dublin Dublin Ireland. Department of Electrical Electronic and Information Engineering «Guglielmo Marconi» University of Bologna Bologna Italy. Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV) University of Bologna Bologna Italy. Grünenthal GmbH Aachen Germany. Department of Neurology University Medical Center Schleswig-Holstein Campus Kiel Kiel Germany. Sagol School of Neuroscien

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Correction for Rando et al., "Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure"

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mSystems 2022年第1期7卷 e0144721页

作者： Halie M Rando Adam L MacLean Alexandra J Lee Ronan Lordan Sandipan Ray Vikas Bansal Ashwin N Skelly Elizabeth Sell John J Dziak Lamonica Shinholster Lucy D'Agostino McGowan Marouen Ben Guebila Nils Wellhausen Sergey Knyazev Simina M Boca Stephen Capone Yanjun Qi YoSon Park David Mai Yuchen Sun Joel D Boerckel Christian Brueffer James Brian Byrd Jeremy P Kamil Jinhui Wang Ryan Velazquez Gregory L Szeto John P Barton Rishi Raj Goel Serghei Mangul Tiago Lubiana Anthony Gitter Casey S Greene Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Philadelphia Pennsylvania USA. Department of Biochemistry and Molecular Genetics University of Colorado School of Medicine Aurora Colorado USA. Center for Health AI University of Colorado School of Medicine Aurora Colorado USA. Department of Quantitative and Computational Biology University of Southern California Los Angeles California USA. Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Department of Biotechnology Indian Institute of Technology Hyderabad Sangareddy Telangana India. Biomedical Data Science and Machine Learning Group German Center for Neurodegenerative Diseases Tübingen Germany. Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Edna Bennett Pierce Prevention Research Center The Pennsylvania State University University Park Pennsylvania USA. Mercer University Macon Georgia USA. Department of Mathematics and Statistics Wake Forest University Winston-Salem North Carolina USA. Department of Biostatistics Harvard School of Public Health Boston Massachusetts USA. Georgia State University Atlanta Georgia USA. Innovation Center for Biomedical Informatics Georgetown University Medical Center Washington DC USA. St. George's University School of Medicine St. George's Grenada. Department of Computer Science University of Virginiagrid.27755.32 Charlottesville Virginia USA. Department of Bioengineering University of Pennsylvania Philadelphia Pennsylvania USA. Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Department of Clinical Sciences Lund University Lund Sweden. University of Michigan School of Medicine Ann Arbor Michigan USA. Depar

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Towards hybrid human-machine scientific information extraction

Towards hybrid human-machine scientific information extracti...

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New York Scientific data Summit (NYSDS)

作者： Roselyne Tchoua Aswathy Ajith Zhi Hong Logan Ward Kyle Chard Debra Audus Shrayesh Patel Juan de Pablo Ian Foster Department of Computer Science University of Chicago Chicago IL USA Data Science and Learning Division Argonne National Laboratory Argonne IL USA Materials Science and Engineering Division National Institute of Standards and Technology Gaithersburg MD USA Institute for Molecular Engineering University of Chicago Chicago IL USA

A wealth of valuable research data is locked within the millions of research articles published every year [1]. Extracting pertinent scientific facts (e.g., materials properties, known variants in genomics, population statistics etc.) from those articles has become an unmanageable task for researchers. This problem hinders the advancement of science, making it difficult to build on existing results, avoid unnecessary repetition, and to translate results into applications. Moreover, since these data are often loosely encoded in esoteric scientific articles intended for human consumption, they are, in general, not machine accessible. Thus, it is not often tractable to develop studies that automatically leverage this valuable information.

