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Reducing over-smoothness in speech synthesis using Generative Adversarial Networks

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Reducing over-smoothness in speech synthesis using Generativ...

2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019

作者： Sheng, Leyuan Pavlovskiy, Evgeniy N. Novosibirsk State University Department of Mathematics and Mechanics Novosibirsk Russia Stream Data Analytics and Machine Learning Laboratory Novosibirsk State University Novosibirsk Russia

ISBN: (纸本)9781728144016

Speech synthesis is widely used in many practical applications. In recent years, speech synthesis technology has developed rapidly. However, one of the reasons why synthetic speech is unnatural is that it often has over-smoothness. In order to improve the naturalness of synthetic speech, we first extract the mel-spectrogram of speech and convert it into a real image, then take the over-smooth mel-spectrogram image as input, and use image-To-image translation Generative Adversarial Networks(GANs) framework to generate a more realistic mel-spectrogram. Finally, the results show that this method greatly reduces the over-smoothness of synthesized speech and is more close to the mel-spectrogram of real speech. © 2019 IEEE.

关键词： Speech synthesis

CLIP: Cheap Lipschitz Training of Neural Networks

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arXiv 2021年

作者： Bungert, Leon Raab, René Roith, Tim Schwinn, Leo Tenbrinck, Daniel Department Mathematics Friedrich-Alexander University Erlangen-Nürnberg Cauerstraße 11 Erlangen91058 Germany Machine Learning and Data Analytics Lab Friedrich-Alexander University Erlangen-Nürnberg Carl-Thiersch-Straße 2b Erlangen91052 Germany

Despite the large success of deep neural networks (DNN) in recent years, most neural networks still lack mathematical guarantees in terms of stability. For instance, DNNs are vulnerable to small or even imperceptible input perturbations, so called adversarial examples, that can cause false predictions. This instability can have severe consequences in applications which influence the health and safety of humans, e.g., biomedical imaging or autonomous driving. While bounding the Lipschitz constant of a neural network improves stability, most methods rely on restricting the Lipschitz constants of each layer which gives a poor bound for the actual Lipschitz constant. In this paper we investigate a variational regularization method named CLIP for controlling the Lipschitz constant of a neural network, which can easily be integrated into the training procedure. We mathematically analyze the proposed model, in particular discussing the impact of the chosen regularization parameter on the output of the network. Finally, we numerically evaluate our method on both a nonlinear regression problem and the MNIST and Fashion-MNIST classification databases, and compare our results with a weight regularization *** Codes 65K10, 68T07 Copyright © 2021, The Authors. All rights reserved.

关键词： Stability

Automatic Diagnosis of Myocarditis Disease in Cardiac MRI Modality using Deep Transformers and Explainable Artificial Intelligence

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arXiv 2022年

作者： Jafari, Mahboobeh Shoeibi, Afshin Ghassemi, Navid Heras, Jonathan Ling, Sai Ho Beheshti, Amin Zhang, Yu-Dong Wang, Shui-Hua Alizadehsani, Roohallah Gorriz, Juan M. Acharya, U. Rajendra Rokny, Hamid Alinejad Internship in BioMedical Machine Learning Lab The Graduate School of Biomedical Engineering UNSW Sydney SydneyNSW2052 Australia Data Science and Computational Intelligence Institute University of Granada Spain Department of Mathematics and Computer Science University of La Rioja La Rioja Spain Australia Data Analytics Lab Department of Computing Macquarie University SydneyNSW2109 Australia School of Computing and Mathematical Sciences University of Leicester Leicester United Kingdom Deakin University VIC3217 Australia Department of Psychiatry University of Cambridge United Kingdom School of Mathematics Physics and Computing University of Southern Queensland Springfield Australia BioMedical Machine Learning Lab The Graduate School of Biomedical Engineering UNSW Sydney SydneyNSW2052 Australia UNSW Data Science Hub The University of New South Wales SydneyNSW2052 Australia Research Centre Macquarie University Sydney2109 Australia

