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Nanomedicine-boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma

Military Medical Research 2023年第3期10卷 403-414页

作者： Yi Lu Yue Gao Huan Yang Yong Hu Xin Li Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China Institute of Biotechnology RWTH Aachen University52074 AachenGermany DWI-Leibniz-Institute for Interactive Materials e.V. 52056 AachenGermany College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China School of Pharmacy Jiangsu UniversityZhenjiang 212013JiangsuChina Institute of Technical and Macromolecular Chemistry RWTH Aachen University52074 AachenGermany

Traditional treatments for advanced hepatocellular carcinoma(HCC),such as surgical resection,transplantation,radiofrequency ablation,and chemotherapy are unsatisfactory,and therefore the exploration of powerful therapeutic strategies is urgently *** has emerged as a promising strategy for advanced HCC treatment due to its minimal side effects and long-lasting therapeutic memory *** studies have demonstrated that icaritin could serve as an immunomodulator for effective immunotherapy of advanced ***,in 2022,icaritin soft capsules were approved by the National Medical Products Administration(NMPA)of China for the immunotherapy of advanced ***,the therapeutic efficacy of icaritin in clinical practice is impaired by its poor bioavailability and unfavorable in vivo delivery ***,functionalized drug delivery systems including stimuli-responsive nanocarriers,cell membrane-coated nanocarriers,and living cell-nanocarrier systems have been designed to overcome the shortcomings of drugs,including the low bioavailability and limited delivery efficiency as well as side *** together,the development of icaritin-based nanomedicines is expected to further improve the immunotherapy of advanced ***,we compared the different preparation methods for icaritin,interpreted the HCC immune microenvironment and the mechanisms underlying icaritin for treatment of advanced HCC,and discussed both the design of icaritin-based nanomedicines with high icaritin loading and the latest progress in icaritinbased nanomedicines for advanced HCC ***,the prospects to promote further clinical translation of icaritin-based nanomedicines for the immunotherapy of advanced HCC were proposed.

关键词： Icaritin Nanomedicine Advanced hepatocellular carcinoma Immunotherapy Clinical translation

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Bio-derived crystalline silk nanosheets for versatile macroscopic assemblies

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Nano Research 2022年第6期15卷 5538-5544页

作者： Baochang Cheng Zhouyue Lei Peiyi Wu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyCenter for Advanced Low-Dimension MaterialsDonghua UniversityShanghai 201620China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai 200433China

Silk fibroin with sophisticated hierarchical architectures from nano to macro scale shows excellent mechanical properties,good biocompatibility,and outstanding *** particular,the crystalline region in silk fibroin contributes high strength and ***,it is difficult to obtain the crystalline silk nanofibrils or nanosheets through top-down *** existing silk-derived components are mainly amorphous and sacrifice the delicate structure of the pristine ***,we report a gentle method to extract the crystalline silk nanosheet(SNS)from the degummed silk *** crystalline SNS has seven strands ofβ-sheet nanocrystal layer and shows a thickness of 2.75 *** can assemble into a membrane via a vacuum filtration process and shows high transparency,excellent thermal stability,outstanding cytocompatibility,and efficient dye ***,without external stimuli,the crystalline SNS is capable of reversibly self-assembling to well-organized *** crystalline SNS is not only a new member of silk fibroin derivatives,but also a promising assemblable unit for versatile *** anticipate this work will provide a new insight into the construction and applications of diverse two-dimensional(2D)functional silk materials.

关键词： silk fibroin hierarchical structure top-down exfoliation crystalline nanosheet reversible self-assembly

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Development of Low-cost and Robust IoT Field Station for Coffee Plantation 15

Development of Low-cost and Robust IoT Field Station for Cof...

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15th International Conference on Knowledge and Smart Technology, KST 2023

作者： Siyang, Satetha Kerdcharoen, Teerakiat Mahidol University Faculty of Science Materials Science and Engineering Program Bangkok10400 Thailand Mahidol University National Nanotechnology Center Faculty of Science and Research Network of NANOTEC Department of Physics Bangkok Thailand