关键词： Polymers Task analysis Manuals data mining Temperature Crowdsourcing Informatics

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Corrigendum to 'Role of electroencephalogram oscillations and the spectrogram in monitoring anaesthesia' [BJA Education 20 (2020) 166-172]

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BJA education 2020年第7期20卷 249页

作者： M C Kim G L Fricchione E N Brown O Akeju Department of Anaesthesia Benson-Henry Institute for Mind Body Medicine Massachusetts General Hospital Harvard Medical School Boston MA USA. Department of Psychiatry Benson-Henry Institute for Mind Body Medicine Massachusetts General Hospital Harvard Medical School Boston MA USA. Department of Brain and Cognitive Science Institute for Medical Engineering and Sciences Picower Institute for Learning and Memory Institute for Data Systems and Society Massachusetts Institute of Technology Cambridge MA USA. McCance Center for Brain Health Massachusetts General Hospital Harvard Medical School Boston MA USA.

[This corrects the article DOI: 10.1016/***.2020.01.004.].

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A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters (vol 14, pg 352, 2018)

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NATURE CHEMICAL BIOLOGY 2018年第9期14卷 901-901页

作者： Piatkevich, Kiryl D. Jung, Erica E. Straub, Christoph Linghu, Changyang Park, Demian Suk, Ho-Jun Hochbaum, Daniel R. Goodwin, Daniel Pnevmatikakis, Eftychios Pak, Nikita Kawashima, Takashi Yang, Chao-Tsung Rhoades, Jeffrey L. Shemesh, Or Asano, Shoh Yoon, Young-Gyu Freifeld, Limor Saulnier, Jessica L. Riegler, Clemens Engert, Florian Hughes, Thom Drobizhev, Mikhail Szabo, Balint Ahrens, Misha B. Flavell, Steven W. Sabatini, Bernardo L. Boyden, Edward S. Media Lab Massachusetts Institute of Technology (MIT) Cambridge MA USA. Howard Hughes Medical Institute Department of Neurobiology Harvard Medical School Boston MA USA. Department of Electrical Engineering and Computer Science MIT Cambridge MA USA. Harvard-MIT Division of Health Sciences and Technology MIT Cambridge MA USA. Simons Center Data Analysis Simons Foundation New York NY USA. Department of Mechanical Engineering MIT Cambridge MA USA. Janelia Research Campus Howard Hughes Medical Institute Ashburn Virginia USA. Picower Institute for Learning & Memory and Department of Brain & Cognitive Sciences MIT Cambridge MA USA. Department of Molecular and Cellular Biology and Center for Brain Science Harvard University Cambridge MA USA. Department of Neurobiology Faculty of Life Sciences University of Vienna Wien Austria. Department of Cell Biology and Neuroscience Montana State University Bozeman Montana USA. Department of Biological Physics Eotvos University Budapest Hungary. Media Lab Massachusetts Institute of Technology (MIT) Cambridge MA USA. esb@media.mit.edu. Department of Biological Engineering MIT Cambridge MA USA. esb@media.mit.edu. MIT Center for Neurobiological Engineering MIT Cambridge MA USA. esb@media.mit.edu. Department of Brain and Cognitive Sciences MIT Cambridge MA USA. esb@media.mit.edu. MIT McGovern Institute for Brain Research MIT Cambridge MA USA. esb@media.mit.edu.

We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing proteins that simultaneously exhibit several specific properties, we can screen hundreds of thousands of proteins in a library in just a few hours, evaluating each along multiple performance axes. To demonstrate the power of this approach, we created a genetically encoded fluorescent voltage indicator, simultaneously optimizing its brightness and membrane localization using our microscopy-guided cell-picking strategy. We produced the high-performance opsin-based fluorescent voltage reporter Archon1 and demonstrated its utility by imaging spiking and millivolt-scale subthreshold and synaptic activity in acute mouse brain slices and in larval zebrafish in vivo. We also measured postsynaptic responses downstream of optogenetically controlled neurons in C. elegans.

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Detecting Respiratory Effort-Related Arousals in Polysomnographic data Using LSTM Networks

Detecting Respiratory Effort-Related Arousals in Polysomnogr...

