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Immunometabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease Comorbidity

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Biological Psychiatry Global Open science 2025年第5期5卷

作者： Angela Koloi Nabila P.R. Siregar Rick Quax Antonis I. Sakellarios Femke Lamers Arja Rydin Kevin Dobretz Costas Papaloukas Dimitrios I. Fotiadis Jos A. Bosch Unit of Medical Technology and Intelligent Information Systems Department of Materials Science and Engineering University of Ioannina Ioannina Greece Department of Biological Applications and Technology University of Ioannina Ioannina Greece Department of Clinical Psychology University of Amsterdam Amsterdam the Netherlands Department of Medical Psychology Amsterdam University Medical Center Amsterdam the Netherlands Computational Science Laboratory Institute of Informatics University of Amsterdam Amsterdam the Netherlands Biomedical Engineering of the Department of Mechanical Engineering and Aeronautics University of Patras Patras Greece Department of Psychiatry Amsterdam University Medical Center VU Amsterdam Amsterdam the Netherlands Amsterdam Public Health Mental Health Program Amsterdam the Netherlands Cardiology Geneva University Hospitals Geneva Switzerland Department of Medicine University of Geneva Geneva Switzerland Biomedical Research Institute Foundation for Research and Technology - Hellas Ioannina Greece

Background Major depressive disorder (MDD) and cardiovascular diseases (CVDs) often co-occur whereby comorbidity results in poorer clinical outcomes, presumably due to shared immunometabolic pathways. Identifying shared biomarkers for MDD-CVD comorbidity may provide targets for prevention or treatment. Methods Using data from the NESDA (Netherlands Study of Depression and Anxiety) ( n = 2256, 66.3% female, mean age 41.86 ± 13.08 years at baseline), validated with the UK Biobank (UKB) data ( n = 35,668, 56.14% female, mean age 63.95 ± 7.74 years), this study aimed to identify 1) biomarkers, closely associated with current MDD, and 2) longitudinal pathways linking MDD and atherosclerotic CVD. Plasma metabolites (nuclear magnetic resonance) and inflammatory markers were used as exposures within a machine learning framework. Influential biomarkers were integrated into a temporal network analysis linking MDD to subsequent CVDs, exploring longitudinal pathways through causal discovery, validated by sensitivity analysis and centrality assessment. External validation included mediation and regression analysis adjusting for covariates. Results Network analysis identified stable direct paths from MDD to CVDs via tumor necrosis factor α (TNF-α), tyrosine, and fatty acids and indirect paths via acetate, high-density lipoprotein (HDL) diameter, interleukin 6, AGP, high-sensitivity C-reactive protein, and low-density lipoprotein triglycerides. Among these, acetate, tyrosine, AGP (α 1 -acid glycoprotein), and HDL diameter potentially mediated the MDD-CVD connection, given that these were identified as key nodes within the network. UKB validation confirmed HDL diameter (β = 0.004) and AGP (β = 0.003) as significant depression-CVD mediators (both p < .001), after adjusting for age, sex, deprivation index, alcohol consumption, smoking status, physical activity, and body mass index. Conclusions These analyses identified biomarkers shared in MDD and CVDs and may drive comorbid patholog

关键词： Biomarkers CVD Machine learning MDD Mediators

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Marangoni convection-driven laser fountains and waves on free surfaces of liquids

arXiv

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arXiv 2021年

作者： Lin, Feng Quraishy, Aamir Nasir Tong, Tian Li, Runjia Yang, Guang Mohebinia, Mohammadjavad Qiu, Yi Vishal, Talari Zhao, Junyi Zhang, Wei Zhong, Hong Zhang, Hang Zhou, Chaofu Tong, Xin Yu, Peng Hu, Jonathan Dong, Suchuan Liu, Dong Wang, Zhiming Schaibley, John R. Bao, Jiming Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China ChengduSichuan610054 China Department of Electrical and Computer Engineering University of Houston HoustonTX77204 United States Department of Physics University of Arizona TucsonAZ85721 United States James C. Wyant College of Optical Sciences University of Arizona TucsonAZ85721 United States Department of Mechanical Engineering University of Houston HoustonTX77204 United States Materials Science and Engineering Program University of Houston HoustonTX77204 United States School of Science Southwest Petroleum University ChengduSichuan610500 China Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Computer Engineering Baylor University WacoTX76798 United States Department of Mathematics Purdue University West LafayetteIN47907 United States Department of Physics Texas Center for Superconductivity University of Houston HoustonTX77204 United States

