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MONGE-AMPÈRE FLOW FOR GENERATIVE MODELING

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arXiv 2018年

作者： Zhang, Linfeng Weinan, E. Wang, Lei Program in Applied and Computational Mathematics Princeton University United States Department of Mathematics and Program in Applied and Computational Mathematics Princeton University United States Center for Data Science Peking University Beijing Institute of Big Data Research Beijing100871 China Institute of Physics Chinese Academy of Sciences Beijing100190 China

We present a deep generative model, named Monge-Ampère flow, which builds on continuous-time gradient flow arising from the Monge-Ampère equation in optimal transport theory. The generative map from the latent space to the data space follows a dynamical system, where a learnable potential function guides a compressible fluid to flow towards the target density distribution. Training of the model amounts to solving an optimal control problem. The Monge-Ampère flow has tractable likelihoods and supports efficient sampling and inference. One can easily impose symmetry constraints in the generative model by designing suitable scalar potential functions. We apply the approach to unsupervised density estimation of the MNIST dataset and variational calculation of the two-dimensional Ising model at the critical point. This approach brings insights and techniques from Monge-Ampère equation, optimal transport, and fluid dynamics into reversible flow-based generative models. Copyright © 2018, The Authors. All rights reserved.

关键词： Statistical mechanics

Clustering of transcriptomic data for the identification of cancer subtypes

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arXiv 2018年

作者： Chen, Xiaochun Wang, Honggang Yan, Donghui Department of Electrical and Computer Engineering University of Massachusetts Dartmouth MA United States Department of Mathematics and Program in Data Science University of Massachusetts Dartmouth MA United States

Cancer is a number of related yet highly heterogeneous diseases. Correct identification of cancer subtypes is critical for clinical decisions. The advance in sequencing technologies has made it possible to study cancer based on abundant genomics and transcriptomic (-omics) data. Such a data-driven approach is expected to address limitations and issues with traditional methods in identifying cancer subtypes. We evaluate the suitability of clustering–a data mining tool to study heterogenous data when there is a lack of sufficient understanding of the subject matters–in the identification of cancer subtypes. A number of popular clustering algorithms and their consensus are explored, and we find cancer subtypes identified by consensus clustering agree well with clinical studies. Copyright © 2018, The Authors. All rights reserved.

关键词： Clustering algorithms

Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J G Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, Herm Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparity Department of Health and Social Care London United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierrasur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen Keskus University of Helsinki Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine University of Sydney Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics U

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Selective dynamical imaging of interferometric data