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Computers in Cardiology (CinC)

作者： Sven Schellenberger Kilin Shi Melanie Mai Jan P Wiedemann Tobias Steigleder Björn Eskofier Robert Weigel Alexander Kölpin Chair of Electronics and Sensor Systems Brandenburg University of Technology Cottbus Germany Institute for Electronics Engineering Friedrich-Alexander University Erlangen-Nuremberg Erlangen Germany Department of Palliative Care Universitätsklinikum Erlangen Erlangen Germany Machine Learning and Data Analytics Lab Friedrich-Alexander University Erlangen-Nuremberg Erlangen Germany

ISBN: (纸本)9781728109244

To diagnose sleep disorders, hours of sleep data from lots of different physiological sensors have to be analyzed. To do so, experts have to look through all the data which is time-consuming and error-prone. Automatic detection and classification of sleep related breathing disorders and arousals would significantly simplify this task. This years Physionet/CinC Challenge deals with this topic. This paper examines the use of a Long Short-Term Memory network for automatic arousal detection. On the test set, an AUPRC score of 0.14 was achieved.

关键词： Training Feature extraction Sleep Electroencephalography Physiology Electromyography Electrocardiography

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Domain-Aware SE network for Sketch-Based Image Retrieval with Multiplicative Euclidean Margin Softmax

arXiv

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arXiv 2018年

作者： Lu, Peng Yang, Wenming Huang, Gao Guo, Guodong Lin, Hangyu Fu, Yanwei Shenzhen International Graduate School Tsinghua University Shenzhen China Shenzhen International Graduate School Department of Electronic Engineering Tsinghua University Shenzhen China Department of Automation Tsinghua University Beijing China IDL Baidu Research National Engineering Lab for Deep Learning Technology and Application Beijing China School of Data Science Fudan University Shanghai China

This paper proposes a novel approach for Sketch-Based Image Retrieval (SBIR), for which the key is to bridge the gap between sketches and photos in terms of the data representation. Inspired by channel-wise attention explored in recent years, we present a Domain-Aware Squeeze-and-Excitation (DASE) network, which seamlessly incorporates the prior knowledge of sample sketch or photo into SE module and make the SE module capable of emphasizing appropriate channels according to domain signal. Accordingly, the proposed network can switch its mode to achieve a better domain feature with lower intra-class discrepancy. Moreover, while previous works simply focus on minimizing intra-class distance and maximizing inter-class distance, we introduce a loss function, named Multiplicative Euclidean Margin Softmax (MEMS), which introduce multiplicative Euclidean margin into feature space and ensure that the maximum intra-class distance is smaller than the minimum inter-class distance. This facilitates learning a highly discriminative feature space and ensures a more accurate image retrieval result. Extensive experiments are conducted on two widely used SBIR benchmark datasets. Our approach achieves better results on both datasets, surpassing the state-of-the-art methods by a large margin. Copyright © 2018, The Authors. All rights reserved.

关键词： Large dataset

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Metadata Concepts for Advancing the Use of Digital Health Technologies in Clinical Research

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Digital Biomarkers 2019年第3期3卷 116-132页

