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Uplink-downlink duality between multiple-access and broadcast channels with compressing relays

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arXiv 2020年

作者： Liu, Liang Liu, Ya-Feng Patil, Pratik Yu, Wei the Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Kong the State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Scientific/Engineering Computing Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing100190 China The Edward S. Rogers Sr. Department of Electrical and Computer Engineering the University of Toronto the Department of Statistics and Data Science and the Machine Learning Department Carnegie Mellon University PittsburghPA15213 United States The Edward S. Rogers Sr. Department of Electrical and Computer Engineering University of Toronto 10 King’s College Road TorontoONM5S3G4 Canada

—Uplink-downlink duality refers to the fact that under a sum-power constraint, the capacity regions of a Gaussian multiple-access channel and a Gaussian broadcast channel with Hermitian transposed channel matrices are identical. This paper generalizes this result to a cooperative cellular network, in which remote access-points are deployed as relays in serving the users under the coordination of a central processor (CP). In this model, the users and the relays are connected over noisy wireless links, while the relays and the CP are connected over noiseless but rate-limited fronthaul links. Based on a Lagrangian technique, this paper establishes a duality relationship between such a multiple-access relay channel and broadcast relay channel, under the assumption that the relays use compression-based strategies. Specifically, we show that under the same total transmit power constraint and individual fronthaul rate constraints, the achievable rate regions of the Gaussian multiple-access and broadcast relay channels are identical, when either independent compression or Wyner-Ziv and multivariate compression strategies are used. The key observations are that if the beamforming vectors at the relays are fixed, the sum-power minimization problems under the achievable rate and fronthaul constraints in both the uplink and the downlink can be transformed into either a linear programming or a semidefinite programming problem depending on the compression technique, and that the uplink and downlink problems are Lagrangian duals of each other. Moreover, the dual variables corresponding to the downlink rate constraints become the uplink powers;the dual variables corresponding to the downlink fronthaul constraints become the uplink quantization noises. This duality relationship enables an efficient algorithm for optimizing the downlink transmission and relaying strategies based on the uplink. Copyright © 2020, The Authors. All rights reserved.

关键词： Linear programming

Generative Artificial Intelligence in Healthcare: Ethical Considerations and Assessment Checklist

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arXiv 2023年

作者： Ning, Yilin Teixayavong, Salinelat Shang, Yuqing Savulescu, Julian Nagaraj, Vaishaanth Miao, Di Mertens, Mayli Wei Ting, Daniel Shu Ling Ong, Jasmine Chiat Liu, Mingxuan Cao, Jiuwen Dunn, Michael Vaughan, Roger Hock Ong, Marcus Eng Sung, Joseph Jao-Yiu Topol, Eric J. Liu, Nan Centre for Quantitative Medicine Duke-NUS Medical School Singapore Singapore Centre for Biomedical Ethics National University of Singapore Singapore Singapore Wellcome Centre for Ethics and Humanities University of Oxford Oxford United Kingdom School of Medicine Imperial College London London United Kingdom Centre for Ethics Department of Philosophy University of Antwerp Antwerp Belgium Antwerp Center on Responsible AI University of Antwerp Antwerp Belgium Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore SingHealth AI Office Singapore Health Services Singapore Singapore Division of Pharmacy Singapore General Hospital Singapore Singapore Machine Learning and I-Health International Cooperation Base of Zhejiang Province Hangzhou Dianzi University Zhejiang China Artificial Intelligence Institute Hangzhou Dianzi University Zhejiang China Programme in Health Services and Systems Research Duke-NUS Medical School Singapore Singapore Department of Emergency Medicine Singapore General Hospital Singapore Singapore Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore State Key Laboratory of Digestive Disease The Chinese University of Hong Kong Hong Kong Scripps Research Translational Institute Scripps Research La Jolla CA United States Institute of Data Science National University of Singapore Singapore Singapore Centre for Quantitative Medicine Duke-NUS Medical School 8 College Road Singapore169857 Singapore