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arXiv 2024年

作者： Farah, Joseph Galison, Peter Akiyama, Kazunori Bouman, Katherine L. Bower, Geoffrey C. Chael, Andrew Fuentes, Antonio Gómez, José L. Honma, Mareki Johnson, Michael D. Kofuji, Yutaro Marrone, Daniel P. Moriyama, Kotaro Narayan, Ramesh Pesce, Dominic W. Tiede, Paul Wielgus, Maciek Zhao, Guang-Yao Alberdi, Antxon Alef, Walter Algaba, Juan Carlos Anantua, Richard Asada, Keiichi Azulay, Rebecca Bach, Uwe Baczko, Anne-Kathrin Ball, David Baloković, Mislav Barrett, John Bauböck, Michi Benson, Bradford A. Bintley, Dan Blackburn, Lindy Blundell, Raymond Boland, Wilfred Boyce, Hope Bremer, Michael Brinkerink, Christiaan D. Brissenden, Roger Britzen, Silke Broderick, Avery E. Broguiere, Dominique Bronzwaer, Thomas Bustamante, Sandra Byun, Do-Young Carlstrom, John E. Ceccobello, Chiara Chan, Chi-Kwan Chatterjee, Koushik Chatterjee, Shami Chen, Ming-Tang Chen, Yongjun Cho, Ilje Christian, Pierre Conroy, Nicholas S. Conway, John E. Cordes, James M. Crawford, Thomas M. Crew, Geoffrey B. Cruz-Osorio, Alejandro Cui, Yuzhu Davelaar, Jordy De Laurentis, Mariafelicia Deane, Roger Dempsey, Jessica Desvignes, Gregory Doeleman, Sheperd S. Dhruv, Vedant Dzib Quijano, Sergio Abraham Eatough, Ralph P. Emami, Razieh Falcke, Heino Fish, Vincent L. Fomalont, Ed Ford, H. Alyson Fraga-Encinas, Raquel Freeman, William T. Friberg, Per Fromm, Christian M. Gammie, Charles F. García, Roberto Gentaz, Olivier Georgiev, Boris Goddi, Ciriaco Gold, Roman Gómez-Ruiz, Arturo I. Gu, Minfeng Gurwell, Mark Hada, Kazuhiro Haggard, Daryl Hecht, Michael H. Hesper, Ronald Ho, Luis C. Ho, Paul Huang, Chih-Wei L. Huang, Lei Hughes, David H. Ikeda, Shiro Impellizzeri, C.M. Violette Inoue, Makoto Issaoun, Sara James, David J. Jannuzi, Buell T. Janssen, Michael Jeter, Britton Jiang, Wu Jimenez-Rosales, Alejandra Jorstad, Svetlana Joshi, Abhishek V. Jung, Taehyun Karami, Mansour Karuppusamy, Ramesh Kawashima, Tomohisa Keating, Garrett K. Kettenis, Mark Kim, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kino, Motoki Koay, Jun Yi Kocherlakota, Prashant Koch, Patrick Las Cumbres Observatory 6740 Cortona Drive Suite 102 GoletaCA93117-5575 United States Department of Physics University of California Santa BarbaraCA93106-9530 United States Black Hole Initiative Harvard University 20 Garden Street CambridgeMA02138 United States Department of History of Science Harvard University CambridgeMA02138 United States Department of Physics Harvard University CambridgeMA02138 United States Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Center for Astrophysics — Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States California Institute of Technology 1200 East California Boulevard PasadenaCA91125 United States Institute of Astronomy and Astrophysics Academia Sinica 645 N. A’ohoku Place HiloHI96720 United States Princeton Center for Theoretical Science Princeton University Jadwin Hall PrincetonNJ08544 United States NASA Hubble Fellowship Program Einstein Fellow United States Instituto de Astrofísica de Andalucía CSIC Glorieta de la Astronomía s/n GranadaE-18008 Spain Mizusawa VLBI Observatory National Astronomical Observatory of Japan 2-12 Hoshigaoka Mizusawa Iwate Oshu023-0861 Japan 2-21-1 Osawa Tokyo Mitaka181-8588 Japan Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Steward Observatory Department of Astronomy University of Arizona 933 N. Cherry Ave. TucsonAZ85721 United States Department of Physics and Astronomy University of Waterloo 200 University Avenue West WaterlooONN2L 3G1 Canada Waterloo Centre for Astrophysics University of Waterloo WaterlooONN2L 3G1 Canada Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Department of Physics Faculty of Science Universiti Malaya Kuala Lumpur50603 Malaysia Department of Physics & Ast

Recent developments in very-long-baseline interferometry (VLBI) have made it possible for the Event Horizon Telescope (EHT) to resolve the innermost accretion flows of the largest supermassive black holes on the sky. The sparse nature of the EHT’s (u, v) coverage presents a challenge when attempting to resolve highly time-variable sources. We demonstrate that the changing (u, v) coverage of the EHT can contain regions of time over the course of a single observation that facilitate dynamical imaging. These optimal time regions typically have projected baseline distributions that are approximately angularly isotropic and radially homogeneous. We derive a metric of coverage quality based on baseline isotropy and density that is capable of ranking array configurations by their ability to produce accurate dynamical reconstructions. We compare this metric to existing metrics in the literature, and investigate their utility by performing dynamical reconstructions on synthetic data from simulated EHT observations of sources with simple orbital variability. We then use these results to make recommendations for imaging the 2017 EHT Sgr A∗ dataset. © 2024, CC BY.

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Ordered magnetic fields around the 3C 84 central black hole

