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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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NANOGrav 15-year gravitational-wave background methods

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Physical Review D 2024年第10期109卷 103012-103012页

作者： Aaron D. Johnson Patrick M. Meyers Paul T. Baker Neil J. Cornish Jeffrey S. Hazboun Tyson B. Littenberg Joseph D. Romano Stephen R. Taylor Michele Vallisneri Sarah J. Vigeland Ken D. Olum Xavier Siemens Justin A. Ellis Rutger van Haasteren Sophie Hourihane Gabriella Agazie Akash Anumarlapudi Anne M. Archibald Zaven Arzoumanian Laura Blecha Adam Brazier Paul R. Brook Sarah Burke-Spolaor Bence Bécsy J. Andrew Casey-Clyde Maria Charisi Shami Chatterjee Katerina Chatziioannou Tyler Cohen James M. Cordes Fronefield Crawford H. Thankful Cromartie Kathryn Crowter Megan E. DeCesar Paul B. Demorest Timothy Dolch Brendan Drachler Elizabeth C. Ferrara William Fiore Emmanuel Fonseca Gabriel E. Freedman Nate Garver-Daniels Peter A. Gentile Joseph Glaser Deborah C. Good Kayhan Gültekin Ross J. Jennings Megan L. Jones Andrew R. Kaiser David L. Kaplan Luke Zoltan Kelley Matthew Kerr Joey S. Key Nima Laal Michael T. Lam William G. Lamb T. Joseph W. Lazio Natalia Lewandowska Tingting Liu Duncan R. Lorimer Jing Luo Ryan S. Lynch Chung-Pei Ma Dustin R. Madison Alexander McEwen James W. McKee Maura A. McLaughlin Natasha McMann Bradley W. Meyers Chiara M. F. Mingarelli Andrea Mitridate Cherry Ng David J. Nice Stella Koch Ocker Timothy T. Pennucci Benetge B. P. Perera Nihan S. Pol Henri A. Radovan Scott M. Ransom Paul S. Ray Shashwat C. Sardesai Carl Schmiedekamp Ann Schmiedekamp Kai Schmitz Brent J. Shapiro-Albert Joseph Simon Magdalena S. Siwek Ingrid H. Stairs Daniel R. Stinebring Kevin Stovall Abhimanyu Susobhanan Joseph K. Swiggum Jacob E. Turner Caner Unal Haley M. Wahl Caitlin A. Witt Olivia Young Center for Gravitation Cosmology and Astrophysics Department of Physics University of Wisconsin-Milwaukee P.O. Box 413 Milwaukee Wisconsin 53201 USA Division of Physics Mathematics and Astronomy California Institute of Technology Pasadena California 91125 USA Department of Physics and Astronomy Widener University One University Place Chester Pennsylvania 19013 USA Department of Physics Montana State University Bozeman Montana 59717 USA Department of Physics Oregon State University Corvallis Oregon 97331 USA NASA Marshall Space Flight Center Huntsville Alabama 35812 USA Department of Physics Texas Tech University Box 41051 Lubbock Texas 79409 USA Department of Physics and Astronomy Vanderbilt University 2301 Vanderbilt Place Nashville Tennessee 37235 USA Jet Propulsion Laboratory California Institute of Technology 4800 Oak Grove Drive Pasadena California 91109 USA Institute of Cosmology Department of Physics and Astronomy Tufts University Medford Massachusetts 02155 USA Department of Astronomy University of Maryland College Park Maryland 20742 Center for Research and Exploration in Space Science and Technology NASA/GSFC Greenbelt Maryland 20771 NASA Goddard Space Flight Center Greenbelt Maryland 20771 USA Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut) Callinstrasse 38 D-30167 Hannover Germany Newcastle University NE1 7RU Newcastle United Kingdom X-Ray Astrophysics Laboratory NASA Goddard Space Flight Center Code 662 Greenbelt Maryland 20771 USA Physics Department University of Florida Gainesville Florida 32611 USA Cornell Center for Astrophysics and Planetary Science and Department of Astronomy Cornell University Ithaca New York 14853 USA Cornell Center for Advanced Computing Cornell University Ithaca New York 14853 USA Institute for Gravitational Wave Astronomy and School of Physics and Astronomy University of Birmingham Edgbaston Birmingham B15 2TT United Kingdom Department of Physics and Astronomy West