Myocarditis is a significant cardiovascular disease (CVD) that poses a threat to the health of many individuals by causing damage to the myocardium. The occurrence of microbes and viruses, including the likes of HIV, plays a crucial role in the development of myocarditis disease (MCD). The images produced during cardiac magnetic resonance imaging (CMRI) scans are low contrast, which can make it challenging to diagnose cardiovascular diseases. In other hand, checking numerous CMRI slices for each CVD patient can be a challenging task for medical doctors. To overcome the existing challenges, researchers have suggested the use of artificial intelligence (AI)-based computer-aided diagnosis systems (CADS). The presented paper outlines a CADS for the detection of MCD from CMR images, utilizing deep learning (DL) methods. The proposed CADS consists of several steps, including dataset, preprocessing, feature extraction, classification, and post-processing. First, the Z-Alizadeh dataset was selected for the experiments. Subsequently, the CMR images underwent various preprocessing steps, including denoising, resizing, as well as data augmentation (DA) via CutMix and MixUp techniques. In the following, the most current deep pre-trained and transformer models are used for feature extraction and classification on the CMR images. The findings of our study reveal that transformer models exhibit superior performance in detecting MCD as opposed to pre-trained architectures. In terms of DL architectures, the Turbulence Neural Transformer (TNT) model exhibited impressive accuracy, reaching 99.73% utilizing a 10-fold cross-validation approach. Additionally, to pinpoint areas of suspicion for MCD in CMRI images, the Explainable-based Grad Cam method was employed. © 2022, CC BY-NC-ND.

关键词： Diseases

T-Cell Receptor Optimization with Reinforcement learning and Mutation Policies for Precision Immunotherapy

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arXiv 2023年

作者： Chen, Ziqi Min, Martin Renqiang Guo, Hongyu Cheng, Chao Clancy, Trevor Ning, Xia Computer Science and Engineering The Ohio State University ColumbusOH43210 United States Machine Learning Department NEC Labs PrincetonNJ08540 United States Digital Technologies Research Centre National Research Council Canada ON Canada Department of Medicine Baylor College of Medicine HoustonTX77030 United States NEC Oncolmmunity AS Oslo Cancer Cluster Innovation Park Ullernchausséen 64 Oslo0379 Norway Biomedical Informatics The Ohio State University ColumbusOH43210 United States Translational Data Analytics Institute The Ohio State University ColumbusOH43210 United States

T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is known as TCR recognition and constitutes a key step for immune response. Optimizing TCR sequences for TCR recognition represents a fundamental step towards the development of personalized treatments to trigger immune responses killing cancerous or virus-infected cells. In this paper, we formulated the search for these optimized TCRs as a reinforcement learning (RL) problem, and presented a framework TCRPPO with a mutation policy using proximal policy optimization. TCRPPO mutates TCRs into effective ones that can recognize given peptides. TCRPPO leverages a reward function that combines the likelihoods of mutated sequences being valid TCRs measured by a new scoring function based on deep autoencoders, with the probabilities of mutated sequences recognizing peptides from a peptide-TCR interaction predictor. We compared TCRPPO with multiple baseline methods and demonstrated that TCRPPO significantly outperforms all the baseline methods to generate positive binding and valid TCRs. These results demonstrate the potential of TCRPPO for both precision immunotherapy and peptide-recognizing TCR motif discovery. © 2023, CC BY.

关键词： Reinforcement learning

Fast emulation of two-point angular statistics for photometric galaxy surveys

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arXiv 2022年

作者： Bonici, Marco Biggio, Luca Carbone, Carmelita Guzzo, Luigi INAF-IASF Milano Via Alfonso Corti 12 MilanoI-20133 Italy Data Analytics Lab Institute of Machine Learning Department of Computer Science ETH Zürich Switzerland Dipartimento di Fisica Aldo Pontremoli Università Degli Studi di Milano INFN Sez. di Milano Via Celoria 16 MilanoI-20133 Italy INAF Osservatorio Astronomico di Brera Milano Italy

We develop a set of machine-learning based cosmological emulators, to obtain fast model predictions for the C() an-gular power spectrum coefficients characterising tomographic observations of galaxy clustering and weak gravitational lensing from multi-band photometric surveys (and their cross-correlation). A set of neural networks are trained to map cosmological parameters into the coefficients, achieving a speed-up O(103) in computing the required statistics for a given set of cosmological parameters, with respect to standard Boltzmann solvers, with an accuracy better than 0.175% ( Copyright © 2022, The Authors. All rights reserved.