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arXiv 2024年

作者： Paraschos, Georgios Filippos Kim, J.-Y. Wielgus, M. Röder, J. Krichbaum, T.P. Ros, E. Agudo, I. Myserlis, I. Moscibrodzka, M. Traianou, E. Zensus, J.A. Blackburn, L. Chan, C.-K. Issaoun, S. Janssen, M. Johnson, M.D. Fish, V.L. Akiyama, K. Alberdi, A. Alef, W. Algaba, J.C. Anantua, R. Asada, K. Azulay, R. Bach, U. Baczko, A.-K. Ball, D. Baloković, M. Barrett, J. Bauböck, M. Benson, B.A. Bintley, D. Blundell, R. Bouman, K.L. Bower, G.C. Boyce, H. Bremer, M. Brinkerink, C.D. Brissenden, R. Britzen, S. Broderick, A.E. Broguiere, D. Bronzwaer, T. Bustamante, S. Byun, D.-Y. Carlstrom, J.E. Ceccobello, C. Chael, A. Chang, D.O. Chatterjee, K. Chatterjee, S. Chen, M.T. Chen, Y. Cheng, X. Cho, I. Christian, P. Conroy, N.S. Conway, J.E. Cordes, J.M. Crawford, T.M. Crew, G.B. Cruz-Osorio, A. Cui, Y. Dahale, R. Davelaar, J. De Laurentis, M. Deane, R. Dempsey, J. Desvignes, G. Dexter, J. Dhruv, V. Doeleman, S.S. Dougal, S. Dzib, S.A. Eatough, R.P. Emami, R. Falcke, H. Farah, J. Fomalont, E. Ford, H.A. Foschi, M. Fraga-Encinas, R. Freeman, W.T. Friberg, P. Fromm, C.M. Fuentes, A. Galison, P. Gammie, C.F. García, R. Gentaz, O. Georgiev, B. Goddi, C. Gold, R. Gómez-Ruiz, A.I. Gómez, J.L. Gu, M. Gurwell, M. Hada, K. Haggard, D. Haworth, K. Hecht, M.H. Hesper, R. Heumann, D. Ho, L.C. Ho, P. Honma, M. Huang, C.L. Huang, L. Hughes, D.H. Ikeda, S. Impellizzeri, C.M.V. Inoue, M. James, D.J. Jannuzi, B.T. Jeter, B. Jaing, W. Jiménez-Rosales, A. Jorstad, S. Joshi, A.V. Jung, T. Karami, M. Karuppusamy, R. Kawashima, T. Keating, G.K. Kettenis, M. Kim, D.-J. Kim, J. Kim, J. Kino, M. Koay, J.Y. Kocherlakota, P. Kofuji, Y. Koch, P.M. Koyama, S. Kramer, C. Kramer, J.A. Kramer, M. Kuo, C.-Y. La Bella, N. Lauer, T.R. Lee, D. Lee, S.-S. Leung, P.K. Levis, A. Li, Z. Lico, R. Lindahl, G. Lindqvist, M. Lisakov, M. Liu, J. Liu, K. Liuzzo, E. Lo, W.-P. Lobanov, A.P. Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Department of Astronomy and Atmospheric Sciences Kyungpook National University Daegu702-701 Korea Republic of Institute of Physics Silesian University in Opava Bezručovo nám. 13 OpavaCZ-746 01 Czech Republic Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n GranadaE-18008 Spain Avenida Divina Pastora 7 Local 20 GranadaE-18012 Spain Radboud University P.O. Box 9010 Nijmegen6500 GL Netherlands Black Hole Initiative Harvard University 20 Garden Street CambridgeMA02138 United States Center for Astrophysics Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States Steward Observatory Department of Astronomy University of Arizona 933 N. Cherry Ave. TucsonAZ85721 United States Data Science Institute University of Arizona 1230 N. Cherry Ave. TucsonAZ85721 United States Program in Applied Mathematics University of Arizona 617 N. Santa Rita TucsonAZ85721 United States NASA Hubble Fellowship Program Einstein Fellow United States Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Physics Faculty of Science Universiti Malaya Kuala Lumpur50603 Malaysia Department of Physics & Astronomy The University of Texas at San Antonio One UTSA Circle San AntonioTX78249 United States Institute of Astronomy and Astrophysics Academia Sinica 11F of Astronomy-Mathematics Building AS/NTU No. 1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Departament d’Astronomia i Astrofísica Universitat de València C. Dr. Moliner 50 Burjassot ValènciaE-46100 Spain Observatori Astronòmic Universitat de València C. Catedrático José Beltrán 2 València PaternaE-46980 Spain Department of Space Earth and Environment Chalmers University of Technology Onsala Space Observatory OnsalaSE-43992 Sweden Yale C

Context. 3C 84 is a nearby radio source with a complex total intensity structure, showing linear polarisation and spectral patterns. A detailed investigation of the central engine region necessitates the use of very-long-baseline interferometry (VLBI) above the hitherto available maximum frequency of 86 GHz. Aims. Using ultrahigh resolution VLBI observations at the currently highest available frequency of 228 GHz, we aim to perform a direct detection of compact structures and understand the physical conditions in the compact region of 3C 84. Methods. We used Event Horizon Telescope (EHT) 228 GHz observations and, given the limited (u, v)-coverage, applied geometric model fitting to the data. Furthermore, we employed quasi-simultaneously observed, ancillary multi-frequency VLBI data for the source in order to carry out a comprehensive analysis of the core structure. Results. We report the detection of a highly ordered, strong magnetic field around the central, supermassive black hole of 3C 84. The brightness temperature analysis suggests that the system is in equipartition. We also determined a turnover frequency of νm = (113 ± 4) GHz, a corresponding synchrotron self-absorbed magnetic field of BSSA = (2.9 ± 1.6) G, and an equipartition magnetic field of Beq = (5.2 ± 0.6) G. Three components are resolved with the highest fractional polarisation detected for this object (mnet = (17.0 ± 3.9)%). The positions of the components are compatible with those seen in low-frequency VLBI observations since 2017-2018. We report a steeply negative slope of the spectrum at 228 GHz. We used these findings to test existing models of jet formation, propagation, and Faraday rotation in 3C 84. Conclusions. The findings of our investigation into different flow geometries and black hole spins support an advection-dominated accretion flow in a magnetically arrested state around a rapidly rotating supermassive black hole as a model of the jet-launching system in the core of 3C 84. However,