Pulsar timing arrays (PTAs) use an array of millisecond pulsars to search for gravitational waves in the nanohertz regime in pulse time of arrival data. This paper presents rigorous tests of PTA methods, examining their consistency across the relevant parameter space. We discuss updates to the 15-year isotropic gravitational-wave background analyses and their corresponding code representations. Descriptions of the internal structure of the flagship algorithms enterprise and ptmcmcsampler are given to facilitate understanding of the PTA likelihood structure, how models are built, and what methods are currently used in sampling the high-dimensional PTA parameter space. We introduce a novel version of the PTA likelihood that uses a two-step marginalization procedure that performs much faster in gravitational wave searches, reducing the required resources facilitating the computation of Bayes factors via thermodynamic integration and sampling a large number of realizations for computing Bayesian false-alarm probabilities. We perform stringent tests of consistency and correctness of the Bayesian and frequentist analysis methods. For the Bayesian analysis, we test prior recovery, simulation recovery, and Bayes factors. For the frequentist analysis, we test that the optimal statistic, when modified to account for a non-negligible gravitational-wave background, accurately recovers the amplitude of the background. We also summarize recent advances and tests performed on the optimal statistic in the literature from both gravitational wave background detection and parameter estimation perspectives. The tests presented here validate current analyses of PTA data.

关键词： Gravitational waves Gravitational wave detection

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Hard convex lens-shaped particles: Characterization of dense disordered packings

arXiv

引用

arXiv 2019年

作者： Cinacchi, Giorgio Torquato, Salvatore Instituto de Ciencias de Materiales "Nicolás Cabrera" Universidad Autónoma de Madrid Ciudad Universitaria de Cantoblanco MadridE-28049 Spain Department of Chemistry Department of Physics Institute for the Science and Technology of Materials Program for Applied and Computational Mathematics Princeton University PrincetonNJ08544 United States

Among the family of hard convex lens-shaped particles (lenses), the one with aspect ratio equal to 2/3 is ‘optimal’ in the sense that the maximally random jammed (MRJ) packings of such lenses achieve the highest packing fraction φMRJ ' 0.73. This value is only a few percent lower than φDKP = 0.76210 . . . , the packing fraction of the corresponding densest-known crystalline (degenerate) packings. By exploiting the appreciably reduced propensity that a system of such optimal lenses has to positionally and orientationally order, disordered packings of them are progressively generated by a Monte Carlo method-based procedure from the dilute equilibrium isotropic fluid phase to the dense nonequilibrium MRJ state. This allows one to closely monitor how the (micro)structure of these packings changes in the process of formation of the MRJ state. The gradual changes undergone by the many structural descriptors calculated can coherently and consistently be traced back to the gradual increase in contacts between the hard particles until the isostatic mean value of 10 contact neighbors per lens is reached at the effectively hyperuniform MRJ state. Compared to the MRJ state of hard spheres, the MRJ state of such optimal lenses is denser (less porous), more disordered, and rattler-free. This set of characteristics makes them good glass formers. It is possible that this conclusion may also hold for other hard convex uniaxial particles with a correspondingly similar aspect ratio, be they oblate or prolate, and that, by using suitable biaxial variants of them, that set of characteristics might further improve. Copyright © 2019, The Authors. All rights reserved.

关键词： Aspect ratio

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Multifunctional Composites for Elastic and Electromagnetic Wave Propagation

arXiv

引用

arXiv 2019年

作者： Kim, Jaeuk Torquato, Salvatore Department of Physics Princeton University PrincetonNJ08544 United States Department of Chemistry Princeton University PrincetonNJ08544 United States Princeton Institute for the Science and Technology of Materials Princeton University PrincetonNJ08544 United States Program in Applied and Computational Mathematics Princeton University PrincetonNJ08544 United States