ISBN: (纸本)9781665477123

Thailand has a growing demand in coffee consumption every year. Currently, the nation's capacity for producing coffee is limited, necessitating a significant amount of imports from overseas. The Arabica coffee in the north of Thailand, where the scent and taste of coffee have a distinct identity based on varied cultivation locations, has reasonably good quality. Because of the impact of the environment, it is still challenging to maintain the quality of coffee beans from season to season. Moreover, fierce competition with nearby nations like Laos and Vietnam leads to lower prices of coffee beans. This forces Thai farmers and entrepreneurs to embrace more advanced technologies in order to comprehend the environment of each plantation region and boost their level of competition. This project aims to develop a trustworthy and cost-effective IoT field monitoring solution to assist farmers in understanding the climate conditions in various plantation areas. In order to examine the relationship between the environments, the data collected by the devices can be transferred back to the public cloud server. Then, it can be used as knowledge to raise Thai coffee beans' quality to a premium level so they can continue to compete with coffee beans from other countries. © 2023 IEEE.

关键词： Cultivation

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Smart Soft materials with Multiscale Architecture and Dynamic Surface Topographies

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Accounts of materials Research 2022年第11期3卷 1115-1126页

作者： Songshan Zeng Andrew T.Smith Kuangyu Shen Luyi Sun Polymer Program Institute of Materials Science and Department of Chemical&Biomolecular EngineeringUniversity of ConnecticutStorrsConnecticut 06269United StatesPresent Address:Macao Institute of Materials Science and Engineering(MIMSE)Zhuhai MUST Science and Technology Research InstituteFaculty of Innovation EngineeringMacao University of Science and TechnologyTaipa999078MacaoChina Polymer Program Institute of Materials Science and Department of Chemical&Biomolecular EngineeringUniversity of ConnecticutStorrsConnecticut 06269United States

CONSPECTUS:Smart soft materials have one or more characteristics that can be significantly altered in convertible fashions by external stimuli,such as light,moisture,mechanical force,temperature,electric/magnetic fields,pH,and so *** materials can lead to widespread application in multifunctional smart ***,various smart soft materials have been developed under the inspiration of the intriguing multiscale structures,adaptive mechanisms,and dynamic responses of natural life,with an aim to further design advanced material systems with novel,intriguing,and unprecedented properties.

关键词： Smart properties. Dynamic

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Technoeconomically competitive four-terminal perovskite/graphenesilicon tandem solar cells with over 20% efficiency

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Journal of Energy Chemistry 2021年第12期30卷 477-483,I0011页

作者： Pengjie Hang Jingkun Cong Ge Li Lijian Zuo Chenxia Kan Biao Li Jiangsheng Xie Yuxin Yao Ying Wang Hongzheng Chen Deren Yang Xuegong Yu State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina

Perovskite/Silicon(PS) tandem solar cells have attracted much interest over recent years. However, the most popular crystalline silicon solar cells utilized in tandems require complicated fabrication processes mainly including texturization, diffusion, passivation and metallization, which takes up much cost in photovoltaic market. Here, we report a facile graphene/silicon(Gr/Si) solar cell featuring of lowtemperature( 200 °C) processing and an efficiency of 13.56%. For reducing the heat dissipation loss of high energy photon, the perovskite solar cell(PSC) with a wide band gap of 1.76 e V was adopted as the top cell for the tandem. To reduce the loss of parasitic absorption in hole transport layers(HTLs),thickness of Spiro-OMe TAD is re-optimized by compromising the efficiency and the optical transmittance of the devices. As a result, the semitransparent top perovskite solar cell yields a highest efficiency of13.35%. Furthermore, we firstly achieved a low-temperature-processed four-terminal(4-T) perovskite/graphene-silicon(PGS) heterojunction tandem solar cell with the efficiency of 20.37%. The levelized cost of electricity(LCOE) of PGS 4-T modules were estimated to a competitive price, exhibiting much greater potential for practical application compared to that of PS 4-T modules.

关键词： Perovskite/graphene-silicon tandem sola cells Low temperature Transmittance Technoeconomic competitiveness

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面向水环境中神经形态计算的聚电解质-受限流体忆阻器

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science Bulletin 2023年第8期68卷 767-769页

作者：刘越陈培宁彭慧胜 State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China

Artificial synapse devices with co-location memory and logic functions have attracted enormous attention since they are the indispensable components for neuromorphic computing systems[1].Extensive efforts have been made to mimic neural electric pulse patterns through solid-state devices like two-terminal memristors and three-terminal transistors.

