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Advances of surface modification to alleviate oxidative stress-induced valve degeneration

Smart materials in Medicine 2024年第3期5卷 409-424页

作者： Peng, Pai Hu, Xinman Wang, Beiduo Wang, Xuelong Li, Shifen Kang, Yongyuan Dong, Xiaofei Yang, Xiayan Yu, Qifeng Gao, Changyou MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310058 China Center for Healthcare Materials Shaoxing Institute Zhejiang University Shaoxing312099 China Shanghai NewMed Medical Technology Co. Ltd Pudong New Area Shanghai201318 China The State Key Laboratory of Transvascular Implantation Devices Zhejiang University Hangzhou310009 China

Valvular heart disease (VHD) is a significant public health threat, with heart valve replacement surgery being the standard treatment for severe cases. Despite of advancements in artificial heart valves, their longevity remains limited due to in vivo degeneration. In consequence, there is an urgent need for effective methods to enhance the durability of artificial heart valves. Because oxidative stress (OS) is a key driving factor contributing to the failure of cardiovascular implants, this review focuses on how OS plays a critical role in heart valve degeneration, and its relationship with four major physiological mechanisms: extracellular matrix (ECM) degradation, immune response, thrombosis and lipid metabolism. By highlighting OS as a potential therapeutic target, we explore surface modification strategies that incorporate these fundamental mechanisms, refer to passive approaches including OS elimination, immunosuppression, blocking surface-degradation active groups, and anticoagulation, and active approaches such as regulating biological function recovery, and surface endothelial remodeling. These strategies aim to delay or reverse artificial valves degeneration via combining with the perspective of OS regulation, ultimately extending the prognosis period after heart valve replacement surgeries. © 2024 The Authors

关键词： Heart valve prostheses

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Unravelling the strong interplay for interfacial magnetic switching in metal-organic-based spintronics

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Journal of materials Chemistry C 2024年第11期12卷 3931-3942页

作者： Chen, Wan-Ting Yu, Li-Chung Lin, Jiu-Hua Cheng, Su Ling Shiu, Hung Wei Lai, Yu-Ling Chu, Ying-Hao Chin, Yi-Ying Wang, Jeng-Han Hsu, Yao-Jane National Synchrotron Radiation Research Center Hsinchu30076 Taiwan Graduate Program for Science and Technology of Accelerator Light Sources National Yang Ming Chiao Tung University Hsinchu30076 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Chemistry National Taiwan Normal University Taipei11677 Taiwan Department of Photonics National Cheng Kung University Tainan70101 Taiwan Department of Physics National Chung Cheng University Chiayi62102 Taiwan

Organic semiconductors are promising building blocks for multifunctional spintronics. The spinterface plays a key role in affecting the magnetic properties of the performance of spin-based devices. Herein, we reveal the strong interfacial interplay affecting the magnetic switching at the interface of the synthetic paramagnetic tris(8-hydroxyquinoline)iron(iii) (Feq3) layer on the ferromagnetic surface. In combination with synchrotron-based analysis and density functional theory (DFT) calculations, we observed that the robust magnetic interactions of the Co/Feq3 system were strongly influenced by the interfacial reaction between Co and Feq3. As the charge transferred from the contacted Co to Feq3, the central iron was reduced from Fe(iii) to Fe(ii) and hybridized with the 8-hydroxyquinoline, causing spin polarization at the interface. The reduced central Fe(ii) exhibited apparent ferromagnetic ordering after contact with the ferromagnetic Co substrate. With increasing the Feq3 layer thickness, the central Fe reverted to its original Fe(iii) state, resulting in the disappearance of ferromagnetic ordering. The thickness dependence of the Feq3 layer on the magnetic response could be used to tune the spinterface properties and thus the interfacial magnetic interplay. These findings reveal the effect of the strong interfacial redox on the spinterface and open up a promising approach for the use of metal-organic materials in oragnic spintronic devices. © 2024 The Royal Society of Chemistry.