Composites are ideally suited to achieve desirable multifunctional effective properties, since the best properties of different materials can be judiciously combined with designed microstructures. Here we establish the first cross-property relations for two-phase composite media that link effective elastic and electromagnetic wave characteristics to one another, including effective wave speeds and attenuation coefficients. This is achieved by deriving accurate formulas for the effective elastodynamic properties that depend on the microstructure via the spectral density and utilizing previous analogous results for effective electromagnetic properties. Our formulas enable us to explore the wave characteristics of a broad class of disordered microstructures, including exotic disordered "hyperuniform" varieties, that can have advantages over crystalline ones, such as nearly optimal, direction-independent properties and robustness against defects. We specifically show that disordered "stealthy" hyperuniform/nonhyperuniform microstructures exhibit novel elastic wave characteristics that have the potential for future applications, e.g., low-pass or narrow-band-pass (using negative Poisson ratio materials) filters that transmit or absorb elastic waves "isotropically" for a range of wavenumbers. We also demonstrate that two-phase media with engineered disorder and phase properties can exhibit "anomalous dispersion" with resonance-like attenuation. Our cross-property relations for effective wave characteristics can be applied to design multifunctional composites via inverse techniques, including exterior components of spacecraft or building materials that require both excellent stiffness and electromagnetic absorption, and heat-sinks for CPUs that have to efficiently emit thermal radiation and suppress mechanical vibrations, and nondestructive evaluation of the elastic moduli of materials from the effective dielectric response. DR Copyright © 2019, The Authors. All rights res

关键词： Microstructure

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New tessellation-based procedure to design perfectly hyperuniform disordered dispersions for materials discovery

arXiv

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arXiv 2019年

作者： Kim, J. Torquato, S. Department of Physics Princeton University PrincetonNJ08544 United States Department of Chemistry Princeton University PrincetonNJ08544 United States Princeton Institute for the Science and Technology of Materials Princeton University PrincetonNJ08544 United States Program in Applied and Computational Mathematics Princeton University PrincetonNJ08544 United States

Disordered hyperuniform dispersions are exotic amorphous two-phase materials characterized by an anomalous suppression of long-wavelength volume-fraction fluctuations, which endows them with novel physical properties. While such unusual materials have received considerable attention, a stumbling block has been an inability to create large samples that are truly hyperuniform due to current computational and experimental limitations. To overcome such barriers, we introduce a new and simple construction procedure that guarantees perfect hyperuniformity for very large sample sizes. This methodology involves tessellating space into cells and then inserting a particle into each cell such that the local-cell particle packing fractions are identical to the global packing fraction. We analytically prove that such dispersions are perfectly hyperuniform in the infinite-sample-size limit. Our methodology enables a remarkable mapping that converts a very large nonhyperuniform disordered dispersion into a perfectly hyperuniform one, which we numerically demonstrate in two and three dimensions. A similar analysis also establishes the hyperuniformity of the famous Hashin-Shtrikman multiscale dispersions, which possess optimal transport and elastic properties. Our hyperuniform designs can be readily fabricated using modern photolithographic and 3D printing technologies. The exploration of the enormous class of hyperuniform dispersions that can be designed and tuned by our tessellation-based methodology paves the way for accelerating the discovery of novel hyperuniform materials. Copyright © 2019, The Authors. All rights reserved.

关键词： 3D printers

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Methodology to construct large realizations of perfectly hyperuniform disordered packings

arXiv

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arXiv 2019年

Disordered hyperuniform packings (or dispersions) are unusual amorphous two-phase materials that are endowed with exotic physical properties. Such hyperuniform systems are characterized by an anomalous suppression of volume-fraction fluctuations at infinitely long-wavelengths, compared to ordinary disordered materials. While there has been growing interest in such singular states of amorphous matter, a major obstacle has been an inability to produce large samples that are perfectly hyperuniform due to practical limitations of conventional numerical and experimental methods. To overcome these limitations, we introduce a general theoretical methodology to construct perfectly hyperuniform packings in d-dimensional Euclidean space Rd. Specifically, beginning with an initial general tessellation of space by disjoint cells that meets a "bounded-cell" condition, hard particles are placed inside each cell such that the local-cell particle packing fractions are identical to the global packing fraction. We prove that the constructed packings with a polydispersity in size in Rd are perfectly hyperuniform in the infinite-sample-size limit and the hyperuniformity of such packings is independent of particle shapes, positions, and numbers per cell. We use this theoretical formulation to devise an efficient and tunable algorithm to generate extremely large realizations of such packings. We employ two distinct initial tessellations: Voronoi as well as sphere tessellations. Beginning with Voronoi tessellations, we show that our algorithm can remarkably convert extremely large nonhyperuniform packings into hyperuniform ones in R2 and R3. Implementing our theoretical methodology on sphere tessellations, we establish the hyperuniformity of the classical Hashin-Shtrikman multiscale coated-spheres structures, which are known to be two-phase media microstructures that possess optimal effective transport and elastic properties. A consequence of our work is a rigorous demonstration that pack