关键词： Magnetic fields

Mid-Range science Objectives for the Event Horizon Telescope

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arXiv 2024年

作者： Akiyama, Kazunori Albentosa-Ruíz, Ezequiel Alberdi, Antxon Alef, Walter Algaba, Juan Carlos Anantua, Richard Asada, Keiichi Azulay, Rebecca Bach, Uwe Baczko, Anne-Kathrin Ball, David Balokovi, Mislav Bandyopadhyay, Bidisha Barrett, John Baubck, Michi Benson, Bradford A. Bintley, Dan Blackburn, Lindy Blundell, Raymond Bouman, Katherine L. Bower, Geoffrey C. Bremer, Michael Brissenden, Roger Britzen, Silke Broderick, Avery E. Broguiere, Dominique Bronzwaer, Thomas Bustamante, Sandra Carlstrom, John E. Chael, Andrew Chan, Chi-Kwan Chang, Dominic O. Chatterjee, Koushik Chatterjee, Shami Chen, Ming-Tang Chen, Yongjun Cheng, Xiaopeng Cho, Ilje Christian, Pierre Conroy, Nicholas S. Conway, John E. Crawford, Thomas M. Crew, Geoffrey B. Cruz-Osorio, Alejandro Cui, Yuzhu Curd, Brandon Dahale, Rohan Davelaar, Jordy De Laurentis, Mariafelicia Deane, Roger Dempsey, Jessica Desvignes, Gregory Dexter, Jason Dhruv, Vedant Dihingia, Indu K. Doeleman, Sheperd S. Dzib, Sergio A. Eatough, Ralph P. Emami, Razieh Falcke, Heino Farah, Joseph Fish, Vincent L. Fomalont, Edward Ford, H. Alyson Foschi, Marianna Fraga-Encinas, Raquel Freeman, William T. Friberg, Per Fromm, Christian M. Fuentes, Antonio Galison, Peter Gammie, Charles F. García, Roberto Gentaz, Olivier Georgiev, Boris Goddi, Ciriaco Gold, Roman Gómez-Ruiz, Arturo I. Gómez, JoséL Gu, Minfeng Gurwell, Mark Hada, Kazuhiro Haggard, Daryl Hesper, Ronald Heumann, Dirk Ho, Luis C. Ho, Paul Honma, Mareki Huang, Chih-Wei L. Huang, Lei Hughes, David H. Ikeda, Shiro Impellizzeri, C.M. Violette Inoue, Makoto Issaoun, Sara James, David J. Jannuzi, Buell T. Janssen, Michael Jeter, Britton Jiang, Wu Jiménez-Rosales, Alejandra Johnson, Michael D. Jorstad, Svetlana Jones, Adam C. Joshi, Abhishek V. Jung, Taehyun Karuppusamy, Ramesh Kawashima, Tomohisa Keating, Garrett K. Kettenis, Mark Kim, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kino, Motoki Koay, Jun Yi Kocherlakota, Prashant Kofuji, Yutaro Koch, Patrick M. Koyama, Shoko Kramer, Carsten Kramer, Joana A. Kramer, Michael Krichbaum, T Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Black Hole Initiative Harvard University 20 Garden Street CambridgeMA02138 United States Departament d’Astronomia i Astrofísica Universitat de València C. Dr. Moliner 50 Burjassot ValènciaE-46100 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n GranadaE-18008 Spain Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Department of Physics Faculty of Science Universiti Malaya Kuala Lumpur50603 Malaysia Center for Astrophysics Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States Department of Physics & Astronomy The University of Texas at San Antonio One UTSA Circle San AntonioTX78249 United States Institute of Astronomy and Astrophysics Academia Sinica 11F of Astronomy-Mathematics Building AS/NTU No. 1 Sec. 4 Roosevelt Rd. Taipei106216 Taiwan Observatori Astronòmic Universitat de València C. Catedrático JoséBeltrán 2 Paterna ValènciaE-46980 Spain Department of Space Earth and Environment Chalmers University of Technology Onsala Space Observatory OnsalaSE-43992 Sweden Steward Observatory Department of Astronomy University of Arizona 933 N. Cherry Ave. TucsonAZ85721 United States Yale Center for Astronomy & Astrophysics Yale University 52 Hillhouse Avenue New HavenCT06511 United States Astronomy Department Universidad de Concepción Casilla 160-C Concepción Chile Department of Physics University of Illinois 1110 West Green Street UrbanaIL61801 United States Fermi National Accelerator Laboratory MS209 P.O. Box 500 BataviaIL60510 United States Department of Astronomy and Astrophysics University of Chicago 5640 South Ellis Avenue ChicagoIL60637 United States East Asian Observatory 660 N. A’ohoku Place HiloHI96720 United States 660 N. A’ohoku Place HiloHI