作者： Badawy, Reham Hameed, Farhan Bataille, Lauren Little, Max A. Claes, Kasper Saria, Suchi Cedarbaum, Jesse M. Stephenson, Diane Neville, Jon Maetzler, Walter Espay, Alberto J. Bloem, Bastiaan R. Simuni, Tanya Karlin, Daniel R. School of Computer Science University of Birmingham Birmingham United Kingdom Digital Medicine and Pfizer Innovation Research Lab Early Clinical Development Pfizer Inc. CambridgeMA United States College of Computer and Information Science Northeastern University BostonMA United States Analytics Informatics and Business Intelligence Chief Digital Office Pfizer Inc. New YorkNY United States Michael J. Fox Foundation for Parkinson's Research New YorkNY United States Media Lab Massachusetts Institute of Technology CambridgeMA United States UCB Biopharma Brussels Belgium Machine Learning and Healthcare Laboratory Departments of Computer Science Statistics and Health Policy Malone Center for Engineering in Healthcare Armstrong Institute for Patient Safety and Quality Johns Hopkins University BaltimoreMD United States Biogen CambridgeMA United States Critical Path Institute TucsonAZ United States Clinical Data Interchange Standards Consortium AustinTX United States Department of Neurology Christian Albrecht University Kiel Germany James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders University of Cincinnati CincinnatiOH United States Department of Neurology Donders Institute for Brain Cognition and Behavior Radboud University Medical Center Nijmegen Netherlands Department of Neurology Gardner Center for Parkinson's Disease and Movement Disorders UC Gardner Neuroscience Institute University of Cincinnati CincinnatiOH United States Tufts University School of Medicine BostonMA United States HealthMode New YorkNY United States School of Engineering and Applied Science Aston University BirminghamB47ET United Kingdom

Digital health technologies (smartphones, smartwatches, and other body-worn sensors) can act as novel tools to aid in the diagnosis and remote objective monitoring of an individual's disease symptoms, both in clinical care and in research. Nonetheless, such digital health technologies have yet to widely demonstrate value in clinical research due to insufficient data interpretability and lack of regulatory acceptance. Metadata, i.e., data that accompany and describe the primary data, can be utilized to better understand the context of the sensor data and can assist in data management, data sharing, and subsequent data analysis. The need for data and metadata standards for digital health technologies has been raised in academic and industry research communities and has also been noted by regulatory authorities. Therefore, to address this unmet need, we here propose a metadata set that reflects regulatory guidelines and that can serve as a conceptual map to (1) inform researchers on the metadata they should collect in digital health studies, aiming to increase the interpretability and exchangeability of their data, and (2) direct standard development organizations on how to extend their existing standards to incorporate digital health technologies. The proposed metadata set is informed by existing standards pertaining to clinical trials and medical devices, in addition to existing schemas that have supported digital health technology studies. We illustrate this specifically in the context of Parkinson's disease, as a model for a wide range of other chronic conditions for which remote monitoring would be useful in both care and science. We invite the scientific and clinical research communities to apply the proposed metadata set to ongoing and planned research. Where the proposed metadata fall short, we ask users to contribute to its ongoing revision so that an adequate degree of consensus can be maintained in a rapidly evolving technology landscape. © 2019 The Author(s

关键词： Metadata

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Towards an Integrated Approach to Simultaneously Estimating the Frequency and Amplitude Modulations of SSVEP Signals from Consumer-grade EEG

arXiv

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arXiv 2018年

作者： Autthasan, Phairot Du, Xiangqian Perera, Maneesha Lamyai, Sirakorn Itthipuripat, Sirawaj Yagi, Tohru Manoonpong, Poramate Wilaiprasitporn, Theerawit Rayong Thailand Department of Psychology Vanderbilt University Tennessee and Neurosciences Graduate Program University of California California USA and Learning Institute King Mongkuts University of Technology Thonburi Bangkok Thailand BRAIN Lab IST VISTEC Rayong Thailand Embodied AI & Neurorobotics Centre for BioRobotics Msk McKinney Mller Institute University of Southern Denmark Odense MDK-5230 Denmark Yagi Lab Department of Mechanical Engineering Tokyo Institute of Technology Tokyo Japan Data Analysis and Knowledge Discovery Laboratory Department of Computer Engineering Kasetsart University Bangkok Thailand department of Computer Engineering Sirindhorn International Institute of Technology Pathum Thani Thailand