The widespread use of ChatGPT and other emerging technology powered by generative artificial intelligence (GenAI) has drawn much attention to potential ethical issues, especially in high-stakes applications such as healthcare, but ethical discussions are yet to translate into operationalisable solutions. Furthermore, ongoing ethical discussions often neglect other types of GenAI that have been used to synthesise data (e.g., images) for research and practical purposes, which resolved some ethical issues and exposed others. We conduct a scoping review of ethical discussions on GenAI in healthcare to comprehensively analyse gaps in the current research, and further propose to reduce the gaps by developing a checklist for comprehensive assessment and transparent documentation of ethical discussions in GenAI research. The checklist can be readily integrated into the current peer review and publication system to enhance GenAI research, and may be used for ethics-related disclosures for GenAI-powered products, healthcare applications of such products and beyond. © 2023, CC BY.

关键词： Artificial intelligence

Think-aloud interviews: A tool for exploring student statistical reasoning

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arXiv 2019年

作者： Reinhart, Alex Evans, Ciaran Luby, Amanda Orellana, Josue Meyer, Mikaela Wieczorek, Jerzy Elliott, Peter Burckhardt, Philipp Nugent, Rebecca Department of Statistics & Data Science Carnegie Mellon University United States Department of Mathematics and Statistics Wake Forest University United States Department of Mathematics & Statistics Swarthmore College United States Center for the Neural Basis of Cognition Machine Learning Department Carnegie Mellon University United States Department of Statistics Colby College United States

Think-aloud interviews have been a valuable but underused tool in statistics education research. Think-alouds, in which students narrate their reasoning in real time while solving problems, differ in important ways from other types of cognitive interviews and related education research methods. Beyond the uses already found in the statistics literature-mostly validating the wording of statistical concept inventory questions and studying student misconceptions-we suggest other possible use cases for think-alouds and summarize best-practice guidelines for designing think-aloud interview studies. Using examples from our own experiences studying the local student body for our introductory statistics courses, we illustrate how research goals should inform study-design decisions and what kinds of insights think-alouds can provide. We hope that our overview of think-alouds encourages more statistics educators and researchers to begin using this method. © 2019, CC BY.

关键词： Statistics

Nonparametric density estimation with adversarial losses

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arXiv 2018年

作者： Singh, Shashank Uppal, Ananya Li, Boyue Li, Chun-Liang Zaheer, Manzil Póczos, Barnabás Machine Learning Department Department of Statistics and Data Science Department of Mathematical Sciences Language Technologies Institute Carnegie Mellon University

We study minimax convergence rates of nonparametric density estimation under a large class of loss functions called "adversarial losses", which, besides classical Lp losses, includes maximum mean discrepancy (MMD), Wasserstein distance, and total variation distance. These losses are closely related to the losses encoded by discriminator networks in generative adversarial networks (GANs). In a general framework, we study how the choice of loss and the assumed smoothness of the underlying density together determine the minimax rate. We also discuss implications for training GANs based on deep ReLU networks, and more general connections to learning implicit generative models in a minimax statistical sense. Copyright © 2018, The Authors. All rights reserved.