The first images of the black holes in Sgr A∗ and M87∗ have created a wide range of new scientific opportunities in gravitational physics, compact objects, and relativistic astrophysics. We discuss here the scientific opportunities that arise from the rich data sets that have already been obtained and the new data sets that will be obtained, exploiting a wide range of technical advances, including observational agility, receiver upgrades, and the addition of new stations. This document provides a 5-year framework for Event Horizon Telescope (EHT) science structured around four fundamental questions that are used to prioritize the analysis of existing data, guide technical upgrades, and determine the optimal use of future observational opportunities with EHT, ALMA, and multi-wavelength facilities. Through enhancements over this period, the EHT will create the first movie of M87∗ connecting black hole and jet physics, provide detailed studies of the structure and dynamics of Sgr A∗, characterize the magnetospheres of both systems through polarimetric imaging, and explore the spacetime properties of black holes with greater precision and range. © 2024, CC BY.

关键词： Astrophysics

Charm- and bottom-quark production in Au+Au collisions at sNN=200 GeV

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Physical Review C 2024年第4期109卷 044907-044907页

作者： N. J. Abdulameer U. Acharya A. Adare C. Aidala N. N. Ajitanand Y. Akiba M. Alfred N. Apadula H. Asano B. Azmoun V. Babintsev M. Bai N. S. Bandara B. Bannier K. N. Barish S. Bathe A. Bazilevsky M. Beaumier S. Beckman R. Belmont A. Berdnikov Y. Berdnikov L. Bichon B. Blankenship D. S. Blau J. S. Bok V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj V. Bumazhnov S. Campbell V. Canoa Roman C.-H. Chen M. Chiu C. Y. Chi I. J. Choi J. B. Choi T. Chujo Z. Citron M. Connors R. Corliss Y. Corrales Morales M. Csanád T. Csörgő T. W. Danley A. Datta M. S. Daugherity G. David C. T. Dean K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond A. Dion P. B. Diss J. H. Do V. Doomra A. Drees K. A. Drees J. M. Durham A. Durum A. Enokizono R. Esha B. Fadem W. Fan N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald S. L. Fokin J. E. Frantz A. Franz A. D. Frawley P. Gallus C. Gal P. Garg H. Ge M. Giles F. Giordano A. Glenn Y. Goto N. Grau S. V. Greene M. Grosse Perdekamp T. Gunji T. Hachiya J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks S. Y. Han M. Harvey S. Hasegawa T. O. S. Haseler K. Hashimoto T. K. Hemmick X. He J. C. Hill A. Hodges R. S. Hollis K. Homma B. Hong T. Hoshino N. Hotvedt J. Huang K. Imai M. Inaba A. Iordanova D. Isenhower D. Ivanishchev B. V. Jacak M. Jezghani X. Jiang Z. Ji B. M. Johnson D. Jouan D. S. Jumper S. Kanda J. H. Kang D. Kawall A. V. Kazantsev J. A. Key V. Khachatryan A. Khanzadeev A. Khatiwada B. Kimelman C. Kim D. J. Kim E.-J. Kim G. W. Kim M. Kim T. Kim D. Kincses A. Kingan E. Kistenev R. Kitamura J. Klatsky D. Kleinjan P. Kline T. Koblesky B. Komkov D. Kotov L. Kovacs B. Kurgyis K. Kurita M. Kurosawa Y. Kwon J. G. Lajoie D. Larionova A. Lebedev S. Lee S. H. Lee M. J. Leitch N. A. Lewis S. H. Lim M. X. Liu X. Li D. A. Loomis D. Lynch S. Lökös T. Majoros Y. I. Makdisi M. Makek A. Manion V. I. Manko E. Mannel M. McCumber P. L. McGaughey D. McGlinchey C. McKinney A. Meles M. Mendoza A. C. Mignerey A. Milov D. K. Mishra J. T. Mitchell M. Mitrankova Iu. Mitrankov S. Miyas Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary Georgia State University Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Department of Physics University of Michigan Ann Arbor Michigan 48109-1040 USA Chemistry Department Stony Brook University SUNY Stony Brook New York 11794-3400 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center Brookhaven National Laboratory Upton New York 11973-5000 USA Department of Physics and Astronomy Howard University Washington DC 20059 USA Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy Stony Brook University SUNY Stony Brook New York 11794-3800 USA Kyoto University Kyoto 606-8502 Japan Physics Department Brookhaven National Laboratory Upton New York 11973-5000 USA IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Brookhaven National Laboratory Upton New York 11973-5000 USA Department of Physics University of Massachusetts Amherst Massachusetts 01003-9337 USA University of California-Riverside Riverside California 92521 USA Baruch College City University of New York New York New York 10010 USA Physics and Astronomy Department University of North Carolina at Greensboro Greensboro North Carolina 27412 USA Saint Petersburg State Polytechnic University St. Petersburg 195251 Russia Vanderbilt University Nashville Tennessee 37235 USA National Research Center “Kurchatov Institute” Moscow 123098 Russia National Research Nuclear University MEPhI Moscow Engineering Physics Institute Moscow 115409 Russia New Mexico State University Las Cruces New Mexico 88003 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Columbia University New York New York 10027 and Nevis Laboratories Irvington New York 10533 USA University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA Je

