检索结果-内蒙古大学图书馆

Growing heterogeneous tumors in silico

Physical Review E 2009年第5期80卷 051910-051910页

作者： Jana Gevertz S. Torquato Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 USA Department of Chemistry Princeton University Princeton New Jersey 08544 USA Princeton Center for Theoretical Science Princeton University Princeton New Jersey 08544 USA Princeton Institute for the Science and Technology of Materials Princeton University Princeton New Jersey 08544 USA School of Natural Sciences Institute for Advanced Study Princeton New Jersey 08540 USA

An in silico tool that can be utilized in the clinic to predict neoplastic progression and propose individualized treatment strategies is the holy grail of computational tumor modeling. Building such a tool requires the development and successful integration of a number of biophysical and mathematical models. In this paper, we work toward this long-term goal by formulating a cellular automaton model of tumor growth that accounts for several different inter-tumor processes and host-tumor interactions. In particular, the algorithm couples the remodeling of the microvasculature with the evolution of the tumor mass and considers the impact that organ-imposed physical confinement and environmental heterogeneity have on tumor size and shape. Furthermore, the algorithm is able to account for cell-level heterogeneity, allowing us to explore the likelihood that different advantageous and deleterious mutations survive in the tumor cell population. This computational tool we have built has a number of applications in its current form in both predicting tumor growth and predicting response to treatment. Moreover, the latent power of our algorithm is that it also suggests other tumor-related processes that need to be accounted for and calls for the conduction of new experiments to validate the model’s predictions.

关键词： Tumors

来源：评论

学校读者我要写书评

暂无评论

Mean survival times of absorbing triply periodic minimal surfaces

引用

Physical Review E 2009年第1期80卷 011102-011102页

Understanding the transport properties of a porous medium from a knowledge of its microstructure is a problem of great interest in the physical, chemical, and biological sciences. Using a first-passage time method, we compute the mean survival time τ of a Brownian particle among perfectly absorbing traps for a wide class of triply periodic porous media, including minimal surfaces. We find that the porous medium with an interface that is the Schwartz P minimal surface maximizes the mean survival time among this class. This adds to the growing evidence of the multifunctional optimality of this bicontinuous porous medium. We conjecture that the mean survival time (like the fluid permeability) is maximized for triply periodic porous media with a simply connected pore space at porosity ϕ=1/2 by the structure that globally optimizes the specific surface. We also compute pore-size statistics of the model microstructures in order to ascertain the validity of a “universal curve” for the mean survival time for these porous media. This represents the first nontrivial statistical characterization of triply periodic minimal surfaces.

关键词： Porous materials

来源：评论

学校读者我要写书评

暂无评论

Dense packings of polyhedra: Platonic and Archimedean solids

引用

Physical Review E 2009年第4期80卷 041104-041104页

作者： S. Torquato Y. Jiao Department of Chemistry Princeton University Princeton New Jersey 08544 USA Princeton Center for Theoretical Science Princeton University Princeton New Jersey 08544 USA Princeton Institute for the Science and Technology of Materials Princeton University Princeton New Jersey 08544 USA Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 USA School of Natural Sciences Institute for Advanced Study Princeton New Jersey 08540 USA Department of Mechanical and Aerospace Engineering Princeton University Princeton New Jersey 08544 USA

Understanding the nature of dense particle packings is a subject of intense research in the physical, mathematical, and biological sciences. The preponderance of previous work has focused on spherical particles and very little is known about dense polyhedral packings. We formulate the problem of generating dense packings of nonoverlapping, nontiling polyhedra within an adaptive fundamental cell subject to periodic boundary conditions as an optimization problem, which we call the adaptive shrinking cell (ASC) scheme. This optimization problem is solved here (using a variety of multiparticle initial configurations) to find the dense packings of each of the Platonic solids in three-dimensional Euclidean space R3, except for the cube, which is the only Platonic solid that tiles space. We find the densest known packings of tetrahedra, icosahedra, dodecahedra, and octahedra with densities 0.823…, 0.836…, 0.904…, and 0.947…, respectively. It is noteworthy that the densest tetrahedral packing possesses no long-range order. Unlike the densest tetrahedral packing, which must not be a Bravais lattice packing, the densest packings of the other nontiling Platonic solids that we obtain are their previously known optimal (Bravais) lattice packings. We also derive a simple upper bound on the maximal density of packings of congruent nonspherical particles and apply it to Platonic solids, Archimedean solids, superballs, and ellipsoids. Provided that what we term the “asphericity” (ratio of the circumradius to inradius) is sufficiently small, the upper bounds are relatively tight and thus close to the corresponding densities of the optimal lattice packings of the centrally symmetric Platonic and Archimedean solids. Our simulation results, rigorous upper bounds, and other theoretical arguments lead us to the conjecture that the densest packings of Platonic and Archimedean solids with central symmetry are given by their corresponding densest lattice packings. This can be regarded to be