It is well accepted that an outward Marangoni convection from a low surface tension region will make the surface depressed. Here, we report that this established perception is only valid for thin liquid films. Using surface laser heating, we show that in deep liquids a laser beam actually pulls up the fluid above the free surface generating fountains with different shapes. Whereas with decreasing liquid depth a transition from fountain to indentation with fountain-in-indentation is observed. Further, high-speed imaging reveals a transient surface process before steady elevation is formed, and this dynamic deformation is subsequently utilized to resonantly excite giant surface waves by a modulated laser beam. Computational fluid dynamics models reveal the underlying flow patterns and quantify the depth-dependent and time-resolved surface deformations. Our discoveries and techniques have upended the century-old perception and opened up a new regime of interdisciplinary research and applications of Marangoni-induced interface phenomena and optocapillary fluidic surfaces - the control of fluids with light. © 2021, CC BY.

关键词： Deformation

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Thermopower across the phase diagram of the cuprate La1.6−xNd0.4SrxCuO4: Signatures of the pseudogap and charge density wave phases

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Physical Review B 2021年第15期103卷 155102-155102页

作者： C. Collignon A. Ataei A. Gourgout S. Badoux M. Lizaire A. Legros S. Licciardello S. Wiedmann J.-Q. Yan J.-S. Zhou Q. Ma B. D. Gaulin Nicolas Doiron-Leyraud Louis Taillefer Institut Quantique Département de physique & RQMP Université de Sherbrooke Sherbrooke Québec J1K 2R1 Canada SPEC CEA CNRS-UMR 3680 Universite Paris-Saclay 91191 Gif sur Yvette Cedex France High Field Magnet Laboratory (HFML-EMFL) & Institute for Molecules and Materials Radboud University 6525 ED Nijmegen The Netherlands Materials Science and Engineering Program Mechanical Engineering University of Texas at Austin Austin Texas 78712 USA Department of Physics and Astronomy McMaster University Hamilton Ontario L8S 4M1 Canada Canadian Institute for Advanced Research Toronto Ontario M5G 1M1 Canada

The Seebeck coefficient (thermopower) S of the cuprate superconductor La1.6−xNd0.4SrxCuO4 was measured across its doping phase diagram (from p=0.12 to p=0.25), at various temperatures down to T≃2 K, in the normal state accessed by suppressing superconductivity with a magnetic field up to H=37.5 T. The magnitude of S/T in the T=0 limit is found to suddenly increase, by a factor ≃5, when the doping is reduced below p★=0.23, the critical doping for the onset of the pseudogap phase. This confirms that the pseudogap phase causes a large reduction of the carrier density n, consistent with a drop from n=1+p above p★ to n=p below p★, as previously inferred from measurements of the Hall coefficient, resistivity, and thermal conductivity. When the doping is reduced below p=0.19, a qualitative change is observed whereby S/T decreases as T→0, eventually to reach negative values at T=0. In prior work on other cuprates, negative values of S/T at T→0 were shown to result from a reconstruction of the Fermi surface caused by charge density wave (CDW) order. We therefore identify pCDW≃0.19 as the critical doping beyond which there is no CDW-induced Fermi surface reconstruction. The fact that pCDW is well separated from p★ reveals that there is a doping range below p★ where the transport signatures of the pseudogap phase are unaffected by CDW correlations, as previously found in YBa2Cu3Oy and La2−xSrxCuO4.

