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Zwitterionic peptides:Tunable next-generation stealth nanoparticle modifications

Bioactive materials 2023年第9期27卷 113-124页

作者： Clyde Overby Soomin Park Austin Summers Danielle S.W.Benoit Department of Biomedical Engineering University of Rochester RochesterNYUSA Center for Musculoskeletal Research University of RochesterRochesterNYUSA Department of Biology University of Rochester RochesterNYUSA Department of Biology Duquesne UniversityPAUSA Department of Chemical Engineering University of RochesterRochesterNYUSA Materials Science Program University of RochesterRochesterNYUSA Knight Campus for Accelerating Scientific Impact Department of BioengineeringUniversity of OregonEugeneORUSA

Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity through surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charges along the sequence(charge motif).These findings pave the way for developing tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charge motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investigating relationships between protein corona and biological ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.

关键词： Nanoparticles Protein corona Surface functionalization Peptide design Cellular uptake

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Cytometry in the Short-Wave Infrared

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ACS Nano 2024年第28期18卷 18534-18547页

作者： Liu, Te-I Wang, Jhih-Shan Nguyen, Ai-Phuong Raabe, Marco Quiroz Reyes, Carlos Jose Lin, Chih-Hsin Lin, Ching-Wei Institute of Atomic and Molecular Sciences Academia Sinica Taipei City106319 Taiwan Department of Materials Science and Engineering National Taiwan University Taipei City106319 Taiwan Department of Physics University of Stuttgart Stuttgart70174 Germany Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Ph.D. Program in Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University New Taipei City235603 Taiwan

Cytometry plays a crucial role in characterizing cell properties, but its restricted optical window (400-850 nm) limits the number of stained fluorophores that can be detected simultaneously and hampers the study and utilization of short-wave infrared (SWIR;900-1700 nm) fluorophores in cells. Here we introduce two SWIR-based methods to address these limitations: SWIR flow cytometry and SWIR image cytometry. We develop a quantification protocol for deducing cellular fluorophore mass. Both systems achieve a limit of detection of ∼0.1 fg cell-1 within a 30 min experimental time frame, using individualized, high-purity (6,5) single-wall carbon nanotubes as a model fluorophore and macrophage-like RAW264.7 as a model cell line. This high-sensitivity feature reveals that low-dose (6,5) serves as an antioxidant, and cell morphology and oxidative stress dose-dependently correlate with (6,5) uptake. Our SWIR cytometry holds immediate applicability for existing SWIR fluorophores and offers a solution to the issue of spectral overlapping in conventional cytometry. © 2024 The Authors. Published by American Chemical Society.

关键词： Oxygen

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An expandable chamber for safe brain retraction: new technologies in the field of transcranial endoscopic surgery

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2023年第4期24卷 326-335页

作者： Elena ROCA Anna GOBETTI Giovanna CORNACCHIA Oscar VIVALDI Barbara BUFFOLI Giorgio RAMORINO Head and Neck Department NeurosurgeryIstituto Ospedaliero Fondazione Poliambulanza25124 BresciaItaly Technology for Health PhD Program University of Brescia25124 BresciaItaly Materials Science and Technology at Department of Mechanical and Industrial Engineering University of Brescia25123 BresciaItaly Metallurgy at Department of Mechanical and Industrial Engineering University of Brescia25123 BresciaItaly Anatomy and Physiopathology Division Department of Clinical and Experimental SciencesUniversity of Brescia25123 BresciaItaly

Neurosurgery is a highly specialized field:it often involves surgical manipulation of noble structures and cerebral retraction is frequently necessary to reach deep-seated brain *** are still no reliable methods preventing possible retraction *** objective of this study was to design work chambers well suited for transcranial endoscopic surgery while providing safe retraction of the surrounding brain *** chamber is designed to be inserted close to the intracranial point of interest;once it is best placed it can be *** should guarantee an appreciable workspace similar to that of current neurosurgical *** experimental aspect of this study involved the use of a force sensor to evaluate the pressures exerted on the brain tissue during the retraction *** pterional craniotomy,pressure measurements were made during retraction with the use of a conventional metal spatula with different *** that,although the force values necessary for retraction and exerted on the spatula by the neurosurgeon are the same,the local pressure exerted on the parenchyma at the edge of the spatula at different inclinations varied greatly.A new method of cerebral retraction using a chamber retractor(CR)has been designed to avoid any type of complication due to spatula edge overpressures and to maintain acceptable pressure values exerted on the parenchyma.