关键词： Organometallics

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Size Effect of Magnetic Core-Shell Nanodrugs on Efficiency of Targeted Cell Uptake and Drug Delivery

SSRN

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SSRN 2024年

作者： Fei, Weiwei Guo, Jia Wang, Changchun State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Laboratory of Advanced Materials Fudan University Shanghai200433 China

Nanoparticle size plays an important role in the cellular uptake and anticancer efficacy for targeting drug delivery. However, little research has been done on the effect of nanoparticle size on the targeting agent binding, drug loading and releasing, cytotoxicity and so on. In this work, benzoboroxole modified core-shell magnetic nanoparticles (MPAn NPs) with four different sizes were fabricated by reflux-precipitation polymerization. Transferrin (Tf) was used as a targeting ligand and covalently immobilized on the nanoparticle surface through the reaction with benzoboroxole moieties. Then, therapeutic drug doxorubicin (DOX) was encapsulated in the polymer shell network via electrostatic interaction for preparation of nanodrugs (MPAn-Tf-DOX NPs). The influence of nanoparticle size on the Tf binding, drug loading and releasing, cellular uptake and in vitro cytotoxicity was systemically investigated. Increasing the nanoparticle size facilitated the Tf binding and thus resulted in an enhanced intracellular internalization within a certain size range. Besides, all four kinds of nanoparticles showed a high DOX encapsulating efficiency (> 80%), and large nanoparticle size was favorable for a faster drug release. Moreover, MPA3-Tf-DOX NPs with suitable particle size (422 nm) and Tf density (202 mg/g NPs) exhibited the best cancer cell killing performance evaluated by Tf-mediated endocytosis experiments. This study investigated the combination effects of nanoparticle size on the targeting agent modification, drug loading, cellular uptake and therapeutic efficacy, which provided the fundamental data for the nanocarrier design through structural regulation to enhance targeted delivery and anticancer applications. © 2024, The Authors. All rights reserved.

关键词： Cytotoxicity

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Endotaxial Polytype engineering: Enhancement of Incommensurate Charge Density Waves in TaS2

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1646-1647页

作者： Sung, Suk Hyun Kezer, Pat Agarwal, Nishkarsh Goh, Yin Min Schnitzer, Noah Baggari, Ismail El Sun, Kai Kourkoutis, Lena F. Heron, John T. Hovden, Robert Department of Materials Science and Engineering University of Michigan Ann Arbor MI United States Department of Physics University of Michigan Ann Arbor MI United States Department of Materials Science and Engineering Cornell University Ithaca NY United States Rowland Institute at Harvard University Cambridge MA United States Kavli Institute at Cornell for Nanoscale Science Ithaca NY United States School of Applied and Engineering Physics Cornell University Ithaca NY United States Applied Physics Program University of Michigan Ann Arbor MI United States

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Editorial

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European Physical Journal E 2024年第6期47卷 1-4页

作者： Andelman, David Di Meglio, Jean-Marc Safinya, Cyrus R. Tel Aviv University School of Physics and Astronomy Ramat Aviv Tel Aviv69978 Israel MSCmed Lab Université Paris Cité Paris75006 France Materials Department Molecular Cellular and Developmental Biology Department Department of Physics and Biomolecular Science & ampEngineering Program University of California Santa Barbara Santa BarbaraCA93106 United States

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Synthesis and characterization of chicken feather derived rachis fiber-bamboo particulate hybrid reinforced epoxy composites for sustainable structural applications

Journal of Responsible Production and Consumption

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Journal of Responsible Production and Consumption 2024年第1期1卷 1-17页

作者： Isiaka Oluwole Oladele Omoye Oseyomon Odemilin Samson Oluwagbenga Adelani Anuoluwapo Samuel Taiwo Olajesu Favor Olanrewaju Department of Metallurgical and Materials Engineering Federal University of Technology Akure Akure Nigeria and Department of Chemical and Mining Engineering University of Johannesburg Johannesburg South Africa Department of Metallurgical and Materials Engineering Federal University of Technology Akure Akure Nigeria Department of Materials Science and Engineering Program University of Colorado at Boulder Boulder Colorado USA Department of School of Aerospace Transport and Manufacturing School of Aerospace Transport and Manufacturing Cranfield University Cranfield UK Department of Materials Science and Engineering Iowa State University Ames Iowa USA