关键词： Optimization

来源：评论

学校读者我要写书评

暂无评论

Method for obtaining upper bounds on photonic band gaps

引用

Physical Review B 2009年第15期80卷 155126-155126页

作者： Mikael C. Rechtsman Salvatore Torquato Courant Institute of Mathematical Sciences 251 Mercer Street New York New York 10012 USA Department of Chemistry Princeton University Princeton New Jersey 08544 USA Princeton Center for Theoretical Physics Princeton New Jersey 08544 USA Program in Applied and Computational Mathematics Princeton Institute for the Science and Technology of Materials Princeton New Jersey 08544 USA School of Natural Sciences Institute for Advanced Study Princeton New Jersey 08544 USA

We present a method to calculate upper bounds on the photonic band gaps of two-component photonic crystals. The method involves calculating both upper and lower bounds on the frequency bands for a given structure, and then maximizing over all possible two-component structures. We apply this method to a number of examples, including a one-dimensional photonic crystal (or “Bragg grating”) and two-dimensional photonic crystals (in both the TM and TE polarizations) with both four and sixfold rotational symmetries. We compare the bounds to band gaps of numerically optimized structures and find that the bounds are extremely tight. We prove that the bounds are “sharp” in the limit of low dielectric contrast ratio between the two components. This method and the bounds derived here have important implications in the search for optimal photonic band-gap structures.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Domain Formation in the Plasma Membrane: Roles of Nonequilibrium Lipid Transport and Membrane Proteins

引用

Physical Review Letters 2008年第17期100卷 178102-178102页

作者： Jun Fan Maria Sammalkorpi Mikko Haataja Department of Mechanical and Aerospace Engineering Princeton Institute for the Science and Technology of Materials (PRISM) and Program in Applied and Computational Mathematics (PACM) Princeton University Princeton New Jersey 08544 USA

Compositional lipid domains (“lipid rafts”) in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering.

关键词： Lipids

来源：评论

学校读者我要写书评

暂无评论

Erratum: Toward the jamming threshold of sphere packings: Tunneled crystals (Journal of Applied Physics (2007) 102 (093511))

引用

Journal of Applied Physics 2008年第12期103卷 129902-129902-2页

作者： Torquato, S. Stillinger, F.H. Department of Chemistry Princeton University Princeton NJ 08544 United States Program in Applied and Computational Mathematics Princeton University Princeton NJ 08544 United States Princeton Institute for the Science and Technology of Materials Princeton University Princeton NJ 08544 United States Princeton Center for Theoretical Physics Princeton University Princeton NJ 08544 United States

No abstract available

关键词：

来源：评论

学校读者我要写书评

暂无评论

Modeling heterogeneous materials via two-point correlation functions. II. Algorithmic details and applications

引用

Physical Review E 2008年第3期77卷 031135-031135页

作者： Y. Jiao F. H. Stillinger S. Torquato Department of Chemistry Princeton University Princeton New Jersey 08544 USA Princeton Institute for the Science and Technology of Materials Princeton University Princeton New Jersey 08544 USA Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 USA Princeton Center for Theoretical Physics Princeton University Princeton New Jersey 08544 USA and School of Natural Sciences Institute for Advanced Study Princeton New Jersey 08540 USA

In the first part of this series of two papers, we proposed a theoretical formalism that enables one to model and categorize heterogeneous materials (media) via two-point correlation functions S2 and introduced an efficient heterogeneous-medium (re)construction algorithm called the “lattice-point” algorithm. Here we discuss the algorithmic details of the lattice-point procedure and an algorithm modification using surface optimization to further speed up the (re)construction process. The importance of the error tolerance, which indicates to what accuracy the media are (re)constructed, is also emphasized and discussed. We apply the algorithm to generate three-dimensional digitized realizations of a Fontainebleau sandstone and a boron-carbide/aluminum composite from the two-dimensional tomographic images of their slices through the materials. To ascertain whether the information contained in S2 is sufficient to capture the salient structural features, we compute the two-point cluster functions of the media, which are superior signatures of the microstructure because they incorporate topological connectedness information. We also study the reconstruction of a binary laser-speckle pattern in two dimensions, in which the algorithm fails to reproduce the pattern accurately. We conclude that in general reconstructions using S2 only work well for heterogeneous materials with single-scale structures. However, two-point information via S2 is not sufficient to accurately model multiscale random media. Moreover, we construct realizations of hypothetical materials with desired structural characteristics obtained by manipulating their two-point correlation functions.