The invariant yield of electrons from open-heavy-flavor decays for 1<pT<8 GeV/c at midrapidity |y|<0.35 in Au+Au collisions at sNN = 200 GeV has been measured by the PHENIX experiment at the BNL Relativistic ... 详细信息

The invariant yield of electrons from open-heavy-flavor decays for 1

关键词： Hadronic decays Jets & heavy flavor physics Particle & resonance production Bottom quark Charm quark Hadron colliders

The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI

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arXiv 2023年

作者： Moawad, Ahmed W. Janas, Anastasia Baid, Ujjwal Ramakrishnan, Divya Saluja, Rachit Ashraf, Nader Jekel, Leon Amiruddin, Raisa Adewole, Maruf Albrecht, Jake Anazodo, Udunna Aneja, Sanjay Anwar, Syed Muhammad Bergquist, Timothy Calabrese, Evan Chiang, Veronica Chung, Verena Conte, Gian Marco Marco Dako, Farouk Eddy, James Ezhov, Ivan Familiar, Ariana Farahani, Keyvan Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Kazerooni, Anahita Fathi Kofler, Florian Krantchev, Kiril LaBella, Dominic Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Link, Katherine E. Liu, Xinyang Maleki, Nazanin Meier, Zeke Menze, Bjoern H. Moy, Harrison Osenberg, Klara Piraud, Marie Reitman, Zachary Shinohara, Russel Takeshi Tahon, Nourel hoda Nada, Ayman Velichko, Yuri S. Wang, Chunhao Wiestler, Benedikt Wiggins, Walter Shafique, Umber Willms, Klara Avesta, Arman Bousabarah, Khaled Chakrabarty, Satrajit Gennaro, Nicolo Holler, Wolfgang Kaur, Manpreet LaMontagne, Pamela Lin, MingDe Lost, Jan Marcus, Daniel S. Maresca, Ryan Merkaj, Sarah Nada, Ayaman Pedersen, Gabriel Cassinelli von Reppert, Marc Sotiras, Aristeidis Teytelboym, Oleg Tillmans, Niklas Westerhoff, Malte Youssef, Ayda Godfrey, Devon Floyd, Scott Rauschecker, Andreas Villanueva-Meyer, Javier Pflüger, Irada Cho, Jaeyoung Bendszus, Martin Brugnara, Gianluca Cramer, Justin Perez-Carillo, Gloria Guzman J. Johnson, Derek R. Kam, Anthony Kwan, Benjamin Yin Ming Lai, Lillian Lall, Neil U. Memon, Fatima Patro, Satya Narayana Petrovic, Bojan So, Tiffany Y. Thompson, Gerard Wu, Lei Schrickel, E. Brooke Bansal, Anu Barkhof, Frederik Besada, Cristina Chu, Sammy Druzgal, Jason Dusoi, Alexandru Farage, Luciano Feltrin, Fabricio Fong, Amy Fung, Steve H. Gray, R. Ian Ikuta, Ichiro Iv, Michael Postma, Alida A. Mahajan, Amit Joyner, David Krumpelman, Chase Letourneau-Guillon, Laurent Lincoln, Christie M. Maros, Mate E. Miller, Elka Morón, Fanny Nimchinsky, Esther A. Ozsarlak, Ozkan Patel, Uresh Rohatgi, Saurabh Saha, Atin Sayah, Anousheh Schwartz, Eric D. Shih, Robert Shiroishi, Mark Trinity health Mid Atlantic Hosiptals DarbyPA United States Department of Radiology and Biomedical Imaging Yale School of Medicine New HavenCT United States Division of Computational Pathology Department of Pathology and Laboratory Medicine School of Medicine Indiana University IndianapolisIN United States Department of Electical and Computer Engineering Cornell University Cornell Tech New YorkNY United States Department of Radiology Weill Cornell Medicine New YorkNY United States ImagineQuant Children’s Hospital of Philadelphia PhiladelphiaPA United States College of Medicine Alfaisal University Riyadh Saudi Arabia DKFZ Division of Translational Neurooncology The WTZ German Cancer Consortium DKTK Partner Site University Hospital Essen Essen Germany Medical Artificial Intelligence Lab Crestview Radiology Lagos Nigeria Sage Bionetworks SeattleWA United States Montreal Neurological Institute McGill University Montreal Canada lab Crestview Radiology Lagos Nigeria Department of Therapeutic Radiology Yale School of Medicine New HavenCT United States Sheikh Zayed Institute for Pediatric Surgical Innovation Children’s National Hospital WashingtonDC United States Department of Radiology Mayo Clinic RochesterMN United States Department of Radiology Duke University Medical Center DurhamNC United States Department of Neurosurgery Yale School of Medicine New HavenCT United States Center for Global Health Perelman School of Medicine University of Pennsylvania PA United States Department of Informatics Technical University Munich Germany Children’s Hospital of Philadelphia University of Pennsylvania PhiladelphiaPA United States Cancer Imaging Program National Cancer Institute National Institutes of Health BethesdaMD United States Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital BostonMA United States Children’s National Hospital WashingtonDC United States PrecisionFDA U.S. Food and Drug Administration S