关键词： Generative adversarial networks

Analysis of the BraTS 2023 Intracranial Meningioma Segmentation Challenge

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arXiv 2024年

作者： LaBella, Dominic Baid, Ujjwal Khanna, Omaditya McBurney-Lin, Shan McLean, Ryan Nedelec, Pierre Rashid, Arif Tahon, Nourel Hoda Altes, Talissa Bhalerao, Radhika Dhemesh, Yaseen Godfrey, Devon Hilal, Fathi Floyd, Scott Janas, Anastasia Kazerooni, Anahita Fathi Kirkpatrick, John Kent, Collin Kofler, Florian Leu, Kevin Maleki, Nazanin Menze, Bjoern Pajot, Maxence Reitman, Zachary J. Rudie, Jeffrey D. Saluja, Rachit Velichko, Yury Wang, Chunhao Warman, Pranav Adewole, Maruf Albrecht, Jake Anazodo, Udunna Anwar, Syed Muhammad Bergquist, Timothy Chen, Sully Francis Chung, Verena Conte, Gian-Marco Dako, Farouk Eddy, James Ezhov, Ivan Khalili, Nastaran Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Liu, Xinyang Mahtabfar, Aria Meier, Zeke Moawad, Ahmed W. Mongan, John Piraud, Marie Shinohara, Russell Takeshi Wiggins, Walter F. Abayazeed, Aly H. Akinola, Rachel Jakab, András Bilello, Michel de Verdier, Maria Correia Crivellaro, Priscila Davatzikos, Christos Farahani, Keyvan Freymann, John Hess, Christopher Huang, Raymond Lohmann, Philipp Moassefi, Mana Pease, Matthew W. Vollmuth, Phillipp Sollmann, Nico Diffley, David Nandolia, Khanak K. Warren, Daniel I. Hussain, Ali Fehringer, Pascal Bronstein, Yulia Deptula, Lisa Stein, Evan G. Taherzadeh, Mahsa de Oliveira, Eduardo Portela Haughey, Aoife Kontzialis, Marinos Saba, Luca Turner, Benjamin Brüßeler, Melanie M.T. Ansari, Shehbaz Gkampenis, Athanasios Weiss, David Maximilian Mansour, Aya Shawali, Islam H. Yordanov, Nikolay Stein, Joel M. Hourani, Roula Moshebah, Mohammed Yahya Abouelatta, Ahmed Magdy Rizvi, Tanvir Willms, Klara Martin, Dann C. Okar, Abdullah D'Anna, Gennaro Taha, Ahmed Sharifi, Yasaman Faghani, Shahriar Kite, Dominic Pinho, Marco Haider, Muhammad Ammar Aristizabal, Alejandro Karargyris, Alexandros Kassem, Hasan Pati, Sarthak Sheller, Micah Alonso-Basanta, Michelle Villanueva-Meyer, Javier Rauschecker, Andreas M. Nada, Ayman Aboian, Mariam Flanders, Adam E. Wiestler, Benedikt Bakas, Spyridon Ca Duke University Medical Center Department of Radiation Oncology DurhamNC United States Division of Computational Pathology Department of Pathology Laboratory Medicine Indiana University School of Medicine IndianapolisIN United States Center for Federated Learning in Medicine Indiana University IndianapolisIN United States Department of Neurosurgery Thomas Jefferson University PhiladelphiaPA United States University of California San FranciscoCA United States Yale University New HavenCT United States Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States University of Missouri ColumbiaMO United States Department of Biostatistics and Health Data Science Indiana University School of Medicine IndianapolisIN United States Children's Hospital of Philadelphia University of Pennsylvania PhiladelphiaPA United States University of Pennsylvania PhiladelphiaPA United States Helmholtz AI Helmholtz Munich Germany Department of Informatics Technical University Munich Germany TranslaTUM - Central Institute for Translational Cancer Research Technical University of Munich Germany Department of Diagnostic and Interventional Neuroradiology School of Medicine Klinikum rechts der Isar Technical University of Munich Germany San FranciscoCA United States Biomedical Image Analysis and Machine Learning Department of Quantitative Biomedicine University of Zurich Switzerland Department of Neuroradiology Technical University of Munich Munich Germany University of San Diego CA United States Cornell University IthacaNY United States Department of Radiology Northwestern University EvanstonIL United States Duke University Medical Center School of Medicine DurhamNC United States Lab Crestview Radiology Lagos Nigeria Sage Bionetworks United States McGill University MontrealQC Canada Children's National Hospital WashingtonDC United States George Washington University WashingtonDC United State

We describe the design and results from the BraTS 2023 Intracranial Meningioma Segmentation Challenge. The BraTS Meningioma Challenge differed from prior BraTS Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic and anatomical presentation and a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data from the largest multi-institutional systematically expert annotated multilabel multi-sequence meningioma MRI dataset to date, which included 1000 training set cases, 141 validation set cases, and 283 hidden test set cases. Each case included T2, T2/FLAIR, T1, and T1Gd brain MRI sequences with associated tumor compartment labels delineating enhancing tumor, non-enhancing tumor, and surrounding non-enhancing T2/FLAIR hyperintensity. Participant automated segmentation models were evaluated and ranked based on a scoring system evaluating lesion-wise metrics including dice similarity coefficient (DSC) and 95% Hausdorff Distance. The top ranked team had a lesion-wise median dice similarity coefficient (DSC) of 0.976, 0.976, and 0.964 for enhancing tumor, tumor core, and whole tumor, respectively and a corresponding average DSC of 0.899, 0.904, and 0.871, respectively. These results serve as state-of-the-art benchmarks for future pre-operative meningioma automated segmentation algorithms. Additionally, we found that 1286 of 1424 cases (90.3%) had at least 1 compartment voxel abutting the edge of the skull-stripped image edge, which requires further investigation into optimal pre-processing face anonymization steps. © 2024, CC BY.

