The present book develops the mathematical and numerical analysis of linear, elliptic and parabolic partial differential equations (PDEs) with coefficients whose logarithms are modelled as Gaussian random fields (GRFs...
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ISBN:
(数字)9783031383847
ISBN:
(纸本)9783031383830
The present book develops the mathematical and numerical analysis of linear, elliptic and parabolic partial differential equations (PDEs) with coefficients whose logarithms are modelled as Gaussian random fields (GRFs), in polygonal and polyhedral physical domains. Both, forward and Bayesian inverse PDE problems subject to GRF priors are considered.;Adopting a pathwise, affine-parametric representation of the GRFs, turns the random PDEs into equivalent, countably-parametric, deterministic PDEs, with nonuniform ellipticity constants. A detailed sparsity analysis of Wiener-Hermite polynomial chaos expansions of the corresponding parametric PDE solution families by analytic continuation into the complex domain is developed, in corner- and edge-weighted function spaces on the physical domain.;The presented Algorithms and results are relevant for the mathematical analysis of many approximation methods for PDEs with GRF inputs, such as model order reduction, neural network and tensor-formatted surrogates of parametric solution families. They are expected to impact computational uncertainty quantification subject to GRF models of uncertainty in PDEs, and are of interest for researchers and graduate students in both, applied and computational mathematics, as well as in computational science and engineering.
This book compiles research and surveys devoted to the areas of mathematical analysis, approximation theory, and optimization. Being dedicated to A.-M. Legendre's work, contributions to this volume are devoted to ...
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ISBN:
(数字)9783031464874
ISBN:
(纸本)9783031464867;9783031464898
This book compiles research and surveys devoted to the areas of mathematical analysis, approximation theory, and optimization. Being dedicated to A.-M. Legendre's work, contributions to this volume are devoted to those branches of mathematics and its applications that have been influenced, directly or indirectly, by the mathematician. Additional contributions provide a historical background as it relates to Legendre's work and its association to the foundation of Greece's higher education.;Topics covered in this book include the investigation of the Jensen-Steffensen inequality, Ostrowski and trapezoid type inequalities, a Hilbert-Type Inequality, Hardy’s inequality, dynamic unilateral contact problems, square-free values of a category of integers, a maximum principle for general nonlinear operators, the application of Ergodic Theory to an alternating series expansion for real numbers, bounds for similarity condition numbers of unbounded operators, finite element methods with higher order polynomials, generating functions for the Fubini type polynomials, local asymptotics for orthonormal polynomials, trends in geometric function theory, quasi variational inclusions, Kleene fixed point theorems, ergodic states, spontaneous symmetry breaking and quasi-averages.
Targeted therapies, immunotherapies, and improved chemotherapies are being developed to reduce the suffering and mortality that come from human cancer. Although these approaches, and in particular combinations of them...
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Targeted therapies, immunotherapies, and improved chemotherapies are being developed to reduce the suffering and mortality that come from human cancer. Although these approaches, and in particular combinations of them, are expected to succeed eventually to a large degree, they all suffer one obstacle: Populations of replicating cells move away—typically in a high-dimensional space—from any opposing selection pressure they encounter. They evolve resistance. It is possible, however, to develop a precise mathematical understanding of the problem and to design treatment strategies that prevent resistance if possible or manage resistance otherwise. In this article, we present the fundamental equations that characterize the evolution of resistance. We provide formulas for the probability that resistant cells exist at the start of therapy, for the average number and sizes of resistant clones, and for the probability of successful combination treatment. We also demonstrate that developing new therapies that only maximize the killing rate of cancer cells may not be optimal, and that instead the parameters determining the fraction of resistant cells and their growth rate have a larger effect on the long-term control of cancer. These mathematical tools inform the search process for optimal therapies that aim to cure cancer.
This IMA Volume in mathematics and its Applications MULTIDIMENSIONAL HYPERBOLIC PROBLEMS AND COMPUTATIONS is based on the proceedings of a workshop which was an integral part ofthe 1988-89 IMA program on NONLINEAR WAV...
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ISBN:
(数字)9781461391210
ISBN:
(纸本)9781461391234
This IMA Volume in mathematics and its Applications MULTIDIMENSIONAL HYPERBOLIC PROBLEMS AND COMPUTATIONS is based on the proceedings of a workshop which was an integral part ofthe 1988-89 IMA program on NONLINEAR WAVES. We are grateful to the Scientific Commit tee: James Glimm, Daniel Joseph, Barbara Keyfitz, Andrew Majda, Alan Newell, Peter Olver, David Sattinger and David Schaeffer for planning and implementing an exciting and stimulating year-long program. We especially thank the Work shop Organizers, Andrew Majda and James Glimm, for bringing together many of the major figures in a variety of research fields connected with multidimensional hyperbolic problems. A vner Friedman Willard Miller PREFACE A primary goal of the IMA workshop on Multidimensional Hyperbolic Problems and Computations from April 3-14, 1989 was to emphasize the interdisciplinary nature of contemporary research in this field involving the combination of ideas from the theory of nonlinear partial differential equations, asymptotic methods, numerical computation, and experiments. The twenty-six papers in this volume span a wide cross-section of this research including some papers on the kinetic theory of gases and vortex sheets for incompressible flow in addition to many papers on systems of hyperbolic conservation laws. This volume includes several papers on asymptotic methods such as nonlinear geometric optics, a number of articles applying numerical algorithms such as higher order Godunov methods and front tracking to physical problems along with comparison to experimental data, and also several interesting papers on the rigorous mathematical theory of shock waves.
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