关键词： Cells

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Correction to: A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility

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Journal of neurology 2022年第8期269卷 4523-4524页

作者： Melissa Sorosina Nadia Barizzone Ferdinando Clarelli Santosh Anand Sara Lupoli Erika Salvi Eleonora Mangano Roberta Bordoni Tina Roostaei Elisabetta Mascia Miriam Zuccalà Domizia Vecchio Paola Cavalla Silvia Santoro Laura Ferrè Alen Zollo Cristina Barlassina Daniele Cusi Vittorio Martinelli Giancarlo Comi Maurizio Leone Massimo Filippi Nikolaos A Patsopoulos Philip L De Jager Gianluca De Bellis Federica Esposito Sandra D'Alfonso Filippo Martinelli Boneschi Laboratory of Human Genetics of Neurological Disorders Division of Neuroscience IRCCS San Raffaele Scientific Institute 20132 Milan Italy. Department of Health Sciences Interdisciplinary Research Center of Autoimmune Diseases (IRCAD) University of Eastern Piedmont Avogadro University 28100 Novara Italy. Department of Informatics Systems and Communications (DISCo) University of Milano-Bicocca Milan Italy. Department of Health Sciences University of Milan 20139 Milan Italy. Neuroalgology Unit Fondazione IRCCS Istituto Neurologico "Carlo Besta" 20133 Milan Italy. National Research Council of Italy Institute for Biomedical Technologies Segrate 20090 Milan Italy. Center for Translational and Computational Neuroimmunology Department of Neurology and the Taub Institute for Research On Alzheimer's Disease and the Aging Brain Columbia University Irving Medical Center New York NY 10032 USA. MS Centre SCDU Neurology AOU Maggiore Della Carità Department of Translational Medicine Interdisciplinary Research Center of Autoimmune Diseases (IRCAD) University of Eastern Piedmont Avogadro 28100 Novara Italy. MS Center Department of Neuroscience and Mental Health City of Health and Science University Hospital of Torino 10126 Turin Italy. Neurology Unit IRCCS San Raffaele Scientific Institute 20132 Milan Italy. Department of Pathophysiology and Transplantation (DEPT) Dino Ferrari Centre Neuroscience Section University of Milan 20122 Milan Italy. Bio4Dreams Business Nursery for Life Sciences Piazzale Principessa Clotilde 4/A 20121 Milan Italy. SC Neurologia Dipartimento Di Scienze Mediche IRCCS Casa Sollievo Della Sofferenza San Giovanni Rotondo Italy. Vita-Salute San Raffaele University 20132 Milan Italy. Neuroimaging Research Unit Division of Neuroscience IRCCS San Raffaele Scientific Institute 20132 Milan Italy. Neurophysiology Unit IRCCS San Raffaele Scientific Institute IRCCS San Raffaele Scientific Institute 20132 Milan Italy. Systems Biology and Comp