关键词： Tumors

DeePMD-kit v2: A software package for Deep Potential models

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arXiv 2023年

作者： Zeng, Jinzhe Zhang, Duo Lu, Denghui Mo, Pinghui Li, Zeyu Chen, Yixiao Rynik, Marián Huang, Li'ang Li, Ziyao Shi, Shaochen Wang, Yingze Ye, Haotian Tuo, Ping Yang, Jiabin Ding, Ye Li, Yifan Tisi, Davide Zeng, Qiyu Bao, Han Xia, Yu Huang, Jiameng Muraoka, Koki Wang, Yibo Chang, Junhan Yuan, Fengbo Bore, Sigbjørn Løland Cai, Chun Lin, Yinnian Wang, Bo Xu, Jiayan Zhu, Jia-Xin Luo, Chenxing Zhang, Yuzhi Goodall, Rhys E.A. Liang, Wenshuo Singh, Anurag Kumar Yao, Sikai Zhang, Jingchao Wentzcovitch, Renata Han, Jiequn Liu, Jie Jia, Weile York, Darrin M. Weinan, E. Car, Roberto Zhang, Linfeng Wang, Han Laboratory for Biomolecular Simulation Research Institute for Quantitative Biomedicine Department of Chemistry and Chemical Biology Rutgers University PiscatawayNJ08854 United States AI for Science Institute Beijing100080 China DP Technology Beijing100080 China Academy for Advanced Interdisciplinary Studies Peking University Beijing100871 China HEDPS CAPT College of Engineering Peking University Beijing100871 China College of Electrical and Information Engineering Hunan University Changsha China Yuanpei College Peking University Beijing100871 China Program in Applied and Computational Mathematics Princeton University PrincetonNJ08540 United States Department of Experimental Physics Comenius University Mlynská Dolina F2 Bratislava842 48 Slovakia Center for Quantum Information Institute for Interdisciplinary Information Sciences Tsinghua University Beijing100084 China Center for Data Science Peking University Beijing100871 China ByteDance Research Zhonghang Plaza No. 43 North 3rd Ring West Road Haidian District Beijing China College of Chemistry and Molecular Engineering Peking University Beijing100871 China Baidu Inc. Beijing China Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University Zhejiang Hangzhou China Westlake AI Therapeutics Lab Westlake Laboratory of Life Sciences and Biomedicine Zhejiang Hangzhou China Department of Chemistry Princeton University PrincetonNJ08544 United States SISSA Scuola Internazionale Superiore di Studi Avanzati Trieste34136 Italy Laboratory of Computational Science and Modeling Institute of Materials École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Department of Physics National University of Defense Technology Hunan Changsha410073 China State Key Lab of Processors Institute of Computing Technology Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing China School of Electronics Engineerin

DeePMD-kit is a powerful open-source software package that facilitates molecular dynamics simulations using machine learning potentials (MLP) known as Deep Potential (DP) models. This package, which was released in 2017, has been widely used in the fields of physics, chemistry, biology, and material science for studying atomistic systems. The current version of DeePMD-kit offers numerous advanced features such as DeepPot-SE, attention-based and hybrid descriptors, the ability to fit tensile properties, type embedding, model deviation, Deep Potential - Range Correction (DPRc), Deep Potential Long Range (DPLR), GPU support for customized operators, model compression, non-von Neumann molecular dynamics (NVNMD), and improved usability, including documentation, compiled binary packages, graphical user interfaces (GUI), and application programming interfaces (API). This article presents an overview of the current major version of the DeePMD-kit package, highlighting its features and technical details. Additionally, the article benchmarks the accuracy and efficiency of different models and discusses ongoing developments. © 2023, CC BY-NC-ND.