关键词： Electronic structure Pseudogap Seebeck effect Superconductivity Thermopower Cuprates

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Confining and channeling sound through coupled resonators

arXiv

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arXiv 2020年

作者： Zhou, Yun Bandaru, Prabhakar R. Sievenpiper, Daniel F. Department of Mechanical Engineering University of California San Diego San DiegoCA92093 United States Program in Materials Science University of California San Diego San DiegoCA92093 United States Department of Electrical Engineering University of California San Diego San DiegoCA92093 United States

Confining sound is of significant importance for the manipulation and routing acoustic waves. We propose a Helmholtz resonator (HR) based subwavelength sound channel formed at the interface of two metamaterials, for this purpose. The confinement is quantified through (i) a substantial reduction of the pressure, and (ii) an increase in a specific acoustic impedance (defined by the ratio of the local pressure to the sound velocity) - to a very large value outside the channel. The sound confinement is robust to frequency as well as spatial disorder at the interface, as long as the interface related edge mode is situated within the band gap. A closed acoustic circuit was formed by introducing controlled disorder in the HR units at the corners, indicating the possibility of confining sound to a point. Copyright © 2020, The Authors. All rights reserved.

关键词： Acoustic impedance

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Surgical mesh coatings for infection control and temperature sensing: An in-vitro investigation

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OpenNano 2021年 5卷

作者： Houshyar, Shadi Mirzadeh, Nedaossadat Pillai, Mamatha Muraleedharan Saha, Tanushree Khalid, Asma Bhattacharyya, Amitava Dekiwadia, Chaitali Zizhou, Rumbidzai Cryle, Max J. Payne, Jennifer A.E. Bhargava, Suresh Fox, Kate Tran, Phong A. College of Science Engineering and Health School of Engineering RMIT University Melbourne 3001 Australia The Center for Advanced Materials and Industrial Chemistry College of Science Engineering and Health RMIT University GPO Box 2476V Melbourne 3001 VIC Australia Tissue Engineering Laboratory PSG Institute of Advanced Studies Coimbatore 641004 India Department of Textile Engineering Dhaka University of Engineering and Technology Gazipur-1707 Gazipur Bangladesh College of Science Engineering and Health School of Applied Sciences RMIT University Melbourne 3000 Australia Functional Innovative and Smart Textiles PSG Institute of Advanced Studies Coimbatore 641004 India RMIT Microscopy and Microanalysis Facility College of Science Engineering and Health RMIT University Melbourne 3000 Australia School of Fashion and Textiles RMIT University Brunswick Victoria 3056 Australia Department of Biochemistry and Molecular Biology Infection and Immunity Program The Monash Biomedicine Discovery Institute Monash University EMBL Clayton 3800 VIC Australia Centre for Biomedical Technologies 2 George Street Queensland University of Technology (QUT) Brisbane 4000 QLD Australia Interface Science and Materials Engineering Group School of Mechanical Medical and Process Engineering QUT 2 George Street Brisbane 4000 QLD Australia

Polypropylene (PP) remains the primary material for hernia meshes due to its biocompatibility, physical strength and ease of fabrication. However, PP meshes are still subject to complications such as mesh movement and bacterial infection that ultimately lead to mesh failure. This study describes a two-step functionalization of a PP mesh through dopamine-mediated chloro(triphenylphosphine)gold(I)/nanodiamond coatings. The gold compound provided an intrinsic surface with antimicrobial activity to the coatings, whilst the overall improvement in hydrophilicity and roughness allows for efficient adsorption of antibiotics with an aim for eradicating bacteria in the surrounding tissue. The presence of a gold compound on the surface of the mesh enhanced its contrast property, which may provide a surgical application to determine the ease of monitoring the PP mesh location after implantation inside the body to detect possible tears. Photostable negatively charged nitrogen-vacancy centres within the nanodiamonds provides an exciting possibility to optically assess locally elevated temperatures often associated with infection or excessive inflammation. The biocompatibility, antibiotic loading and associated antimicrobial properties of the coated mesh were investigated to show the potential of this new coating for future applications in hernia surgical procedures. © 2021