Purpose This paper aims to reduce waste management and generate wealth by investigating the novelty of combining chicken feather fiber and bamboo particles to produce hybrid biocomposites. This is part of responsible production and sustainability techniques for sustainable development goals. This study aims to broaden animal and plant fiber utilization in the sustainable production of epoxy resins for engineering applications. Design/methodology/approach This research used two reinforcing materials [chicken feather fiber (CFF) and bamboo particles (BP)] to reinforce epoxy resin. The BPs were kept constant at 6 Wt.%, while the CFF was varied within 3–15 Wt.% in the composites to make CFF-BP polymer-reinforced composite (CFF-BP PRC). The mechanical experiment showed a 21% reduction in densities, making the CFF-BP PRC an excellent choice for lightweight applications. Findings It was discovered that fabricated composites with 10 mm CFF length had improved properties compared with the 15 mm CFF length and pristine samples, which confirmed that short fibers are better at enhancing randomly dispersed fibers in the epoxy matrix. However, the ballistic properties of both samples matched. There is a 40% increase in tensile strength and a 54% increase in flexural strength of the CFF-BP PRC compared to the pristine sample. Originality/value According to the literature review, to the best of the authors’ knowledge, this is a novel study of chicken fiber and bamboo particles in reinforcing epoxy composite.

关键词： Green composite Sustainability Rachis fiber Bamboo particles Clean environment

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A Polymer System with Ultra-High Molecular Potential Energy

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Advanced Functional materials 2025年

作者： Wang, Yan-Jie Ni, Jia-Yu Gao, Fan Cui, Chunyan Xu, Ziyang Zheng, Si Yu Sun, Hanshu He, Yang Zhao, Yiping Wu, Zi Liang Liu, Wenguang Chen, Li State Key Laboratory of Separation Membranes and Membrane Processes School of Materials Science and Engineering Tiangong University Tianjin300387 China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin300350 China College of Materials Science and Engineering Zhejiang University of Technology Hangzhou310014 China Cangzhou Institute of Tiangong University Cangzhou061000 China Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China

In contrast to small molecules, macromolecules exhibit distinctive characteristics due to their higher potential energy (EP). These include elevated viscosity, enhanced tensile strength, cohesiveness, and stability. The EP of macromolecules can be modulated through the design of side groups, but this approach may also alter chemical properties. This study introduces an α-methylation strategy that significantly enhances EP without modifying the structure of these side groups. This increase in EP induces a transition in the rheological behavior of polymer systems from a rubbery to a glassy state. Concurrently, it improves hygrothermal tolerance without changing dynamic bond groups. The application of this ultra-high EP strategy results in substantial enhancements in traditional acrylic adhesives: a 1500% increase in adhesion strength and a 33200% rise in adhesion modulus when exposed to hot water. Polymer is endowed with a shape memory function due to ultra-high EP. With the dual interface locking of this function, the adhesion strength can be increased by 70%. This ultra-high EP strategy provides a possible explanation for the origin of vitrification in polymeric systems. © 2025 Wiley-VCH GmbH.

关键词： Macromolecules

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The Production of Soluble Regenerated Silk Fibroin Powder with High Molecular Weight and Silk Protein-Based materials

SSRN

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SSRN 2024年

作者： Shao, Zhengzhong Gu, Kai Tong, Yixuan Mi, Ruixin Leng, Siyan Huang, Hanwen Yao, Jingrong Chen, Xin State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Laboratory of Advanced Materials Fudan University Shanghai200433 China

The aqueous solution of regenerated silk fibroin (RSF) is considered as the raw material to produce various silk protein-based materials, including hydrogel, film, rod and fiber, etc. with significant mechanical properties. However, the aqueous solution of RSF is usually unstable within a few days or even hours in terms of its essential properties, because the conformation of the RSF chain would spontaneously transfer from random coil to β-sheet in water. In this work, we developed a way to harvest the RSF powder through an optimized spray drying method via rapid drying at a relatively low temperature. It was demonstrated that no severe degradation and conformational transition of the RSF chain occurred during powder preparation, and the RSF powder exhibited remarkable solubility in water and long stability at room temperature. Importantly, there are no obvious differences in the mechanical properties of the silk protein-based materials made from the aqueous solution from the spray-dried RSF powder (Sp-RSF) and from fresh RSF solution. Indeed, such amorphous Sp-RSF powder, in which the protein chain was dominated by random coil conformation, not only promised as the raw material for large-scale silk protein-based products in various applications but also provided the basis for fabricating bulk silk protein materials via the untraditional processing of silk fibroin, such as molding with the help of heat and moisture. © 2024, The Authors. All rights reserved.