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A broadband thermal emission spectrum of the ultra-hot Jupiter WASP-18b

arXiv

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arXiv 2023年

作者： Coulombe, Louis-Philippe Benneke, Björn Challener, Ryan Piette, Anjali A.A. Wiser, Lindsey S. Mansfield, Megan MacDonald, Ryan J. Beltz, Hayley Feinstein, Adina D. Radica, Michael Savel, Arjun B. Dos Santos, Leonardo A. Bean, Jacob L. Parmentier, Vivien Wong, Ian Rauscher, Emily Komacek, Thaddeus D. Kempton, Eliza M.-R. Tan, Xianyu Hammond, Mark Lewis, Neil T. Line, Michael R. Lee, Elspeth K.H. Shivkumar, Hinna Crossfield, Ian J.M. Nixon, Matthew C. Rackham, Benjamin V. Wakeford, Hannah R. Welbanks, Luis Zhang, Xi Batalha, Natalie M. Berta-Thompson, Zachory K. Changeat, Quentin Désert, Jean-Michel Espinoza, Néstor Goyal, Jayesh M. Harrington, Joseph Knutson, Heather A. Kreidberg, Laura López-Morales, Mercedes Shporer, Avi Sing, David K. Stevenson, Kevin B. Aggarwal, Keshav Ahrer, Eva-Maria Alam, Munazza K. Bell, Taylor J. Blecic, Jasmina Caceres, Claudio Carter, Aarynn L. Casewell, Sarah L. Crouzet, Nicolas Cubillos, Patricio E. Decin, Leen Fortney, Jonathan J. Gibson, Neale P. Heng, Kevin Henning, Thomas Iro, Nicolas Kendrew, Sarah Lagage, Pierre-Olivier Leconte, Jérémy Lendl, Monika Lothringer, Joshua D. Mancini, Luigi Mikal-Evans, Thomas Molaverdikhani, Karan Nikolov, Nikolay K. Ohno, Kazumasa Palle, Enric Piaulet, Caroline Redfield, Seth Roy, Pierre-Alexis Tsai, Shang-Min Venot, Olivia Wheatley, Peter J. Department of Physics Trottier Institute for Research on Exoplanets Université de Montréal MontréalQC Canada Department of Astronomy University of Michigan Ann ArborMI United States Earth and Planets Laboratory Carnegie Institution for Science WashingtonDC United States School of Earth and Space Exploration Arizona State University TempeAZ United States Steward Observatory University of Arizona TucsonAZ United States NHFP Sagan Fellow United States Department of Astronomy Carl Sagan Institute Cornell University NY United States Department of Astronomy and Astrophysics University of Chicago ChicagoIL United States NSF Graduate Research Fellow United States Department of Astronomy University of Maryland College ParkMD United States Center for Computational Astrophysics Flatiron Institute New YorkNY United States Space Telescope Science Institute BaltimoreMD United States Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange France NASA Goddard Space Flight Center GreenbeltMD United States NASA Postdoctoral Program Fellow United States Tsung-Dao Lee Institute Shanghai Jiao Tong University Shanghai China School of Physics and Astronomy Shanghai Jiao Tong University Shanghai China Atmospheric Oceanic and Planetary Physics Department of Physics University of Oxford Oxford United Kingdom Department of Mathematics and Statistics Faculty of Environment Science and Economy University of Exeter Exeter United Kingdom Center for Space and Habitability University of Bern Bern Switzerland Anton Pannekoek Institute for Astronomy University of Amsterdam Amsterdam Netherlands Department of Physics & Astronomy University of Kansas LawrenceKS United States Department of Earth Atmospheric and Planetary Sciences Massachusetts Institute of Technology CambridgeMA United States Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA United States 51 Pegasi b Fellow France School of

Close-in giant exoplanets with temperatures greater than 2,000 K ("ultra-hot Jupiters") have been the subject of extensive efforts to determine their atmospheric properties using thermal emission measurements from the Hubble and Spitzer Space Telescopes1;2;3. However, previous studies have yielded inconsistent results because the small sizes of the spectral features and the limited information content of the data resulted in high sensitivity to the varying assumptions made in the treatment of instrument systematics and the atmospheric retrieval analysis3;4;5;6;7;8;9;10;11;12. Here we present a dayside thermal emission spectrum of the ultrahot Jupiter WASP-18b obtained with the NIRISS13 instrument on JWST. The data span 0.85 to 2.85 µm in wavelength at an average resolving power of 400 and exhibit minimal systematics. The spectrum shows three water emission features (at >6σ confidence) and evidence for optical opacity, possibly due to H−, TiO, and VO (combined significance of 3.8σ). Models that fit the data require a thermal inversion, molecular dissociation as predicted by chemical equilibrium, a solar heavy element abundance ("metallicity", M/H = 1.03+1.11−0.51 × solar), and a carbon-to-oxygen (C/O) ratio less than unity. The data also yield a dayside brightness temperature map, which shows a peak in temperature near the sub-stellar point that decreases steeply and symmetrically with longitude toward the terminators. © 2023, CC BY.