关键词： Surveys

MaxHiC: A robust background correction model to identify biologically relevant chromatin interactions in Hi-C and capture Hi-C experiments (vol 18, e1010241, 2022)

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PLOS COMPUTATIONAL BIOLOGY 2022年第9期18卷 e1010241页

作者： Alinejad-Rokny, Hamid Modegh, Rassa Ghavami Rabiee, Hamid R. Sarbandi, Ehsan Ramezani Rezaie, Narges Tam, Kin Tung Forrest, Alistair R. R. Harry Perkins Institute of Medical Research QEII Medical Centre and Centre for Medical Research The University of Western Australia Perth Australia Bio Medical Machine Learning Lab (BML) The Graduate School of Biomedical Engineering UNSW Sydney Sydney Australia Health Data Analytics Program AI-enabled Processes (AIP) Research Centre Macquarie University Sydney Australia Bioinformatics and Computational Biology Lab Department of Computer Engineering Sharif University of Technology Tehran Iran Center for Complex Biological Systems University of California Irvine Irvine California United States of America

Hi-C is a genome-wide chromosome conformation capture technology that detects interactions between pairs of genomic regions and exploits higher order chromatin structures. Conceptually Hi-C data counts interaction frequencies between every position in the genome and every other position. Biologically functional interactions are expected to occur more frequently than transient background and artefactual interactions. To identify biologically relevant interactions, several background models that take biases such as distance, GC content and mappability into account have been proposed. Here we introduce MaxHiC, a background correction tool that deals with these complex biases and robustly identifies statistically significant interactions in both Hi-C and capture Hi-C experiments. MaxHiC uses a negative binomial distribution model and a maximum likelihood technique to correct biases in both Hi-C and capture Hi-C libraries. We systematically benchmark MaxHiC against major Hi-C background correction tools including Hi-C significant interaction callers (SIC) and Hi-C loop callers using published Hi-C, capture Hi-C, and Micro-C datasets. Our results demonstrate that 1) Interacting regions identified by MaxHiC have significantly greater levels of overlap with known regulatory features (e.g. active chromatin histone marks, CTCF binding sites, DNase sensitivity) and also disease-associated genome-wide association SNPs than those identified by currently existing models, 2) the pairs of interacting regions are more likely to be linked by eQTL pairs and 3) more likely to link known regulatory features including known functional enhancer-promoter pairs validated by CRISPRi than any of the existing methods. We also demonstrate that interactions between different genomic region types have distinct distance distributions only revealed by MaxHiC. MaxHiC is publicly available as a python package for the analysis of Hi-C, capture Hi-C and Micro-C data.

关键词： Genomics Chromatin Genome-wide association studies Single nucleotide polymorphisms Histones Gene regulation Deoxyribonucleases Insulators

Importance of Wearable Health Monitoring Systems Using IoMT;Requirements, Advantages, Disadvantages and Challenges

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Importance of Wearable Health Monitoring Systems Using IoMT;...

International Symposium on Computational Intelligence and Informatics

作者： Fahime Khozeimeh Mohamad Roshanzamir Afshin Shoeibi Mohammad Tayarani Darbandy Roohallah Alizadehsani Hamid Alinejad-Rokny Davood Ahmadian Abbas Khosravi Saeid Nahavandi Institute for Intelligent Systems Research and Innovation (IISRI) Deakin University Victoria Australia Department of Computer Engineering Fasa University Fasa Iran Internship in Health Data Analytics Program AI-enabled Processes (AIP) Research Centre Macquarie University Sydney Australia School of Architecture Islamic Azad University Taft Taft Iran BioMedical Machine Learning Lab The Graduate School of Biomedical Engineering UNSW Sydney Sydney NSW Australia Faculty of Mathematics Statistics and Computer Sciences University of Tabriz Tabriz Iran

ISBN: (纸本)9798350398830

Providing better quality of service is one of the most important goals in medical/healthcare systems. The services provided should have features such as low latency, appropriate geographic distribution, and real-time interaction. Internet of Medical Things (IoMT) technology is one of the solutions to achieve high quality of services with these features. The wearable health monitoring systems which have become popular in the last decade are one of the foundations of achievement to these features. In this paper, the importance of wearable devices under IoMT technology is investigated. There are several reasons for using wearable devices under IoMT technology, such as reducing healthcare costs and long waiting times. Therefore, anyone working on wearable devices needs to have a general understanding of how they are designed and function. In fact, the integration of new devices to monitor and alert patients about their physical health is a promising option for improving health care systems around the world. Overcrowding in medical centers will be prevented by upgrading the facilities for the virtual presence of patients. It can also ensure real-time monitoring and reduce operating costs. In addition, it can accelerate treatment of patients and reduce the cost of investment and increase its coverage.