关键词： Chloro(triphenylphosphine)gold(I) Hernia mesh Nanodiamond Polypropylene Temperature sensing

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Ionic Liquids: Lubrication Mechanism of Phosphonium Phosphate Ionic Liquid in Nanoscale Single-Asperity Sliding Contacts (Adv. Mater. Interfaces 17/2020)

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Advanced materials Interfaces 2020年第17期7卷

作者： Li, Zixuan Dolocan, Andrei Morales-Collazo, Oscar Sadowski, Jerzy T. Celio, Hugo Chrostowski, Robert Brennecke, Joan F. Mangolini, Filippo Texas Materials Institute The University of Texas at Austin AustinTX78712 United States Materials Science and Engineering Program The University of Texas at Austin AustinTX78712 United States McKetta Department of Chemical Engineering The University of Texas at Austin AustinTX78712 United States Center for Functional Nanomaterials Brookhaven National Laboratory UptonNY11973 United States J. Mike Walker Department of Mechanical Engineering The University of Texas at Austin AustinTX78712 United States

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The structural, vibrational, and mechanical properties of jammed packings of deformable particles in three dimensions

arXiv

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arXiv 2021年

作者： Wang, Dong Treado, John D. Boromand, Arman Norwick, Blake Murrell, Michael P. Shattuck, Mark D. O'Hern, Corey S. Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Physics Yale University New HavenCT06520 United States Department of Biomedical Engineering Yale University New HavenCT06520 United States Systems Biology Institute Yale University West HavenCT06516 United States Benjamin Levich Institute and Physics Department The City College of New York New YorkNY10031 United States Department of Applied Physics Yale University New HavenCT06520 United States

We investigate the structural, vibrational, and mechanical properties of jammed packings of deformable particles with shape degrees of freedom in three dimensions (3D). Each 3D deformable particle is modeled as a surface-triangulated polyhedron, with spherical vertices whose positions are determined by a shape-energy function with terms that constrain the particle surface area, volume, and curvature, and prevent interparticle overlap. We show that jammed packings of deformable particles without bending energy possess low-frequency, quartic vibrational modes, whose number decreases with increasing asphericity and matches the number of missing contacts relative to the isostatic value. In contrast, jammed packings of deformable particles with non-zero bending energy are isostatic in 3D, with no quartic modes. We find that the contributions to the eigenmodes of the dynamical matrix from the shape degrees of freedom are significant over the full range of frequency and shape parameters for particles with zero bending energy. We further show that the ensembleaveraged shear modulus hGi scales with pressure P as hGi ∼ pβ, with β ≈ 0.75 for jammed packings of deformable particles with zero bending energy. In contrast, β ≈ 0.5 for packings of deformable particles with non-zero bending energy, which matches the value for jammed packings of soft, spherical particles with fixed shape. These studies underscore the importance of incorporating particle deformability and shape change when modeling the properties of jammed soft materials. © 2021, CC BY.

关键词： Degrees of freedom (mechanics)

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Influence of Morphology on Fracture Propagation of PMMAe/PC Blend in Tensile Tests at High Strain Rate

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Macromolecular Symposia 2020年第1期394卷 2000153-2000153页

作者： Gomes, Felipe Pedro da Costa Reinaldo, Juciklécia da Silva Rodrigues, Antônio Henrique Venâncio de Macedo, Thatiana Cristina Pereira Silva, Bismarck Luiz Ito, Edson Noriyuki Graduate Program in Materials Science and Engineering Federal University of Rio Grande do Norte Avenida Senador Salgado Filho 3000 NatalRio Grande do Norte59078–970 Brazil Mechanical Engineering Department Federal University of Rio Grande do Norte Avenida Senador Salgado Filho 3000 NatalRio Grande do Norte59078–970 Brazil Graduate Program in Materials Science and Engineering Federal University of Sergipe Avenida Marechal Rondon s/n 49100-000 São CristóvãoSergipe Brazil Materials Engineering Department Federal University of Rio Grande do Norte Avenida Senador Salgado Filho 3000 NatalRio Grande do Norte59078–970 Brazil