The translation of AI-generated brain metastases (BM) segmentation into clinical practice relies heavily on diverse, high-quality annotated medical imaging datasets. The BraTS-METS 2023 challenge has gained momentum for testing and benchmarking algorithms using rigorously annotated internationally compiled real-world datasets. This study presents the results of the segmentation challenge and characterizes the challenging cases that impacted the performance of the winning algorithms. Untreated brain metastases on standard anatomic MRI sequences (T1, T2, FLAIR, T1PG) from eight contributed international datasets were annotated in stepwise method: published UNET algorithms, student, neuroradiologist, final approver neuroradiologist. Segmentations were ranked based on lesion-wise Dice and Hausdorff distance (HD95) scores. False positives (FP) and false negatives (FN) were rigorously penalized, receiving a score of 0 for Dice and a fixed penalty of 374 for HD95. The mean scores for the teams were calculated. Eight datasets comprising 1303 studies were annotated, with 402 studies (3076 lesions) released on Synapse as publicly available datasets to challenge competitors. Additionally, 31 studies (139 lesions) were held out for validation, and 59 studies (218 lesions) were used for testing. Segmentation accuracy was measured as rank across subjects, with the winning team achieving a LesionWise mean score of 7.9. The Dice score for the winning team was 0.65 ± 0.25. Common errors among the leading teams included false negatives for small lesions and misregistration of masks in space. The Dice scores and lesion detection rates of all algorithms diminished with decreasing tumor size, particularly for tumors smaller than 100 mm3. In conclusion, algorithms for BM segmentation require further refinement to balance high sensitivity in lesion detection with the minimization of false positives and negatives. The BraTS-METS 2023 challenge successfully curated well-annotated, diverse d

关键词： Image segmentation

Identified charged-hadron production in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and in U+U collisions at sNN=193GeV

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Physical Review C 2024年第5期109卷 054910-054910页