关键词： Costs Medical devices Wearable computers Quality of service Organizations Real-time systems Security

Optimising knee injury detection with spatial attention and validating localisation ability

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arXiv 2021年

作者： Belton, Niamh Welaratne, Ivan Dahlan, Adil Hearne, Ronan T. Hagos, Misgina Tsighe Lawlor, Aonghus Curran, Kathleen M. Science Foundation Ireland Centre for Research Training in Machine Learning School of Medicine University College Dublin Department of Radiology Mater Misericordiae University Hospital Dublin Ireland School of Electronic Engineering University College Dublin School of Computer Science University College Dublin Insight Centre for Data Analytics University College Dublin Dublin Ireland

This work employs a pre-trained, multi-view Convolutional Neural Network (CNN) with a spatial attention block to optimise knee injury detection. An open-source Magnetic Resonance Imaging (MRI) data set with image-level labels was leveraged for this analysis. As MRI data is acquired from three planes, we compare our technique using data from a single-plane and multiple planes (multi-plane). For multi-plane, we investigate various methods of fusing the planes in the network. This analysis resulted in the novel 'MPFuseNet' network and state-of-the-art Area Under the Curve (AUC) scores for detecting Anterior Cruciate Ligament (ACL) tears and Abnormal MRIs, achieving AUC scores of 0.977 and 0.957 respectively. We then developed an objective metric, Penalised Localisation Accuracy (PLA), to validate the model's localisation ability. This metric compares binary masks generated from Grad-Cam output and the radiologist's annotations on a sample of MRIs. We also extracted explainability features in a model-agnostic approach that were then verified as clinically relevant by the radiologist. Copyright © 2021, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

Uncertainty Quantification in machine learning for Engineering Design and Health Prognostics: A Tutorial

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arXiv 2023年

作者： Nemani, Venkat Biggio, Luca Huan, Xun Hu, Zhen Fink, Olga Tran, Anh Wang, Yan Zhang, Xiaoge Hu, Chao Department of Mechanical Engineering Iowa State University AmesIA50011 United States Data Analytics Lab ETH Zürich Switzerland Department of Mechanical Engineering University of Michigan Ann ArborMI48109 United States Department of Industrial and Manufacturing Systems Engineering University of Michigan-Dearborn DearbornMI48128 United States Intelligent Maintenance and Operations Systems EPFL Lausanne12309 Switzerland Scientific Machine Learning Sandia National Laboratories AlbuquerqueNM87123 United States George W. Woodruff School of Mechanical Engineering Georgia Institute of Technology AtlantaGA30332 United States Department of Industrial and Systems Engineering The Hong Kong Polytechnic University Kowloon Hong Kong New Territories Hong Kong Department of Mechanical Engineering University of Connecticut StorrsCT06269 United States

On top of machine learning (ML) models, uncertainty quantification (UQ) functions as an essential layer of safety assurance that could lead to more principled decision making by enabling sound risk assessment and management. The safety and reliability improvement of ML models empowered by UQ has the potential to significantly facilitate the broad adoption of ML solutions in high-stakes decision settings, such as healthcare, manufacturing, and aviation, to name a few. In this tutorial, we aim to provide a holistic lens on emerging UQ methods for ML models with a particular focus on neural networks and the applications of these UQ methods in tackling engineering design as well as prognostics and health management problems. Toward this goal, we start with a comprehensive classification of uncertainty types, sources, and causes pertaining to UQ of ML models. Next, we provide a tutorial-style description of several state-of-the-art UQ methods: Gaussian process regression, Bayesian neural network, neural network ensemble, and deterministic UQ methods focusing on spectral-normalized neural Gaussian process. Established upon the mathematical formulations, we subsequently examine the soundness of these UQ methods quantitatively and qualitatively (by a toy regression example) to examine their strengths and shortcomings from different dimensions. Then, we review quantitative metrics commonly used to assess the quality of predictive uncertainty in classification and regression problems. Afterward, we discuss the increasingly important role of UQ of ML models in solving challenging problems in engineering design and health prognostics. Two case studies with source codes available on GitHub are used to demonstrate these UQ methods and compare their performance in the life prediction of lithium-ion batteries at the early stage (case study 1) and the remaining useful life prediction of turbofan engines (case study 2). © 2023, CC BY.

关键词： machine learning