关键词： RECONSTRUCTING RANDOM-MEDIA TOPOLOGY OPTIMIZATION MICROSTRUCTURES COMPOSITES DESIGN TRANSPORT

来源：评论

学校读者我要写书评

暂无评论

Tilings of space and superhomogeneous point processes

引用

Physical Review E 2008年第3期77卷 031125-031125页

作者： A. Gabrielli M. Joyce S. Torquato SMC-INFM Dipartimento di Fisica Università La Sapienza P.le A. Moro 2 I-00185 Rome Italy ISC-CNR Via dei Taurini 19 I-00185 Rome Italy Laboratoire de Physique Nucléaire et de Hautes Energies UMR-7585 Université Pierre et Marie Curie Paris 6 75252 Paris Cedex 05 France Department of Chemistry Princeton University Princeton New Jersey 08544 USA Program in Applied and Computational Mathematics Princeton University Princeton New Jersey 08544 Princeton Institute for the Science and Technology of Materials Princeton University Princeton New Jersey 08544 USA Princeton Center for Theoretical Physics Princeton University Princeton New Jersey 08544 USA

We consider the construction of point processes from tilings, with equal-volume tiles, of d-dimensional Euclidean space Rd. We show that one can generate, with simple algorithms ascribing one or more points to each tile, point processes which are “superhomogeneous” (or “hyperuniform”)—i.e., for which the structure factor S(k) vanishes when the wave vector k tends to zero. The exponent γ characterizing the leading small-k behavior, S(k→0)∝kγ, depends in a simple manner on the nature of the correlation properties of the specific tiling and on the conservation of the mass moments of the tiles. Assigning one point to the center of mass of each tile gives the exponent γ=4 for any tiling in which the shapes and orientations of the tiles are short-range correlated. Smaller exponents in the range 4−d<γ<4 (and thus always superhomogeneous for d≤4) may be obtained in the case that the latter quantities have long-range correlations. Assigning more than one point to each tile in an appropriate way, we show that one can obtain arbitrarily higher exponents in both cases. We illustrate our results with explicit constructions using known deterministic tilings, as well as some simple stochastic tilings for which we can calculate S(k) exactly. Our results provide an explicit analytical construction of point processes with γ>4. Applications to condensed matter physics, and also to cosmology, are briefly discussed.

关键词： SIMULATIONS CAUSALITY SPECTRUM

来源：评论

学校读者我要写书评

暂无评论

Modeling heterogeneous materials via two-point correlation functions: Basic principles

引用

Physical Review E 2007年第3期76卷 031110-031110页

Heterogeneous materials abound in nature and man-made situations. Examples include porous media, biological materials, and composite materials. Diverse and interesting properties exhibited by these materials result from their complex microstructures, which also make it difficult to model the materials. Yeong and Torquato [Phys. Rev. E 57, 495 (1998)] introduced a stochastic optimization technique that enables one to generate realizations of heterogeneous materials from a prescribed set of correlation functions. In this first part of a series of two papers, we collect the known necessary conditions on the standard two-point correlation function S2(r) and formulate a conjecture. In particular, we argue that given a complete two-point correlation function space, S2(r) of any statistically homogeneous material can be expressed through a map on a selected set of bases of the function space. We provide examples of realizable two-point correlation functions and suggest a set of analytical basis functions. We also discuss an exact mathematical formulation of the (re)construction problem and prove that S2(r) cannot completely specify a two-phase heterogeneous material alone. Moreover, we devise an efficient and isotropy-preserving construction algorithm, namely, the lattice-point algorithm to generate realizations of materials from their two-point correlation functions based on the Yeong-Torquato technique. Subsequent analysis can be performed on the generated images to obtain desired macroscopic properties. These developments are integrated here into a general scheme that enables one to model and categorize heterogeneous materials via two-point correlation functions. We will mainly focus on basic principles in this paper. The algorithmic details and applications of the general scheme are given in the second part of this series of two papers.

关键词： RECONSTRUCTING RANDOM-MEDIA PROBABILITY FUNCTIONS NONLINEAR COMPOSITES POROUS-MEDIA BOUNDS MICROSTRUCTURES OPTIMIZATION SCATTERING

来源：评论

学校读者我要写书评

暂无评论

Guest editorial nonlinear optimization of communication systems

引用

IEEE Journal on Selected Areas in Communications 2006年第8期24卷 1421-1423页

作者： Chiang, Mung Low, Steven H. Luo, Zhi-Quan Shroff, Ness B. Yu, Wei Steenstrup, M. Princeton University Department of Electrical Engineering Program in Applied and Computational Mathematics Princeton NJ 08544 United States California Institute of Technology Department of Computer Science Pasadena CA 91125 United States University of Minnesota Department of Electrical and Computer Engineering Minneapolis MN 55455 United States Purdue University School of Electrical and Computer Engineering West Lafayette IN 47907 United States University of Toronto Edward S. Rogers Sr. Department of Electrical and Computer Engineering Toronto Ont. M4S 3G5 Canada

No abstract available

关键词： Communication systems Design optimization Communication system control Optimization methods Protocols Distributed algorithms Power system modeling Nonlinear control systems Lagrangian functions Surges

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：