关键词： Molecular oxygen

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A search for correlated low-energy electron antineutrinos in KamLAND with gamma-ray bursts

arXiv

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arXiv 2021年

作者： Abe, S. Asami, S. Gando, A. Gando, Y. Gima, T. Goto, A. Hachiya, T. Hata, K. Hosokawa, K. Ichimura, K. Ieki, S. Ikeda, H. Inoue, K. Ishidoshiro, K. Kamei, Y. Kawada, N. Kishimoto, Y. Kinoshita, T. Koga, M. Maemura, N. Mitsui, T. Miyake, H. Nakamura, K. Nakamura, K. Nakamura, R. Ozaki, H. Sakai, T. Sambonsugi, H. Shimizu, I. Shirai, J. Shiraishi, K. Suzuki, A. Suzuki, Y. Takeuchi, A. Tamae, K. Eizuka, M. Kurasawa, M. Nakahata, T. Futagi, S. Watanabe, H. Yoshida, Y. Obara, S. Ichikawa, A.K. Yoshida, S. Umehara, S. Fushimi, K. Berger, B.E. Fujikawa, B.K. Learned, J.G. Maricic, J. Axani, Spencer N. Smolsky, J. Laber-Smith, C. Winslow, L.A. Fu, Z. Ouellet, J. Efremenko, Y. Karwowski, H.J. Markoff, D.M. Tornow, W. Li, A. Detwiler, J.A. Enomoto, S. Decowski, M.P. Grant, C. Song, H. O'Donnell, T. Dell'Oro, S. Research Center for Neutrino Science Tohoku University Sendai980-8578 Japan Institute for the Physics and Mathematics of the Universe The University of Tokyo Kashiwa277-8568 Japan Graduate Program on Physics for the Universe Tohoku University Sendai980-8578 Japan Frontier Research Institute for Interdisciplinary Sciences Tohoku University Sendai980-8578 Japan Department of Physics Tohoku University Sendai980-8578 Japan Graduate School of Science Osaka University Osaka Toyonaka560-0043 Japan Osaka University Osaka Ibaraki567-0047 Japan Graduate School of Advanced Technology and Science Tokushima University Tokushima770-8506 Japan Nuclear Science Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Department of Physics and Astronomy University of Hawaii at Manoa HonoluluHI96822 United States Massachusetts Institute of Technology CambridgeMA02139 United States Department of Physics and Astronomy University of Tennessee KnoxvilleTN37996 United States Triangle Universities Nuclear Laboratory DurhamNC27708 United States The University of North Carolina at Chapel Hill Chapel HillNC27599 United States North Carolina Central University DurhamNC27701 United States Department of Physics Duke University DurhamNC27705 United States Center for Experimental Nuclear Physics and Astrophysics University of Washington SeattleWA98195 United States Nikhef The University of Amsterdam Science Park Amsterdam Netherlands Boston University BostonMA02215 United States Center for Neutrino Physics Virginia Polytechnic Institute State University BlacksburgVA24061 United States

We present the results of a time-coincident event search for low-energy electron antineutrinos in the KamLAND detector with gamma-ray bursts from the Gamma-ray Coordinates Network and Fermi Gamma-ray Burst Monitor. Using a variable coincidence time window of ±500 s plus the duration of each gamma-ray burst, no statistically significant excess above background is observed. We place the world's most stringent 90% confidence level upper limit on the electron antineutrino fluence below 17.5 MeV. Assuming a Fermi-Dirac neutrino energy spectrum from the gamma-ray burst source, we use the available redshift data to constrain the electron antineutrino luminosity and effective temperature. Copyright © 2021, The Authors. All rights reserved.

关键词： Stars

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