作者： N. J. Abdulameer U. Acharya A. Adare C. Aidala N. N. Ajitanand Y. Akiba R. Akimoto J. Alexander M. Alfred V. Andrieux K. Aoki N. Apadula H. Asano E. T. Atomssa T. C. Awes B. Azmoun V. Babintsev M. Bai X. Bai N. S. Bandara B. Bannier K. N. Barish S. Bathe V. Baublis C. Baumann S. Baumgart A. Bazilevsky M. Beaumier S. Beckman R. Belmont A. Berdnikov Y. Berdnikov L. Bichon D. Black B. Blankenship D. S. Blau J. S. Bok V. Borisov K. Boyle M. L. Brooks J. Bryslawskyj H. Buesching V. Bumazhnov S. Butsyk S. Campbell V. Canoa Roman R. Cervantes C.-H. Chen D. Chen M. Chiu C. Y. Chi I. J. Choi J. B. Choi S. Choi P. Christiansen T. Chujo V. Cianciolo Z. Citron B. A. Cole M. Connors R. Corliss Y. Corrales Morales N. Cronin N. Crossette M. Csanád T. Csörgő L. D'Orazio T. W. Danley A. Datta M. S. Daugherity G. David C. T. Dean K. DeBlasio K. Dehmelt A. Denisov A. Deshpande E. J. Desmond L. Ding A. Dion P. B. Diss D. Dixit V. Doomra J. H. Do O. Drapier A. Drees K. A. Drees J. M. Durham A. Durum H. En'yo T. Engelmore A. Enokizono R. Esha K. O. Eyser B. Fadem W. Fan N. Feege D. E. Fields M. Finger, Jr. M. Finger D. Firak D. Fitzgerald F. Fleuret S. L. Fokin J. E. Frantz A. Franz A. D. Frawley Y. Fukao Y. Fukuda T. Fusayasu K. Gainey P. Gallus C. Gal P. Garg A. Garishvili I. Garishvili H. Ge M. Giles F. Giordano A. Glenn X. Gong M. Gonin Y. Goto R. Granier de Cassagnac N. Grau S. V. Greene M. Grosse Perdekamp Y. Gu T. Gunji T. Guo H. Guragain T. Hachiya J. S. Haggerty K. I. Hahn H. Hamagaki H. F. Hamilton J. Hanks S. Y. Han M. Harvey S. Hasegawa T. O. S. Haseler K. Hashimoto R. Hayano T. K. Hemmick T. Hester X. He J. C. Hill K. Hill A. Hodges R. S. Hollis K. Homma B. Hong T. Hoshino N. Hotvedt J. Huang T. Ichihara Y. Ikeda K. Imai Y. Imazu M. Inaba A. Iordanova D. Isenhower A. Isinhue D. Ivanishchev B. V. Jacak S. J. Jeon M. Jezghani X. Jiang Z. Ji B. M. Johnson K. S. Joo D. Jouan D. S. Jumper J. Kamin S. Kanda B. H. Kang J. H. Kang J. S. Kang D. Kapukchyan J. Kapustinsky S. Karthas D. Kawall A. V. Kazantsev J. A. Key V. Khachatrya Debrecen University H-4010 Debrecen Egyetem tér 1 Hungary Georgia State University Atlanta Georgia 30303 USA University of Colorado Boulder Colorado 80309 USA Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Department of Physics University of Michigan Ann Arbor Michigan 48109 USA Chemistry Department State University of New York at Stony Brook Stony Brook New York 11794 USA RIKEN Nishina Center for Accelerator-Based Science Wako Saitama 351-0198 Japan RIKEN BNL Research Center Brookhaven National Laboratory Upton New York 11973 USA Center for Nuclear Study Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo Tokyo 113-0033 Japan Department of Physics and Astronomy Howard University Washington DC 20059 USA KEK High Energy Accelerator Research Organization Tsukuba Ibaraki 305-0801 Japan Iowa State University Ames Iowa 50011 USA Department of Physics and Astronomy State University of New York at Stony Brook Stony Brook New York 11794 USA Kyoto University Kyoto 606-8502 Japan Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Physics Department Brookhaven National Laboratory Upton New York 11973 USA IHEP Protvino State Research Center of Russian Federation Institute for High Energy Physics Protvino 142281 Russia Collider-Accelerator Department Brookhaven National Laboratory Upton New York 11973 USA Science and Technology on Nuclear Data Laboratory China Institute of Atomic Energy Beijing 102413 People's Republic of China Department of Physics University of Massachusetts Amherst Massachusetts 01003 USA University of California-Riverside Riverside California 92521 USA Baruch College City University of New York New York New York 10010 USA Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russia Physics and Astronomy Department University of North Carolina at Greensboro Greensboro North Carolina 27412 USA Vanderbilt University Nashville Tennessee 37235 USA Saint Petersburg Stat

The PHENIX experiment has performed a systematic study of identified charged-hadron (π±, K±, p, p¯) production at midrapidity in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and U+U collisions at sNN=193GeV. Identified charged-hadron invariant transverse-momentum (pT) and transverse-mass (mT) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle ratios of K/π and p/π have been measured in different centrality ranges of large (Cu+Au and U+U) and small (p+Al and He3+Au) collision systems. The values of K/π ratios measured in all considered collision systems were found to be consistent with those measured in p+p collisions. However, the values of p/π ratios measured in large collision systems reach the values of ≈0.6, which is a factor of ≈2 larger than in p+p collisions. These results can be qualitatively understood in terms of the baryon enhancement expected from hadronization by recombination. Identified charged-hadron nuclear-modification factors (RAB) are also presented. Enhancement of proton RAB values over meson RAB values was observed in central He3+Au, Cu+Au, and U+U collisions. The proton RAB values measured in the p+Al collision system were found to be consistent with RAB values of ϕ, π±, K±, and π0 mesons, which may indicate that the size of the system produced in p+Al collisions is too small for recombination to cause a noticeable increase in proton production.

关键词： Hadron production Relativistic heavy-ion collisions Hadrons Kaons Pions Protons