For several decades, researchers have sought several solutions for helping patients who suffer from neuromuscular disorders. One of a few promising approaches is to invent brain-computer interfaces (BCIs) in which brain signals could be used to control computers and prosthetics. Due to their high signal-to-noise ratio, steady-state visually evoked potentials (SSVEPs) or electrical brain signals that oscillate at the same frequency as the frequency of a flickering visual stimulus on the computer screen has been widely used to build BCIs. While researchers have focused on developing frequency recognition algorithms for SSVEP-based BCIs, these algorithms do not precisely predict the modulation of SSVEP amplitude, known to change as a function of stimulus luminance contrast. Thus, in the present study we aimed to develop an integrated approach to simultaneously estimating the frequency and contrast-related amplitude modulations of the SSVEP signal. To do so, we developed a behavioral task in which human participants looked at a visual target flicking at a 7.5 Hz. Critically, across different experimental conditions, the luminance contrast of the visual target could change across time in several ways (i.e., the luminance contrast remained constant, increased gradually, decreased gradually, or increased and then decreased). SSVEPs were measured via an open-source and low-cost consumer-grade EEG device, namely OpenBCI, placed at the central occipital site. Our results displayed that the filter bank canonical correlation analysis (FBCCA) performed generally well in SSVEP frequency recognition, while support vector regression (SVR) outperformed the other supervised machine learning algorithms in predicting the contrast-dependent amplitude modulations of the SSVEP signal. These results demonstrated the applicability and efficiency of our integrated method at simultaneously predicting both frequency and amplitude of visually evoked signals in the human brain, proven useful for

关键词： Brain computer interface

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Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery

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Nature neuroscience 2025年第1期28卷 216页

作者： Boyan Bonev Gonçalo Castelo-Branco Fei Chen Simone Codeluppi M Ryan Corces Jean Fan Myriam Heiman Kenneth Harris Fumitaka Inoue Manolis Kellis Ariel Levine Mo Lotfollahi Chongyuan Luo Kristen R Maynard Mor Nitzan Vijay Ramani Rahul Satijia Lucas Schirmer Yin Shen Na Sun Gilad S Green Fabian Theis Xiao Wang Joshua D Welch Ozgun Gokce Genevieve Konopka Shane Liddelow Evan Macosko Omer Ali Bayraktar Naomi Habib Tomasz J Nowakowski Helmholtz Pioneer Campus Helmholtz Zentrum München Neuherberg Germany. Physiological Genomics Biomedical Center Ludwig-Maximilians-Universität München Munich Germany. Laboratory of Molecular Neurobiology Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. The Broad Institute of MIT and Harvard Cambridge MA USA. Moleculent Stockholm Sweden. Gladstone Institute of Neurological Disease San Francisco CA USA. Gladstone Institute of Data Science and Biotechnology San Francisco CA USA. Department of Neurology University of California San Francisco San Francisco CA USA. Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA. Department of Brain and Cognitive Sciences MIT Cambridge MA USA. The Picower Institute for Learning and Memory MIT Cambridge MA USA. UCL Queen Square Institute of Neurology University College London London UK. Institute for the Advanced Study of Human Biology (WPI-ASHBi) Kyoto University Kyoto Japan. Computer Science and Artificial Intelligence Lab Massachusetts Institute of Technology Cambridge MA USA. Spinal Circuits and Plasticity Unit National Institute of Neurological Disorders and Stroke Bethesda MD USA. Institute of Computational Biology Helmholtz Center Munich - German Research Center for Environmental Health Neuherberg Germany. Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK. Department of Human Genetics University of California Los Angeles Los Angeles CA USA. Lieber Institute for Brain Development Baltimore MD USA. Department of Psychiatry Johns Hopkins School of Medicine Baltimore MD USA. Department of Neuroscience Johns Hopkins School of Medicine Baltimore MD USA. School of Computer Science and Engineering The Hebrew University of Jerusalem Jerusalem Israel. Racah Institute of Physics The Hebrew University of Jerusalem Jerusalem Israel. Faculty of Medicine The Hebrew University of Jerusalem Jerusalem Israel. Department of Biochemis

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