关键词： Brain retraction Spatula Brain retractor design Brain retraction injury Retraction complication Transcranial endoscopic surgery

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Atomistic observation of in situ fractured surfaces at a V-doped WC–Co interface

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Journal of materials science & Technology 2022年第15期110卷 103-108页

作者： Congying Xiang Min Shen Chongze Hu Lok Wing Wong Hongbo Nie Huasheng Lei Jian Luo Jiong Zhao Zhiyang Yu State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China Department of NanoEngineering Program of Materials Science and EngineeringUniversity of California San DiegoLa JollaCA 92093United States Department of Applied Physics Hong Kong Polytechnic UniversityHong Kong 999077China School of Materials Science and Engineering Baise UniversityBaise 533000China

*** Cemented carbides are composites of WC ceramic phases and metallic Co binders that endow them with superior hardness and excellent *** metals are widely used as metal cutting and rock drilling tools[1,2].Their hardness is believed to be inversely proportional to the sizes of WC grains^([3]).Grain growth inhibitors are widely employed to achieve smaller grain sizes.

关键词： toughness grain sizes

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Self-Attenuating Graphene-Based Antennas Utilizing Polyvinylidene Fluoride (PVDF) Substrates

Self-Attenuating Graphene-Based Antennas Utilizing Polyvinyl...

引用

Microwave and Antenna Symposium (IMAS), International

作者： Josef Frankhouse Evans Addo-Mensah Uche Wejinya Department of Mechanical Engineering University of Arkansas - Fayetteville Materials Science and Engineering Graduate Program University of Arkansas - Fayetteville

ISBN: (数字)9798350356359

ISBN: (纸本)9798350356366

In this study, a Terahertz (THz) band antenna which can regulate its own resonant frequency without the requirement of manual adjustment is simulated. A polyvinylidene fluoride (PVDF) substrate is applied onto a rectangular graphene patch antenna. With a voltage potential applied onto the PVDF, the patch antenna can attenuate its frequency by physically changing the shape of the antenna, and in turn its resonant frequency. These antennas are within a 0.1 THz band between 1.32 THz to 1.22 THz measured from a radial bend of a flat surface to r = 75 μm, fitting into a return loss (S11) above -30 dB. Although the return loss did not show consistency, the resonating frequency shifted at a linear rate relative to the cylindrical bending.

关键词： Microwave antennas Patch antennas Graphene Resonant frequency Prototypes Bandwidth Bending Loss measurement Substrates Terahertz communications

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Fully rubbery synaptic transistors made out of all-organic materials for elastic neurological electronic skin

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Nano Research 2022年第2期15卷 758-764页

作者： Hyunseok Shim Seonmin Jang Jae Gyu Jang Zhoulyu Rao Jong-ln Hong Kyoseung Sim Cunjiang Yu Materials Science and Engineering Program University of HoustonHoustonTX 77204 USA Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Mechanical Engineering University of HoustonHoustonTX 77204 USA Department of Biomedical Engineering University of HoustonHoustonTX 77204USA Department of Electrical and Computer Engineering University of HoustonHoustonTX 77204 USA Texas Center for Superconductivity University of HoustonHoustonTX 77204USA

Neurologic function implemented soft organic electronic skin holds promise for wide range of applications,such as skin prosthetics,neurorobot,bioelectronics,human-robotic interaction(HRI),***,we report the development of a fully rubbery synaptic transistor which consists of all-organic materials,which shows unique synaptic characteristics existing in biological *** synaptic characteristics retained even under mechanical stretch by 30%.We further developed a neurological electronic skin in a fully rubbery format based on two mechanoreceptors(for synaptic potentiation or depression)of pressure-sensitive rubber and an all-organic synaptic *** converting tactile signals into Morse Code,potentiation and depression of excitatory postsynaptic current(EPSC)signals allow the neurological electronic skin on a human forearm to communicate with a robotic *** collective studies on the materials,devices,and their characteristics revealed the fundamental aspects and applicability of the all-organic synaptic transistor and the neurological electronic skin.

关键词： synaptic transistor stretchable electronic skin all-organic

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Highly stable hybrid single-micelle:A universal nanocarrier for hydrophobic bioimaging agents

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Nano Research 2022年第5期15卷 4582-4589页

作者： Qiaoyu Zhou Tiancong Zhao Mengli Liu Dongrui Yin Minchao Liu Ahmed AElzatahry Fan Zhang Dongyuan Zhao Xiaomin Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Materials Science and Technology Program College of Arts and SciencesQatar UniversityPO Box 2713DohaQatar

As the first-line technology,micelles play a pivotal role in in vivo delivery of theranostic agents because of their high biocompatibility and ***,in complex physiological environments(extreme dilution,pH,and oxidation or reduction,etc.),they generally suffer from structural instability and insufficient protection for encapsulated *** is urgent to reinforce the structural stability of the micelles at the single-micelle *** using the FDA-approved Pluronic F127 surfactants and indocyanine green(ICG)bioimaging agents as model,herein,we propose the silane-crosslinking assisted strategy to reinforce the structural stability of the *** from the traditional silane hydrolysis under the harsh experimental conditions(acidic,alkaline,and high temperature hydrothermal,etc.),the ICG loaded F127@SiO_(2) hybrid single-micelles(ICG@H-micelles)with controllable sizes(15-35 nm)are synthesized at neutral pH and room temperature,which is crucial for the maintenance of the physicochemical properties of the encapsulated *** the ultra-thin SiO_(2)(<5 nm)at hydrophilic layer of the single-micelle,the structural and fluorescence stability of ICG@H-micelles are much higher than the conventional micelle(ICG@micelles)in the simulated physiological environments of dilution,oxidation or reduction,and low *** of the high structural and fluorescence stability,the ICG@H-micelles also exhibit longer duration time in the tumor and gastrointestinal tract bioimaging.