关键词： Molecular dynamics

Nonparametric density estimation with adversarial losses 18

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Nonparametric density estimation with adversarial losses

Proceedings of the 32nd International Conference on Neural Information Processing Systems

作者： Shashank Singh Ananya Uppal Boyue Li Chun-Liang Li Manzil Zaheer Barnabás Póczos Machine Learning Department Carnegie Mellon University and Department of Statistics & Data Science Carnegie Mellon University Department of Mathematical Sciences Carnegie Mellon University Language Technologies Institute Carnegie Mellon University Machine Learning Department Carnegie Mellon University

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Modern applications of machine learning in quantum sciences

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arXiv 2022年

作者： Dawid, Anna Arnold, Julian Requena, Borja Gresch, Alexander Plodzien, Marcin Donatella, Kaelan Nicoli, Kim A. Stornati, Paolo Koch, Rouven Büttner, Miriam Okula, Robert Muñoz–Gil, Gorka Vargas–Hernández, Rodrigo A. Cervera-Lierta, Alba Carrasquilla, Juan Dunjko, Vedran Gabrié, Marylou Huembeli, Patrick van Nieuwenburg, Evert Vicentini, Filippo Wang, Lei Wetzel, Sebastian J. Carleo, Giuseppe Greplová, Eliška Krems, Roman Marquardt, Florian Tomza, Michal Lewenstein, Maciej Dauphin, Alexandre Faculty of Physics University of Warsaw Poland ICFO - Institut de Ciències Fotòniques The Barcelona Institute of Science and Technology Castelldefels Barcelona08860 Spain Center for Computational Quantum Physics Flatiron Institute New York United States Department of Physics University of Basel Switzerland Institute for Theoretical Physics Heinrich Heine University Düsseldorf Germany Institute for Quantum Inspired and Quantum Optimization Hamburg University of Technology Germany Université de Paris CNRS Laboratoire Matériaux et Phénomènes Quantiques France Machine Learning Group Technische Universität Berlin Germany BIFOLD Berlin Institute for the Foundations of Learning and Data Berlin10587 Germany Department of Applied Physics Aalto University Espoo Finland Institute of Physics Albert-Ludwig University of Freiburg Germany International Centre for Theory of Quantum Technologies University of Gdańsk Poland Department of Algorithms and System Modeling Faculty of Electronics Faculty of Electronics Telecommunications and Informatics Gdańsk University of Technology Poland Institute for Theoretical Physics University of Innsbruck Austria Department of Chemistry University of Toronto Canada Vector Institute for Artificial Intelligence MaRS Centre Toronto Canada Department of Chemistry and Chemical Biology McMaster University Hamilton Canada Barcelona Supercomputing Center Spain LIACS Leiden University Netherlands CMAP École Polytechnique France Switzerland Menten AI Inc. Palo AltoCA United States Niels Bohr Institute Copenhagen Denmark CPHT CNRS École Polytechnique Institut Polytechnique de Paris PalaiseauF-91128 France Beijing National Lab for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing China Songshan Lake Materials Laboratory Dongguan China Perimeter Institute for Theoretical Physics Waterloo Canada Kavli Institute of Nanoscience Delft University of Technology DelftNL-2600 GA Netherlands Department of

In this book, we provide a comprehensive introduction to the most recentadvances in the application of machine learning methods in quantum sciences. Wecover the use of deep learning and kernel methods in supervised, unsupervised,and reinforcement learning algorithms for phase classification, representationof many-body quantum states, quantum feedback control, and quantum circuitsoptimization. Moreover, we introduce and discuss more specialized topics suchas differentiable programming, generative models, statistical approach tomachine learning, and quantum machine learning. © 2022, CC BY.