The aim of this study is to evaluate toughness mechanism of elastomeric poly(methyl methacrylate) (PMMAe) and polycarbonate (PC) blend through crack propagation at high speed tensile tests. Samples are processed using two types of extruders, single and twin screw, in order to eliminate the influence of processing in the final product's properties. Pure polymers and polymer blend samples are cryo-ultramicrotomed and their morphology is characterized using atomic force microscopy (AFM). Fractured samples obtained from uniaxial tensile tests at high strain rate are inspected using optical microscopy (OM) and scanning electron microscopy (SEM). The results obtained for the PMMAe/PC blend in tests at high deformation rate showed that the shear rate during the mixing process influences the maximum strength of the polymer blend near its region of co-continuous morphology. The visual evaluation of the fracture surface and the fractographic analysis corroborated the results of this study of polymer toughening. © 2020 Wiley-VCH GmbH

关键词： Fracture

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Perspective: mechanical properties of stabilized nanocrystalline FCC metals

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Journal of Applied Physics 2019年第11期126卷

作者： Spearot, Douglas E. Tucker, Garritt J. Gupta, Ankit Thompson, Gregory B. Department of Mechanical and Aerospace Engineering University of Florida GainesvilleFL32611 United States Department of Mechanical Engineering Materials Science Program Colorado School of Mines GoldenCO80401 United States Department of Metallurgical and Materials Engineering University of Alabama TuscaloosaAB35487 United States

In this perspective, recent advances and current research challenges concerning the mechanical properties of stabilized nanocrystalline face-centered cubic (FCC) metals are discussed. First, a brief review of key experiments and modeling efforts over the last two decades is provided, with a focus on elucidating the mechanisms associated with plastic yield, hardening, and microstructure stabilization in nanocrystalline metals. This prior work has provided an understanding of the transition between dislocation-based and grain boundary-mediated mechanisms in plasticity and has identified several strategies to mitigate temperature or stress driven grain growth. Yet, the consequence of various stabilization methods on mechanical properties is not well understood. Future research challenges are presented in order to address this scientific gap, most critically the need to include grain boundary chemistry or grain boundary phases resulting from stabilization methods in new mechanistic theories for mechanical properties of nanocrystalline FCC metals. © 2019 Author(s).

关键词： Grain boundaries

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A facile method for fabrication of nano-structured Ni-Al_2O_3 graded coatings: Structural characterization

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Transactions of Nonferrous Metals Society of China 2018年第1期28卷 77-87页

作者： Arash YAZDANI Taghi ISFAHANI Materials Science and Engineering Program University of California Department of Mechanical and Aerospace Engineering University of California Metallurgy & Materials Engineering Department Golpayegan University of Technology

Powder charges of micron-size Ni and Al2O3were utilized to deposit nano-structured Ni-Al2O3composite coatings on analuminum plate fixed at the top end of a milling vial using a planetary ball *** coatings were fabricated using powdermixtures with a wide range of Ni/Al2O3mass ratio varying from1:1to plain ***,SEM and TEM techniques were employed tostudy the structural characteristics of the *** was found that the composition of the starting mixture strongly affects the Al2O3content and the microstructure of the final *** containing higher contents of Al2O3yield higher volume fractions of theAl2O3particles in the *** Ni-Al2O3composite coatings with about50%of Al2O3particles were successfully deposited,well-compacted and free of cracks and/or voids coatings included less than20%(volume fraction)of Al2O3particles which weredeposited from powder mixtures with Ni/Al2O3mass ratios of4:1or ***,mechanical and metallurgical bondings arethe main mechanisms of the adhesion of the coating to the Al ***,functionally graded composite coatings withnoticeable compaction and integrity were produced by deposition of two separate layers under identical coating conditions.

关键词： metal matrix composite Ni-Al2O3 graded coating structural characterization

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