关键词： micelle SiO_(2) inorganic-organic hybrid mesoporous material bioimaging

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A physics-constrained deep learning surrogate model of the runaway electron avalanche growth rate

arXiv

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arXiv 2024年

作者： Arnaud, Jonathan Mark, Tyler McDevitt, Christopher J. Nuclear Engineering Program Department of Materials Science and Engineering University of Florida GainesvilleFL32611 United States

A surrogate model of the runaway electron avalanche growth rate in a magnetic fusion plasma is developed. This is accomplished by employing a physics-informed neural network (PINN) to learn the parametric solution of the adjoint to the relativistic Fokker-Planck equation. The resulting PINN is able to evaluate the runaway probability function across a broad range of parameters in the absence of any synthetic or experimental data. This surrogate of the adjoint relativistic Fokker-Planck equation is then used to infer the avalanche growth rate as a function of the electric field, synchrotron radiation and effective charge. Predictions of the avalanche PINN are compared against first principle calculations of the avalanche growth rate with excellent agreement observed across a broad range of parameters. © 2024, CC BY.

关键词： Fokker Planck equation

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An ultraefficient surface functionalized Ti3C2Tx MXene piezocatalyst: synchronous hydrogen evolution and wastewater treatment

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Journal of materials Chemistry A 2023年第6期12卷 3340-3351页

作者： Lai, Sz-Nian Chen, Winston Yenyu Yen, Chao-Chun Liao, Yin-Song Chen, Po-Han Stanciu, Lia Wu, Jyh Ming Department of Materials Science and Engineering National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan PhD Program in Prospective Functional Materials Industry National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan High Entropy Materials Center National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan Tsing Hua Interdisciplinary Program National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan School of Materials Engineering Purdue University 610 Purdue Mall West LafayetteIN47907 United States Department of Materials Science and Engineering National Chung Hsing University 145 Xingda Road Taichung402 Taiwan

The Ti3C2Tx surface contains hydroxyl groups that can be modified through self-assembled monolayers by using (3-chloropropyl) trimethoxysilane (CPTMS) and fluoroalkylsilane (FOTS). This study demonstrates that an ultrahigh level of piezoelectricity can be achieved by modifying the Si-O bond of organo-silane headgroups in Ti3C2Tx. The theoretical calculation of surface functionalized Ti3C2Tx-FOTS reveals that its Si-O bond causes localized lattice distortion and enhances the noncentrosymmetric structure on the Ti3C2Tx surface. Ti3C2Tx-FOTS exhibits significantly higher butterfly loops than pristine Ti3C2Tx. The calculated rate constant of Ti3C2Tx-FOTS for dye degradation was 0.9 min−1, 15-fold higher than that of Ti3C2Tx-CPTMS and 111-fold higher than that of pristine Ti3C2Tx. The hydrogen evolution rate of Ti3C2Tx-FOTS is 900.46 μmo1 g−1 h−1, three times higher than that of Ti3C2Tx. The bifunctional surface functionalized Ti3C2Tx-FOTS can simultaneously catalyse the hydrogen evolution reaction (HER) and decomposition of wastewater, demonstrating that Ti3C2Tx-FOTS, obtained through the surface engineering of Ti3C2Tx, is a superior piezocatalyst. © 2024 The Royal Society of Chemistry.

关键词： Rate constants

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Terahertz phonon polariton concentrator based on perovskite oxides

Terahertz phonon polariton concentrator based on perovskite ...

引用

2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Xu, Rui Lin, Tong Luo, Jiaming Chen, Xiaotong Blackert, Elizabeth R. Moon, Alyssa R. JeBailey, Khalil M. Zhu, Hanyu Department of Materials Science and Nano Engineering Rice University Houston United States Applied Physics Graduate Program Rice University Houston United States Program Rice University Houston United States

ISBN: (纸本)9781957171258

We report the experimental demonstration of surface phonon-polaritonic devices in a broad spectral range of 7-13 THz based on SrTiO3. We designed planar ultrafast concentrators that amplifies transient electric field by 6 times and measured an average field of 0.5 GV/m in an optically resolvable area in the far field. © 2023 The Author(s)

关键词： Perovskite

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