关键词： Deep learning

Feasibility of multiomics tumor profiling for guiding treatment of melanoma

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Nature medicine 2025年 2025 May 27页

作者： Nicola Miglino Nora C Toussaint Alexander Ring Ximena Bonilla Marina Tusup Benedict Gosztonyi Tarun Mehra Gabriele Gut Francis Jacob Stephane Chevrier Kjong-Van Lehmann Ruben Casanova Andrea Jacobs Sujana Sivapatham Laura Boos Parisa Rahimzadeh Manuel Schuerch Bettina Sobottka Natalia Chicherova Shuqing Yu Rebekka Wegmann Julien Mena Emanuela S Milani Sandra Goetze Cinzia Esposito Jacobo Sarabia Del Castillo Anja L Frei Marta Nowak Anja Irmisch Jack Kuipers Monica-Andreea Baciu-Drăgan Pedro F Ferreira Franziska Singer Anne Bertolini Michael Prummer Ulrike Lischetti Rudolf Aebersold Marina Bacac Gerd Maass Holger Moch Michael Weller Alexandre P A Theocharides Markus G Manz Niko Beerenwinkel Christian Beisel Lucas Pelkmans Berend Snijder Bernd Wollscheid Viola Heinzelmann Bernd Bodenmiller Mitchell P Levesque Viktor H Koelzer Gunnar Rätsch Reinhard Dummer Andreas Wicki Department of Medical Oncology and Hematology University of Zurich and University Hospital Zurich Switzerland. NEXUS Personalized Health Technologies ETH Zurich Zurich Switzerland. SIB Swiss Institute of Bioinformatics Lausanne Switzerland. Swiss Data Science Center SDSC Zurich Switzerland. Department of Computer Science Institute of Machine Learning ETH Zurich Zurich Switzerland. Department of Dermatology University Hospital Zurich University of Zurich Zurich Switzerland. Department of Biomedicine University Hospital Basel and University of Basel Basel Switzerland. Department of Quantitative Biomedicine University of Zurich Zurich Switzerland. Department of Biology RWTH Aachen Aachen Germany. Department of Pathology and Molecular Pathology University of Zurich and University Hospital Zurich Switzerland. Department of Biology Institute of Molecular Systems Biology ETH Zurich Zurich Switzerland. Department of Health Sciences and Technology ETH Zurich Zurich Switzerland. ETH PHRT Swiss Multi-Omics Center (SMOC) ETH Zurich Zurich Switzerland. Department of Molecular Life Sciences University of Zurich Zurich Switzerland. Roche Pharmaceutical Research and Early Development Roche Innovation Center Zurich Switzerland. Department of Biosystems Science and Engineering ETH Zurich Basel Switzerland. Roche Diagnostics GmbH MWG Penzberg Germany. Department of Neurology University Hospital and University of Zurich Zurich Switzerland. Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland. Biomedical Informatics University Hospital Zurich Zurich Switzerland. AI Center at ETH Zurich ETH Zurich Zurich Switzerland. Department of Biology ETH Zurich Zurich Switzerland. Department of Medical Oncology and Hematology University of Zurich and University Hospital Zurich Switzerland. andreas.wicki@usz.ch.

There is limited evidence supporting the feasibility of using omics and functional technologies to inform treatment decisions. Here we present results from a cohort of 116 melanoma patients in the prospective, multicentric observational Tumor Profiler (TuPro) precision oncology project. Nine independent technologies, mostly at single-cell level, were used to analyze 126 patient samples, generating up to 500 Gb of data per sample (40,000 potential markers) within 4 weeks. Among established and experimental markers, the molecular tumor board selected 54 to inform its treatment recommendations. In 75% of cases, TuPro-based data were judged to be useful in informing recommendations. Patients received either standard of care (SOC) treatments or highly individualized, polybiomarker-driven treatments (beyond SOC). The objective response rate in difficult-to-treat palliative, beyond SOC patients (n = 37) was 38%, with a disease control rate of 54%. Progression-free survival of patients with TuPro-informed therapy decisions was 6.04 months, (95% confidence interval, 3.75-12.06) and 5.35 months (95% confidence interval, 2.89-12.06) in ≥third therapy lines. The proof-of-concept TuPro project demonstrated the feasibility and relevance of omics-based tumor profiling to support data-guided clinical decision-making. *** identifier: NCT06463509 .

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