关键词： neural 忆阻器聚电解质

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High-throughput design of perpendicular magnetic anisotropy at quaternary Heusler and MgO interfaces

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npj Computational materials 2023年第1期9卷 1084-1091页

作者： Sicong Jiang Kesong Yang Department of Nano and Chemical Engineering University of California San DiegoLa JollaCA 92093-0448USA Program of Materials Science and Engineering University of California San DiegoLa JollaCA 92093-0418USA Center for Memory and Recording Research University of California San DiegoLa JollaCA 92093-0401USA

Heusler alloys combined with MgO interfaces exhibit interfacial perpendicular magnetic anisotropy, making them attractive forenergy-efficient spintronic technologies. However, finding suitable Heusler/MgO heterostructures with desired properties ischallenging due to the vast range of compositions available and the complexity of interfacial structures, particularly for theemerging quaternary Heusler compounds. In this study, we report a high-throughput screening of quaternary-Heusler/MgOheterostructures for spintronic applications. By analyzing various materials descriptors, including formation energy, convex hulldistance, magnetic ordering, lattice misfit, magnetic anisotropy constant, tunnel magnetoresistance, Curie temperature, and atomicsite disordering, we identified 5 promising compounds out of 27,000 quaternary Heusler compounds. These compounds, namelyIrCrAlTi, IrCrGaTi, IrMnZnTi, OsCrAlTa, and TaGaOsCr, show potential for designing energy-efficient perpendicular magnetic tunneljunctions. This work demonstrates an efficient approach using open quantum materials repositories, effective materials descriptors,and high-throughput computational techniques to accelerate the discovery of quaternary-Heusler-based functional materials.

关键词： quaternary anisotropy magnetic

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Functionally graded structure of a nitride-strengthened Mg_(2)Si-based hybrid composite

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Journal of Magnesium and Alloys 2024年第3期12卷 1239-1256页

作者： Jeongho Yang Woongbeom Heogh Hogi Ju Sukhyun Kang Tae-Sik Jang Hyun-Do Jung Mohammad Jahazi Seung Chul Han Seong Je Park Hyoung Seop Kim Susmita Bose Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae-kyeom Kim Rigoberto CAdvincula Clodualdo Aranas Jr Sang Hoon Kim School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Mechanical Design Engineering Hanyang UniversitySeoul 04763Republic of Korea Process Research 3 Team LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea Institute of Well-Aging Medicare&Chosun University LAMP Center Chosun UniversityGwangju 61452Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Mechanical Engineering École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Material&Component Convergence R&D Center Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Graduate Institute of Ferrous&Eco Materials Technology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164USA School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA Research Institute of Advanced Manufacturing Technology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOhio 44106USA Department of Chemical and Biomolecular Engineering and Joint Institute for Advanced Materials University of TennesseeKnoxvilleTennessee 37996USA Center for Nanophase Materials and Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37830USA Department of Mechanical Engineering University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The ex-situ incorporation of the secondary SiC reinforcement,along with the in-situ incorporation of the tertiary and quaternary Mg_(3)N_(2) and Si_(3)N_(4) phases,in the primary matrix of Mg_(2)Si is employed in order to provide ultimate wear resistance based on the laser-irradiation-induced inclusion of N_(2) gas during laser powder bed *** is substantialized based on both the thermal diffusion-and chemical reactionbased metallurgy of the Mg_(2)Si–SiC/nitride hybrid *** study also proposes a functional platform for systematically modulating a functionally graded structure and modeling build-direction-dependent architectonics during additive *** strategy enables the development of a compositional gradient from the center to the edge of each melt pool of the Mg_(2)Si–SiC/nitride hybrid ***,the coefficient of friction of the hybrid composite exhibits a 309.3%decrease to–1.67 compared to–0.54 for the conventional nonreinforced Mg_(2)Si structure,while the tensile strength exhibits a 171.3%increase to 831.5 MPa compared to 485.3 MPa for the conventional *** outstanding mechanical behavior is due to the(1)the complementary and synergistic reinforcement effects of the SiC and nitride compounds,each of which possesses an intrinsically high hardness,and(2)the strong adhesion of these compounds to the Mg_(2)Si matrix despite their small sizes and low concentrations.

关键词： Laser powder bed fusion Mg_(2)Si-SiC/nitride hybrid composite Both the thermal diffusion-and chemical reaction-based metallurgy Functionally graded structure Compositional gradient Wear resistance.

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Efficient Automatic External Defibrillator Using the Slope of Hilbert Transformed ECG Signals 11

Efficient Automatic External Defibrillator Using the Slope o...

