The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of ***,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug ***,sim...
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The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of ***,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug ***,simultaneous delivery of the iron sources,ferroptosis inducers,drugs,and enhanced circulation carriers within matrices remains a significant ***,we designed and fabricated a defect self-assembly of metal-organic framework(MOF)-red blood cell(RBC)membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant *** and chemotherapeutic drugs are embedded in the centre of the iron(III)-based MOF at defect sites by coordination with metal clusters during a one-pot solvothermal synthesis *** RBC membrane could camouflage the nanoplatform for longer *** results demonstrate that this defect self-assembly-enabled MOF-membrane-camouflaged nanoplatform could deplete the glutathione,amplify the reactive oxidative species oxidative stress,and enable remarkable anticancer *** work provides an alternative strategy for overcoming multidrug resistance,which could regulate the fluidity and permeability of the cell membrane by ferroptosis to downregulate of P-glycoprotein protein expression by *** defect self-assembly-enabled MOF-membrane-camouflaged multi-drug-delivery nanoplatform has great therapeutic potential.
The demand for electronic devices that utilize lithium is steadily increasing in this rapidly advancing technological *** high-purity lithium in an environmentally friendly way is challenging by using commercialized *...
The demand for electronic devices that utilize lithium is steadily increasing in this rapidly advancing technological *** high-purity lithium in an environmentally friendly way is challenging by using commercialized ***,we propose the first fuel cell system for continuous lithium-ion extraction using a lithium superionic conductor membrane and advanced *** fuel cell system for extracting lithium-ion has demonstrated a twofold increase in the selectivity of Li+/Na+while producing electricity.
The inherent uncertainty of chain length in synthetic polymers casts doubt on the explicit understanding of fundamental *** study quantitatively assesses the critical role of chain-length distribution in the self-asse...
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The inherent uncertainty of chain length in synthetic polymers casts doubt on the explicit understanding of fundamental *** study quantitatively assesses the critical role of chain-length distribution in the self-assembly process,aiming to identify the point at which discernible discrepancies begin to *** blending discrete diblock copolymers of varying sizes,chain-length nonuniformity can be precisely regulated while the average composition remains *** a minor heterogeneity leads to an expansion of lattice dimension,while a phase transition occurs as the difference exceeds a ***,a transition from the Frank–Kasperσphase to the body-centered cubic phase was triggered by enlarging the size difference of the corona block,while introducing heterogeneity in the core block stabilized the hexagonally close-packed spheres.A self-consistent field theory calculation reveals that the synergy between the long and short chains effectively releases packing frustration,leading to substantial changes in the free-energy landscape and stabilizing unconventional phases otherwise *** work calls particular attention to the importance of chain-length heterogeneity and provides a robust approach to finely tuning the phase behavior and physical properties of block copolymers without altering their chemical composition.
Graphene aerogel fibers(GAFs)combine the advantages of lightweight,high specific strength and conductivity of graphene,showing great potential in multifunctional wearable ***,the fabrication and application of GAF tex...
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Graphene aerogel fibers(GAFs)combine the advantages of lightweight,high specific strength and conductivity of graphene,showing great potential in multifunctional wearable ***,the fabrication and application of GAF textiles are considerably limited by the low structural robustness of ***,we report a plastic-swelling method to fabricate GAF textiles with high performance and *** textiles were achieved by plastic-swelling,the prewoven graphene oxide fiber(GOF)tow *** near-solid plastic-swelling process allows GAFs in textiles to maintain high structural order and controllable density,and exhibit record-high tensile strength up to 103 MPa and electrical conductivity up to 1.06.104 S m−1 at the density of 0.4 g cm−*** textiles exhibit high strength of 113 MPa,multiple electrical and thermal functions,and high porosity to serve as host materials for more functional *** plastic-swelling provides a general strategy to fabricate diverse aerogel fiber textiles,paving the road for their realistic application.
Flexible and stretchable stress and strain sensing materials have gained a lot of research interest recently as the development of wearable sensors for health monitoring, motion capturing and soft robotics. In these a...
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In current in situ X-ray diffraction(XRD)techniques,data generation surpasses human analytical capabilities,potentially leading to the loss of *** techniques require human intervention,and lack the performance and ada...
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In current in situ X-ray diffraction(XRD)techniques,data generation surpasses human analytical capabilities,potentially leading to the loss of *** techniques require human intervention,and lack the performance and adaptability required for material *** the critical need for high-throughput automated XRD pattern analysis,we present a generalized deep learning model to classify a diverse set of materials’crystal systems and space *** our approach,we generate training data with a holistic representation of patterns that emerge from varying experimental conditions and crystal *** also employ an expedited learning technique to refine our model’s expertise to experimental *** addition,we optimize model architecture to elicit classification based on Bragg’s Law and use evaluation data to interpret our model’s *** evaluate our models using experimental data,materials unseen in training,and altered cubic crystals,where we observe state-of-the-art performance and even greater advances in space group classification.
Mg alloysMagnesium alloys (Mg alloys) have high corrosion rateCorrosion Rate that inhibits their application as biomaterialBiomaterials. For safe use as biomaterial, it is essential to control their corrosion ratesCor...
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With the rise of flexible wearable electronics,the demands for flexible energy storage devices have significantly increased to power other flexible electronics[1].Lithium-ion batteries(LIBs),renowned for their high en...
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With the rise of flexible wearable electronics,the demands for flexible energy storage devices have significantly increased to power other flexible electronics[1].Lithium-ion batteries(LIBs),renowned for their high energy density,long cycle lifespan,and high operating voltage,have been widely used as commercial power sources for various portable electronics[2].However,traditional LIBs,typically characterized by rigid and bulky structures,fail to meet the requirements of next-generation electronic ***.
Northern Thailand is home to several Arabica coffee-growing regions, including Mae-kampong, Teentok, Mae-lord, and Monngo Valleys, whose coffees are featured throughout this study. These coffees have distinct aromas a...
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The NH2-graphene/polyaniline composites are synthesized by in situ electropolymerization of aniline monomer and NH2-functionalized graphene ('NH2-graphene') sheets in acidic electrolyte solution by constant-po...
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