Bacteriorhodopsin is a well-known photoresponsive protein in the cell membrane of Halobacterium salinarum and exists in the patch called the purple membrane(PM).This letter reports,for the first time,its new function ...
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Bacteriorhodopsin is a well-known photoresponsive protein in the cell membrane of Halobacterium salinarum and exists in the patch called the purple membrane(PM).This letter reports,for the first time,its new function as a natural non-fouling substance for resisting cell *** cells such as murine preosteocytes MC3T3-E1 were seeded on the PM film.A significant resistance to cell adhesion on the film was found.
Defects in liquid crystals are used to model topological entities ranging from Skyrmions in high-energy physics to early-universe cosmic strings, as well as find practical applications in self-assembly of diffraction ...
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Defects in liquid crystals are used to model topological entities ranging from Skyrmions in high-energy physics to early-universe cosmic strings, as well as find practical applications in self-assembly of diffraction gratings and in scaffolding of plasmonic nanoparticles, but they are hard to control and organize into three-dimensional lattices. We laterally scan focused laser beams to produce periodic arrays of twist-stabilized defects forming either linear (fingers) or axially symmetric (torons) configurations in partially polymerizable liquid crystal films. Polymerization allows for stabilization of these structures and the formation of three-dimensional arrays of defects by stacking of the thin cholesteric films on top of each other. In the process of fabrication of such arrays, we polymerize the liquid crystal film with an array of torons or fingers and then sequentially produce and photopolymerize new liquid crystal layers on top of it, thus obtaining a three-dimensional structure of twist-stabilized defects in a layer-by-layer fashion. Templating by the polymerized layer spontaneously yields ordered organization of fingers and torons in the new cholesteric layer, thus enabling a three-dimensional ordered structure of defects. Nondestructive three-dimensional imaging of director fields by use of three-photon excitation fluorescence polarizing microscopy reveals the nature of topological singularities and physical underpinnings behind the observed templating effect. Three-dimensional patterning of defects templates the self-assembly of plasmonic nanoparticles into individual singularities and their arrays, laying the groundwork for potential applications in nanophotonics, plasmonics, metamaterial fabrication, and nanoscale energy conversion.
The research on aggregation-induced emission(AIE)has drawn increasing interests in the past *** the efforts scientists paid,a variety of AIE systems have been developed,among which the tetraphenylethelene and silole d...
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The research on aggregation-induced emission(AIE)has drawn increasing interests in the past *** the efforts scientists paid,a variety of AIE systems have been developed,among which the tetraphenylethelene and silole derivatives are the most *** of new AIE systems could further enrich the AIE molecules and promote the development of AIE *** this communication,we prepared a new AIE system based on1,2,4,6-tetraphenylpyridinium ions according to the restriction of intramolecular rotation *** molecules could be facilely synthesized via one-step and one-pot *** ionic AIE-active molecules could find wide application in sensing and optoelectronic areas.
Ferromagnetic Ising systems with competing interactions are considered in the presence of a random field. We find that in three space dimensions the ferromagnetic phase is disordered by a random field which is conside...
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Ferromagnetic Ising systems with competing interactions are considered in the presence of a random field. We find that in three space dimensions the ferromagnetic phase is disordered by a random field which is considerably smaller than the typical interaction strength between the spins. This is the result of a novel disordering mechanism triggered by an underlying spin-glass phase. Calculations for the specific case of the long-range dipolar LiHoxY1−xF4 compound suggest that the above mechanism is responsible for the peculiar dependence of the critical temperature on the strength of the random field and the broadening of the susceptibility peaks as temperature is decreased, as found in recent experiments by Silevitch et al.. [Nature (London) 448, 567 (2007)]. Our results thus emphasize the need to go beyond the standard Imry-Ma argument when studying general random-field systems.
This article was originally published online on 29 September 2014 with an error in the journal title of Ref. 36. The corrected reference appears below:
This article was originally published online on 29 September 2014 with an error in the journal title of Ref. 36. The corrected reference appears below:
The A-site ordered perovskite (AA3′)B4O12 can accommodate transition metals on both A′ and B sites in the crystal structure. Because of this structural feature, it is possible to have narrow-band electrons interacti...
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The A-site ordered perovskite (AA3′)B4O12 can accommodate transition metals on both A′ and B sites in the crystal structure. Because of this structural feature, it is possible to have narrow-band electrons interacting with broadband electrons from different sublattices. Here we report a new A-site ordered perovskite (CaCu3)Ir4O12 synthesized under high pressure. The coupling between localized spins on Cu2+ and itinerant electrons from the Ir-O sublattice makes Kondo-like physics take place at a temperature as high as 80 K. Results from the local density approximation calculation have confirmed the relevant band structure. The magnetization anomaly found at 80 K can be well rationalized by the two-fluid model.
Splicing factor 3b subunit 1, SF3B1 contributes to the formation of ring sideroblasts (RS) in Myelodysplastic syndromes (MDS). Abnormalities in iron trafficking have been implicated in the pathogenesis of refractory a...
Splicing factor 3b subunit 1, SF3B1 contributes to the formation of ring sideroblasts (RS) in Myelodysplastic syndromes (MDS). Abnormalities in iron trafficking have been implicated in the pathogenesis of refractory anemia with RS (RARS) and RARS with thrombocytosis (RARS-T). In RARS/-T, light microscopy and traditional iron profiles do not accurately reflect intracellular iron status. SF3B1 mutant (MUT, n=25) and wild type (WT, n=8) RARS patients (pts) have no difference in iron profiles (ferritin (ng/mL): 1244 ng/mL ± 926 vs 1215 ± 1065; total iron binding capacity (ug/dL): 252 ± 80 vs 234 ± 50). We previously reported distinct differences in iron distribution between SF3B1 MUT and WT pts based on transmission electron microscopy (EM). Coarse iron deposits are present in the mitochondria of SF3B1 MUT while smaller iron deposits are found in WT. We hypothesized that SF3B1 mutations affect distinct downstream targets leading to the iron phenotype differences in MUT vs WT. To study these differences, we performed a series of EM, flow cytometric (FC) and RNA-sequencing experiments. Quantification of iron by scoring deposits of iron/grid showed higher amount of mitochondrial iron in MUT vs WT by EM. We used a FC based-approach to quantify the cytoplasmic and mitochondrial iron utilizing the properties of two cell-permeant compounds (calcein-AM and rhodamine-B) being retained in the cytoplasm and the mitochondria, respectively. In keeping with our EM studies, we found that SF3B1 MUT have a higher % of rhodamine-B+ cells compared to WT RARS pts and healthy subjects (77 vs 19 vs 0.87%; n=6) indicating that MUT accumulates more mitochondrial iron compared to WT. Cytoplasmic iron was not different between MUT and WT (57 vs 43%) but higher than healthy subjects (1.5%; p=0.02), suggesting that MUT store more mitochondrial iron compared to WT pts. Sf3b1+/- mice also showed higher iron stores in the mitochondria rather than in the cytosplasm (85 vs 16%; n=4). To understand the
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