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11th International Japan-Africa Conference on Electronics, Communications, and Computations, JAC-ECC 2023

作者： Elsagheer, Samir A. Sayed, Mohammed S. Hassan, Mohsen A. Egypt-Japan University of Science and Technology Computer Science and Information Technology Alexandria21934 Egypt Aswan Universty Facurlty of Engineering Aswan Egypt Egypt-Japan University of Science and Technology Department of Electronics and Communications Engineering Alexandria21934 Egypt Zagazig University Department of Electronics and Communications Engineering Zagazig Egypt Egypt-Japan University of Science and Technology Materials science and engineering program IDE Alexandria21934 Egypt

ISBN: (纸本)9798350369328

Sudden cardiac arrest (SCA) is a life-threatening condition that demands immediate intervention. The key to survival often lies in the timely and precise analysis of electrocardiogram (ECG) signals to determine the necessity of a shock from an Automatic External Defibrillator (AED). In this paper, we address the critical need for improved accuracy in AED decision-making by presenting a novel approach that leverages the Hilbert Transform to calculate the slope of ECG signals by harnessing the analytical power of Hilbert Transformed ECG signals. By scrutinizing the heart's electrical activity through this method, we aim to enhance the AED's ability to differentiate between cases of ventricular fibrillation and other non-shockable rhythms, ultimately leading to more efficient and effective treatment. Our research explores two distinct approaches for signal analysis and correlates their findings to achieve higher precision in defibrillation decisions. To validate the effectiveness of our approach, we employ a diverse and publicly available dataset containing various heart conditions, allowing us to demonstrate the robustness of our method across a wide spectrum of cases. This study represents a significant advancement in the field of automatic external defibrillation, with the potential to save countless lives through more accurate and timely interventions. © 2023 IEEE.

关键词： Defibrillators

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Thermomechanical Characterization of Hot Surface Ignition Device Using Phenomenological Heat Flux Model

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JOURNAL OF PROPULSION AND POWER 2022年第4期38卷 656-670页

作者： Kang, Sang-Guk Ryu, Je Ir Motily, Austen H. Numkiatsakul, Prapassorn Lee, Tonghun Kriven, Waltraud M. Kim, Kenneth S. Kweon, Chol-Bum M. U.S. Army Research Laboratory Aberdeen Proving Ground MD 21005 Aerospace Engineer Weapons and Materials Research Directorate Postdoctoral Fellow Computational and Information Sciences Directorate University of Illinois at Urbana-Champaign Urbana IL 61801 Graduate Student Department of Mechanical Science and Engineering. Student Member AIAA Graduate Student Department of Materials Science and Engineering Professor Department of Mechanical Science and Engineering. Associate Fellow AIAA Professor Department of Materials Science and Engineering Mechanical Engineer Computational and Information Sciences Directorate. Member AIAA Program Manager Computational and Information Sciences Directorate. Member AIAA.

Modern aircraft compression ignition engines that seek to achieve fuel-flexible operation require ignition-assisting devices to perform reliably. Many military propulsion systems, and unmanned aircraft in particular, can use hot surface energy addition to improve engine performance. An analysis of the thermomechanical stress behavior of hot surface ignition devices is therefore critical to ensure that they can satisfy new operational requirements. In this paper, a phenomenological heat-flux model is proposed to simulate heat generation inside a heating element. Two finite element analysis models are established using the proposed heat-flux model in order to characterize the transient thermomechanical behavior of an ignition assistant: a two-dimensional (2-D) axisymmetric model with an equivalent cylindrical heating element and a three-dimensional (3-D) solid model with realistic heating element geometry. The transient behavior of the ignition assistant is investigated at standard conditions by characterizing the temperature and thermal stress inside the device for various input voltages. The effect of the nonaxisymmetric heating element geometry on the temperature and thermal stress distribution is assessed. Furthermore, the 3-D ignition assistant model is used to analyze the thermomechanical behavior of an ignition device subjected to a combustion event inside a rapid compression machine. Multiple circumferential orientations of the heating element plane relative to the spray axis are investigated. Results demonstrate that the observed maximum principal stress depends significantly on heating element orientation.

关键词： Heat Flux Stress Distribution Heat Generation Unmanned Aerial Vehicle Propulsion System Surface Energy Adaptive Mesh Refinement Fuel Injection CFD Simulation Fracture Toughness

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