关键词： Proteins

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Scalable Arrays of Pneumatic Sensors for Multitouch Soft Skins

Scalable Arrays of Pneumatic Sensors for Multitouch Soft Ski...

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IEEE International Conference on Soft Robotics (RoboSoft)

作者： Xiaoran Zha Saurabh Jadhav Iman Adibnazari Yichen Zhai Michael T. Tolley Mechanical and Aerospace Engineering Department Materials Science and Engineering Program University of California San Diego San Diego CA USA

Soft robotic systems necessitate accurate and reliable sensor readings to detect environmental interactions and provide precise feedback for control. To be effective, soft sensors must exhibit sensitivity, reliability, repeatability, and flexibility. A versatile approach to sensing for soft robots uses soft air-filled deformable structures with pressure transducers to detect pressure changes due to applied forces. However, the common approach of employing one pressure transducer per sensing chamber limits the scalability of this sensing approach (e.g., for large arrays able to detect touch at many locations). Here we present an approach to the design of pneumatic sensor arrays that reduces the number of required transducers. We develop mathematical models to analyze the pressure variations within the sensor arrays in response to applied forces at various locations. We also introduce a method of rapidly fabricating sensor arrays by laminating elastomeric sheets patterned with laser-cut sacrificial layers. We then use our model to optimize the geometry of the sensors and evaluate the results experimentally. Finally, we devise an algorithm capable of determining the location of multiple touches anywhere within the sensor array. This work represents a step towards the practical application of soft pneumatic sensors, particularly for robotic sensing and haptic devices, enhancing the safety of human-robot interactions.

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In vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing

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Bioactive materials 2023年第10期28卷 448-466页

作者： Vasanth C.Shunmugasamy Marwa AbdelGawad Muhammad Umar Sohail Talal Ibrahim Talha Khan Thomas Daniel Seers Bilal Mansoor Mechanical Engineering Program Texas A&M University at QatarEducation CityDohaQatar Department of Mechanical Engineering Texas A&M University3123 TAMUCollege StationTX 77843USA Proteomics Core Weill Cornell MedicineEducation CityDohaQatar Department of Surgery Division of Orthopedic SurgerySidra MedicineDohaQatar Clinical Orthopedic Surgery Weill Cornell MedicineEducation CityDohaQatar Petroleum Engineering Program Texas A&M University at QatarEducation CityDohaQatar Department of Materials Science and Engineering Texas A&M University3003 TAMUCollege StationTX 77843USA

Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use as biodegradeable implants, it is essential to control their corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between the α-Mg matrix and secondary precipitates exists which results in increased corrosion rate. To address this challenge, we engineered the microstructure of a biodegradable Mg-Zn-RE-Zr alloy by friction stir processing (FSP), improving its corrosion resistance and mechanical properties simultaneously. The FS processed alloy with refined grains and broken and uniformly distributed secondary precipitates showed a relatively uniform corrosion morphology accompanied with the formation of a stable passive layer on the alloy surface. In vivo corrosion evaluation of the processed alloy in a small animal model showed that the material was well-tolerated with no signs of inflammation or harmful by-products. Remarkably, the processed alloy supported bone until it healed till eight weeks with a low in vivo corrosion rate of 0.7 mm/year. Moreover, we analyzed blood and histology of the critical organs such as liver and kidney, which showed normal functionality and consistent ion and enzyme levels, throughout the 12- week study period. These results demonstrate that the processed Mg-Zn-RE-Zr alloy offers promising potential for osseointegration in bone tissue healing while also exhibiting controlled biodegradability due to its engineered microstructure. The results from the present study will have profound benefit for bone fracture management, particularly in pediatric and elderly patients.

关键词： Biodegradable magnesium Bone healing Friction stir processing Microstructure Corrosion resistance

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